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111results about How to "High sample throughput" patented technology
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Flow-injection analysis and variable-flow light-scattering methods and apparatus for characterizing polymers
InactiveUS6175409B1Avoid backlogImprove throughputSequential/parallel process reactionsSamplingFlow injection analysisPolymer
Rapid characterization and screening of polymer samples to determine average molecular weight, molecular weight distribution and other properties is disclosed. Rapid flow characterization systems and methods, including liquid chromatography and flow-injection analysis systems and methods are preferably employed. High throughput, automated sampling systems and methods, high-temperature characterization systems and methods, and rapid, indirect calibration compositions and methods are also disclosed. The described methods, systems, and devices have primary applications in combinatorial polymer research and in industrial process control.
Owner:INTERMOLECULAR
High-temperature characterization of polymers
InactiveUS6260407B1Avoid backlogImprove throughputSequential/parallel process reactionsComponent separationElutionChromatography column
Rapid characterization and screening of polymer samples to determine average molecular weight, molecular weight distribution and other properties is disclosed. Rapid flow characterization systems and methods, including liquid chromatography and flow-injection analysis systems and methods are preferably employed. High throughput, automated sampling systems and methods, high-temperature characterization systems and methods, and rapid, indirect calibration compositions and methods are also disclosed. In preferred high-temperature embodiments, the polymer sample is maintained at a temperature of not less than about 75° C. during sample preparation, loading into a liquid chromatography or flow-injection analysis system, injection into a mobile phase of a liquid chromatography or flow-injection analysis system, and / or elution from chromatographic column. The described methods, systems, and device have primary applications in combinatorial polymer research and in industrial process control.
Owner:INTERMOLECULAR
Rapid characterization of polymers
InactiveUS6406632B1More separatedHigh sample throughputSequential/parallel process reactionsSamplingFluid phasePhysical chemistry
Rapid characterization and screening of polymer samples to determine average molecular weight, molecular weight distribution and other properties is disclosed. Rapid flow characterization systems and methods, including liquid chromatography and flow-injection analysis systems and methods are preferably employed. High throughput, automated sampling systems and methods, high-temperature characterization systems and methods, and rapid, indirect calibration compositions and methods are also disclosed. The described methods, systems, and devices have primary applications in combinatorial polymer research and in industrial process control.
Owner:INTERMOLECULAR
Indirect calibration of polymer characterization systems
InactiveUS6294388B1Avoid backlogImprove throughputIon-exchange process apparatusSamplingPolymer characterizationFlow injection analysis
Rapid characterization and screening of polymer samples to determine average molecular weight, molecular weight distribution and other properties is disclosed. Rapid flow characterization systems and methods, including liquid chromatography and flow-injection analysis systems and methods are preferably employed. High throughput, automated sampling systems and methods, high-temperature characterization systems and methods, and rapid, indirect calibration compositions and methods are also disclosed. The described methods, systems, and devices have primary applications in combinatorial polymer research and in industrial process control.
Owner:INTERMOLECULAR
Parallel high-performance liquid chromatography with post-separation treatment
InactiveUS6436292B1High sample throughputEasy to findIon-exchange process apparatusSamplingChromatographic separationCombinatorial synthesis
High-performance liquid chromatography (HPLC) methods and systems are disclosed that combine parallel chromatographic separation of a plurality of samples with a detection technique that involves post-separation treatment of the plurality of samples to enhance one or more properties of the sample or of a component thereof, followed by detection of the one or more enhanced properties. Selective, tunable detection schemes are achievable, and are particularly advantageous as applied in connection with combinatorial chemistry, combinatorial material science and more particularly, combinatorial synthesis and screening of polymeric materials.
Owner:FREESLATE
Automated high volume slide processing system
ActiveUS20050186114A1High throughput stainingMinimize the possibilityPreparing sample for investigationSurgeryWorkstationBiomedical engineering
An automated system is provided for performing slide processing operations on slides bearing biological samples. In one embodiment, the disclosed system includes a slide tray holding a plurality of slides in a substantially horizontal position and a workstation that receives the slide tray. In a particular embodiment, a workstation delivers a reagent to slide surfaces without substantial transfer of reagent (and reagent borne contaminants such as dislodged cells) from one slide to another. A method for automated processing of slides also is provided.
