311 results about "Radiation injury" patented technology

The invention relates to the field of drug development against acute radiation injury caused by exposure to high-energy electromagnetic waves (X-rays, gamma rays) or particles (alpha particles, beta particles, neutrons). To date, there is no effective drug to ameliorate radiation injury after accidental exposure to ionizing irradiation. The invention provides a method of treating radiation injury of a subject in need thereof comprising administering to the subject a peptide, or functional analogue or derivative thereof, of smaller than 30 amino acids. Furthermore, the invention provides use of a peptide, or functional analogue or derivative thereof, of smaller than 30 amino acids for the production of a pharmaceutical composition for the treatment of a subject suffering from or believed to be suffering from radiation injury. In particular, the invention provides anti-radiation peptides having a dose reduction factor (DRF) against acute gamma irradiation of at least 1.10, said DRF determinable by testing which dose of radiation results in 50% mortality at 30 days (LD50/30) after whole body radiation (WBI) in a test group of mice treated with said peptide at 72 hours after WBI and, testing which dose of radiation results in 50% mortality at 30 days (LD50/30) after whole body radiation (WBI) in a control group of mice treated only with the vehicle of said peptide at 72 hours after WBI and wherein the DRF is calculated by dividing the LD50/30 of the peptide-treated animals by the LD50/30 of the vehicle-treated animals.

The invention belongs to the field of bone surgery osteotomy orthotics devices, and particularly relates to a computer-aided design orthopedics department osteotomy, orthotics and immobilization integrated guide plate and a manufacturing method. The manufacturing method comprises the following steps: collecting bilateral bone data, and establishing a bilateral bone three-dimensional model; if a patient has an uninjured side limb, taking an uninjured side mirror model as a reference to determine an osteotomy angle and an osteotomy position, and performing orthotics and immobilization on an affected side; if a patient has no uninjured side limb for reference, performing osteotomy and orthotics on the affected side according to a normal structure and functional parameters, thus obtaining an angle needing to be corrected and a corresponding osteotomy angle, and achieving orthotics and immobilization; manufacturing the guide plate according to the osteotomy position, a position of an implanted steel plate and the like. The computer-aided design orthopedics department osteotomy, orthotics and immobilization integrated guide plate has the beneficial effects that by applying the guide plate, osteotomy, orthotics and immobilization are achieved in one step, immediate correction is realized, fluoroscopy during operation is not needed, operation time is shortened while radiation injury to the patient and doctors is reduced, risks such as bleeding and anesthetic accidents are reduced, the operation of orthopedics department osteotomy and orthotics is simplified, and operation accuracy is improved.

Inositol hexaphosphate (IP-6) is a polyphosphorylated carbohydrate with potent antioxidant activity to prevent active oxygen species-mediated mutagenesis, cell injury and carcinogenesis. IP-6 also activates DNA repair mechanisms. Sublethal radiation causes DNA damage through the formation of free radicals, reactive oxygen species, and pyrimidine crosslinks leading to cellular proliferation, cell cycle arrest and apoptosis. In the skin it results in the induction of skin cancer, premature skin aging, immuno-suppression, inflammation, and cell death. Likewise sublethal exposure to ionizing radiation as in nuclear blasts (war-time, accidental, terrorist-induced etc), cosmic radiation, etc. also causes the same spectrum of damage to the cells and the organisms with acute symptoms and eventual high risk of many cancers. IP-6 and/or inositol and their pharmaceutically acceptable salts and derivatives, including pyrophosphates and citrate derivatives, significantly counteract the harmful effects of radiation, affecting cell cycle progression in a protective manner (more cells in the protective GI phase) as well as decreasing apoptosis and caspase-3 activation. Various salts of IP-6 are used with comparable efficacy and the combination of IP-6+inositol affords the best protection against radiation-induced cell injury. Thus IP-6 and inositol are effective agents for protection against nuclear, solar and other radiation injuries.

The invention discloses a CT machine. The CT machine comprises a CT rack and a vertical elevating mechanism, wherein the CT rack is installed on the vertical elevating mechanism in such a mode that a scanning plane of the CT rack is parallel to the ground or is approximately parallel to the ground, and the vertical elevating mechanism can drive the CT rack to perform vertical elevating motion. According to the CT machine, CT scanning of a patient can be performed when the patient is in a standing state, on one hand, no hospital bed is required and the radiation injury to the patient is reduced, and on the other hand, the CT scanning and imaging quality of sickness areas which have special requirements for imaging is guaranteed.

