The invention discloses a method for degrading moxifloxacin hydrochloride in waste water. Hydroxyl radicals.OH which is high in oxidizing ability and generated through ionizing irradiation are used for promoting degrading of moxifloxacin hydrochloride in the waste water, and Cu2+ and Zn2+ are added into the waste water to catalyze degrading of moxifloxacin hydrochloride, reduce the absorption dose required by waste water irradiation treatment and reduce cost. According to the specific scheme, a certain amount of Cu2+ and Zn2+ are added into the moxifloxacin hydrochloride waste water with the concentration being 10 mg / L-100 mg / L, the concentration range of Cu2+ is 0.2-0.6 mg / L, the concentration range of Zn2+ is 0.4-0.8 mg / L, irradiation treatment is carried out through gamma rays or high-power electron beams, the dose ranges from 1kGy to 3kGy, and therefore moxifloxacin hydrochloride has an irradiation degrading reaction. Cu2+ and Zn2+ are used at the same time for joint irradiation treatment, the use amount of Cu2+ and Zn2+ is reduced, and secondary pollution is reduced. Meanwhile, the irradiation dose is greatly reduced, the treatment effect is good, secondary pollution is little, and energy is saved.