200 results about "Infrared fluorescence" patented technology

The invention discloses an ultra-wide-spectrum endoscopic imaging device capable of being used for short-wave infrared fluorescence imaging, which is used for in-vivo minimally invasive imaging and comprises an illumination module, a wide-spectrum image transmission module, an imaging module and an image processing module. The illumination module consists of a light source and a light guide optical fiber, and is used for generating illumination light from ultraviolet to short wave infrared band and transmitting the illumination light to the wide-spectrum image transmission module; the wide-spectrum image transmission module consists of a few-interface optical imaging channel and a light guide illumination channel, and is used for illuminating an imaging target, exciting target fluorescence and collecting image signals from ultraviolet to short-wave infrared bands; the imaging module is composed of an optical filter and an imaging camera, and the imaging camera can be a wide spectral response image sensor or can be formed by combining cameras working in different wavebands and is used for converting optical images in different wavebands into image data; and the image processing module is used for registering and fusing image data of different wavebands in real time and displaying the image data.

The invention belongs to the technical field of organic dye synthesis and application, and discloses a conjugated compound containing a benzothiophenazine structure as well as a preparation method and application thereof, and the conjugated compound containing the benzothiophenazine structure has excellent photophysical properties, singlet oxygen yield and superoxide anion generation capacity. The novel conjugated compounds ENBO-NI and ENBS-NI containing benzothiophenazine structures are successfully prepared by replacing a benzene ring of Nile blue with a cycloalkane structure and adjusting the electron donating ability of an R1 group. The two compounds have near infrared fluorescence emission, good solubility and relatively high ROS yield. Compared with a classical photosensitizer NB, the singlet oxygen yield of ENBO-NI is increased by about 117.65%, and the singlet oxygen yield of ENBS-NI is as high as 70%. The absorption wavelength of the conjugated compound is in a red light wave band. The preparation process is simple and efficient, large-scale production is easy, and the preparation method has a wide clinical application prospect.

The invention discloses a near-infrared confocal microscopic imaging system and a near-infrared confocal microscopic imaging method, and relates to the technical field of optical microscopic imaging. The method comprises the following steps that near-infrared exciting light sequentially passes through a beam expanding system, a liquid lens and a confocal scanning light path to irradiate a to-be-detected sample so as to generate a near-infrared fluorescence signal, and the liquid lens is used for adaptively adjusting the focal length and wavefront morphology according to the depth of the to-be-detected sample; a photomultiplier detects the near-infrared fluorescence signal after non-focus scattered light is filtered out through the confocal scanning light path and the pinhole, and a fluorescence signal image is obtained; and according to the fluorescence signal image, carrying out iterative optimization on the focal length and phase modulation parameters of the liquid lens to maximize the image sharpness or the signal-to-noise ratio and realize the three-dimensional microscopic imaging of the deep tissue. According to the near-infrared confocal microscopic imaging method provided by the invention, deep near-infrared microscopic imaging with low phototoxicity, low cost and high resolution can be realized.

The application discloses a near-infrared fluorescent powder and a light-emitting device. The near-infrared fluorescent powder comprises a composition formula LiA a Sc 1‑a‑p‑d‑ c D d P p An inorganic compound of EO4:cCr, wherein A elements include one or two of Li, Na and K, D elements include two of Ga, In, Al, Ce and Bi, and E elements include two or three of Hf, Ge and Si; wherein 0

This invention discloses a method for preparing HVC NPs for the diagnosis and treatment of Parkinson's disease and their applications. The probe HV in the HVC NPs responds to H2O2 and viscosity, utilizing near-infrared fluorescence imaging capabilities to achieve real-time monitoring of Parkinson's disease biomarkers, helping us better understand the occurrence and development of Parkinson's disease. With the assistance of RVG29, the HVC NPs effectively cross the blood-brain barrier. The curcumin within them can reduce cell apoptosis, lower oxidative stress levels, scavenge excess reactive oxygen species, combat inflammation, and reduce α-synuclein aggregation, demonstrating effective anti-Parkinson's disease effects at the cellular and experimental animal levels. This nanomaterial provides a new strategy for integrated research on the diagnosis and treatment of Parkinson's disease.

