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Novel application of PIKfyve inhibitor for resisting radiation injury

An inhibitor, anti-radiation technology, used in the field of medicine

Active Publication Date: 2016-09-28
INST OF RADIATION MEDICINE ACAD OF MILITARY MEDICAL SCI OF THE PLA
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  • Abstract
  • Description
  • Claims
  • Application Information

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  • Novel application of PIKfyve inhibitor for resisting radiation injury
  • Novel application of PIKfyve inhibitor for resisting radiation injury
  • Novel application of PIKfyve inhibitor for resisting radiation injury

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Embodiment Construction

[0075] This specification discloses methods of preventing and / or treating damage from ionizing radiation.

[0076] Groups in need include those who may be exposed to radiation, such as nuclear weapons attack, nuclear dirty bomb terrorist attack, or are about to enter a radioactively contaminated area, and receive an effective dose of PIKfyve inhibitor prophylaxis several hours or at least 1 day before (possible) radiation exposure treat.

[0077] Individuals in need, including wounded or accident patients who have received radiation doses that may cause hematopoietic damage, receive effective doses of PIKfyve inhibitors immediately, several hours or at least 1 day after exposure.

[0078] The specification also discloses methods of treating myelosuppression caused by radiation therapy.

[0079] Radiation therapy and radiotherapy are used interchangeably herein and include external irradiation and internal irradiation, also referred to as brachytherapy, intracavitary brachythe...

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Abstract

The invention belongs to the technical field of medicine, and a novel application of a PIKfyve inhibitor for resisting radiation injury, and mainly relates to a medical application of the PIKfyve inhibitor in prevention and treatment of nuclear / radiation injury and radiation injury during tumor radiotherapy. Accurately, the invention relates to usage of the PIKfyve inhibitor for preventing and / or treating various radiation injuries by individually using or combing other treatment methods.

Description

technical field [0001] The invention belongs to the technical field of medicine, and relates to the new application of PIKfyve inhibitor for anti-radiation damage, mainly its medical application in the prevention and treatment of nuclear / radiation damage and the prevention and treatment of radiation damage caused by tumor radiotherapy. More specifically, the present invention relates to the use of PIKfyve inhibitors, alone or in combination with other treatments, for the prevention and / or treatment of various radiation injuries. Background technique [0002] Nuclear energy and nuclear technology are increasingly widely used in various fields such as industrial and agricultural production, medical and health care, scientific research, and national defense. While they bring huge benefits to mankind, they also pose potential threats. Nuclear wars, nuclear-related terrorist attacks, earthquakes or tsunamis, etc. cause nuclear leakage in nuclear power plants, as well as civilian ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/5377A61P39/00
Inventor 余祖胤邢爽熊国林何新华从玉文罗庆良
Owner INST OF RADIATION MEDICINE ACAD OF MILITARY MEDICAL SCI OF THE PLA
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