427 results about "Infrared fluorescence" patented technology

A near infrared fluorescent contrast agent comprising a compound having three or more sulfonic acid groups in a molecule, and a method of fluorescence imaging comprising introducing the near infrared fluorescent contrast agent of the present invention into a living body, exposing the body to an excitation light, and detecting near infrared fluorescence from the contrast agent. The near infrared fluorescent contrast agent of the present invention is excited by an excitation light and emits near infrared fluorescence. This infrared fluorescence is superior in transmission through biological tissues. Thus, detection of lesions in the deep part of a living body has been made possible. In addition, the inventive contrast agent is superior in water solubility and low toxic, and therefore, it can be used safely.

The invention relates to a method based on near infrared fluorescence molecules and nano particle marks as well as an immunochromatography quantitative detection reagent based on near infrared fluorescence nanoparticles. According to the invention, infrared fluorescence is connected with nanoparticles to prepare an immunochromatography test strip based on the near infrared fluorescence nanoparticles. During the detection, an infrared light scanner is utilized, and a quality control line and a sample line are respectively scanned by utilizing near infrared light; and after the fluorescence intensity of a detection line is rectified by utilizing the fluorescence intensity of a quality control line, and a standard curve in a fluorescence analyzer is taken in, the concentration of a to-be-detected matter in a sample can be analyzed and detected. Compared with the direct connection of the near infrared fluorescence molecules and detecting molecules, the near infrared fluorescence nanoparticle immunochromatography improves the detection flexibility obviously, and the lowers the background fluorescence intensity. The marking method and the reagent can be applied to microorganism detection, food safety detection, poison detection as well as rapid dangerous chemical product detection.

The invention belongs to the technical field of fluorescent materials, particularly relates to near-infrared fluorescent powder, and further discloses a preparation method of the fluorescent powder, and a light-emitting device containing the fluorescent powder. The near-infrared fluorescent powder comprises an inorganic compound having a composition formula of AxRrQqZy:zD, an excitation wavelengthof the compound is 200-700 nm, and the compound has broadband emission with an emission main peak of 700-1600 nm in a near-infrared light region. The near-infrared fluorescent powder provided by theinvention has a wider excitation wavelength, can well absorb ultraviolet light, blue light and red light, and has stronger near-infrared luminescence than gallium germanate system near-infrared fluorescent powder without Gd.

A method and a portable device for assessing the occurrence of an agent in a sample. A sample is illuminated with photons emanating from a portable device to produce photons reflected, emitted, or absorbed from a set of multiple points in the sample having a defined geometric relationship. The portable device is used to simultaneously illuminate the sample and analyze the photons reflected, emitted, or absorbed from the set of multiple points using spectroscopic methods, including infrared, fluorescence, and UV / visible. The agent assessed may include a hazardous agent, a chemical agent, a biological agent, a microorganism, a bacterium, a protozoan, a virus, and combinations thereof.

The invention discloses a near-infrared fluorescent magnetic micro-emulsion nanometer particle, its preparation method and application in tumor treatment, wherein magnetic nano-particles and near-infrared luminescent quantum dot nano-particles or near-infrared luminescent organic dyestuff molecules are embedded into water-in-oil micro-emulsion, anti-cancer drugs can also be embedded into the micro-emulsion, the magnetic steering action of the magnetic nano particles will target the micro-emulsion embedded near-infrared fluorescent substances to tumor positions or secure them onto tumor positions under the excitation of near-infrared lights, the thermal effects produced by the near-infrared lights can kill tumor cells, the OH and O2 free radicals with high activity and the optical catalytic activity of the quantum dots can also have synergic actions in destroying tumor cells.

The invention discloses a synthesis method for a near-infrared fluorescent probe copper nano-cluster and a detection method for glycoprotein. The near-infrared fluorescent probe copper nano-cluster is synthesized through a one-pot method, aminophenylboronic acid is used for functionally transforming the synthesized copper nano-cluster, and the functionalized copper nano-cluster is obtained. Due to the specific action of boric acid groups on aminophenylboronic acid and cis diol in glycoprotein, the fluorescence intensity of the copper nano-cluster is quenched. A fluorescent probe can detect glycoprotein at high specificity and sensitivity. Glycoprotein widely exists in mucus, plasma, cytoplasm and cell membranes, is tightly related to living organisms, is an important physiological active material, and is tightly related to certain genetic diseases, and therefore important practical significance is provided for detecting glycoprotein.