The invention discloses a near-infrared fluorescence imaging agent of a targeted folate receptor, an imaging system and application of the imaging agent and the imaging system, and belongs to the technical field of biomedical treatment. The technical problem to be solved is to provide the folate receptor-targeted near-infrared fluorescence imaging system, an imaging agent in the system can specifically target the folate receptor FR-alpha, and the folate receptor-targeted near-infrared fluorescence imaging system is used in application scenes of lung cancer and ovarian cancer and can show higher TNR, display tumor boundaries in real time and reduce the positive edge cutting rate. According to the technical scheme, the near-infrared fluorescence imaging agent of the targeted folic acid receptor is characterized by comprising a compound of the targeted folic acid receptor, a solvent and pharmaceutically acceptable auxiliary materials, the structure of the compound of the targeted folic acid receptor is F-L-D, F is the structure of the targeted folic acid receptor, D is a near-infrared dye, L is a connexon, and L is an electron donor. The structural formula is shown in the specification or pharmaceutically acceptable salts thereof.

The present application relates to the technical field of nanoprobes, and particularly relates to a near-infrared fluorescence / magnetic resonance dual-mode probe and a preparation method and application thereof. The present application adopts a Brij98 amphiphilic molecule to wrap an IR824Et-PhDTA-Gd near-infrared fluorescence / magnetic resonance dual-response molecule to prepare the probe, so that the probe has an absorption wavelength of 650-850 nm, generates a fluorescence signal under excitation of 785 nm laser, and the generated fluorescence wavelength can reach 1000 nm, which is in a near-infrared region (780-1700 nm); the probe has good positive magnetic resonance response characteristics, and a longitudinal relaxation rate (r1) of the probe is 28 mM ‑1 s ‑1 , which is 7 times of that of a clinically used Magnevist; the probe can be applied in the fields of fluorescence and / or magnetic resonance imaging, and has a wide application prospect. The preparation method of the near-infrared fluorescence / magnetic resonance dual-mode probe is simple in operation and low in cost.

The invention relates to the technical field of biological detection, in particular to an HClO near-infrared fluorescent probe as well as a preparation method and application thereof. The structure of the HClO near-infrared fluorescent probe is shown in the specification. The emission wavelength of the near-infrared fluorescent probe developed by the invention is 750nm, and the near-infrared fluorescent probe has high selectivity, high sensitivity (the detection limit is as low as 49 nM) and quick response capability to HClO, and has low cytotoxicity and excellent in-vivo imaging capability, so that visual observation of HClO in a living Parkinson's disease model mouse body is successfully realized, and the near-infrared fluorescent probe has a wide application prospect. The method has great potential in the aspect of tracking HClO related pathological states in real time.

The invention belongs to the technical field of fluorescent probes and biological detection, and particularly relates to a hypochlorous acid response type near-infrared fluorescent probe for screening Alzheimer's disease antioxidants as well as a preparation method and application of the hypochlorous acid response type near-infrared fluorescent probe. The near-infrared fluorescent probe FP-MT-HClO provided by the invention is subjected to a specific reaction under the action of HClO, generates obvious fluorescence signal enhancement, outputs near-infrared fluorescence signals at about 665 nm, and has the characteristics of quick response, high sensitivity, good selectivity, strong anti-interference capability and the like. An in-vitro screening model used for simulating an inflammatory oxidative stress link related to the Alzheimer's disease is constructed based on the probe, and rapid screening and activity evaluation of candidate antioxidants capable of reducing the HClO level in cells are achieved. The method disclosed by the invention is good in repeatability, is suitable for in-vitro screening of candidates related to inflammatory oxidative stress, and can be used for early evaluation and mechanism research of an oxidative stress process related to Alzheimer's disease.

