5results about How to "Provide flexibility" patented technology

The present invention relates to an anti-angiopoietin-2 (Ang2) antibody or an antigen-binding fragment thereof that specifically binds to Ang2 and induces Tie2 activation, comprising: (a) a heavy-chain complementarity-determining region (CDR) comprising CDRH1 of the amino acid sequence of SEQ ID NO: 2, SEQ ID NO: 10, SEQ ID NO: 18, or SEQ ID NO: 26, CDRH2 of the amino acid sequence of SEQ ID NO: 3, SEQ ID NO: 11, SEQ ID NO: 19, or SEQ ID NO: 27, and CDRH3 of the amino acid sequence of SEQ ID NO: 4, SEQ ID NO: 12, SEQ ID NO: 20, or SEQ ID NO: 28; and (b) a light-chain CDR comprising CDRL1 of the amino acid sequence of SEQ ID NO: 5, SEQ ID NO: 13, SEQ ID NO: 21, or SEQ ID NO: 29, CDRL2 of the amino acid sequence of SEQ ID NO: 6, SEQ ID NO: 14, SEQ ID NO: 22, or SEQ ID NO: 30, and CDRL3 of the amino acid sequence of SEQ ID NO: 7, SEQ ID NO: 15, SEQ ID NO: 23, or SEQ ID NO: 31.

The utility model discloses a kind of drainage mechanism for air compressor air receiver, belong to air compressor auxiliary equipment technical field, a kind of drainage mechanism for air compressor air receiver, including main pipeline, the one side of the main pipeline is equipped with stop valve, the one side of the stop valve is equipped with three-way joint, the one side of the three-way joint and side are respectively threadedly connected with connecting pipe one and connecting pipe two;By setting up the automatic drainage assembly formed by U-shaped pipe and check valve, using siphon principle and gravity effect, the timed automatic discharge of condensate is realized.When the pressure generated by the weight of the water accumulated in the U-shaped pipe is sufficient to overcome the opening pressure of the check valve, the valve opens, and the water is quickly discharged under the action of negative pressure and gravity. This process does not require power drive, there is no risk of jamming of moving parts, the structure is extremely simple, reliable and durable, and has strong resistance to oil contamination and impurity interference. It fundamentally solves the problem of easy clogging and damage of traditional automatic water drain.

Provided is an anti-B7-H4 antibody containing a VH, wherein the VH contains the following CDRs or a mutation thereof: CDR1 as shown in the amino acid sequence of SEQ ID NO: 4 or 5, CDR2 as shown in the amino acid sequence of SEQ ID NO: 15, and CDR3 as shown in the amino acid sequence of SEQ ID NO: 24 or 25, and wherein the mutation is an insertion, deletion or substitution of 3, 2 or 1 amino acid(s) in the amino acid sequences of the CDRs. The antibody has the activity of binding to human B7-H4 and cynomolgus monkey B7-H4. The antibody still retains the activity of binding to human B7-H4 and cynomolgus monkey B7-H4 when prepared into a B7-H4×CD3 bispecific antibody, and has a strong killing effect on tumor cells. The antibody induces a very low expression of nonspecific cytokines such as IL-6 and IFN-y, and exhibits a strong in vivo anti-tumor activity.

The utility model discloses an eccentric bolt, and relates to the field of eccentric bolts, the eccentric bolt comprises a bolt head, the bolt head is provided with threads, one end of the bolt head is fixedly provided with a head plate, the bolt head is provided with a circular groove, and the tail end of the bolt head is in threaded connection with a nut. On the basis of an existing bolt head, the circular groove is cut, so that the bolt head can be placed in the circular groove for installation and positioning, the nut is screwed at the tail end, overall installation and positioning can be completed, convenience and flexibility during installation can be achieved, and the installation efficiency is improved. Under the matching action of the first reinforcing teeth and the like on the first gasket, the contact area can be increased, the pressure stress of the pressure-bearing surface can be reduced, the surface of a connected piece is protected, meanwhile, the excellent durability is achieved, and under the strong vibration environment, the service life of the connected piece is prolonged. The anti-loose gasket can effectively keep the clamping force of the connecting piece, and bolt looseness caused by vibration is prevented.

The present invention relates to a novel antibody and a use thereof, and more specifically, to: an antibody-drug conjugate or a bispecific antibody comprising the antibody produced by substituting an existing antibody sequence or an antigen-binding fragment thereof, wherein the antibody does not have any glycation-related substances generated in a production process; a pharmaceutical composition comprising the antibody-drug conjugate or bispecific antibody for preventing or treating cancer; a nucleic acid encoding the antibody or an antigen-binding fragment thereof; a vector and a host cell comprising the nucleic acid; and a method for preparing an antibody or an antigen-binding fragment thereof.