An intramolecularly-quenched, near-infrared fluorescence probe that emits substantial fluorescence only after interaction with a target tissue (i.e., activation) is disclosed. The probe includes a polymeric backbone and a plurality of near-infrared fluorochromes covalently linked to the backbone at fluorescence-quenching interaction-permissive positions separable by enzymatic cleavage at fluorescence activation sites. The probe optionally includes protective chains or fluorochrome spacers, or bothours. Also disclosed are methods of using the intramolecularly-quenched, near-infrared fluorescence probes for in vivo optical imaging.

The invention relates to a dark red / near-infrared multifunctional aggregation-induced light-emitting material, a preparation method and application thereof. According to the dark red / near-infrared multifunctional aggregation-induced light-emitting material, a pyridine ring in the molecular structure endows the molecule with electropositivity, and meanwhile, the molecule has appropriate lipo-hydropartition coefficient (with ClogP being greater than 3 and less than 5) and space structure, and is beneficial to combination with gram-positive bacteria. During co-culture of the molecule with bacteria, specific "lightening" imaging of gram-positive bacteria can be realized; the strong electron donating (D)-electron withdrawing (A) effect of the molecule itself causes absorption and emission wavelength red shift of the molecule, thus having dark red / near-infrared fluorescence emission and strong ROS generation capacity. Meanwhile, the aggregation-induced light-emitting material provided by the invention can efficiently kill gram-positive bacteria.

Use of near-infrared fluorescence imaging in performing an endoscopic surgery, such as laparoscopic cholecystectomy. A composite video image of the surgical field (e.g. the biliary anatomy) is shown on a display screen. The composite video image combines a visible color image and a fluorescence image of the surgical field. Using various techniques, selective fluorescence imaging of a particular area of interest in the surgical field is made possible. For example, in a cholecystectomy procedure, the biliary ducts may be the particular area of interest for the selective fluorescence imaging.

The present invention provides particles comprising either a water-soluble polymer or a phospholipid, wherein at least one near infrared (NIR) fluorescent probe and optionally at least one active agent such as a targeting moiety, capable of selectively recognizing a particular cellular marker, are non-covalently bound to the outer surface of the particles. Pharmaceutical compositions comprising these particles may be used, inter alia, for detection and treatment of tumors in the gastrointestinal tract

The invention relates to two novel difluoro boron dipyrromethene compounds which can be used as near-infrared fluorescent dyes and a preparation method thereof and belongs to the techcnial field of fluorescent probes. 8-(4-(chloromethyl) phenyl)-4,4-difluoro-1,3,5,7-tetramethyl-4-boron-3a,4a-dipyrrole (labeled as BODIPY-C), 1,2,3,4-tetrahydro naphthalene, 5-hydroxyl isophthalate and p-anisaldehyde are used as raw materials to synthesize the two novel difluoro boron dipyrromethene (BODIPY) derivatives. The two compounds are compounds for near-infrared absorption and near-infrared fluorescence emission and can be expected to be used as fluorescent probes for imaging in cells or organisms, and background interference is reduced.

The invention relates to a multifunctional nanomicelle for early diagnosis and phototherapy of tumors. The multifunctional nanomicelle comprises a monolayer functionalized lipid membrane shell, photosensitive molecules and optothermal absorbents, wherein the photosensitive molecules and the optothermal absorbents are embedded into the monolayer functionalized lipid membrane shell. The multifunctional nanomicelle has the advantages that the nanomicelle can be used for multi-modal imaging diagnosis such as early magnetic resonance imaging, photoacoustic imaging or near-infrared fluorescence imaging of cancer; multiple kinds of diagnosis effects can be achieved as long as a patient suffers from one contrast medium administration; since sensitivity is improved, contrast medium injecting dosage is further decreased, and toxic and side effects on the patient can be alleviated; when the tumors are under single-wavelength near-infrared laser radiation, chlorine 6 and Pdots inside the nanomicelle are capable of converting light energy into chemical energy and thermal energy effectively to produce a great number of ROS (reactive oxygen species) oxygen free radicals and overhigh heat at 50-60 DEG C, and the ROS oxygen free radicals and the overhigh heat are used for inducing apoptosis and necrosis of cancer cells, so that a photodynamic and photothermal collaborative therapy function is achieved; the multifunctional nanomicelle not only can be used as a contrast medium for cancer diagnosis, but also can be used as a therapeutic agent for collaborative therapy of the cancer.

