85results about How to "Improve detection sensitivity" patented technology

A device is described for pre-concentration and purification of analytes from biological samples (such as human serum, plasma, homogenized solid tissue, etc.) to be analyzed by Matrix-Assisted Laser Desorption Ionization Mass Spectrometry (MALDI MS) and methods of use thereof are provided.

Methods and compositions for detecting nucleic acid polymorphisms are provided.

The invention relates to a method for detecting the welding quality of a hot-melt even joint of a polyethylene pipeline and a detection device thereof. The aim of the invention is that the provided detection method and the detection device have the characteristics of high sensitivity, high detection precision, high reliability, high detection efficiency and low misoperation rate. The technical proposal is a method for the coupling focusing ultrasonic detection of the hot-melt even joint of the polyethylene pipeline, which comprises the following steps: (1) a coupling agent liquid is positioned on the outer surface of a pipeline joint fusion region; (2) an ultrasonic probe adopting a spherical curved wafer is immersed into the coupling agent liquid in order that the focus is positioned in the centerline of the pipeline joint fusion region; and (3) the ultrasonic probe does linear scanning motion along the diameter direction of the pipeline and does uniform scanning motion along the circumferential direction of the pipeline; and obtained signal data is processed by a computer to form a C scanning picture. The ultrasonic detection device comprises a coupling receiving device, the ultrasonic probe adopting the spherical curved wafer, a mechanical scanning device, a signal processing and controlling system, and the computer.

The invention relates to a surface-enhanced Raman scattering optical fiber probe, comprising an optical fiber which can be simultaneously used for transmitting exciting light and receiving Raman scattering spectrum, a tapered optical fiber and one quartz microballoon, wherein the tapered optical fiber is formed on one end of the optical fiber, and then one quartz microballoon is thermally welded on the tip of the tapered optical fiber; when the exciting light passes through the tapered optical fiber and the quartz microballoon, evanescent waves transmitted by the tapered optical fiber and the quartz microballoon can excite the Raman spectrum of a solution or a gas molecule to be tested; meanwhile, metal nano particles are coated on the optical fiber and the surface of the quartz microballoon, so that the Raman scattering strength can be enhanced. In addition, a sensing structure of the combination of the tapered optical fiber and the quartz microballoon also has the functions of reflecting, focusing and collecting the surface-enhanced Raman scattering spectrum. The optical fiber probe is combined with a monochromatic source and a high-sensitivity Raman spectrometer so that a Raman detection sensing device can be formed. The invention has simple structure, strong capacity of resisting disturbance and high sensitivity, thereby being suitable for information acquisition and transmission of on-line analysis occasions, real-time detection occasions, live sample analysis occasions, trace hazardous and noxious substance measurement occasions and the like.

The invention relates to a room-temperature terahertz wave detector which uses a transistor with high electron mobility as a basic structure and comprises an antenna capable of efficiently coupling with terahertz waves, wherein the antenna and the transistor with high electron mobility are integrally arranged, but the antenna is mutually independent from the source electrode and drain electrode of the transistor with high electron mobility; a pair of butterfly antennae are connected between the source electrode and the drain electrode so as to generate a crosswise terahertz electric field in an electron channel; and one butterfly antenna is connected to the drain electrode of the transistor with high electron mobility so as to generate a lengthways terahertz electric field in the electron channel. By utilizing the detector provided by the invention, the regulation and control carried out on the two-dimensional plasma wave by the grid electrode of the transistor with high electron mobility can be effectively enhanced, and the terahertz wave can be detected with high speed, high efficiency, high sensitivity and low noise; simultaneously, under the working condition of room temperature, the application scope of terahertz wave can be obviously widened, and the application cost can be lowered; and, the room-temperature terahertz wave detector can be manufactured by using a semiconductor micro-processing technique with minimized device structure and high integrated level.

A positron emission tomography apparatus installs a plurality of detector units in the circumference of a bed. The detector unit installs a plurality of combined substrates including detectors, analogue ASICs, and a digital ASIC and a voltage adjustment device inside a housing. A partition plate installed inside the housing separates the region inside the housing into a first region installed with the combined substrates and a second region installed with the voltage adjustment device. The partition plate blocks noise generated in the voltage adjustment device so as not to affect γ-ray detection signals outputted from the detectors, thereby preventing the effect of the noise generated in the voltage adjustment device toward γ-ray detection signals and shortening the examination time.