The invention discloses a water-based environmental agate marble coating, which is prepared from the following raw materials in parts by weight (W/W): 12.4-19.7 parts of water, 8-20 parts of synthetic resin emulsion, 65-70 parts of pigment filler and 2.3-2.6 parts of assistant, wherein the assistant comprises one or a mixture of more than two of a corrosion remover, a dispersing agent, a wetting agent, a defoamer, an antifreeze agent, a coalescing agent, cellulose and a thickener; the pigment filler is a filler and a mill base and also comprises titanium dioxide. The water-based environmental agate marble coating has a vivid marble decorating effect which cannot be matched by a common coating after being coated, achieves the characteristics of seamless coating, good protectiveness, and easy repairing after being damaged, and overcomes the defects that wallpaper decoration has an edge joint, and is easily damaged and affected with damp to fall off, and difficult to repair, meanwhile, the problems that natural marble has a radiation injury on a human body is solved, the storage period exceeds 36 months, and the water-based environmental agate marble coating is good in storage stability, healthy and environment-friendly. The invention also discloses a preparation method and a construction method of the water-based environmental agate marble coating.

The disclosed antenna assembly is composed of N pieces (N is larger than or equal to 1) of antenna unit and M pieces (M is larger than or equal to 1) of ground of antenna. K pieces (K larger than zero and smaller than N) of antenna unit are positioned on the ground of antenna between main body and case of wireless communication terminal. Other (N-K) pieces of antenna unit are positioned on the ground of antenna between back of screen of turnable cover and case of wireless communication terminal. Through feeder apparatus, N pieces of antenna unit are connected to relevant transmitter or receiver. Features are: low spatial correlation, no radiation injury, low cost and easy of manufacturing. The invention can be widely applied for wireless communication for obtaining space diversity, angle diversity or polarization diversity of radio wave propagation, or in use for transmitting or receiving time-space coding or multiple inputs and outputs wireless communication system.

The present invention uses a shielding metal on a motherboard of a mobile phone as a natural anti-radiation shield to design a monopole antenna hidden in the housing of the mobile phone to prevent the mobile phone from breakage, and to reduce radiation in the user direction from the monopole antenna. Moreover, the monopole antenna may be further connected to a helical coil antenna wherein the helical coil antenna is located in a direction perpendicular to the monopole antenna for enhancing the radiation effect and reducing the human injury by the radiation.

Methods and kits are provided for assessing radiation injury and exposure in a mammal. The methods comprise the steps of: obtaining one or more test samples from the mammal, contacting the test samples with an antibody immunoreactive with a citrullinated protein to form an immunocomplex; and detecting the immunocomplex with an ELISA; wherein a decrease in the quantity of the immunocomplex in the test samples, as compared to the quantity of immunocomplexes formed under identical conditions with the same antibody and a control sample from one or more mammals known to have a lower degree of radiation injury or exposure, indicates a higher degree of radiation injury and exposure to the mammal. The information obtained from such methods can be used by a clinician to accurately assess the extent of radiation injury/exposure in the mammal, and thus will provide a valuable tool for determining treatment protocols on a subject by subject basis.

The present invention provides compositions and methods for the prophylactic and therapeutic treatment of animals, including humans from radiation injury. In particular, the present invention provides methods and compositions comprising the isoflavone genistein (4′,5,7-trihydroxyflavone) or phytoestrogenic isoflavonoids.

Methods and kits are provided for assessing radiation injury and exposure in a subject. The methods comprise measuring the levels of at least two (2) protein biomarkers from different biological pathways and correlating the levels with an assessment of radiation injury and exposure. Additional use of peripheral blood cell counts and serum enzyme biomarkers, evaluated in the early time frame after a suspected radiation exposure, and use of integrated multiple parameter triage tools to enhance radiation exposure discrimination and assessment are also provided. The information obtained from such methods can be used by a clinician to accurately assess the extent of radiation injury/exposure in the subject, and thus will provide a valuable tool for determining treatment protocols on a subject by subject basis.

The invention relates to compounds and their use in the treatment of thrombocytopenia resulting from diseases or conditions such as immune thrombocytopenic purpura, cancer chemotherapy, surgery, bone marrow or stem cell transplantation, radiation injury or treatment, chronic viral infection, and pancytopenia. The invention further relates to pharmaceutical compositions containing the compounds and compositions of the invention as well as methods for treating such diseases or conditions in a mammal, including a human, by administering to such mammal an effective amount of a selected thrombopoietin receptor agonist.

The invention discloses an anti-radiation Chinese medicine preparation and a preparation method thereof. The preparation is a capsule which is prepared by mixing extract powder of a Chinese medicine composition and microcrystalline cellulose with the weight ratio of 2:1, wherein the Chinese medicine composition consists of ingredients according to parts by weight: 160-200 parts of astragalus mongholicus, 110-130 parts of fructus psoraleae, 80-100 parts of angelica sinensis, 160-200 parts of herba epimedii, 135-165 parts of madder root, 110-130 parts of fructus ligustri lucidi, 110-130 parts of radix paeoniae alba, 110-130 parts of radix rehmanniae preparata, 80-100 parts of ligusticum wallichii, 215-265 parts of rhizoma dioscoreae and 35-45 parts of radix glycyrrhizae preparata, and the extract powder is dry powder of ethanol solution extract of the Chinese medicine composition. The anti-radiation Chinese medicine preparation is precise in anti-radiation treatment effect, low in toxicside effects, simple in preparation method, low in cost, convenient to carry, easy to store, convenient to take and accurate in dosage, thus having good development and application prospect in the prevention and treatment of radiation injury.