The invention belongs to the technical field of luminescent materials, particularly relates to near-infrared fluorescent powder, and further discloses a preparation method of the near-infrared fluorescent powder and a luminescent device containing the fluorescent powder, wherein the near-infrared fluorescent powder comprises an inorganic compound with a composition formula of AxRpOr, an AxRpOr structure is used as a matrix and is doped with specific rare earth ions or transition metal ions to form the compound, the excitation peak of the prepared fluorescent powder is located at 350-750 nm, broadband emission is shown under the excitation of ultraviolet light, blue light or red light, and the emission main peak is located at 700-1600 nm. According to the invention, the near-infrared fluorescent powder materials with different emission wavelengths can be prepared by constructing solid solutions through ion substitution and other methods due to the influence of crystal field splitting, so that the luminous intensity of the fluorescent powder is remarkably improved, the spectrum adjustability is realized, and the application range of the fluorescent powder material is further expanded.

The invention belongs to the technical field of analysis and detection, and provides a lysosome-targeted Cys near-infrared fluorescent probe and a preparation method and application thereof. The near-infrared fluorescent probe is 3-(2-(3-(dicyanomethylene)-5,5-dimethylcyclohexen-1-yl)vinyl)-4-morpholinyl coumarin-7-acrylate which is abbreviated as DCICA. The prepared lysosome-targeted Cys near-infrared fluorescent probe has the characteristics of novel structure, lysosome targeting performance and near-infrared fluorescence emission (wherein an emission wavelength is 680 nm), can realize high-selectivity high-sensitivity detection of a Cys content of a solution, conducts specific detection of Cys in cell lysosome by using a laser confocal imaging technology, is of important guiding significance to research on the molecular mechanism of participation of the Cys in the life activity of the lysosome, and has a wide application prospect.

The invention relates to the technical field of intermediate infrared rare earth doped luminescent glass application, and aims at solving the technical problem of providing a method for preparing oxygen fluorine chlorine tellurate glass with intermediate infrared fluorescence output at 4 mu m. The glass is good in glass forming property, high in infrared light transmission rate, good in luminescence property and beneficial to output of fluorescence and laser of 4 mu m. The oxygen fluorine chlorine tellurate glass prepared by using a fusion method is tellurate glass which contains zinc fluoride and zinc chloride, and due to the appropriate amount of contains zinc fluoride and zinc chloride, the hydroxyl content and the phonon energy in the system are greatly reduced, so that the forming capability of the glass is effectively improved, the doping amount of rare earth ions is increased, and the fluorescence service lives of the rare earth ions are prolonged. By adopting the doping amount of the external doping rare earth ions, namely, Ho<3+> and Yb<3+>, the pumping efficiency of 980nm is greatly improved, and tests show that the oxygen fluorine chlorine tellurate glass has remarkable fluorescence output at 4 mu m.

Disclosed are nanostructured gold films which may be produced by solution-phase depositions of gold ions onto a variety of surfaces. The resulting plasmonic gold films are used for enhanced spectroscopic-based immunoassays in multiplexed microarray format with detection mechanisms based on either surface-enhanced Raman scattering or near-infrared fluorescence enhancement. The preparation of the films and subsequent modifications of the gold film surfaces afford increased sensitivity for various microarrays. The films are discontinuous, forming gold “islands.” Sensitivity, size, shape, and density of the nanoscopic gold islands comprising the discontinuous nanostructured gold film are controlled to enhance the intensity of Raman scattering and fluorescence in the near-infrared, allowing for improved measurements in clinical diagnostic or biomedical research applications.

A method and a portable device for assessing the occurrence of an agent in a sample. A sample is illuminated with photons emanating from a portable device to produce photons reflected, emitted, or absorbed from a set of multiple points in the sample having a defined geometric relationship. The portable device is used to simultaneously illuminate the sample and analyze the photons reflected, emitted, or absorbed from the set of multiple points using spectroscopic methods, including infrared, fluorescence, and UV / visible. The agent assessed may include a hazardous agent, a chemical agent, a biological agent, a microorganism, a bacterium, a protozoan, a virus, and combinations thereof.