The invention relates to the technical field of biological medicine, in particular to a TREM-1 targeted fluorescent molecular probe as well as a preparation method and application thereof, and discloses a fluorescent molecular probe named as' TREM-1 targeted fluorescent molecular probe as well as a preparation method and application thereof '. The invention aims to solve the problems of large molecular weight, poor pharmacokinetic performance, limited tissue penetration, high imaging background and poor imaging timeliness of the existing antibody fluorescent probe. The probe comprises a TREM-1 targeting module (TDM), a near-infrared fluorescence reporter group, a dark quenching group and a conformational sensitive connecting arm (CSL). The fluorescence of the probe is quenched before the probe is combined with TREM-1, and after the probe is combined with a target spot, TDM specific binding induces CSL conformation rearrangement, so that a reporter group and a quenching group are spatially separated, fluorescence resonance energy transfer (FRET) is relieved, and fluorescence activation is realized. According to the invention, rapid, high-contrast and low-background fluorescence imaging of atherosclerotic plaques is realized, and the probe is small in molecular size, strong in tissue penetrability and rapid in-vivo clearing.

The invention relates to a compound as shown in a formula (I) and / or a formula (II) and / or a formula (III) or a tautomer or pharmaceutically acceptable salt thereof, a preparation method and application of the compound or the tautomer or the pharmaceutically acceptable salt in medicine. Specifically, the fluorescent probe can be used as a fluorescent probe for cytological imaging, can also be used as a near-infrared fluorescent imaging probe for diagnosing benign / malignant lesions such as fibrosis, nodules and tumors, and can also be applied to research of related biological events in cytobiology and molecular biology. The fluorescent probe can be particularly applied to fluorescent navigation in tumor resection surgery.

The invention discloses an application of a tumor-associated macrophage targeting nanoprobe in ultrasensitive magnetic resonance molecular imaging of in-vivo in-situ lung cancer. The tumor-associated macrophage targeting nanoprobe prepared by the method provided by the invention is loaded with water-insoluble supramolecular celopphane, so that Xe'molecular cage 'celopphane can be uniformly dispersed in water and a biological system, and is used for in-vivo hyperpolarized 129Xe magnetic resonance imaging. According to the nanoprobe, mannose modification is carried out on the surface of the nanoprobe, so that the nanoprobe can effectively target tumor-related macrophages in a tumor area, and targeted detection of in-situ lung cancer tumors is realized; the surface of the nanoprobe is subjected to near-infrared fluorescence molecular modification, so that fluorescence / magnetic resonance bimodal detection of solid tumors can be realized. In combination with the advantage that local drug concentration can be improved by pulmonary drug delivery, a strong 129Xe magnetic resonance signal of the developed probe can be directly detected in vivo, and in-vivo 129Xe magnetic resonance molecular imaging is realized on an in-situ lung cancer model mouse through a direct sampling imaging mode.

The invention discloses a near-infrared photosensitizer for specifically recognizing fibroblast activation protease (FAP-alpha) as well as a preparation method and application of the near-infrared photosensitizer. A cyanine derivative is used as a fluorescent parent nucleus (ICyOH) of the photosensitizer, the fluorescence of the photosensitizer can be almost completely masked by modifying the photosensitizer, and after the photosensitizer reacts with FAP-alpha for 60 minutes, the fluorescence intensity is rapidly enhanced, so that high sensitivity, good selectivity and anti-interference performance are shown. The ZGP-LL-ICy is a photosensitizer with a cyanine structure, FAP-alpha fluorescence enhancement and high selectivity to FAP-alpha, the reagent shows high selective response to FAP-alpha enzyme, active ICyOH molecules with near-infrared fluorescence are released under the action of enzymolysis, and tumor fluorescence imaging of deep tissue penetration is achieved. Meanwhile, the activated ICyOH can generate cytotoxic active oxygen under the illumination condition, and photodynamic therapy on pancreatic cancer is achieved. The reagent has the advantages of low background fluorescence, deep tissue penetration, diagnosis and treatment integration and the like, and has important application value in the fields of early diagnosis and precise treatment of pancreatic cancer.

