67results about How to "Minimize dose" patented technology

A dose counter for a metered dose inhaler includes a force sensor, an electronic controller, a memory for storing data indicative of a remaining number of doses and an electronic display device coupled to the controller for displaying the remaining number of doses. The dose counter is attached or integrated into a base of a canister containing medicament such that force applied to the base of the canister is registered by the force sensor, the controller being configured to measure force applied to the dose counter when depressing the canister and being responsive to measured force to decrement the remaining number of doses stored in the memory and shown on the display device.

An optical reduction system with polarization dose sensitive output for use in the photolithographic manufacture of semiconductor devices having variable compensation for reticle retardation before the long conjugate end. The variable compensation component(s) before the reticle provides accurate adjustment of the polarization state at or near the reticle. The variable compensation components can be variable wave plates, layered wave plates, opposing mirrors, a Berek's compensator and / or a Soleil-Babinet compensator. The catadioptric optical reduction system provides a relatively high numerical aperture of 0.7 capable of patterning features smaller than 0.25 microns over a 26 mm×5 mm field. The optical reduction system is thereby well adapted to a step and scan microlithographic exposure tool as used in semiconductor manufacturing. Several other embodiments combine elements of different refracting power to widen the spectral bandwidth which can be achieved.

Systems and methods for providing independent exposure detection, X-ray spectrum and timing compensation, and providing an exposure termination signal to an X-ray system. The system incorporates an interface for receiving exposure characteristic data such as kVp, spectral filter, and focal spot. The system through a programmed controller determines one or more control parameters based on the received exposure characteristic data and generates a control signal for controlling an X-ray source.

The present invention relates to a method for dosing a pharmaceutical product in a packaging machine comprising at least one volumetric dosing unit with a dosing chamber. The method comprises metering a volume of a first component, weighing the first component, introducing the first component into a package and metering a volume of a second component, introduceg the second component into the package and weighing of the package into which the components have being introduced.The invention further relates to a system for dosing a pharmaceutical product in a packaging machine comprising at least one volumetric dosing unit with a dosing chamber. The system comprises at least one volumetric dosing unit for metering a volume of the components. Further, means for introducing the said components into a package and means for weighing the components and the package are comprised. The means for weighing comprises a first weighing unit for weighing the package and the components, and a second weighing unit for weighing the first component after metering the first component by volume and before introducing the first component into the package.

Systems and methods are provided for treating cervical and / or uterine cancers in brachytherapy with an intracavitary brachytherapy applicator. The system comprises a tandem adapted for insertion into a cervix of a patient. An ovoid assembly comprises first and second inflatable ovoids and an ovoid support mechanism. The first and second inflatable ovoids are adapted for insertion within fornices of a patient. First and second retractors are adapted to be coupled to the ovoid assembly. The first retractor is adapted to be positioned to retract the bladder of a patient during treatment. The second retractor is adapted to be positioned to retract the rectum of a patient during treatment. The tandem and the first and second inflatable ovoids are adapted to be coupled to a radioactive source to deliver an implant radiation dose suitable for cancer treatment at a cancerous cervical treatment site in a patient.

The invention relates generally to the field of nucleic acids and more particularly to aptamers capable of binding to von Willebrand Factor useful as therapeutics in and diagnostics of thrombotic diseases and / or other diseases or disorders in which von Willebrand Factor mediated platelet aggregation has been implicated. The invention further relates to materials and methods for the administration of aptamers capable of binding to von Willebrand Factor.

Systems and methods for providing independent exposure detection, X-ray spectrum and timing compensation, and providing an exposure termination signal to an X-ray system. The system incorporates an interface for receiving exposure characteristic data such as kVp, spectral filter, and focal spot. The system through a programmed controller determines one or more control parameters based on the received exposure characteristic data and generates a control signal for controlling an X-ray source.

The invention relates generally to the field of nucleic acids and more particularly to aptamers capable of binding to von Willebrand Factor useful as therapeutics in and diagnostics of thrombotic diseases and / or other diseases or disorders in which von Willebrand Factor mediated platelet aggregation has been implicated. The invention further relates to materials and methods for the administration of aptamers capable of binding to von Willebrand Factor.