The invention relates to an LC/MS interface provided with structure that the end of a spray capillary is rarely damaged and the object is to provide the LC/MS interface which a general user can easily operate, which inhibits the extension of a separation band and the deterioration of detection sensitivity and which enables high separation and sensitive analysis. A metallic member having a hole for connecting a separation column and a spray capillary and a resin member for fixing the upstream side of the short spray capillary are used. Further, to enhance operability, spray ionization using gas spraying is used.

A target substance-detecting apparatus for detecting a target substance in an analyte comprises a detecting device having a substrate and metal structures capable of causing a plasmon resonance arranged thereon, an illumination optical system for illuminating an incident light containing a polarization component polarized in a first direction onto the detecting device to cross the arranged metal structures, a light-receiving device for receiving light containing the polarization component polarized in the first direction and transmitted through or reflected by the detecting device, and an arithmetic unit for calculating on signals from the light-receiving device to analyze a characteristic of the analyte; the metal structures arranged at first intervals not more than 1/10 of a plasmon resonance wavelength in lines in the first direction and at second intervals not less than ¼ of the plasmon resonance wavelength and not more than the wavelength in lines parallel in a second direction.

The invention discloses a photoacoustic spectroscopy telemetering method and device based on a micro quartz tuning fork optoacoustic effect. The method comprises the following steps of: modulating continuous light of which the wavelength changes continuously into light of which the light intensity changes according to a certain frequency, and irradiating the light of which the light intensity changes to an object to be tested; collecting light reflected by the object to be tested by a concave mirror, and irradiating the collected light to a micro quartz tuning fork, wherein the amplitude of the micro quartz tuning fork changes along with the wavelength of incident light waves; and irradiating an arm of the micro quartz tuning fork by another beam of laser, wherein the light spot position of the reflected laser beam moves along with the vibration of the micro quartz tuning fork, the reflected light is irradiated to a light spot position detector after the light path of the reflected light is lengthened through a folded path, the amplitude size of the micro quartz tuning fork can be obtained by detecting the movement of the light spot, and the absorption spectrum of the tested object can be obtained by continuously changing the output wavelength of a variable wavelength laser. The method does not need sample preparation and pre-concentration processes or a photoacoustic cell, and can be used for directly and remotely measuring objects in an open environment.

A radio-frequency ion guide (20) for converging ions by a radio-frequency electric field and simultaneously transporting the ions into the subsequent stage is composed of eight rod electrodes (21 through 28) arranged in such a manner as to surround an ion optical axis (C). Each of the rod electrodes (21 through 28) is disposed at a tilt with respect to the ion optical axis (C) so that the radius r2 of the inscribed circle (29b) at the end face of the ion exit side is larger than the radius r1 of the inscribed circle (29a) at the end face of the ion injection side. Accordingly, the gradient of the magnitude or depth of the pseudopotential is formed in the ion's traveling direction in the space surrounded by the rod electrodes (21 through 28). Ions are accelerated in accordance with this gradient. Therefore, even in the case where the gas pressure is relatively high and ions have many chances to collide with gas, it is possible to moderate the ions' slowdown and prevent the ions' delay and stop.

The present invention has a laser and a second energy source act in combination to produce a plasma that emits characteristic radiation for a prolonged period of time. The laser energy is directed to a sample for a period of time to ignite a plasma containing the sample material and to either ablate or vaporize the sample. Energy from a second energy source is supplied to the plasma for a second period of time so that the characteristic radiation emitted by the plasma is maintained. The emitted radiation is used to identify chemical elements contained in the sample. The second period of time is typically larger than the first period of time and may be as long as many milliseconds.

Supplying energy for this longer period of time allows the plasma to grow in size and contributes to the large enhancement in the detection sensitivity of the present invention.

The invention relates to the technical field of laser ablation spectrum analysis and discloses a double-pulse laser induction breakdown spectrum analysis device and a double-pulse laser induction breakdown spectrum analysis method. The device comprises a control system, an environment detection module, a double-pulse laser transmitter module and a spectrum collection and analysis module which are arranged in a constant-temperature chassis, and a camera module arranged on the outer part of the constant-temperature chassis, wherein the control system is electrically connected with the environment detection module and the camera module respectively. The double-pulse laser induction breakdown spectrum analysis device can realize rapid and accurate analysis on sample ores and soil components of the lunar surface under original-position, online and remote control condition on the lunar surface, and can carry out deep analysis on all elements; meanwhile, the device can be used for carrying out three-dimensional analyzing imaging on all interested elements; furthermore, a double-pulse laser induction breakdown spectrum technology is applied so as to guarantee that a detection system has high detection sensitivity under an ultra-low air pressure (near vacuum) environment.

