422 results about "Infrared fluorescence" patented technology

A near infrared fluorescent contrast agent comprising a compound having three or more sulfonic acid groups in a molecule, and a method of fluorescence imaging comprising introducing the near infrared fluorescent contrast agent of the present invention into a living body, exposing the body to an excitation light, and detecting near infrared fluorescence from the contrast agent. The near infrared fluorescent contrast agent of the present invention is excited by an excitation light and emits near infrared fluorescence. This infrared fluorescence is superior in transmission through biological tissues. Thus, detection of lesions in the deep part of a living body has been made possible. In addition, the inventive contrast agent is superior in water solubility and low toxic, and therefore, it can be used safely.

Disclosed are nanostructured gold films which may be produced by solution-phase depositions of gold ions onto a variety of surfaces. The resulting plasmonic gold films are used for enhanced spectroscopic-based immunoassays in multiplexed microarray format with detection mechanisms based on either surface-enhanced Raman scattering or near-infrared fluorescence enhancement. The preparation of the films and subsequent modifications of the gold film surfaces afford increased sensitivity for various microarrays. The films are discontinuous, forming gold “islands.” Sensitivity, size, shape, and density of the nanoscopic gold islands comprising the discontinuous nanostructured gold film are controlled to enhance the intensity of Raman scattering and fluorescence in the near-infrared, allowing for improved measurements in clinical diagnostic or biomedical research applications.

The invention relates to a method based on near infrared fluorescence molecules and nano particle marks as well as an immunochromatography quantitative detection reagent based on near infrared fluorescence nanoparticles. According to the invention, infrared fluorescence is connected with nanoparticles to prepare an immunochromatography test strip based on the near infrared fluorescence nanoparticles. During the detection, an infrared light scanner is utilized, and a quality control line and a sample line are respectively scanned by utilizing near infrared light; and after the fluorescence intensity of a detection line is rectified by utilizing the fluorescence intensity of a quality control line, and a standard curve in a fluorescence analyzer is taken in, the concentration of a to-be-detected matter in a sample can be analyzed and detected. Compared with the direct connection of the near infrared fluorescence molecules and detecting molecules, the near infrared fluorescence nanoparticle immunochromatography improves the detection flexibility obviously, and the lowers the background fluorescence intensity. The marking method and the reagent can be applied to microorganism detection, food safety detection, poison detection as well as rapid dangerous chemical product detection.

The invention discloses a near-infrared fluorescent magnetic micro-emulsion nanometer particle, its preparation method and application in tumor treatment, wherein magnetic nano-particles and near-infrared luminescent quantum dot nano-particles or near-infrared luminescent organic dyestuff molecules are embedded into water-in-oil micro-emulsion, anti-cancer drugs can also be embedded into the micro-emulsion, the magnetic steering action of the magnetic nano particles will target the micro-emulsion embedded near-infrared fluorescent substances to tumor positions or secure them onto tumor positions under the excitation of near-infrared lights, the thermal effects produced by the near-infrared lights can kill tumor cells, the OH and O2 free radicals with high activity and the optical catalytic activity of the quantum dots can also have synergic actions in destroying tumor cells.

The invention relates to a dark red/near-infrared multifunctional aggregation-induced light-emitting material, a preparation method and application thereof. According to the dark red/near-infrared multifunctional aggregation-induced light-emitting material, a pyridine ring in the molecular structure endows the molecule with electropositivity, and meanwhile, the molecule has appropriate lipo-hydropartition coefficient (with ClogP being greater than 3 and less than 5) and space structure, and is beneficial to combination with gram-positive bacteria. During co-culture of the molecule with bacteria, specific "lightening" imaging of gram-positive bacteria can be realized; the strong electron donating (D)-electron withdrawing (A) effect of the molecule itself causes absorption and emission wavelength red shift of the molecule, thus having dark red/near-infrared fluorescence emission and strong ROS generation capacity. Meanwhile, the aggregation-induced light-emitting material provided by the invention can efficiently kill gram-positive bacteria.

Use of near-infrared fluorescence imaging in performing an endoscopic surgery, such as laparoscopic cholecystectomy. A composite video image of the surgical field (e.g. the biliary anatomy) is shown on a display screen. The composite video image combines a visible color image and a fluorescence image of the surgical field. Using various techniques, selective fluorescence imaging of a particular area of interest in the surgical field is made possible. For example, in a cholecystectomy procedure, the biliary ducts may be the particular area of interest for the selective fluorescence imaging.

The invention relates to two novel difluoro boron dipyrromethene compounds which can be used as near-infrared fluorescent dyes and a preparation method thereof and belongs to the techcnial field of fluorescent probes. 8-(4-(chloromethyl) phenyl)-4,4-difluoro-1,3,5,7-tetramethyl-4-boron-3a,4a-dipyrrole (labeled as BODIPY-C), 1,2,3,4-tetrahydro naphthalene, 5-hydroxyl isophthalate and p-anisaldehyde are used as raw materials to synthesize the two novel difluoro boron dipyrromethene (BODIPY) derivatives. The two compounds are compounds for near-infrared absorption and near-infrared fluorescence emission and can be expected to be used as fluorescent probes for imaging in cells or organisms, and background interference is reduced.

