113 results about "Intraoperative navigation" patented technology

The invention provides a control method of an intestinal tumor resection robot combining preoperative images and intraoperative navigation, and relates to the technical field of medical instrument control. The method comprises the following steps: acquiring preoperative multi-modal image data of the intestinal tract of a patient, and performing three-dimensional reconstruction on the image data to generate an initial three-dimensional model; dividing a navigation area in the enteric cavity according to the initial three-dimensional model; based on the core area, collecting a dynamic image of the intestinal tract inner cavity in real time through intraoperative navigation equipment, extracting anatomical mark points in the dynamic image, registering the dynamic image with the initial three-dimensional model, updating tissue deformation parameters in the three-dimensional model, and obtaining an updated three-dimensional model; on the basis of the updated three-dimensional model, obstacles in the intestinal tract are recognized, and the minimum space distance between the obstacles and the robot tail end instrument is calculated; and according to the spatial distribution and the minimum spatial distance of the obstacles, an initial motion path of the robot tail end instrument is planned. According to the invention, the efficiency and accuracy of the intestinal tumor resection operation can be improved.

The invention provides a catheter tip positioning method and system in central venous catheterization and a medium, and relates to the field of medical image data processing. The system comprises a CT center line extraction module, a puncture position prediction module, a catheterization target calculation module, an ultrasonic center line extraction module, an image fusion module, a catheter position projection module and a catheterization completion judgment module. According to the intelligent navigation positioning technology in the central venous catheterization based on ultrasonic, CT and electromagnetic navigation multi-mode fusion, ultrasonic, CT, electromagnetic positioning and deep learning are creatively fused, accurate positioning and real-time monitoring of the tip of the catheter in the central venous catheterization are achieved, and the learning threshold is lowered.

The invention relates to the field of data processing, and discloses a neurosurgery operation data processing method for precision medical treatment, which is used for solving the problem that mark points cannot be captured due to the fact that a navigation camera is shielded when intraoperative data is collected. The method comprises the following steps: acquiring preoperative image data, intra-operative navigation image data and spatial information of an intra-operative reference mark point, constructing a preoperative three-dimensional navigation model through the preoperative image data, obtaining a navigation coordinate system, obtaining an intra-operative image frame sequence through the intra-operative navigation image data, carrying out spatial registration, extracting intra-operative navigation information, and obtaining an intra-operative image frame sequence. The method comprises the following steps: acquiring intraoperative navigation information, judging whether occlusion occurs in an operation or not according to the intraoperative navigation information, if yes, generating missing image frame data during occlusion through a dynamic trajectory prediction model, and effectively judging the missing image frame data according to a newest instrument space pose, thereby effectively improving data integrity and coherence, improving operation data accuracy and improving operation accuracy. The operation risk is reduced.

The invention discloses an intraoperative pulmonary nodule positioning method and system based on fusion of a CT image and an endoscope video. The method comprises the following steps: firstly, constructing a three-dimensional lung model containing a pulmonary nodule position based on preoperative high-resolution CT data; generating a real-time lung surface model by using an endoscope video stream through a three-dimensional reconstruction technology during the operation; a feature point extraction and matching algorithm is adopted, and a non-rigid registration technology is combined to realize accurate registration of the preoperative model and the intraoperative dynamic model; projection display of pulmonary nodules in a real-time endoscope visual field is established through space coordinate mapping, and a dynamic compensation algorithm is developed to solve the problem of tissue deformation caused by respiratory movement and instrument operation. Meanwhile, the virtual nodule position is overlaid to an endoscope video picture through the augmented reality technology, and visual intraoperative navigation is provided for surgeons. The method effectively solves the technical bottleneck that a traditional method depends on a metal marker and cannot adapt to intraoperative tissue deformation and the like, and has clinical practical value.

The invention discloses a lung three-dimensional reconstruction method and system for intraoperative positioning, and the method comprises the steps: processing a lung CT image in a DICOM format through an improved lung parenchyma segmentation algorithm, precisely extracting a lung structure through a global threshold method, connected region analysis and mathematical morphology processing, and then processing a mask generated through segmentation through a real-time smooth interpolation method, and through a dynamic parameter adaptation technology, accurate matching of a segmentation result and a gray value range of modeling data is ensured. According to the method, the problems of artifacts, redundant surfaces and gray level jump of the lung parenchyma area caused by separation of segmentation and reconstruction in a traditional method are avoided, full-process automation from data reading and lung parenchyma segmentation to three-dimensional modeling and visualization is achieved, meanwhile, a user-friendly interaction interface is designed, and a convenient tool is provided for intraoperative navigation.