The invention discloses a tumor microvascular imaging instrument and a tumor microvascular imaging method. The tumor microvascular imaging instrument comprises an infrared confocal imaging part and a control part, wherein the infrared confocal imaging part comprises a near-infrared laser, a dichroscope, a two-dimensional scanning galvanometer, a scanning lens system, an imaging objective, a near-infrared fluorescence filter, a convergent lens, a pinhole and a detector; the scanning lens system is composed of a field lens and a cylindrical lens; the control part comprises a two-dimensional scanning control module which is used for controlling the two-dimensional scanning galvanometer, a signal amplification and acquisition module and a data processing and image displaying module; near-infrared quantum dots that a fluorescence excitation spectrum ranges from 1000nm to 1350nm and a fluorescence emission spectrum ranges from 1350nm to 1500nm are injected to blood vessels of a to-be-observed living body; and then a tumor part of the living body is observed under the tumor microvascular imaging instrument. According to the tumor microvascular imaging instrument and the tumor microvascular imaging method provided by the invention, complete three-dimensional imaging of tumor microvessels of the living body can be implemented with a high resolution.

The invention discloses a preparation method and application of a hydroxyl porphyrin-based high-selectivity near-infrared fluorescence sulfur ion probe. The fluorescence probe is prepared by taking 5-hydroxyphenyl-11,15,20-triphenylporphyrin (TPP-OH) and 4-chlorine-7-nitro-1,2,3-benzoxadiazole (NBD-Cl) as materials, taking 4-dimethylamino pyridine (DMAP) as a catalyst, taking dichloromethane as a solvent and performing one step reaction under room temperature. The preparation method of the probe is simple, and a product is easy to separate and purify. Compared with an existing small organic molecule fluorescence probe, the fluorescence probe obtained by the preparation method has higher fluorescence emission wavelength (lumbda em is greater than 650nm), high-sensitivity and high-selectivity quick recognition and detection on a trace of hydrogen sulphide can be realized in a near-infrared region, and the application prospect is great in the field of environmental and biological detection.

The invention relates to the field of optical functional materials, and more specifically relates to an infrared BODIPY fluorochrome. The fluorochrome has a structure shown in a formula (1), wherein R1 and R2 are mutually independent and selected from C1-C10 alkyl, aromatic bases or heterocyclic aromatic bases; R3 is one of H atom, C1-C10 alkyl or aromatic bases. The fluorochrome has the advantages of narrow ultraviolet visible absorption spectroscopy and fluorescence emission spectrum, high molar absorption coefficient, high fluorescence quantum efficiency, good light stability, trace detection, and high sensitivity; and the fluorochrome can be applied to cell imaging, fluorescence probe, laser dye, fluorescence sensor and near infrared dynamics, and different application fields with good practicality.

The invention provides a near infrared fluorescence molecular probe which has a structural formula as described in the specification. The invention further provides a preparation method for the near infrared fluorescence molecular probe. The invention also provides application of the near infrared fluorescence molecular probe in imaging in MCF-7 cells. The near infrared fluorescence molecular probe provided by the invention has a novel structure, is easy to prepare, can effectively shun from interference by biological autofluorescence and endogenous substances of cells, has high sensitivity, good optical stability and good cytomembrane permeability and is applicable as a near infrared fluorescence probe for detection of bioimaging.

The present invention provides for a composition comprising a pigment, wherein the composition is suitable for coating a surface that is, or is expected to be, exposed to the sun. The pigment comprises particles that fluoresce in sunlight, thereby remaining cooler in the sun than coatings pigmented with non-fluorescent particles. The particles comprise solids that fluoresce or glow in the visible or near infrared (NIR) spectra, or that fluoresce when doped. Suitable dopants include, but are not limited to, ions of rare earths and transition metals. A coating composition includes: (i) a film-forming resin; (ii) an infrared reflective pigment; and (iii) an infrared fluorescent pigment different from the infrared reflective pigment. When the coating composition is cured to form a coating and exposed to radiation comprising fluorescence-exciting radiation, the coating has a greater effective solar reflectance (ESR) compared to the same coating exposed to the radiation comprising fluorescence-exciting radiation except without the infrared fluorescent pigment. A multi-layer coating including the coating composition, and a substrate at least partially coated with the coating composition is also disclosed. A method of reducing temperature of an article includes applying the coating composition to at least a portion of the article.