Systems and methods are provided for treating cervical and / or uterine cancers in brachytherapy with an intracavitary brachytherapy applicator. The system comprises a tandem adapted for insertion into a cervix of a patient. An ovoid assembly comprises first and second inflatable ovoids and an ovoid support mechanism. The first and second inflatable ovoids are adapted for insertion within fornices of a patient. First and second retractors are adapted to be coupled to the ovoid assembly. The first retractor is adapted to be positioned to retract the bladder of a patient during treatment. The second retractor is adapted to be positioned to retract the rectum of a patient during treatment. The tandem and the first and second inflatable ovoids are adapted to be coupled to a radioactive source to deliver an implant radiation dose suitable for cancer treatment at a cancerous cervical treatment site in a patient.

A dose counter for a metered dose inhaler includes a force sensor, an electronic controller, a memory for storing data indicative of a remaining number of doses and an electronic display device coupled to the controller for displaying the remaining number of doses. The dose counter is attached or integrated into a base of a canister containing medicament such that force applied to the base of the canister is registered by the force sensor, the controller being configured to measure force applied to the dose counter when depressing the canister and being responsive to measured force to decrement the remaining number of doses stored in the memory and shown on the display device.

A linear accelerator head for use in a medical radiation therapy system can include a housing, an electron generator configured to emit electrons along a beam path, and a microwave generation assembly. The linear accelerator head may include a waveguide that is configured to contain a standing or travelling microwave. The waveguide can include a plurality of cells that are disposed adjacent one another, wherein each of the plurality of cells may define an aperture configured to receive electrons therethrough. The linear accelerator head can further include a converter and a primary collimator.

A stream of products is packaged and biologically treated by the system. The system has an index conveyor with a filling station and a packaging station. Discrete packages are filled with the stream of products, sealed and moved on an index conveyor. The system moves the discrete packages an irradiation chamber at a steady rate on a continuous speed conveyor. A controller matches the cyclical rate of the index conveyor with the steady rate of the continuous speed conveyor and uses a buffer to transition from the cyclical rate to the steady rate.

An X-ray imaging device and alignment / scanning system include at least one multilayer X-ray mirror mounted on a multi-axis adjustable mirror mount pivotable about a scanning axis. A mirror scanner is coupled with the mirror mount and synchronized with the X-ray source so that the mirror scanner moves the mirror mount about the scanning axis. The invention may include a plurality of mirrors, optionally in a stack, and preferably including first and second mirrors respectively adapted to reflect X-rays of first and second energies. A movable attenuation plate having a window selectively allows X-rays to be transmitted by one of the mirrors and blocks X-rays from the other mirror(s). Sets of the mirrors may be configured in blocks or interspersed. The mirror scanner may be operable at variable speeds to enable selective control of the scanning speed of the mirror.

A method and composition for the treatment and / or prevention of stroke is disclosed using N-heterocyclic glyoxamide compounds having the following general formula:wherein X, E, F, R11, R12, R14, R15, R16 and R17 are as defined herein.

The invention relates generally to the field of nucleic acids and more particularly to aptamers capable of binding to von Willebrand Factor useful as therapeutics in and diagnostics of thrombotic diseases and / or other diseases or disorders in which von Willebrand Factor mediated platelet aggregation has been implicated. The invention further relates to materials and methods for the administration of aptamers capable of binding to von Willebrand Factor.

The present invention includes compositions and methods of making an activated polymeric nanoparticle for targeted drug delivery that includes a biocompatible polymer and an amphiphilic stabilizing agent non-covalently associated with a spacer compound that includes at least one electrophile that selectively reacts with any nucleophilic on a targeting agent and places the targeting agent on the exterior surface of a biodegradable nanoparticle, wherein an active agent is encapsulated in or about the nanoparticle.

A method and a suitable x-ray device (1) for carrying out the method are specified for effective and operationally simplified user-specific optimization of a parameter configuration (K) of an x-ray device (1), said configuration comprising at least one recording parameter (U,I,t,F). It is accordingly provided that a user (20) is shown a plurality of reference images (V, V1) for different reference parameter sets (PV) from a reference memory (21) in which are stored a large number of reference images (V, V0) each with an associated reference parameter set (PV), that for each reference image (V, V1) shown the user (20) submits an assessment (BM) of the image quality (V, V1), and that on the basis of the submitted assessments (BM) an optimized parameter configuration (K) is created from the reference parameter sets (PV) of the reference images (V, V1) shown.

A method of operating a waste water treatment plant (WWTP) having at least one of an aerobic digester (AD) and a membrane bioreactor (MBR) is described. The method of operating AD is comprised of monitoring and controlling AD in real-time using an online extended Kalman filter (EKF) having a online dynamic model of AD. The EKF uses real-time AD measured data, and online dynamic model of AD to update adapted model parameters and estimate model based inferred variables for AD, which are used for AD control by AD control system having supervisory and low-level control layers. The method of operating MBR is similar to that of AD. The supervisory control ensures the WWTP satisfying the effluent quality requirement while minimize the operation cost. A WWTP having at least one of AD or MBR is disclosed. The method of operating a WWTP can be implemented using a computer.