The invention provides a multi-modal medical image intelligent analysis system and method based on a large language model, and the system comprises a key frame extraction module which carries out the key frame extraction through a multi-frame quality evaluation algorithm; the coronary artery blood vessel extraction module is used for realizing accurate extraction of a coronary artery tree structure through multi-scale blood vessel enhancement; the pathological recognition module adopts an improved DeepLabV3 + algorithm to construct a cardiac blood vessel blockage region segmentation model; the multi-modal diagnosis module adopts LLaVA-Med multi-modal diagnosis, integrates vision and language understanding ability, and combines DeepSeek to generate a standardized diagnosis report; the model optimization module is used for implementing model parameter iterative updating based on a near-end strategy optimization algorithm; and the visual interaction module is used for visually displaying the lesion position and the spatial relationship thereof, so that a doctor can conveniently carry out preoperative path planning and intraoperative navigation judgment. On the basis of a large language model and a multi-mode technology, full-process support from image uploading to diagnosis decision making is provided.

The invention provides a training method of a CT and DSA real-time automatic fusion registration system for structural heart disease intervention and a storage medium. The training method comprises the following steps: establishing a registration system data set; establishing an initial registration system; based on the registration system data set, training an initial registration system to obtain a trained CT and DSA intraoperative registration system; and inputting the preoperative CT image data and the intraoperative real-time DSA image data of the person to be identified into the trained CT and DSA intraoperative registration system to obtain an intraoperative real-time fusion navigation image and intraoperative risk graphical prompt information. According to the method, cross-modal and cross-time-point dynamic registration can be realized, higher-precision intraoperative navigation support is provided for structural heart disease intervention, the operation safety is improved, and radiation exposure is reduced.

A surgical system and method for markerless intraoperative navigation is provided. The system can includes a structured light system that can be utilized to intraoperatively sense three-dimensional surface geometry. The computer system is configured to segment a depth image to obtain surface geometry data of an anatomical structure embodied within the depth image, register the surface geometry data of the anatomical structure to a model, and update the surgical plan according to the registered surface geometry data. The surgical system is an endoscopic surgical system.

The invention provides a maxillofacial operation planning navigation method and system, relates to the technical field of operation planning navigation, and solves the technical problems that the existing maxillofacial operation planning navigation method cannot adapt to the change of an intraoperative anatomical structure due to a preoperative planning static state, and the intraoperative navigation efficiency and precision are insufficient. The method specifically comprises the following steps: acquiring first image data of a to-be-operated region; preprocessing the first image data based on an image processing algorithm to determine second image data; performing three-dimensional reconstruction and segmentation on the second image data to obtain a three-dimensional data model; analyzing the three-dimensional data model through an AI intelligent auxiliary diagnosis model, and generating a diagnosis report; inputting the three-dimensional data model and the diagnosis report into a two-channel model, and outputting an operation path scheme and a bone fracture plate scheme; in the operation, non-rigid registration is adopted to compensate real-time deformation delay for first image data before the operation and in the operation, and an AR real-time navigation technology is combined to realize maxillofacial operation planning navigation. The method is used for maxillofacial surgery planning navigation.

The invention discloses a human-derived hysteromyoma targeting peptide and application thereof, the sequence of the targeting peptide is selected from SEQ ID NO: 1 to SEQ ID NO: 5, and the SEQ ID NO: 1 (VN12) is the most preferable. The fusion protein is obtained by screening through a phage display technology, and has high hysteromyoma targeting specificity and low immunogenicity. The targeting peptide can be coupled with nuclide or fluorescent dye, and is used for accurate PET imaging, fluorescent diagnosis and intraoperative navigation of hysteromyoma. Experiments prove that the molecular marker is specifically enriched in tumor tissues (the tumor / muscle ratio is 60), the biological safety is good, the problems of insufficient diagnosis sensitivity and large treatment wound in the prior art are solved, and the molecular marker has a great application prospect in diagnosis and treatment of hysteromyoma.

