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Rare earth upconversion nanoparticles, preparation method and uses thereof

A rare earth up-conversion and nano-particle technology, applied in the field of nanoparticles, can solve the problems of high excitation light source intensity and low conversion luminescence quantum yield, and achieve the effect of improving the up-conversion luminescence quantum yield

Active Publication Date: 2015-12-23
THE NAT CENT FOR NANOSCI & TECH NCNST OF CHINA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Nevertheless, the rare earth up-conversion nanoparticles require high excitation light source intensity, and their up-conversion luminescence quantum yield is still low.

Method used

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  • Rare earth upconversion nanoparticles, preparation method and uses thereof
  • Rare earth upconversion nanoparticles, preparation method and uses thereof
  • Rare earth upconversion nanoparticles, preparation method and uses thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0067] Example 1: Rare earth up-conversion nanoparticles NaYF 4 :Yb,Er@NaYF 4 :Yb@NaNdF 4 :Yb

[0068] Will be stoichiometric ratio CF 3 COONa:(CF 3 COO) 3 Y:(CF 3 COO) 3 Yb:(CF 3 COO) 3 Er=1mmol: 0.78mmol: 0.3mmol: 0.02mmol The prepared mixed powder was added to the mixed system of oleic acid (10mL) and octadecene (20mL), stirred under vacuum at 120°C for 30min, and then heated to 320°C for 1 hour; after cooling, centrifuge, wash with ethanol for 1-2 times, and disperse with 2mL cyclohexane to obtain dispersion I.

[0069] Add dispersion I to CF 3 COONa:(CF 3 COO) 3 Y:(CF 3 COO) 3 Yb=0.3mmol:0.27mmol:0.9mmol, in a mixed solution of oleic acid (20mL) and octadecene (20mL), stirred under vacuum at 120°C for 30min, then heated to 300°C under argon protection and continued for 1h; cooled Afterwards, centrifuge, wash with ethanol for 1-2 times, and disperse with 2 mL of cyclohexane to obtain dispersion II.

[0070] Add dispersion II to CF 3 COONa:(CF 3 COO) 3 Y:...

Embodiment 2

[0073] Example 2: Rare earth up-conversion nanoparticles NaYF 4 :Yb,Tm@NaYF 4 :Yb@NaNdF 4 :Yb

[0074] Will be stoichiometric ratio CF3 COONa:(CF 3 COO) 3 Y:(CF 3 COO) 3 Yb:(CF 3 COO) 3 Tm=1mmol: 0.71mmol: 0.32mmol: 0.005mmol The prepared mixed powder was added to the mixed system of oleic acid (10mL) and octadecene (20mL), stirred at 120°C for 30min under vacuum, and then heated up to 320°C for 1 hour; after cooling, centrifuge, wash with ethanol for 1-2 times, and disperse with 2mL cyclohexane to obtain dispersion I.

[0075] Add dispersion I to CF 3 COONa:(CF 3 COO) 3 Y:(CF 3 COO) 3 Yb=1mmol:0.75mmol:0.25mmol, in a mixed solution of oleic acid (20mL) and octadecene (20mL), stirred at 120°C under vacuum for 30min, then heated to 300°C under the protection of argon for 1h; after cooling , centrifuged, washed with ethanol for 1-2 times, and then dispersed with 2 mL of cyclohexane to obtain dispersion II.

[0076] Add dispersion II to CF 3 COONa:(CF 3 COO) 3 Y...

Embodiment 3

[0078] Example 3: Rare earth up-conversion nanoparticles NaYF 4 :Yb,Ho@NaYF 4 :Yb@NaNdF 4 :Yb

[0079] Will be stoichiometric ratio CF 3 COONa:(CF 3 COO) 3 Y:(CF 3 COO) 3 Yb:(CF 3 COO) 3 Ho=1mmol: 0.9mmol: 0.35mmol: 0.015mmol The prepared mixed powder was added into the mixed system of oleic acid (10mL) and octadecene (20mL), stirred under vacuum at 120°C for 30min, and then heated to 320°C for 1 hour; after cooling, centrifuge, wash with ethanol for 1-2 times, and disperse with 2mL cyclohexane to obtain dispersion I.

[0080] Add dispersion I to CF 3 COONa:(CF 3 COO) 3 Y:(CF 3 COO) 3 Yb=1mmol:0.9mmol:0.9mmol, in a mixed solution of oleic acid (20mL) and octadecene (20mL), stirred under vacuum at 120°C for 30min, then heated to 300°C under argon protection and continued for 1h; after cooling , centrifuged, washed with ethanol for 1-2 times, and then dispersed with 2 mL of cyclohexane to obtain dispersion II.

[0081] Add dispersion II to CF 3 COONa:(CF 3 COO)...

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Abstract

The present invention relates to rare earth upconversion nanoparticles, a preparation method and uses thereof, wherein the rare earth upconversion nanoparticles sequentially comprise an activator shell layer, an energy transfer agent shell layer and a sensitizing agent shell layer from inside to outside, each layer contains Yb<3+>, and the doping concentration of Yb<3+> is gradually reduced from inside to outside. According to the present invention, the ytterbium ion doping concentration gradient is set to effectively transfer the excitation state energy of the sensitizing agent to the activator, such that the upconversion luminescence quantum yield of the rare earth upconversion nanoparticles is effectively improved and achieves 0.22%, and the 800 nm continuous laser excitation at the excitation light source intensity of 2W / cm<2> is achieved; and the rare earth upconversion nanoparticles can produce strong upconversion luminescence under the infrared LED light source excitation, and the potable detection equipment based on the rare earth upconversion nanoparticle luminescence probe can be designed by using the unique packaging and array technology of the infrared LED light source so as to further expand the application of the upconversion luminescence material in the biomedical field.

Description

technical field [0001] The present invention relates to the field of nanoparticles, in particular to a rare-earth up-conversion nano-particle and its preparation method and application, in particular to a high-brightness rare-earth up-conversion nano-particle (UCNPs) that can use an infrared light-emitting diode (LED) as an excitation light source and Its preparation method and use. Background technique [0002] Rare earth upconversion nanoparticles (UCNPs) refer to a new class of bioluminescent probe materials that can emit high-energy visible light under the excitation of low-energy near-infrared light by using the multi-photon absorption energy transfer mechanism. [0003] In recent years, with the rapid development of nanotechnology, UCNPs have begun to show unique advantages in the fields of biological analysis and medical imaging: 1. Using near-infrared lasers as excitation light sources can effectively avoid the interference of autofluorescence and scattered light of ...

Claims

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Application Information

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IPC IPC(8): C09K11/02C09K11/85G01N21/63
Inventor 胡志远钟业腾王子华
Owner THE NAT CENT FOR NANOSCI & TECH NCNST OF CHINA
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