The invention discloses a tyrosinase near-infrared fluorescent probe as well as a preparation method and application thereof, and belongs to the technical field of analytical chemistry. According to the technical scheme, the tyrosinase near-infrared fluorescent probe is characterized in that the structural formula of the tyrosinase near-infrared fluorescent probe is shown in the specification. The invention further specifically discloses a preparation method of the tyrosinase near-infrared fluorescent probe and application of the tyrosinase near-infrared fluorescent probe to selective detection of tyrosinase in a water environment, a biological cell system and living organisms. The near-infrared fluorescent probe disclosed by the invention has the advantages of fluorescence emission in a near-infrared region, good selectivity, high sensitivity and the like.

This invention relates to ONOO ‑ In the field of detection technology, specifically involving an ONOO ‑ Near-infrared fluorescent probe, its preparation method, and its application. This invention constructs a novel fluorescent probe specifically for detecting ONOO. ‑ The ONOO ‑ Near-infrared fluorescent probe for ONOO ‑ It exhibits good reactivity and is capable of specifically imaging endogenous ONOO in living cells or in vivo systems. ‑ Furthermore, it exhibits a large Stokes shift and an emission wavelength of 760 nm, significantly higher than other near-infrared fluorescent probes based on hemicyanine dye structures. In addition, this ONOO... ‑ The near-infrared emission characteristics of near-infrared fluorescent probes enable them to penetrate deeper into tissues and reduce background interference in bioimaging, which is significant for improving imaging sensitivity and accuracy. Based on these characteristics, ONOO... ‑ Near-infrared fluorescent probes can be used for the diagnosis and research of diseases such as atherosclerosis, neurodegenerative diseases, inflammation, and cancer.

The invention discloses a near-infrared fluorescence immunoassay analyzer, and relates to the field of biomedical engineering.The near-infrared fluorescence immunoassay analyzer comprises an analyzer body, a dome-type fluorescence collector is installed in an inner cavity of a sealing seat, a narrow-band light filter is installed at the bottom of the dome-type fluorescence collector, and a piezoelectric focusing lens set is installed at the bottom of a light source sliding block; a light source sliding block is arranged in the analyzer body, a laser range finder and an optical fiber beam splitter are respectively arranged on two sides of the light source sliding block, a double-layer reagent card base body is arranged in the center of the top of the analyzer body, a snakelike microfluidic channel is formed in the top of the double-layer reagent card base body, a shape memory alloy is arranged at the bottom of the double-layer reagent card base body, and a thermosensitive actuator array is arranged at the bottom of the shape memory alloy. According to the near-infrared fluorescence immunoassay analyzer, eight-path parallel scanning is combined with dynamic focusing, so that the single-sample full-index detection time can be greatly shortened, the near-infrared fluorescence immunoassay analyzer can be compatible with various complex biological samples, a chemical color developing agent is not needed, and the experiment cost and the environmental pollution risk are reduced.

The invention relates to a chromium ion single-doped ultra-wideband near-infrared fluorescent material, a preparation method thereof and an LED device, and belongs to the technical field of luminescent materials. The chemical composition formula of the material is Ca2Sc1-yYyGa3-3xSn2O12: xCr, x is larger than or equal to 0.003 and smaller than or equal to 0.10, and y is larger than or equal to 0.00 and smaller than or equal to 1.00. The material is high in phase purity, simple in preparation process, simple and convenient to operate, environment-friendly and high in synthesis efficiency. Under excitation of 475-500 nm, the emission spectrum of the material covers the range of 600-1600 nm, the material has high luminous intensity in a first near-infrared region (about 855 nm) and a second near-infrared region (about 1300 nm), and the full width at half maximum can reach 200-655 nm. Meanwhile, the material has good absorption in the range of 400-700 nm, can be effectively matched with a commercial blue light LED chip, and is suitable for preparing a high-performance near-infrared LED light source. Compared with the prior art, the material provided by the invention not only can realize ultra-wideband emission covering a first near-infrared area and a second near-infrared area, but also is adjustable in emission peak position and high in absorption characteristic and commercial blue light chip compatibility, and is beneficial to development of high-efficiency and high-stability near-infrared LED devices.