The invention provides a Chinese medicinal preparation for preventing and treating radiation and a preparation method thereof and relates to the Chinese medicinal preparation for treating and preventing radiation injury and the preparation method thereof. The Chinese medicinal preparation is specifically prepared from heterophylly falsestarwort root, indian buead, bighead atractylodes rhizome, liquorice, Szechuan lovage rhizome, Chinese angelica, red paeony root, rehmannia root, barbed skullcap herb, honeysuckle, mulberry leaf, hairyvein agrimonia herb, medlar and green tea in a certain proportion. Pharmacodynamic experiments carried out by adopting an animal model with reduced tangible hemocytes and nucleated cells in bone marrow of a white mouse due to 60Co-gamma rays show that the preparation has a good effect on hemocytes and hemopoietic tissues injured by nuclear radiation.

The invention relates to an optical thin film structure used for laser crystals, and a preparation method thereof. The invention is characterized in that a hard film buffer layer is added between the conventional complex film systems of media/metal used for laser crystals, plays a role in increasing the binding force of the media-metal complex film systems and improving the anti-laser radiation injury threshold of the complex film systems, and meets the development requirements of a high-power laser. The film of the buffer layer is prepared through the thermal evaporation of electron beams. During the growth process, TiN grains and a cleaned supporting base are arranged in a vacuum growth cabinet; the growth cabinet is vacuumized; electron beams are used for irradiating the TiN grains; a given amount of nitrogen or nitrogen ions is introduced into the vacuum cabinet; and the film of the TiN buffer layer is deposited on the supporting base. The TiN buffer layer can significantly improve the binding force of the complex film systems and the anti-laser radiator injury threshold. The optical thin film structure is very theoretically and practically significant for the high-power lasers developing quickly.

The invention belongs to the technical field of medicine, and a novel application of a PIKfyve inhibitor for resisting radiation injury, and mainly relates to a medical application of the PIKfyve inhibitor in prevention and treatment of nuclear/radiation injury and radiation injury during tumor radiotherapy. Accurately, the invention relates to usage of the PIKfyve inhibitor for preventing and/or treating various radiation injuries by individually using or combing other treatment methods.

The invention belongs to the technology field of traditional Chinese medicine, in particular to an enema for the treatment of radioactive rectitis, which can solve the problem that the prior art has no ideal drug and effective method for the radioactive rectitis. The enema for the treatment of the radioactive rectitis is prepared by the raw materials with the following weight ratio of 3 to 6g of sanchi, 3 to 6g of catechu, 5 to 10g of donkey-hide glue, 10 to 30g of common bletilla pseudobulb, 15 to 45g of garden burnet root, 6 to 9g of rhubarb and 15 to 30g of hairyvein agrimonia herb and bud. The enema of the invention can significantly ease mucous bloody stool, diarrhea, abdominal pain, tenesmus, anal burning pain and bearing-down pain and other clinical symptoms, improve the positive of fecal occult blood test, the colonoscopy mucous membrane lesions and the radiation injuries and improve the quality of lives of the patients; and the enema has low recurrence rate, reliable efficacy, stable function, no toxicity or side effects, thus being the more satisfied drug for the treatment of the radioactive rectitis.

The invention provides an intraoperative mobile C-arm X-ray machine positioning auxiliary device, comprising: a C-shaped arm, which is arranged on a bracket, and the C-shaped arm can rotate and slide along the bracket; an image receiving intensifier, which is arranged on the bracket One end of the C-shaped arm; emitting X-ray tube, which is arranged on the other end of the C-shaped arm, and above the image receiving intensifier; 4 laser generators, which are equidistantly arranged on the emitting On the circumference of the X-ray tube, the connecting lines of the four laser generators are in the shape of a "ten", the power of the laser generators is less than 5mmw, and the wavelength is 650nm. The intraoperative mobile C-arm X-ray machine positioning auxiliary device provided by the present invention has a simple structure and low cost, enables doctors to quickly and accurately determine the shooting range during the operation, has high precision and good stability, significantly reduces the number of fluoroscopy times, and improves operation safety. Sex, shorten operation time, reduce radiation exposure caused by repeated fluoroscopy, reduce tissue trauma and complications, and reduce radiation damage to patients and medical staff.