The present application relates to the technical field of medical devices, and discloses a method for simulating stress distribution of a guide wire on a heart valve and perivalvular tissue, comprising: obtaining image data of the heart valve and perivalvular tissue of a patient before surgery, and obtaining strain of each structure; constructing a material constitutive equation of the heart valve and perivalvular tissue to determine stress-strain relationship of each structure under different stress conditions; determining first stress distribution of the heart valve and perivalvular tissue according to the strain of each structure in the heart valve and perivalvular tissue and the stress-strain relationship of each structure under different stress conditions; obtaining second stress distribution of the guide wire when the guide wire is in different morphological positions in the heart valve; and determining third stress distribution of the guide wire on the heart valve and perivalvular tissue when the guide wire is in different morphological positions in the heart valve according to the first stress distribution and the second stress distribution, so as to accurately perform intraoperative navigation of the guide wire.

The present invention provides a system and method for a two-step registration procedure that enables complete surgical intervention by a robot. [Solution] A system for intraoperative navigation is provided, comprising a processing unit and a tracking device for real-time or near-real-time tracking of an object in a 3D coordinate system, wherein the processing unit is configured to receive an X-ray image depicting an anatomical structure including at least one bone, and to determine an incomplete registration of the position of the anatomical structure in the 3D coordinate system. The incomplete registration is determined based on a 3D dataset of the received anatomical structure and a plurality of virtual X-ray images generated from different directions based on the 3D dataset of the anatomical structure. The incomplete registration can be understood as an approximation of the position of the anatomical structure. Based on the incomplete registration, instructions for the navigation of the device are provided.

The utility model discloses a special skull drape structure for an intraoperative navigation frame, which comprises a skull drape main body and a navigation port covering sheet, a navigation frame abdicating port is arranged on the skull drape main body at the head position of a patient, a rod part through hole is arranged at the center of the navigation port covering sheet, and the navigation port covering sheet is sewed and mounted at the navigation frame abdicating port through a connecting part. The navigation opening covering piece can completely cover the navigation frame receding opening through overturning, the navigation opening covering piece is of a circular structure and is provided with an opening, and the opening extends into the rod portion penetrating hole from the edge of the navigation opening covering piece in the radius direction of the navigation opening covering piece. The device is suitable for the skull drape, the navigation opening covering sheet is designed to be of the circular sheet-shaped structure with the opening, therefore, after the navigation frame is installed, the navigation frame can be directly wound around the navigation frame and turned over to cover the navigation frame receding opening, and the navigation opening covering sheet can completely and flatly cover the navigation frame receding opening; and the condition that the positions of the navigation frames are uneven is avoided.

The invention provides a surgical navigation system and method based on electromagnetic positioning and augmented reality, and the system comprises an image data three-dimensional reconstruction module which is used for importing preoperative medical image data into the system, and generating a visual model through a three-dimensional reconstruction algorithm; the pre-operation registration module is used for realizing space mapping of an image coordinate system and an operation coordinate system through a registration method based on mark points; the electromagnetic positioning and coordinate mapping module is used for tracking the pose of the surgical instrument in real time and mapping the coordinates of the instrument to the surgical coordinate system; the augmented reality and high-precision navigation module is used for fusing and displaying the registered virtual navigation image and a real operation scene; the electromagnetic positioning and coordinate mapping module and the augmented reality and high-precision navigation module form a surgical navigation platform integrating electromagnetic tracking and augmented reality display; by fusing the high-precision anti-shielding capability of electromagnetic positioning and the visual visualization effect of augmented reality, stable, accurate and visual intraoperative navigation can be realized.

The application relates to the technical field of image processing, and provides a preoperative image registration processing method, device, system and storage medium, which can provide navigation information for intraoperative navigation in the scene of preoperative image guided puncture and lack of intraoperative real-time scanning image. According to each group in the respiratory phase sequence from the respiratory phase change of the preoperative image to the intraoperative respiratory phase, the image statistical shape model and the deformation field statistical shape model are determined according to the two respiratory phases of the group; the image weight of the group is obtained according to the image statistical shape model of the group and the image corresponding to the preceding respiratory phase; the weight proportion coefficient target value of the group is obtained based on the joint of the image statistical shape model and the deformation field statistical shape model of the group, and then the deformation field weight of the group is obtained in combination with the image weight; the deformation field of the group is obtained according to the deformation field weight and the deformation field statistical shape model of the group; and the preoperative image is registered and deformed according to the deformation fields of the groups.