The application provides a near-infrared fluorescent pH probe and a preparation method and application thereof, and belongs to the technical field of biosensing; the chemical structural formula of the probe is as follows: the novel near-infrared fluorescent pH probe can detect in a more acidic range, for example, when the pH changes from 6.40 to 3.00, the fluorescence intensity at 790 nm is enhanced by nearly 70 times, and the fluorescent effect is better; the fluorescent pH probe has low cytotoxicity, high stability and good biocompatibility; and can effectively perform fluorescence imaging on different intracellular pH.

The invention belongs to the technical field of biological medicine analysis, and particularly relates to a fluorescent probe sequentially responding to gamma-glutamyltranspeptidase and monoamine oxidase and application of the fluorescent probe. The structure of the fluorescent probe is as shown in a formula 1, the fluorescent probe in the formula 1 is constructed by sequentially covalently connecting gamma-glutamyltranspeptidase and specific recognition groups of monoamine oxidase and integrating the gamma-glutamyltranspeptidase and the specific recognition groups of monoamine oxidase into a benzothiazole-xanthene fluorescent parent structure, and the fluorescent probe has near-infrared fluorescence luminescence performance. The probe adopts a double enzyme response activation strategy, and can be activated and generate a fluorescence signal only when gamma-glutamyltranspeptidase and monoamine oxidase exist at the same time, so that the fluorescence probe is high in specificity and has excellent accuracy and specificity in the aspects of pathological imaging, drug safety evaluation and the like.

The invention discloses an application of a near-infrared fluorescent probe in preparation of a near-infrared first region and near-infrared second region diagnosis, prevention and / or treatment medicine, and belongs to the technical field of organic fluorescent molecules. The near-infrared fluorescent probe specifically targets cMet, has good tumor targeting capability and water solubility, also has near-infrared two-region developing capability, and has huge development potential and application prospect in fluorescence-guided intraoperative navigation.

This invention relates to the field of bacterial infection treatment technology, and discloses an enzyme-responsive probe, its preparation method, and its applications. The probe of this invention constructs an enzyme-responsive "prodrug" structure by introducing cephalosporin derivative linker units that can be specifically cleaved by β-lactamases onto a hemicyanine optical framework. This structure remains optically and therapeutically inert in normal tissues, but is selectively activated at the site of infection by drug-resistant bacteria. When the probe contacts multidrug-resistant bacteria that overexpress β-lactamases, the linker units undergo enzymatic cleavage, releasing hemicyanine active molecules with near-infrared fluorescence emission and highly efficient photothermal conversion capabilities, achieving high-contrast fluorescence imaging and controllable photothermal sterilization of the infection focus. The probe of this invention has a simple synthetic route, mild conditions, and reliable purification methods, making it suitable for large-scale preparation, especially for the precise diagnosis and targeted photothermal synergistic treatment of superficial tissue infections such as bacterial keratitis.

The application discloses a self-activation type deep red near-infrared fluorescent powder and a preparation method and application thereof; the chemical general formula is LiZnNbO4:xA, wherein 0<=x<=0.1, and A is one of Na, Pr, Tm, Sm, Dy, Tb, Er and Ho elements; the deep red-near-infrared fluorescent powder is prepared by taking raw materials according to the stoichiometric ratio of the chemical general formula LiZnNbO4:xA, grinding and uniformly mixing, heating in a corundum crucible, and obtaining a product, and then crushing, grinding, grading, screening and washing the product to obtain the deep red-near-infrared fluorescent powder. The application provides the deep red-near-infrared fluorescent powder which has the advantages of simple preparation method, easy operation, low cost, high environmental protection, stable chemical performance, good luminous efficiency and high ultraviolet excitation efficiency.