The invention relates to a botanical drug compound recipe for preventing and treating microwave radiation injury. According to the invention, it is found that botanical drugs mainly consisting of peony root, milkvetch root, duckweed and red sage root can be used for preparing a medicine used for preventing and treating microwave radiation injury. According to results of abundant experiments of detection of learning and memory capacity of rats, hippocampal amino acid neurotransmitters, sperm motility, the rate of teratosperm, myocardial metabolic enzyme (CK-MB, LDH and AST activity) and the content of Ca<2+> in serum of rats, the number of peripheral blood lymphocytes and the like, the medicine provided in the invention has an obvious treatment effect on injury to the brain, reproduction, the heart and immunity of rats caused by microwave radiation, and the effect is superior to that of medicines on the market.

The invention relates to the fields of traditional Chinese medicines and bioengineering medicines, particularly a novel skin radiation injury protective agent which is capable of preventing and treating skin radiation injury and combines the traditional Chinese medicines with bioengineering medicines. The protective agent is prepared from traditional Chinese medicines, which have the functions of clearing away heat and toxic material, activating blood circulation to dissipate blood stasis, removing saprophytic muscle, nourishing the blood, moisturizing the skin and the like, and cell growth factor, which can promote epithelial cell growth and reproduction, and wound healing; and thus, the protective agent has the functions of preventing skin radiation injury, promoting injured skin to quickly heal, reducing the formation of scar tissues, and the like. The protective agent can be used for preventing and treating skin radiation injury of tumor radiotherapeutic patients and treating various clinic skin injuries (burnt, hurt, frostbite and the like), and can also be used for treating skin radiation injury caused by nuclear and radiation accidents, terrorist attacks and the like.

The invention discloses a protection effect of cyanidin-3-glucoside (C3G) for UVB (ultraviolet B)-induced cell injury. The protection effect particularly includes that generation of ROS (reactive oxygen species) of HaCaT cells due to UVB can be reduced by the C3G, accordingly, antioxidant effects can be realized, DNA (deoxyribonucleic acid) can be protected against injury, the survival rate of the HaCaT cells can be increased after the UVB irradiates on the HaCaT cells, and apoptosis reducing effects and the like can be realized. The protection effect has the advantages that the oxidation injury of the selected representative HaCaT cells which are cultivated in vitro is induced by means of UVB irradiation, light injury models of epidermal cells due to ultraviolet rays are imitated, then the C3G is used as a light injury protector, effects and relevant channels of the C3G for relieving UVB injury of the HaCaT cells are evaluated, the protection effect, action mechanisms and the safety of the C3G for light injury of skins are investigated, and accordingly theoretical foundation is laid for clinically effectively preventing and treating light injury of the skins and studying ultraviolet radiation injury protection action mechanisms of natural plant antioxidants.

The invention relates to anti-ageing health-strengthening tea, and relates to health-strengthening tea. The invention aims at providing the anti-ageing health-strengthening tea having functions on supplementing Qi and nourishing Yin, nourishing the kidney and liver, strengthening the spleen and diuresis, improving eyesight and darkening the hair and soothing the nerves. The anti-ageing health-strengthening tea comprises the following health herb ingredients in part by weight: 4 to 15 parts of medlar, 4 to 15 parts of white chrysanthemum from Hangzhou, 4 to 15 parts of radix polygoni multiflori preparata, 4 to 15 parts of poria cocos, 4 to 15 parts of rose flowers, 4 to 5 parts of dried rhizome of rehmannia, 4 to 15 parts of astragalus roots, 4 to 15 parts of American ginseng, 4 to 15 parts of eucommia ulmoides and 15 to 25 parts of iron Goddess. The anti-ageing health-strengthening tea is low in cost, reasonable in formulation, simple to prepare, easy to store, suitable for being drunk in four seasons and convenient to drink and has good taste. After being drunk by people for long time, the immunity of the human body can be improved, the incidence rate of the tumor can be reduced, arteriosclerosis can be slowed down, radiation injury caused by household appliances can be reduced, blood pressure can be lowered, blood fat can be lowered, and an action on delaying the ageing can be achieved.

The invention relates to a method and a device for extracting rare earth, in particular to a production method and device for extracting the rare earth from monazite ores. The production operation stability is guaranteed by means of a caustic decomposition procedure, a washing procedure, a chlorination procedure, a phosphorus base liquor fine filtration and crystallization procedure as well as a special JQL reactor and a full-automatic metering system; by the aid of the JQL reactor as caustic decomposition equipment, fully-enclosed continuous and automatic operation is realized, heat energy consumption and alkali consumption are reduced, the labor intensity of workers is reduced, wastewater emission is avoided in a production process, the production efficiency is high, the rare earth yield is increased, and the worker bodies are prevented from radiation injury caused by radioactive substances. The clean, automatic, and fully-enclosed continuous production operation mode is realized by the aid of equipment, the utilization rate of the equipment is increased greatly, and the operation cost of the equipment is reduced.