This invention discloses a fluorescence-enhancing nanoparticle, its preparation method, and its applications, relating to the fields of organic fluorescent molecules and bioimaging technology. The nanoparticle comprises: NIR-II fluorescent molecules and an amphiphilic polymer encapsulating the NIR-II fluorescent molecules; the amphiphilic polymer has a hydrophilic segment and a rigid hydrophobic segment. The nanoparticle of this invention, based on "carrier microenvironment engineering," utilizes the rigid confinement and interfacial isolation provided by the amphiphilic polymer with the rigid hydrophobic segment for dual brightening, serving as a universal brightening platform applicable to various NIR-II fluorescent molecules. This nanoparticle can significantly improve aqueous phase quantum yield, enhance contrast and resolution in in vivo vascular imaging, improve deep tissue penetration, increase imaging sensitivity, and facilitate detection under low signal conditions. It also exhibits good stability and biocompatibility, supporting lesion imaging and intraoperative navigation applications.

The application relates to the technical field of orthopedic surgery navigation, and discloses a high-position tibial osteotomy navigation method, a system and a storage medium, and a communication method which comprises the following steps: generating a 3D bone model of a lower limb of a patient based on medical images and performing preoperative osteotomy planning; performing visual positioning system detection and spatial calibration of a surgical instrument; installing an optical marker array, collecting actual bone point cloud data, and realizing alignment of the model and the bone through a registration algorithm; in-surgery real-time calculation and display of deviation of an operation track and planning parameters; post-surgery reconstruction of a lower limb force line, and comparison and evaluation with preoperative planning and in-surgery navigation records. The system comprises a hardware execution unit and preoperative planning, calibration verification, in-surgery registration, real-time navigation and post-surgery evaluation modules. The application realizes full-process integration of preoperative accurate planning, in-surgery real-time closed-loop navigation and post-surgery quantitative evaluation, and significantly improves the precision, repeatability and predictability of clinical effects of surgery.

The invention relates to the technical field of magnetic resonance imaging, in particular to an intra-operative low-field magnetic resonance intelligent navigation method based on preoperative high-field data guidance, which comprises the following steps: acquiring a high-field MRI image of a patient before an operation and extracting a three-dimensional segmentation mask and clinical features of a focus; adjusting according to the clinical features to obtain an intraoperative scanning protocol; and performing low-field magnetic resonance examination during the operation to generate an intra-operation navigation image, and marking focus information. Aiming at the problem that the accuracy of a focus image provided by an ultra-low field system in the operation process in the prior art is not enough, a high-field MRI image collected before the operation is introduced as a reference, scanning sequence parameters of the ultra-low field system used in the operation are dynamically adjusted based on clinical features embodied in the high-field MRI image, a better imaging effect is achieved, and meanwhile, the accuracy of the focus image provided by the ultra-low field system in the operation process is improved. Focus information is marked on the intraoperative navigation image based on the three-dimensional segmentation mask as prior information, so that more refined segmentation of focuses on the intraoperative navigation image is realized, and the surgical requirements are met.

A renal-cleared, long-circulating near-infrared fluorescent probe, its preparation method, and applications. This renal-cleared, long-circulating near-infrared fluorescent probe utilizes a sulfonated calixarene derivative as a renal-clearing moiety and a cyanine dye derivative as a fluorophore, coupled via a click reaction. This probe exhibits broad spectrum compatibility with a variety of fluorophores and exhibits excellent water solubility, biocompatibility, rapid renal clearance, extended blood circulation time, and tumor targeting. As a fluorescent probe, it enables more precise non-invasive imaging of diseases and intraoperative navigation.

The invention relates to the technical field of operation planning navigation systems, in particular to a spinal operation intelligent planning and intraoperative navigation system which comprises a data input module, a spinal model building module, an operation planning module, a dynamic deformation tracking module, a navigation control module and a data output module. A spine is represented as a differential manifold through a manifold parameterization unit, a local coordinate construction unit is utilized to establish a multi-local coordinate system, a deformation field calculation unit calculates a spine deformation field based on optical mark point displacement, a deformation prediction unit generates a prediction deformation field, and a compensation parameter generation unit generates navigation compensation parameters. The system also comprises an operation path mathematical optimization algorithm and a scheme sharing mechanism based on a two-dimensional code, and is provided with a fault-tolerant processing module to ensure the stability of the system. According to the system, the navigation precision is improved from the traditional millimeter level to the submillimeter level, the accuracy and safety of spinal surgery are remarkably improved, and the system has wide clinical application prospects.