Owner:VENTANA MEDICAL SYST INC
Method for simultaneous detection of multiple fluorophores for in situ hybridization and multicolor chromosome painting and banding
InactiveUS6066459AImprove throughputShorten the timeRaman/scattering spectroscopyRadiation pyrometryChromosome paintingFluorophore
A spectral imaging method for simultaneous detection of multiple fluorophores aimed at detecting and analyzing fluorescent in situ hybridizations employing numerous chromosome paints and / or loci specific probes each labeled with a different fluorophore or a combination of fluorophores for color karyotyping, and at multicolor chromosome banding, wherein each chromosome acquires a specifying banding pattern, which pattern is established using groups of chromosome fragments labeled with various fluorophore or combinations of fluorophores.
Owner:APPLIED SPECTRAL IMAGING
Improved Methods and Devices for Concentration and Fractionation of Analytes for Chemical Analysis including Matrix-Assisted Laser Desorption/Ionization (MALDI) Mass Spectrometry (MS)
InactiveUS20060219558A1High throughputConvenient and effectiveSludge treatmentVolume/mass flow measurementMaldi msAnalyte
A device for pre-concentration and purification of analytes from biological samples, such as human serum, to be analyzed by Matrix-Assisted Laser Desorption Ionization Mass Spectrometry (MALDI MS) and methods of use thereof are provided.
Owner:HAFEMAN DEAN G +7
Automated high volume slide processing system
ActiveUS7468161B2Minimize cross-contaminationHigh sample throughputPreparing sample for investigationSurgeryWorkstationBiomedical engineering
An automated system is provided for performing slide processing operations on slides bearing biological samples. In one embodiment, the disclosed system includes a slide tray holding a plurality of slides in a substantially horizontal position and a workstation that receives the slide tray. In a particular embodiment, a workstation delivers a reagent to slide surfaces without substantial transfer of reagent (and reagent borne contaminants such as dislodged cells) from one slide to another. A method for automated processing of slides also is provided.
Owner:VENTANA MEDICAL SYST INC
Automated sampling methods for rapid characterization of polymers
InactiveUS6265226B1Avoid backlogImprove throughputSequential/parallel process reactionsComponent separationFlow injection analysisPolymer
Rapid characterization and screening of polymer samples to determine average molecular weight, molecular weight distribution and other properties is disclosed. Rapid flow characterization systems and methods, including liquid chromatography and flow-injection analysis systems and methods are preferably employed. High throughput, automated sampling systems and methods, high-temperature characterization systems and methods, and rapid, indirect calibration compositions and methods are also disclosed. The described methods, systems, and devices have primary applications in combinatorial polymer research and in industrial process control.
Owner:INTERMOLECULAR
Color display of chromosomes or portions of chromosomes
InactiveUS6055325AMore informationHigh sample throughputRaman/scattering spectroscopyInterferometric spectrometryFluorophoreComputer science
A color display comprising an image of all chromosomes or portions of chromosomes of a cell, each of the chromosomes or portions of chromosomes being painted with a different fluorophore or a combination of fluorophores, the image presenting the chromosomes or portions of chromosomes in different distinctive colors, wherein each of the chromosomes or portions of chromosomes is associated with one of the different distinctive colors.
Owner:APPLIED SPECTRAL IMAGING
Automated high volume slide processing system
ActiveUS20050250211A1Minimize cross-contaminationHigh sample throughputPreparing sample for investigationBiological testingEngineeringWorkstation
Owner:VENTANA MEDICAL SYST INC
Parallel gas chromatograph with microdetector array
InactiveUS20020014106A1More spatially efficientProvide flexibilitySequential/parallel process reactionsComponent separationDetector arrayThermal conductivity
Gas chromatographs of the invention generally comprise four or more analysis channels. Specifically, four or more gas chromatography columns are configured for parallel analysis of four or more gaseous samples with detection being effected using a microdetector array comprising four or more microdetectors. In one embodiment, the four or more microdetectors 510 are microfabricated detectors, and are integrally formed with a substrate or with one or more microchip bodies mounted on a substrate. In a preferred embodiment, a microdetector array comprises four or more thermal conductivity detectors having one or more thin-film detection filaments. A preferred heated environment for highly parallel gas chromatographs is also disclosed.