The invention relates to a multifunctional nanomicelle for early diagnosis and phototherapy of tumors. The multifunctional nanomicelle comprises a monolayer functionalized lipid membrane shell, photosensitive molecules and optothermal absorbents, wherein the photosensitive molecules and the optothermal absorbents are embedded into the monolayer functionalized lipid membrane shell. The multifunctional nanomicelle has the advantages that the nanomicelle can be used for multi-modal imaging diagnosis such as early magnetic resonance imaging, photoacoustic imaging or near-infrared fluorescence imaging of cancer; multiple kinds of diagnosis effects can be achieved as long as a patient suffers from one contrast medium administration; since sensitivity is improved, contrast medium injecting dosage is further decreased, and toxic and side effects on the patient can be alleviated; when the tumors are under single-wavelength near-infrared laser radiation, chlorine 6 and Pdots inside the nanomicelle are capable of converting light energy into chemical energy and thermal energy effectively to produce a great number of ROS (reactive oxygen species) oxygen free radicals and overhigh heat at 50-60 DEG C, and the ROS oxygen free radicals and the overhigh heat are used for inducing apoptosis and necrosis of cancer cells, so that a photodynamic and photothermal collaborative therapy function is achieved; the multifunctional nanomicelle not only can be used as a contrast medium for cancer diagnosis, but also can be used as a therapeutic agent for collaborative therapy of the cancer.

The invention belongs to the technical field of luminescent materials, particularly relates to near-infrared fluorescent powder, and further discloses a preparation method of the near-infrared fluorescent powder and a luminescent device containing the fluorescent powder, wherein the near-infrared fluorescent powder comprises an inorganic compound with a composition formula of AxRpOr, an AxRpOr structure is used as a matrix and is doped with specific rare earth ions or transition metal ions to form the compound, the excitation peak of the prepared fluorescent powder is located at 350-750 nm, broadband emission is shown under the excitation of ultraviolet light, blue light or red light, and the emission main peak is located at 700-1600 nm. According to the invention, the near-infrared fluorescent powder materials with different emission wavelengths can be prepared by constructing solid solutions through ion substitution and other methods due to the influence of crystal field splitting, so that the luminous intensity of the fluorescent powder is remarkably improved, the spectrum adjustability is realized, and the application range of the fluorescent powder material is further expanded.

The invention belongs to the technical field of analysis and detection, and provides a lysosome-targeted Cys near-infrared fluorescent probe and a preparation method and application thereof. The near-infrared fluorescent probe is 3-(2-(3-(dicyanomethylene)-5,5-dimethylcyclohexen-1-yl)vinyl)-4-morpholinyl coumarin-7-acrylate which is abbreviated as DCICA. The prepared lysosome-targeted Cys near-infrared fluorescent probe has the characteristics of novel structure, lysosome targeting performance and near-infrared fluorescence emission (wherein an emission wavelength is 680 nm), can realize high-selectivity high-sensitivity detection of a Cys content of a solution, conducts specific detection of Cys in cell lysosome by using a laser confocal imaging technology, is of important guiding significance to research on the molecular mechanism of participation of the Cys in the life activity of the lysosome, and has a wide application prospect.

A method and a portable device for assessing the occurrence of an agent in a sample. A sample is illuminated with photons emanating from a portable device to produce photons reflected, emitted, or absorbed from a set of multiple points in the sample having a defined geometric relationship. The portable device is used to simultaneously illuminate the sample and analyze the photons reflected, emitted, or absorbed from the set of multiple points using spectroscopic methods, including infrared, fluorescence, and UV/visible. The agent assessed may include a hazardous agent, a chemical agent, a biological agent, a microorganism, a bacterium, a protozoan, a virus, and combinations thereof.

The invention discloses a tumor microvascular imaging instrument and a tumor microvascular imaging method. The tumor microvascular imaging instrument comprises an infrared confocal imaging part and a control part, wherein the infrared confocal imaging part comprises a near-infrared laser, a dichroscope, a two-dimensional scanning galvanometer, a scanning lens system, an imaging objective, a near-infrared fluorescence filter, a convergent lens, a pinhole and a detector; the scanning lens system is composed of a field lens and a cylindrical lens; the control part comprises a two-dimensional scanning control module which is used for controlling the two-dimensional scanning galvanometer, a signal amplification and acquisition module and a data processing and image displaying module; near-infrared quantum dots that a fluorescence excitation spectrum ranges from 1000nm to 1350nm and a fluorescence emission spectrum ranges from 1350nm to 1500nm are injected to blood vessels of a to-be-observed living body; and then a tumor part of the living body is observed under the tumor microvascular imaging instrument. According to the tumor microvascular imaging instrument and the tumor microvascular imaging method provided by the invention, complete three-dimensional imaging of tumor microvessels of the living body can be implemented with a high resolution.