Assay reagents include small metallic particles labeled with a Raman dye and antibody molecules capable of binding the analyte of interest. In the absence of the analyte, the size of the isolated metallic particles is so small that no significant SERS signal can be detected. An analyte molecule binds two metallic particles together through the formation of a sandwich complex, and then more metallic particles are clustered together by the analyte if each metallic particle contains more than two antibodies on the surface. The bonded metallic particles form a cluster structure, which significantly amplifies the SERS effect.

An acceleration sensor outputs a walk signal having a charge corresponding to a walk. The walk signal is converted by charge-voltage conversion means into a voltage walk signal, removed of noise by filter means, amplified by amplification means and converted by binarization means into a digital signal, followed by being inputted to a CPU. The CPU performs open-close control of switches, such that the walking pitch, calculated based on the walk signal, comes within a predetermined walking pitch range stored in the storage means thereby controlling the gain of the amplification means and controlling the walk detection sensitivity properly.

A dual-RE organic match doped temp-sensitive luminescent material used for detecting the low temp (-263-25 deg.C) is proportionally prepared from SiO2, RE ions and organic ligand by sol-gel method, that is, the hydrolysis-polycondensation reaction of organic modified silicone alkoxide precursor to generate SiO2 gel glass while the reaction of RE ions on organic ligand to generate dual-RE organic match.

The invention discloses a radio frequency/laser cooperative rapid capturing, tracking and aligning method, and aims to provide a capturing, tracking and aligning method capable of rapidly capturing and aligning light beams in a high probability in a long-distance whole airspace. The invention is realized through the following technical method: in the radio frequency tracking stage, a beam pointingcontroller extracting an alignment error between a target pointing direction and a current actual pointing direction as a feedback quantity according to radio frequency omnidirectional beam and radiofrequency directional beam detection information, quickly searching for and capturing a laser beam through radio frequency beam assistance in a full airspace range, and switching to laser tracking; in a laser tracking phase, the beam pointing controller extracting an alignment error between a target pointing direction and a current actual pointing direction as a feedback quantity by respectivelyutilizing beam information detected by an optical coarse field of view and a fine field of view, controlling the laser beam pointing direction, further reducing the beam alignment error in a radio frequency tracking alignment error range, and guaranteeing continuous precise tracking alignment of a laser communication link.

The invention provides an optical detector based on BiCuSeO thermoelectric thin-film transverse thermoelectric effect. The optical detector comprises a transverse thermoelectric element. The upper surface of the transverse thermoelectric element is provided with two symmetrical metal electrodes to act as voltage signal output ends. The voltage signal output end of the transverse thermoelectric element and the input end of a voltmeter are connected by an electrode lead wire. The optical detector is characterized in that the transverse thermoelectric element comprises an oxide single crystal substrate and a BiCuSeO thin-film which is grown on the oxide single crystal substrate in a c-axis inclined way. The metal electrodes are arranged on the upper surface of the BiCuSeO thin-film. According to the optical detector based on the BiCuSeO thin-film transverse thermoelectric effect, refrigeration is not needed, response waveband is wide and detection sensitivity is high so that optical and thermal detection can be realized simultaneously.

The invention relates to a high-sensitivity remote sensing image spectrometer which can obtain target image, interference spectrum and polarization information, composed of a polarization interferometer, an image lens and an area detector which are coaxially arranged along incident light. The polarization interferometer is composed of a polarizer, Sawa polariscope and a checker, wherein the Sawa polariscope comprises two natural uniaxle negative crystal Sawa plates in same thickness, vertical optical axis, and corner as 45 degrees with the system optical axis, the polarizer and the checker are both composed of two wedge natural uniaxle negative crystal GeLanTaLe lens with an air space. The signal output of the detector is connected with an external computer signal processing system. Compared with prior art, the invention eliminates an advanced optical system and a slit of traditional device, while the invention uses the Sawa polariscope made from natural crystal as a horizontal shearing beam splitter, with simple structure, small volume, high flux, high signal/noise ratio, high detection sensitivity, high resolution, wide spectrum, and strong detecting ability on remote target and weak signal.

The gas conductance on the ion injection side of a collision cell is made larger than the gas conductance on the ion exit side by providing two ion injection apertures 23, 25 in the collision cell. Due to the different gas conductances, a CID gas supplied through the gas supply tube 31 generally flows in a direction from the ion injection side to the ion exit side in the collision cell, namely, in the ion's passage direction. When the ions injected in the collision cell 20 slow down upon contacting with the CID gas, their progress is assisted by the gas flow, so that the delay of the ions in the collision cell 20 is alleviated. As a result, it is possible to avoid a deterioration in the detection sensitivity of a target product ion and to prevent a ghost peak caused by the stay of the ions.