Owner:FREESLATE
Parallel gas chromatograph with microdetector array
InactiveUS6701774B2More spatially efficientProvide flexibilityIon-exchange process apparatusSequential/parallel process reactionsDetector arrayThermal conductivity
Gas chromatographs of the invention generally comprise four or more analysis channels. Specifically, four or more gas chromatography columns are configured for parallel analysis of four or more gaseous samples with detection being effected using a microdetector array comprising four or more microdetectors. In one embodiment, the four or more microdetectors 510 are microfabricated detectors, and are integrally formed with a substrate or with one or more microchip bodies mounted on a substrate. In a preferred embodiment, a microdetector array comprises four or more thermal conductivity detectors having one or more thin-film detection filaments. A preferred heated environment for highly parallel gas chromatographs is also disclosed.
Owner:FREESLATE
Method and apparatus for multiplexing plural ion beams to a mass spectrometer
ActiveUS20060091308A1Quick checkImprove throughputTime-of-flight spectrometersIsotope separationIon trap mass spectrometryIon beam
A method / apparatus for multiplexing plural ion beams to a mass spectrometer. At least two ion sources are provided with means of transporting the ions from the ion sources to separate two-dimensional ion traps. Each ion trap is used for storage and transmission of the ions and operates between the ion sources and the mass analyzer. Each ion trap has a set of equally spaced, parallel multipole rods, as well as entrance and exit sections into which and from which ions enter and exit the trap, respectively. For each ion trap, the entrance section is placed in a region where background gas pressure is at viscous flow. The pressure at the exit section drops to molecular flow pressure regimes without a break in the structure of the ion trap. Each trap alternately stores and transmits ions by way of a fast voltage switch applied to the ion trap exit lens.
Owner:PERKINELMER HEALTH SCIENCES INC
Methods and apparatus for characterization of polymers using multi-dimensional liquid chromatography with regular second-dimension sampling
InactiveUS6730228B2Less complicatedUniversal applicabilityIon-exchange process apparatusSequential/parallel process reactionsGradient elutionPhase gradient
Methods and apparatus for characterizing a polymer sample and in preferred embodiments, libraries of polymer samples, in a comprehensive, directly-coupled multi-dimensional liquid chromatography system are disclosed. The first and second dimensions are preferably high-performance liquid chromatography dimensions, such as for example, a first dimension adapted for determining composition (e.g. adapted for mobile-phase gradient elution chromatography, including reverse phase chromatography, adsorption chromatography and the like), and a second dimension adapted for determining molecular weight or particle size (e.g., adapted for size exclusion chromatography, including gel permeation chromatography).
Owner:FREESLATE
Methods and apparatus for characterization of polymers using multi-dimensional liquid chromatography with parallel second-dimension sampling
InactiveUS20030089663A1Less complicatedUniversal applicabilityIon-exchange process apparatusSamplingGradient elutionPhase gradient
Methods and apparatus for characterizing a polymer sample and in preferred embodiments, libraries of polymer samples, in a comprehensive, directly-coupled multi-dimensional liquid chromatography system are disclosed. The first and second dimensions are preferably high-performance liquid chromatography dimensions, such as for example, a first dimension adapted for determining composition (e.g. adapted for mobile-phase gradient elution chromatography, including reverse phase chromatography, adsorption chromatography and the like), and a second dimension adapted for determining molecular weight or particle size (e.g., adapted for size exclusion chromatography, including gel permeation chromatography).
Owner:FREESLATE
High-temperature characterization of polymers with HPLC system having multiple mobile-phase reservoirs
InactiveUS6345528B2More separatedHigh sample throughputSequential/parallel process reactionsComponent separationFlow injection analysisPolymer
Rapid characterization and screening of polymer samples to determine average molecular weight, molecular weight distribution and other properties is disclosed. Rapid flow characterization systems and methods, including liquid chromatography and flow-injection analysis systems and methods are preferably employed. High throughput, automated sampling systems and methods, high-temperature characterization systems and methods, and rapid, indirect calibration compositions and methods are also disclosed. The described methods, systems, and devices have primary applications in combinatorial polymer research and in industrial process control.
Owner:INTERMOLECULAR
Characterization of non-biological polymers using flow-injection analysis with light-scattering detection
InactiveUS6577392B1More separatedHigh sample throughputIon-exchange process apparatusSequential/parallel process reactionsBiopolymerFlow injection analysis
Rapid characterization and screening of polymer samples to determine average molecular weight, molecular weight distribution and other properties is disclosed. Rapid flow characterization systems and methods, including liquid chromatography and flow-injection analysis systems and methods are preferably employed. High throughput, automated sampling systems and methods, high-temperature characterization systems and methods, and rapid, indirect calibration compositions and methods are also disclosed. The described methods, systems, and devices have primary applications in combinatorial polymer research and in industrial process control.