The application discloses a beta-galactosidase near-infrared fluorescent probe with a large stokes shift and a preparation method and application thereof. The structure of CPD-gal is shown in formula I. When a 580nm excitation wavelength is used for excitation, CPD-gal has weak fluorescence at 713nm, but can selectively undergo a fluorescence opening reaction with beta-gal. With the increase of the concentration of beta-gal, the fluorescence intensity at 713nm is gradually enhanced, and other interfering ions and species will not interfere with the detection of beta-gal by CPD-gal. Since the emission wavelength is in the near-infrared region and a large stokes shift is generated, the system background fluorescence interference is greatly reduced, and the sensitivity of the detection of beta-gal is improved. Therefore, CPD-gal is suitable for the fluorescence detection of beta-gal with high selectivity and high sensitivity. The probe is successfully applied to the fluorescence imaging of endogenous beta-gal in HeLa cells and SK-OV-3 cells.

The application provides a short-wave infrared fluorescent ceramic and a preparation method and application thereof. The short-wave infrared fluorescent ceramic has a chemical composition of Y 2‑z (Ca 1‑x M x )Al 4‑y SiO 12 :yCr 3+ ,zEr 3+ ; wherein M is one or more of Mg, Sr and Ba elements. The preparation method comprises the following steps: S1, taking oxides, nitrates, halides or carbonates containing Y, Ca, M, Al, Si, Cr and Er elements as raw materials according to the chemical composition and the metering ratio, wherein M is one or more of Mg, Sr and Ba, and then mixing the raw materials to obtain a uniform mixture; S2, subjecting the uniform mixture to a melting treatment, and then cooling to obtain a transparent glass sample; and S3, placing the transparent glass sample into a tube furnace with an atmosphere, and subjecting the transparent glass sample to a heat treatment at 900-1300 DEG C under normal pressure, and then sequentially cooling and polishing to obtain the short-wave infrared fluorescent ceramic. The short-wave infrared fluorescent ceramic prepared by the application has high transmittance, a wide emission spectrum coverage range, high luminescent quantum efficiency and excellent thermal stability.

The invention relates to preparation and application of a malignant tumor targeting gambogic acid preparation. An inner core-middle layer-shell three-layer structure is adopted, wherein the inner core is a gambogic acid-black phosphorus quantum dot compound and has chemical treatment and photo-thermal treatment functions; the middle layer is nano vesicles derived from frozen NK92 MI cells and provides natural immune targeting and killing ability; a shell is a hyaluronic acid chelate, and active targeting and pH / photo-thermal response type drug controlled release are achieved. The core of the preparation method is that a coaxial electrojet technology is adopted, three layers of materials are formed in one step, the process is efficient, and the preparation stability is good. The preparation can realize photo-thermal-chemical-immune triple synergistic treatment, has near-infrared fluorescence and photo-acoustic multimode imaging functions, effectively solves the problems of poor targeting property, large toxic and side effects and lack of real-time monitoring of traditional chemotherapy, and shows significant advantages and application potential in precise treatment and diagnosis of solid tumors.

The application discloses a chromium-doped ultra-wideband near-infrared fluorescent material and a preparation method thereof. 2‑x A x Si2O7:yCr M , wherein A is one or more of Y, Sm, Eu, Gd, Tb, Dy, Ho, Er, Tm, Yb, Lu and Ga, 0<=x<=0.5, 0.001<=y<=0.3, and M is one or more of 3+ and 4+. The preparation method comprises the following steps: taking raw materials according to the stoichiometric ratio, grinding and mixing; pre-calcining at 600-1200 DEG C under an air atmosphere; grinding again after cooling, calcining at 1200-1600 DEG C, keeping warm, and cooling to room temperature. The fluorescent powder can be efficiently excited by blue light, emits near-infrared light covering the NIR-I and NIR-II regions, and the peak position and half-height width of the emission spectrum can be regulated by adjusting the molar concentration of A ion replacing Sc and the chromium ion doping concentration.