The invention relates to a waveguide magnetic field/current sensor based on surface plasmons. The provided sensor is used for detection of a magnetic field intensity or a current intensity. The magnetic field/current sensor comprises a magnetic field generator and also comprises a first metal waveguide, a dielectric medium channel and a second metal waveguide which are arranged in the magnetic field generator from top to bottom in order. A resonant cavity is formed in the first metal waveguide and/or the second metal waveguide. The resonant cavity is communicated with the dielectric medium channel through a metal seam formed in the corresponding metal waveguide. The resonant cavity is filled with magnetic sensitive substances. The magnetic field/current sensor has the following beneficial effects: a measuring space is shrank to an order of magnitude of an optical waveguide width dimension, and the magnetic field/current sensor can be made to be very small, and facilitates integration and arraying via technicians; because the magnetic field/current sensor can be prevented from influence of external conditions of light source fluctuation or the like, the magnetic field/current sensor has high detection sensitivity.

Disclosed is an electrode member for specific detection of an analyte using a photocurrent. The electrode member has at least a conductive substrate and an electron-accepting substance provided on said conductive substrate. The aforementioned electron-accepting substance consists at least of a first substance layer that is made of a semiconductor and a second substance that is made of a semiconductor of a kind different from that of the aforementioned semiconductor, a metal or a metal oxide, and is carried on the surface of said first substance layer. With the electrode member, improved detection sensitivity for the test substance and improved measurement precision can be achieved with specific detection of an analyte using a photocurrent.

The invention belongs to the field of adaptive optics and relates to an optimized distribution method for light energy between a corrosion imaging subcircuit and a wavefront sensing subcircuit in a liquid crystal adaptive optical system. The basic thought of the method is that: the polarizing beam splitting design of the sensing subcircuit and the corrosion imaging subcircuit is changed into spectrophotometry; a beam splitting wavelength is calculated according to a response signal intensity ratio of the receiving terminal devices of the two subcircuits, which is 1:1; the light energy of a wide short wave band with dispersion and a high wave front distortion change speed is distributed to the sensing subcircuit and the light energy of a narrow long wave band without dispersion and with a low wave front distortion change speed is distributed to the correction imaging subcircuit; light in the correction imaging subcircuit is split into two paths of polarized light by using a polarizing beam splitter (PSB), and two liquid crystal correctors are arranged correspondingly; and after correction, a light beam is combined to form an image. The method can improve the sensing capacity of the liquid crystal adaptive optical system considerably, and correspondingly improve the correction speed of the liquid crystal adaptive optical system.

The present invention belongs to the field of fire detecting and warning technology. The smoke concentration detector includes air filter, semiconductor laser, laser beam space correcting lens, laser beam space filtering diaphragm, detecting chamber, detecting chamber rack, smoke scattering detector, laser power detector, extinction mechanism, reflector and casing. All the parts are installed inside the casing except the air filter inserted to the air inlet of the casing.

The invention provides an array micro-beam unit deflection angle measurement system, comprising an illumination light source, a condenser, a filter needle hole, a collimating system, a polarizer, a polarizing beam splitter, a one quarter wave plate, a fourier conversion system, a filter edge, a fourier reverse conversion system and a CCD camera; the light emitted by the illumination light source passes through the beam filter which consists of the condenser and the filter needle hole, is converted into parallel light by the collimating system, and is converted into a linearly polarized light beam by the polarizer; the linearly polarized light beam illuminates the array micro-beam by the reflection of the polarizing beam splitter and reaches the polarizing beam splitter again after being reflected by the array micro-beam; the linearly polarizing light beam passes through the one quarter wave plate between the polarizing beam splitter and the array micro-beam twice, with the phase change of Pi/ 2; the imaging beam reflected by the array micro-beam can pierce the polarizing beam splitter and is imaged on the CCD camera after passing through a 4f filter system which consists of the fourier conversion system, the filter edge and the fourier reverse conversion system. By controlling the polarizing state of the illumination light, the array micro-beam unit deflection angle measurement system reduces the background noise of the measured signal, improves the signal-noise-ratio of the system, and presents unique advantages.