This invention discloses a method for intraoperative navigation of craniostomy based on curvature guidance and online pose maintenance, belonging to the field of intraoperative navigation of craniostomy. This invention constrains the curvature prior of the natural human structure: curvature estimation uses the auricle (along the arcuate ridge line of the helix / antihelix) and the nasal ala (along the arcuate ridge line of the nasal ala rim / nasal groove) as anatomical references, preferentially preserving these curvature features and suppressing their tangential "sawtooth" jitter; it provides a continuous and stable 6DoF initial pose on the time axis, and gating freeze / backoff is used to avoid initial value jumps in case of occlusion or mismatch; spatially, curvature-guided filtering is used, combined with anisotropic diffusion of prior constraints to complete edges and holes, improving effective overlap and connectivity. The correspondence between point clouds is more reliable, and the initial values ​​are closer to the true solution, thus enabling robust kernel ICP to converge stably under normal / distance gating, meeting the requirements of high-precision rigid registration and continuous navigation of intraoperative-preoperative 3D models.

According to the skeleton local reduction robot system, a skeleton traction nail is fixed through a positioning sleeve, the positioning sleeve is rotationally connected with a support body, so that rigid connection is established between a tracer arranged on the support body and a skeleton, and an intraoperative navigation module can generate a real-time skeleton position map based on the tracer; planning a bone reduction path of the six-axis manipulator; the invention further provides a dynamic restoration method of the restoration path, through multi-source data complementation of the optical tracer, the micro inertial measurement unit and the ultrasonic positioning chip, positioning interruption caused by shielding of traditional single optical positioning is avoided, continuity and accuracy of bone position data are ensured, and the dynamic restoration method of the restoration path is achieved by arranging the six-dimensional force sensor at the six-axis mechanical arm. The traction force, pressure and torque data borne by the fracture end in the reduction process are collected in real time so as to judge the magnitude of resistance encountered in the reduction process of moving the bone, and the moving path is dynamically repaired.

The embodiment of the invention discloses a three-dimensional myocardial scar visualization system. According to one specific embodiment, the system comprises a data processing end configured to perform heart structure and scar segmentation on target heart magnetic resonance data to obtain a binary tag graph for the heart and the myocardium; constructing an individualized ventricular network and a scar three-dimensional surface model based on the binary label graph; generating an initial myocardial scar three-dimensional model; generating lead implantation track information; generating a myocardial scar three-dimensional model according to the lead implantation track information; and the model application end is configured to perform model rendering on a target application page according to the model parameters corresponding to the myocardial scar three-dimensional model sent by the data processing end so as to provide an interactive operation function and generate a clinical report. According to the embodiment, accurate and visual three-dimensional visual decision support can be provided for preoperative planning and intraoperative navigation of heart diseases, so that the accuracy of surgical planning and the clinical working efficiency are remarkably improved.

The invention provides a unicompartmental knee arthroplasty surgical robot system and a control method, and the system comprises a preoperative planning module which is used for carrying out the segmentation and reconstruction of a knee joint according to an obtained knee joint medical image, carrying out the preoperative planning, and determining a unicompartmental knee arthroplasty scheme; the positioning navigation module is used for carrying out registration on the intraoperative entity knee joint and the preoperative knee joint three-dimensional model according to the navigator and the tracer so as to map a unicompartmental knee replacement scheme and track the poses of the guide equipment and the entity knee joint in real time; and the mechanical arm control module is used for planning a path from the mechanical arm to the preparation position and controlling the mechanical arm guide equipment to move to the thighbone preparation position and the tibia preparation position. In this way, the mechanical arm can be controlled to assist in completing the osteotomy operation of unicompartmental knee arthroplasty in a pre-operation planning and intra-operation navigation mode, and the problems that the operation level is uneven and the operation effect is not expected due to different individuals in the current manual operation are solved.

The invention relates to the technical field of animal medicine, in particular to a self-adaptive control system and method for animal tracheal instillation. The system comprises a preoperative planning module which is used for reconstructing a three-dimensional model based on an individual animal airway CT image, simulating and optimizing administration parameters through computational fluid mechanics, and generating a personalized operation plan; the intraoperative navigation and execution module guides a catheter to reach a target pose through electromagnetic navigation, and performs closed-loop regulation and control on the instillation process through a respiration synchronous triggering algorithm and a pressure self-adaptive control algorithm based on real-time respiration and pressure signals; the central control module coordinates the work of each module; and the postoperative verification module quantifies actual and predicted deposition effects through image comparison. The problems that a traditional method depends on experience, cannot adapt to physiological changes in real time and is poor in drug administration precision are solved, the spanning from experience operation to individualized precise self-adaptive control is achieved, and the safety, repeatability and scientificity of animal experiments are remarkably improved.