Owner:INTERMOLECULAR
Method and apparatus for multiplexing plural ion beams to a mass spectrometer
ActiveUS7217919B2High sample throughputCompromise sensitivityTime-of-flight spectrometersIsotope separationIon trap mass spectrometryIon beam
A method / apparatus for multiplexing plural ion beams to a mass spectrometer. At least two ion sources are provided with means of transporting the ions from the ion sources to separate two-dimensional ion traps. Each ion trap is used for storage and transmission of the ions and operates between the ion sources and the mass analyzer. Each ion trap has a set of equally spaced, parallel multipole rods, as well as entrance and exit sections into which and from which ions enter and exit the trap, respectively. For each ion trap, the entrance section is placed in a region where background gas pressure is at viscous flow. The pressure at the exit section drops to molecular flow pressure regimes without a break in the structure of the ion trap. Each trap alternately stores and transmits ions by way of a fast voltage switch applied to the ion trap exit lens.
Owner:PERKINELMER HEALTH SCIENCES INC
Micromixer
InactiveUS20050252840A1Efficient mixingEnhanced mixing processIon-exchange process apparatusFlow mixersComputer scienceDynamic range
Methods and apparatus for mixing fluids are provided. The devices and methods operate without moving parts, and generate well-mixed fluids over a broad dynamic range of flow rates. Preferred embodiments include junction-type mixers, bundled mixers, and co-axial mixers. The devices and methods are optimized to produce rapid, accurate gradients to improve associated system throughput and reproducibility.
Owner:EKSIGENT TECH
Mass spectrometry with multiple ionization sources and multiple mass analyzers
InactiveUS20070057172A1High duty-cyclesHigh sample throughputStability-of-path spectrometersIsotope separationMass analyzerProtein mass spectrometry
Multiple ionization ion sources and multiple mass analyzers are combined into one mass spectrometer instrument by a six-electrodes ion trap or an array of six-electrodes ion traps. The six-electrodes ion trap can be operated as an independent two-dimensional ion guide or linear ion tap in an arbitrarily selected direction among three orthogonal XYZ directions. The two-dimensional ion guide / linear ion trap can be alternated from one direction to another among the three orthogonal directions electrically. A six-electrodes ion trap generates six equivalent importing and exporting interfaces, each of the interfaces can be used to trap external ions and transfer the trapped ions to any of the other five interfaces. The six-electrodes ion trap provide a mass spectrometer with versatility, multiply functions, high duty-cycles and high sample throughput.
Owner:WANG YANG
System and Method for Regulating Flow in Fluidic Devices
ActiveUS20110045599A1High sample throughputHigh level of automationWithdrawing sample devicesMaterial analysis by optical meansBack pressureEngineering
Disclosed are a system and method for regulating flow in an exemplary fluidic device comprising a fluidic stream carrying a transport medium, sample and one or more reagents for analysis and synthesis of reaction products. The flow rate of the fluidic stream is maintained constant by adjusting the flow rate of transport medium to compensate for the introduction of sample and reagents. An embodiment controls the flow rate of transport medium using a pump, a back pressure regulator, and a variable-sized orifice. Single and multiple channel embodiments are disclosed.
Owner:O I CORP
Electron beam apparatus and a device manufacturing method by using said electron beam apparatus
InactiveUS7005641B2Improve throughputIncrease exposureMaterial analysis using wave/particle radiationSemiconductor/solid-state device testing/measurementOptical axisCrystal orientation
Owner:EBARA CORP
Methods for characterization of polymers using multi-dimensional liquid chromatography with parallel second-dimension sampling
InactiveUS6855258B2Less complicatedUniversal applicabilityIon-exchange process apparatusSamplingGradient elutionPhase gradient
Methods and apparatus for characterizing a polymer sample and in preferred embodiments, libraries of polymer samples, in a comprehensive, directly-coupled multi-dimensional liquid chromatography system are disclosed. The first and second dimensions are preferably high-performance liquid chromatography dimensions, such as for example, a first dimension adapted for determining composition (e.g. adapted for mobile-phase gradient elution chromatography, including reverse phase chromatography, adsorption chromatography and the like), and a second dimension adapted for determining molecular weight or particle size (e.g., adapted for size exclusion chromatography, including gel permeation chromatography).