The invention relates to a novel beta coronavirus (SARS-CoV-2) variation detection kit. The kit is characterized by comprising the following parts: an RNA probe group, primers, a blocking buffer, an RNA enzyme blocking solution, a hybridization buffer, a binding buffer, an SSC rinsing solution with 1 time concentration, an SSC rinsing solution with 0.1 time concentration, a PCR reaction solution and a TE buffer, wherein the RNA probe group comprises 311 RNA probes, and the sequences of the RNA probes are shown as SEQ ID NO.1 to SEQ ID NO.311. The novel beta coronavirus (SARS-CoV-2) variation detection kit provided by the invention can enrich beta coronavirus nucleic acid sequences in a library, improves the detection sensitivity, detects beta coronaviruses of all people and animals at thesame time, and is used for beta coronavirus detection and hereditary variation detection.

A mask inspection system with Fourier filtering and image compare can include a first detector, a dynamic Fourier filter, a controller, and a second detector. The first detector can be located at a Fourier plane of the inspection system and can detect a first portion of patterned light produced by an area of a mask. The dynamic Fourier filter can be controlled by the controller based on the detected first portion of the patterned light. The second detector can detect a second portion of the patterned light produced by the section of the mask and transmitted through the dynamic Fourier filter. Further, the mask inspection system can include a data analysis device to compare the second portion of patterned light with another patterned light. Consequently, the mask inspection system is able to detect any possible defects on the area of the mask more accurately and with higher resolution.

The invention belongs to the field of weak optical signal detection, and provides a solar blind ultraviolet imaging background light suppression optical system and method for detecting weak ultraviolet signals under the condition of strong sunlight, improving the detection reliability and the measurement sensitivity. The incident light is divided into two paths by using a total reflection total lens A, a visible light imaging light path is arranged on a transmission light path, and the visible light is imaged on a visible light CCD after passing through a visible light imaging objective lens;ultraviolet light is reflected, an ultraviolet light imaging light path is arranged on a reflection light path, the ultraviolet light is incident to a total reflection total lens B, residual visible light in an ultraviolet light path is transmitted out of the ultraviolet light imaging light path from the total reflection total lens B, the ultraviolet light reflected by the total reflection total lens B is imaged on an ultraviolet solar blind CCD after passing through an ultraviolet imaging object lens, and pixel level fusion is carried out on ultraviolet channel signals through an image fusionsystem; and under the condition of larger background light intensity, the detection sensitivity of the solar blind signal is improved.

The invention provides a continuous zooming ultrasonic probe. The continuous zooming ultrasonic probe comprises a shell, an annular ultrasonic transducer and a continuous zooming acoustic lens, wherein the annular ultrasonic transducer is arranged on the inner wall of the shell, and is provided with an emitting/receiving surface for emitting/receiving ultrasonic waves; the continuous zooming acoustic lens comprises a first lens part with acoustic impedance capable of changing continuously and a second lens part provided with a hemispherical groove; and the annular ultrasonic transducer, the inner wall of the shell and the second lens part define a sealed accommodating cavity. The invention further relates to a continuous zooming method. According to the continuous zooming ultrasonic probe and the continuous zooming method, the special acoustic lens capable of realizing continuous zooming is adopted, therefore, the multi-level depth imaging can be realized, the aberration of the special acoustic lens is corrected till reaching the degree of high-resolution imaging having transverse resolution and depth resolution, and the continuous zooming ultrasonic probe and the continuous zooming method belong to the field of nondestructive testing.

The invention provides a non-linear target harmonic detection method based on a noise frequency modulation technology. The non-linear target harmonic detection method comprises the steps that a noisesequence is generated; the noise sequence is subjected to frequency modulation to generate a harmonic radar transmission signal, and the harmonic radar transmission signal is sent through a transmitting antenna; the signal is received by a receiving antenna, band-pass filtering is conducted on the signal at frequency bands corresponding to the doubled and triple frequencies to improve the signal-to-noise ratio of the received signal, and actual measurement signals of the doubled and triple frequencies are obtained; the noise sequence is subjected to doubled frequency modulation and triple frequency modulation to generate harmonic radar original copy signals, namely the doubled and triple frequency production signals; the doubled and triple frequency production signals and the actual measurement signals of the doubled and triple frequencies are separately subjected to matching filtration; non-linear target detection is conducted. In the method, the noise frequency modulation technology,the Doppler compensation technology and the transmit-receive signal matching filtration technology are adopted, the formed harmonic radar has the performance of resisting electromagnetic interferenceand resisting Doppler frequency shift, the detection sensitivity is high, and the applicable field is wider.