The invention relates to the technical field of intra-operative navigation, in particular to an intra-operative brain glioma deep learning detection method and system based on hyperspectral imaging, and the method comprises the steps: analyzing the internal heterogeneity of brain glioma based on spectral difference, and evaluating the coverage earnings of a pre-operative planning path and an intra-operative detour path; analyzing oxyhemoglobin saturation distribution based on absorption peak characteristics of hemoglobin in a specific wave band, and evaluating the ischemia risk of a pre-operation planning path and an intra-operation bypassing path; respectively mapping the pre-operation planning path and the intra-operation bypassing path to a brain functional region topology network, and evaluating a functional injury risk corresponding to the paths based on a topology connection relation and a local ischemia risk; and carrying out expected income and risk trend analysis on the pre-operation planning path and the intra-operation bypassing path, and generating an operation path decision suggestion. According to the method, the accuracy and the safety of operation path decision making are effectively improved by quantifying the path coverage income and the function damage risk of the operation path.

1. The name of this design product: Graphical user interface for laparoscopic minimally invasive surgery for display screen panel. 2. Purpose of this design product: This design product is a graphical user interface for laparoscopic minimally invasive surgery used to display a display screen panel. The display screen panel can be used for any of computers, notebook computers, tablet computers and multimedia terminals. 3. The key design point of this design product lies in the graphical user interface. 4. The picture or photo that best illustrates the key points of the design: Interface change state diagram 6. 5. The design for which protection is sought includes color. 6. If there is no design key point, the rear view will be omitted; if there is no design key point, the left view will be omitted; if there is no design key point, the right view will be omitted; if there is no design key point, the bottom view will be omitted; if there is no design key point, the top view will be omitted. 7. Purpose of the graphical user interface: Used on the main operating console page during laparoscopic minimally invasive surgery to display dynamic images collected by the endoscope, real-time status information of the instrument, intraoperative navigation and risk warnings. 8. Description of the changing states of the graphical user interface: The main view is the user login interface. After filling in the relevant information in the user login interface, click the "Tap to Login" button to enter the interface change state diagram 1 and enter the waiting state; after the connection is successful, enter the interface change state diagram 2 to display "Surgery Information". This interface has the login "User Name" button, "System Settings" and "Operation Mode" options; click "System Settings" to enter the interface change state diagram 3; click "Operation Mode" to enter the interface change state diagram 4. After the surgical instrument is successfully installed, enter the interface change state diagram 5. A highlight of the successful instrument installation pops up at the bottom of the interface, and the instrument name is displayed at the same time; when the surgical instrument is successfully activated and is in the startup state, enter the interface change state diagram 6. The instrument area is highlighted in orange at the bottom of the interface, and there are "Pre-cutting Line Navigation" and "Risk Warning" buttons above the interface; click "User Name" to enter the interface change state diagram 7. A "Confirm to Exit System Login" prompt box pops up. Select "Confirm to Exit" on this interface to exit the system, and select "Continue Surgery" to return to the surgery information interface.

The invention belongs to the technical field of biomedicine, and particularly relates to a responsive near-infrared first-zone fluorescent compound as well as a preparation method and application thereof. The compound mainly comprises a fluorescent probe of three functional modules including a fluorescent chromophore, a fibrosis specific enzyme response group and a quenching group, and on the basis, an active / passive targeting group of a targeted disease organ is introduced to form a more excellent fluorescent probe of four functional modules. The effect of the probe is verified in a time-varying progress experiment of a fibrosis disease model, and the probe not only has high specificity and sensitivity, but also has relatively good safety and biocompatibility; the near-infrared first-area fluorescent compound and pharmaceutically acceptable salts or solvates, enantiomers, diastereoisomers and tautomers thereof can be used for preparing fluorescent molecular probes, and diagnosis, intraoperative navigation treatment, tissue and organ function evaluation and the like can be more accurately carried out on diseases.

The application relates to the field of organic chemistry and high polymer chemistry, in particular to a functionalized double-block copolymer and a preparation method and application thereof. The application provides a functionalized double-block copolymer, and a chemical structural formula of the functionalized double-block copolymer is shown as formula I. The functionalized double-block copolymer or polymer particle provided by the application can be widely applied in the fields of tumor imaging and tumor treatment, and has not only good safety, realizes faster and adjustable (by changing the number of pipe groups) degradation and removal of the polymer under an acidic condition, but also has excellent specific high-quality imaging effects at a target site, has characteristics of high signal-to-noise ratio, clear boundary, long half-life and the like, solves the problem of real-time intraoperative navigation of the fluorescence imaging technology, and thus has good industrialization prospects.