Owner:FREESLATE
Chromatographic column for rapid characterizations of polymers
InactiveUS6416663B1More separatedHigh sample throughputIon-exchange process apparatusSequential/parallel process reactionsChromatographic columnFlow injection analysis
Rapid characterization and screening of polymer samples to determine average molecular weight, molecular weight distribution and other properties is disclosed. Rapid flow characterization systems and methods, including liquid chromatography and flow-injection analysis systems and methods are preferably employed. High throughput, automated sampling systems and methods, high-temperature characterization systems and methods, and rapid, indirect calibration compositions and methods are also disclosed. The described methods, systems, and devices have primary applications in combinatorial polymer research and in industrial process control.
Owner:INTERMOLECULAR
Methods and apparatus for characterization of polymers using multi-dimensional liquid chromatography with regular second-dimension sampling
InactiveUS20030080062A1Less complicatedUniversal applicabilityIon-exchange process apparatusSequential/parallel process reactionsGradient elutionPhase gradient
Methods and apparatus for characterizing a polymer sample and in preferred embodiments, libraries of polymer samples, in a comprehensive, directly-coupled multi-dimensional liquid chromatography system are disclosed. The first and second dimensions are preferably high-performance liquid chromatography dimensions, such as for example, a first dimension adapted for determining composition (e.g. adapted for mobile-phase gradient elution chromatography, including reverse phase chromatography, adsorption chromatography and the like), and a second dimension adapted for determining molecular weight or particle size (e.g., adapted for size exclusion chromatography, including gel permeation chromatography).
Owner:FREESLATE
Automated sampling methods with integral serial sample preparation for rapid characterization of polymers
InactiveUS6492184B1More separatedHigh sample throughputIon-exchange process apparatusSequential/parallel process reactionsRapid identificationFlow injection analysis
Rapid characterization and screening of polymer samples to determine average molecular weight, molecular weight distribution and other properties is disclosed. Rapid flow characterization systems and methods, including liquid chromatography and flow-injection analysis systems and methods are preferably employed. High throughput, automated sampling systems and methods, high-temperature characterization systems and methods, and rapid, indirect calibration compositions and methods are also disclosed. The described methods, systems, and devices have primary applications in combinatorial polymer research and in industrial process control.
Owner:INTERMOLECULAR
Method for bisulfite treatment
ActiveUS20040241704A1Increase speedImprove accuracySugar derivativesMicrobiological testing/measurementGlass fiberCytosine
The present application is directed to a method for performing a bisulfite reaction to determine methylation positions in a nucleic acid, i.e. methylated and non-methylated cytosines, whereby the nucleic acid is bound to a solid phase during the deamination and / or desulfonation step of the bisulfite reaction. The solid phase is preferably a material comprising glass or silica, more preferably a glass fleece, glass membrane or a magnetic glass particle. Further, the use of a solid phase for binding a nucleic acid during the deamination and / or desulfonation step of the bisulfite reaction is disclosed and a kit containing a bisulfite reagent and a solid phase.
Owner:QIAGEN GMBH
Optical analytic measurement device for fluorescence measurements in multisample carriers
InactiveUS20050218338A1High sample throughputMeasurement time be increaseChemiluminescene/bioluminescencePhotometryFluorescenceMeasurement device
The invention is directed to a device for optical analytic measurement in a multisample carrier, particularly for measuring fluorescence or bioluminescence. The object of the invention, to find a novel possibility for measuring fluorescence or luminescence in multisample carriers, wherein, during excitation of all of the wells, the secondary radiation of each well is measured simultaneously without impermissible contributions of background radiation which falsify the characteristic emission of the sample material, is met according to the invention in that the excitation light from a light source unit is directed on the multisample carrier coaxially in a ring-shaped manner around an optical axis wherein the optical axis is oriented in direction of a surface normal of the multisample carrier and coaxial to the direction of the readout beam path, and a ring mirror unit with at least one curved ring mirror, which is arranged coaxial to the optical axis in such a way that the excitation light; illuminates the multisample carrier homogeneously on all sides at an oblique incident angle, is provided for orientation of the excitation light on the multisample carrier.
Owner:CYBIO AG
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