The invention discloses a preparation method and application of a hydroxyl porphyrin-based high-selectivity near-infrared fluorescence sulfur ion probe. The fluorescence probe is prepared by taking 5-hydroxyphenyl-11,15,20-triphenylporphyrin (TPP-OH) and 4-chlorine-7-nitro-1,2,3-benzoxadiazole (NBD-Cl) as materials, taking 4-dimethylamino pyridine (DMAP) as a catalyst, taking dichloromethane as a solvent and performing one step reaction under room temperature. The preparation method of the probe is simple, and a product is easy to separate and purify. Compared with an existing small organic molecule fluorescence probe, the fluorescence probe obtained by the preparation method has higher fluorescence emission wavelength (lumbda em is greater than 650nm), high-sensitivity and high-selectivity quick recognition and detection on a trace of hydrogen sulphide can be realized in a near-infrared region, and the application prospect is great in the field of environmental and biological detection.

The invention relates to the field of optical functional materials, and more specifically relates to an infrared BODIPY fluorochrome. The fluorochrome has a structure shown in a formula (1), wherein R1 and R2 are mutually independent and selected from C1-C10 alkyl, aromatic bases or heterocyclic aromatic bases; R3 is one of H atom, C1-C10 alkyl or aromatic bases. The fluorochrome has the advantages of narrow ultraviolet visible absorption spectroscopy and fluorescence emission spectrum, high molar absorption coefficient, high fluorescence quantum efficiency, good light stability, trace detection, and high sensitivity; and the fluorochrome can be applied to cell imaging, fluorescence probe, laser dye, fluorescence sensor and near infrared dynamics, and different application fields with good practicality.

The present invention provides for a composition comprising a pigment, wherein the composition is suitable for coating a surface that is, or is expected to be, exposed to the sun. The pigment comprises particles that fluoresce in sunlight, thereby remaining cooler in the sun than coatings pigmented with non-fluorescent particles. The particles comprise solids that fluoresce or glow in the visible or near infrared (NIR) spectra, or that fluoresce when doped. Suitable dopants include, but are not limited to, ions of rare earths and transition metals. A coating composition includes: (i) a film-forming resin; (ii) an infrared reflective pigment; and (iii) an infrared fluorescent pigment different from the infrared reflective pigment. When the coating composition is cured to form a coating and exposed to radiation comprising fluorescence-exciting radiation, the coating has a greater effective solar reflectance (ESR) compared to the same coating exposed to the radiation comprising fluorescence-exciting radiation except without the infrared fluorescent pigment. A multi-layer coating including the coating composition, and a substrate at least partially coated with the coating composition is also disclosed. A method of reducing temperature of an article includes applying the coating composition to at least a portion of the article.

The invention discloses an augmented reality near-infrared fluorescence navigation system and method. The system comprises a near-infrared fluorescence navigation device, which is used for exciting and capturing a fluorescence signal, converting the fluorescence signal into a fluorescence image, and processing the fluorescence image and then generating a projection image, and comprises an excitation light source, an optical filter group, an imaging lens group and a spectroscope; and a projection module, used for receiving the generated projection image and generating projection light accordingto the projection image, wherein the generated projection light passes through the spectroscope, and is imaged on an observation tissue after being focused by the imaging lens group. Through the projection technology, invisible near-infrared fluorescence is visualized, the reality enhancement effect is achieved, and the problem that traditional intraoperative navigation equipment needs to repeatedly observe a display image and check the position of an actual biological tissue fluorescence signal is solved.

The invention discloses a near-infrared fluorescence detection kit for C-reactive protein and application of the near-infrared fluorescence detection kit. The near-infrared fluorescence detection kit comprises a reagent strip positioned on a back plate, wherein the reagent strip is a sample pad, a glass cellulose membrane marked with an immune fluorescent probe, a nitrocellulose membrane coated with a C-reactive protein antibody and water absorbing paper from the sampling end in sequence. The near-infrared fluorescence detection kit disclosed by the invention can quickly and accurately detect the C-reactive protein in human whole blood, serum or plasma in combination with a near-infrared fluorescence detection technology.

The invention discloses a near-infrared fluorescent molecular probe for detecting hydrogen sulfide and a preparation method and application of the near-infrared fluorescent molecular probe. The near-infrared fluorescent molecular probe has a molecular formula of C31H29N4O+, and has a structure formula shown in the description. Compared with the prior art, the near-infrared fluorescent molecular probe disclosed by the invention is good in selectivity and good in response effect on hydrogen sulfide, and in addition, can be well applied to living imaging and the like because of the properties ofnear-infrared absorption and fluorescence emission. In addition, the near-infrared fluorescent molecular probe is simple in synthesis process, low in cost and high in yield.

The invention relates to a carbazolyl-based organic double-heterocyclic near-infrared fluorescent probe, which has a structural formula I shown in the specification. The near-infrared fluorescent probe has strong emission in a near-infrared wavelength region, and has high photo-thermal property and chemical stability. The near-infrared fluorescent probe is simple in preparation method, high in fluorescence quantum yield and large in Stokes shift, and has important application prospects in development of near-infrared fluorescent probes and bioluminescence imaging, wherein X is O or S.