The present invention includes compositions and methods of making a nanoparticle composition comprising a polymeric core comprising one or more polymers and one or more active agents, and at least one layer of one or more lipids on the surface of the polymeric core; more specifically, the invention relates to the use of curcumin within such a lipid-polymer nanoparticle formulation for minimizing QT prolongation associated with curcumin in treatment of cancer.

We disclose a radiotherapy apparatus with a dose verification system in which the portal image is displayed against a background of a better-quality image diagnostic image, such as a two-dimensional radiograph, an ultrasound image, or a section taken from a three-dimensional magnetic-resonance image, cone-beam CT image, or the like.

A method of multileaf collimator (MLC) leaf positioning in tracking-based adaptive radiotherapy is provided. The method includes determining a radiotherapy beam pattern by transforming a treatment beam plan into radiotherapy beam coordinates, determining a dose discrepancy between the radiotherapy beam pattern and a deliverable MLC aperture, where the dose discrepancy includes a sum of an overdose cost and an underdose cost to a treatment volume, and minimizing the dose discrepancy, where the dose discrepancy minimization provides a determined deliverable MLC aperture for the radiotherapy beam.

Methods of making iterative low-dose computed tomography (CT) efficient and applicable to clinical practice employ selection of optimal views for CT reconstruction. By optimizing the views for CT reconstruction, the method of the present invention can generate reconstructions at a pre-specified low radiation dose and / or in near real-time. A feature-oriented framework for a task-driven, object-driven, and dose-minimizing selection of X-ray views is provided, which can utilize models of features to be mapped. The models can be derived from a patient population to minimize the dose per exam and / or from a specific patient to minimize the dose per procedure. The method of the present disclosure can be incorporated into a CT system, or can be embodied in a data storage medium as a program.

A linear accelerator head for use in a medical radiation therapy system can include a housing, an electron generator configured to emit electrons along a beam path, and a microwave generation assembly. The linear accelerator head may include a waveguide that is configured to contain a standing or travelling microwave. The waveguide can include a plurality of cells that are disposed adjacent one another, wherein each of the plurality of cells may define an aperture configured to receive electrons therethrough. The linear accelerator head can further include a converter and a primary collimator.

The present invention provides electron beam therapies with improved feedback control that delivers controlled and adjustable doses of electron beam radiation to variable shallow depths with little radiation exposure to both nearby tissues and tissues below the target. In order to control radiation to accurately penetrate to shallow depths and to allow the radiation to be adjusted to other depth settings in very small or even continuous increments, the present invention senses a plurality of different electron beam characteristics and then uses these to derive a composite characteristic, or analog, of the electron beam energy. The composite analog provides a strong correlation to energy that allows this precision. In another aspect, the present invention relates to implementing this feedback control by adjusting power levels used to establish the electron beam. In other embodiments, feedback control adjusts absorbing components with variable electron beam absorption depending on how such components are presented to the electron beam.

An X-ray imaging device and alignment / scanning system include at least one multilayer X-ray mirror mounted on a multi-axis adjustable mirror mount pivotable about a scanning axis. A mirror scanner is coupled with the mirror mount and synchronized with the X-ray source so that the mirror scanner moves the mirror mount about the scanning axis. The invention may include a plurality of mirrors, optionally in a stack, and preferably including first and second mirrors respectively adapted to reflect X-rays of first and second energies. A movable attenuation plate having a window selectively allows X-rays to be transmitted by one of the mirrors and blocks X-rays from the other mirror(s). Sets of the mirrors may be configured in blocks or interspersed. The mirror scanner may be operable at variable speeds to enable selective control of the scanning speed of the mirror.

Disclosed is a direct-conversion-type X-ray detector, including a first electrode on a substrate, a semiconductor structure including a photoconductor using a perovskite material on the first electrode, and a second electrode on the semiconductor structure.

A steam iron (500) comprises a housing (520) that includes a water tank (580), a steam chamber (600) and a pressure equalization conduit (760). The housing (520) includes an airing means (660). The steam iron is further provided with a mechanism for allowing air selectively into the water tank (580). The mechanism comprises a steam trigger (680) that is arranged to close or open the pressure equalization conduit (760) and the airing means (660) inversely. The mechanism may also comprise a spring loaded plunger or an electronic hand sensor.