The invention discloses a near-infrared light-emitting material, a near-infrared fluorescent powder conversion type light-emitting diode and a preparation method, and relates to the technical field of light-emitting materials. The chemical formula of the near-infrared luminescent material is Cs2Hf (1-a) ReaCl6, and a ranges from 0.005 to 0.08. The near-infrared luminescent material Cs2Hf1-aReaCl6 provided by the invention does not contain lead and organic components, has low toxicity, good humidity and thermal stability and good biocompatibility, and can effectively inhibit self-absorption of the organic components of the near-infrared luminescent material Cs2Hf1-aReaCl6. In addition, Cs2Hf1-aReaCl6 also has excellent luminescence stability and has strong multi-peak emission crossing a first near-infrared window and a second near-infrared window, and emission peaks are respectively located at the wavelength of 726nm and 1342nm; in addition, due to the multi-stage distribution emission of the Cs2Hf1-aReaCl6, the rare photoluminescence quantum yield as high as 91.88% is achieved.

The invention discloses a compound and a composition of a targeted folate receptor as well as a preparation method and application of the compound and the composition, and belongs to the technical field of medical biology, the compound of the targeted folate receptor is F-L-D, F is a structure of the targeted folate receptor, D is a near-infrared dye, L is a connexon, and the structural formula is shown in the specification or a pharmaceutically acceptable salt thereof. The compound of the targeted folate receptor is used as a targeted near-infrared fluorescence imaging agent, can be matched with a near-infrared fluorescence imaging system for use, can specifically target the folate receptor FR-alpha, and is used for auxiliary diagnosis of identifying malignant lesions in a tumor patient operation. In application scenarios of lung cancer and ovarian cancer, the compound can show higher TNR and can display tumor boundaries in real time so as to help to identify intraoperative lesions, reduce the positive edge cutting rate and the false positive rate and realize accurate excision.

The invention discloses a seleno-heptamethine indocyanine compound and a preparation method and application thereof.The seleno-heptamethine indocyanine compound is of a structure shown in the formula Se-Cys, the seleno-heptamethine indocyanine compound can be specifically accumulated in cell mitochondria, excessive reactive oxygen species (ROS) generated by radiation-induced mitochondria is efficiently removed, and the compound can be used for preparing a medicine for treating the mitochondria. Therefore, the radiation damage of normal cells is reduced. Meanwhile, the compound has an ROS concentration-dependent near-infrared fluorescence enhancement effect, and can synchronously realize the effects of monitoring the ROS level in real time, avoiding excessive oxidation resistance, reducing the toxicity of anti-radiation drugs and the like.

The invention provides an LED lamp bead and an LED light source, and belongs to the technical field of LED illumination, the LED lamp bead comprises a substrate, an LED chip and a light conversion layer, the LED chip is located on the substrate and used for generating exciting light, the light conversion layer is located on the substrate and the LED chip and used for generating exciting light, and the light conversion layer is located on the substrate and the LED chip and used for generating exciting light. The light conversion layer at least comprises visible light fluorescent powder, first infrared fluorescent powder and second infrared fluorescent powder, the first infrared fluorescent powder generates infrared light with the wavelength smaller than 850 nm after being excited, and the second infrared fluorescent powder generates infrared light with the wavelength larger than or equal to 850 nm after being excited. Therefore, the wide-spectrum light source capable of covering the visible light wave band, the near-infrared wave band and the far-infrared wave band is realized, high color rendering index and accurate color temperature control can be realized, and the wide-spectrum light source can be applied to scenes with extremely high requirements on spectrum continuity and color rendering, such as medical illumination, museum illumination, high-end home illumination and the like.