The invention discloses a leucine aminopeptidase and monoamine oxidase-activated near-infrared fluorescent probe as well as a synthetic method and biological application thereof. The adopted syntheticmethod includes the following step: (1) synthesizing the novel leucine aminopeptidase and monoamine oxidase-activated near-infrared fluorescent probe (NML); and the biological application comprises the following step: (1) applying the probe to biological imaging and serum detection. The leucine aminopeptidase and monoamine oxidase-responsive fluorescent probe is synthesized for the first time, and the problem of low specificity of a traditional single-enzyme fluorescent probe is overcome; the fluorescent probe has near-infrared fluorescence properties, the background fluorescence signal can be effectively reduced, and the sensitivity of the probe can be improved; and the fluorescent probe has a good staining effect on living cells and high staining efficiency, and can detect cell endogenous leucine aminopeptidase and monoamine oxidase.

The present disclosure relates to compounds that are useful as near-infrared fluorescence probes, wherein the compounds include i) a pteroyl ligand that binds to a target receptor protein, ii) a dye molecule, and iii) a linker molecule that comprises an amino acid or derivative thereof. The disclosure further describes methods and compositions for making and using the compounds, methods incorporating the compounds, and kits incorporating the compounds.

The invention relates to a rapid detection method for ochratoxin A. The method comprises the following steps that A, an aptamer (Apt) of the ochratoxin A is hybridized with single-stranded signal probe DNA (ssDNA) to form a hybridized chain; B, the hybridized chain is made to make contact with a sample to be tested, and when the ochratoxin A exists in the sample to be tested, the hybridized chain and the ochratoxin A are subjected to a reaction to release the single-stranded signal probe DNA (ssDNA); C, DNA amplification is utilized for making the hybridized chain into a double-stranded DNA, then, an excision enzyme is used for selectively catalyzing the hydrolysis of the double-stranded DNA to form mononucleotide, and the single-stranded signal probe DNA (ssDNA) is not hydrolyzed and reserved; D, under the induction of the ssDNA, copper ions are reduced to generate near infrared fluorescence copper nanometer particles; the system fluorescence strength is detected, and therefore the content of the ochratoxin A in the sample to be tested is tested. The method has the advantages of being high in sensitivity, easy to operate, low in cost and the like.

The invention discloses a near-infrared organic electroluminescent material and device and making method, which is three-source copolymer of infrared fluorescent dye, II-VI semiconductor nanometer particle and conductive polymer, wherein the semiconductive nanometer particle is doped in the polymer through physical method, which is composited on the polymer through chemical method; the electroluminescent device is prepared by simple rotary-coating method; the device structure is ITO / / PEDOT:PSS / / polymer luminous layer / / metal cathode. The invention can launch center wavelength at 890 nm, which makes maximum luminous strength at 115nw.

The invention discloses an augmented reality near-infrared fluorescence navigation system and method. The system comprises a near-infrared fluorescence navigation device, which is used for exciting and capturing a fluorescence signal, converting the fluorescence signal into a fluorescence image, and processing the fluorescence image and then generating a projection image, and comprises an excitation light source, an optical filter group, an imaging lens group and a spectroscope; and a projection module, used for receiving the generated projection image and generating projection light accordingto the projection image, wherein the generated projection light passes through the spectroscope, and is imaged on an observation tissue after being focused by the imaging lens group. Through the projection technology, invisible near-infrared fluorescence is visualized, the reality enhancement effect is achieved, and the problem that traditional intraoperative navigation equipment needs to repeatedly observe a display image and check the position of an actual biological tissue fluorescence signal is solved.

The near-infrared wavelengths (700 nm-900 nm) are a suitable optical window for light penetration and deep tissue imaging. The present invention provides a near-infrared fluorescent blood pool contrast agent. The agent is of use to detect and quantify pathological capillary leak in live animals, e.g., serially imaging of traumatized tissue (muscle) as well as tumors.

The invention discloses a near-infrared fluorescence detection kit for C-reactive protein and application of the near-infrared fluorescence detection kit. The near-infrared fluorescence detection kit comprises a reagent strip positioned on a back plate, wherein the reagent strip is a sample pad, a glass cellulose membrane marked with an immune fluorescent probe, a nitrocellulose membrane coated with a C-reactive protein antibody and water absorbing paper from the sampling end in sequence. The near-infrared fluorescence detection kit disclosed by the invention can quickly and accurately detect the C-reactive protein in human whole blood, serum or plasma in combination with a near-infrared fluorescence detection technology.