32 results about "Ionizing irradiation" patented technology

This invention provides a radiation dosimeter and new method of operation which comprise two types of the metal-oxide-semiconductor field-effect transistor (MOSFET) circuits allowing to amplify the threshold voltage changes due to radiation and provide temperature compensation. The first type dosimeter is a radiation integrated circuit (RADIC) which includes two radiation field-effect transistors (RADFET) and two MOSFETs, integrated into the same substrate. The second type of radiation circuit includes two RADFETs, integrated into the same substrate, and two resistors. The amplification of the threshold voltage change is achieved by using amplification principles of an MOSFET inverter. In both cases, under the ionizing irradiation, the gate of first RADFET is forward biased and the gate of second RADFET is biased off. In the reading mode the amplified differential threshold voltage change is measured. The increased radiation sensitivity allows to measure of the milli-rad doses. The temperature effect and drift is substantially eliminated. These radiation integrated circuits can be used as a personal dosimeter in the nuclear, industrial and medical fields.

The present invention provides methods for treating a subject that has suffered combined exposure to total body ionizing irradiation and burns by administering a peptide of at least 5 amino acids of a peptide of SEQ ID NO:1 (Asp-Arg-Nle-Tyr-Ile-His-Pro), or a pharmaceutical salt thereof in an amount effective to treat the radiation effects and / or the burn.

Disclosed herein are methods of terminally sterilizing bacterial minicells or compositions comprising bacterial minicells by exposure to ionizing irradiation. Also disclosed are terminally sterilized bacterial minicells, pharmaceutical compositions comprising the bacterial minicells, and methods of use the bacterial minicells and pharmaceutical compositions.

The invention relates to the field of drug development against acute radiation injury caused by exposure to high-energy electromagnetic waves (X-rays, gamma rays) or particles (alpha particles, beta particles, neutrons). To date, there is no effective drug to ameliorate radiation injury after accidental exposure to ionizing irradiation. The invention provides a method of treating radiation injury of a subject in need thereof comprising administering to the subject a peptide, or functional analogue or derivative thereof, of smaller than 30 amino acids. Furthermore, the invention provides use of a peptide, or functional analogue or derivative thereof, of smaller than 30 amino acids for the production of a pharmaceutical composition for the treatment of a subject suffering from or believed to be suffering from radiation injury. In particular, the invention provides anti-radiation peptides having a dose reduction factor (DRF) against acute gamma irradiation of at least 1.10, said DRF determinable by testing which dose of radiation results in 50% mortality at 30 days (LD50 / 30) after whole body radiation (WBI) in a test group of mice treated with said peptide at 72 hours after WBI and, testing which dose of radiation results in 50% mortality at 30 days (LD50 / 30) after whole body radiation (WBI) in a control group of mice treated only with the vehicle of said peptide at 72 hours after WBI and wherein the DRF is calculated by dividing the LD5O / 3O of the peptide-treated animals by the LD50 / 30 of the vehicle-treated animals.

Disclosed herein are methods of terminally sterilizing bacterial minicells or compositions comprising bacterial minicells by exposure to ionizing irradiation. Also disclosed are terminally sterilized bacterial minicells, pharmaceutical compositions comprising the bacterial minicells, and methods of use the bacterial minicells and pharmaceutical compositions.

The invention discloses a method for improving the performance of a lead-free ferroelectric film and the lead-free ferroelectric film prepared by the same, in particular to a method for reducing the drain current of a lead-free ferroelectric film by utilizing the ionizing irradiation effect and the lead-free ferroelectric film obtained by the same, belonging to the field of lead-free ferroelectric films. Energy carrying particle beams such as charged particles or gamma rays and the like are used for irradiating the lead-free ferroelectric film at room temperature, the total irradiation dose is 10Mrad-100Mrad, and the ferroelectric film with the reduced drain current can be obtained after irradiation. The invention has significance of improving the working stability and the service life ofa ferroelectric memory and reducing the heating productivity.

The invention provides an integrated treatment method of heavy metal passivation and nutrient nitrogen and phosphorus recovery for domestic animal sewage. Heavy metal element passivation and activation and release of nutrients nitrogen and phosphorus are achieved by adopting an integration technology of ionizing irradiation / iron-carbon micro-electrolysis fluidized bed, and efficient recovery of the nutrients nitrogen and phosphorus is achieved by adopting an integration technology of disc tube reverse osmosis / struvite crystal / hydrated molten iron oxide-carrying hot carbon. The copper-zinc-lead-chromium passivation rate is greater than 90%, the nitrogen element recovery rate is greater than 90% and the phosphorus element recovery rate is greater than 95%.