100results about How to "Shorten bleeding time" patented technology

Disclosed are methods for treating bleeding disorders, such as hemophilia, in subjects in need thereof by administering an antibody that specifically binds CD73. The methods reduce production of adenosine, increase platelet activation and / or enhance the level of coagulation on the platelet surface to reduce and / or stop bleeding. In some embodiments, the methods can further include co-administering Factor VIII to treat the bleeding disorder.

Devices, systems and methods for stimulating (e.g., noninvasively) a subject's inflammatory reflex are provided to reduce bleed time. The method may include the step of non-invasively stimulating the inflammatory reflex (e.g., the vagus nerve, the splenic nerve, the hepatic nerve, the facial nerve, and the trigeminal nerve) of a subject, such as by mechanical stimulation, in a manner which significantly reduces bleed time in the subject. Devices for non-invasively stimulating the inflammatory reflex may include a movable tip or actuator that is controlled to mechanically stimulate the ear. The devices may be hand-held or wearable, and may stimulate the cymba conchae region of the subject's ear.

The invention relates generally to the field of nucleic acids and more particularly to aptamers capable of binding to von Willebrand Factor useful as therapeutics in and diagnostics of thrombotic diseases and / or other diseases or disorders in which von Willebrand Factor mediated platelet aggregation has been implicated. The invention further relates to materials and methods for the administration of aptamers capable of binding to von Willebrand Factor.

The invention relates generally to the field of nucleic acids and more particularly to aptamers capable of binding to von Willebrand Factor useful as therapeutics in and diagnostics of thrombotic diseases and / or other diseases or disorders in which von Willebrand Factor mediated platelet aggregation has been implicated. The invention further relates to materials and methods for the administration of aptamers capable of binding to von Willebrand Factor.

The invention relates generally to the field of nucleic acids and more particularly to aptamers capable of binding to von Willebrand Factor useful as therapeutics in and diagnostics of thrombotic diseases and / or other diseases or disorders in which von Willebrand Factor mediated platelet aggregation has been implicated. The invention further relates to materials and methods for the administration of aptamers capable of binding to von Willebrand Factor.

Disclosed is a Chinese compound formulation for nourishing blood, regulating menstruation, stopping bleeding to prevent abortion and preparation method, which is prepared from prepared rehmannia root, Ligusticum wallichii, root of herbaceous peony, Chinese mugwort leafmulberry leaf, Chinese angelica root, licorice root and donkey-hide gelatin, and can be made into preparations with the forms of electuary, granule, tablet or capsule.

A medicine in the form of gel for treating internal pile, external pile, mixed pile and fissure in gelling agent is prepared from 9 Chinese-medicinal materials including amber, borneol, borax, pearl, etc, 9 Chemicals including monoglyceride stearate, white vaseline, glycerin, VC, etc, and distilled water. Its preparing process is also disclosed.

The invention relates to a drug for treating purpura. Raw materials to make effective components of the drug include radix astragali (prepared), sweet potato stem and leaf, ligustrum fruit, eclipta, elaginella (prepared), panax notoginseng, peanut sead-coat and liquorice. The raw materials can be made into various oral and external preparations through properly processing and / or acceptable auxiliary materials in pharmaceutics. With efficacies of Qi invigorating and Yin replenishing, and blood cooling and bleeding stopping, the invention is mainly used to treat purpura diseases caused by blood heat from Yin deficiency and Qi deficiency and blood absorbing failure, particularly mild and moderate thrombocytopenia.

The invention relates to a Chinese medicinal sugar-free gynaecopathia treating particle for treating gynaecopathia and a preparation method thereof. The particle is prepared from the following raw and auxiliary materials in parts by weight: 115 parts of prepared rehmannia root, 46 parts of szechuan lovage rhizome, 93 parts of white paeony root, 46 parts of Chinese mugwort leaf, 69 parts of Chinese angelica, 46 parts of liquoric root, 69 parts of donkey-hide gelatin, and non-cane-sugar auxiliary materials consisting of 100-800 parts of a diluent, 0-100 parts of a wetting agent, 0-50 parts of a bonding agent and 0-10 parts of a flavoring agent. The preparation method comprises the following steps of: extracting volatile oil from Chinese angelica, Chinese mugwort leaf and szechuan lovage rhizome, adding water into decoction dregs, white paeony root, prepared rehmannia root and liquoric root for decocting twice for 3 hours in a first time and 2 hours in a second time, combining decoctions, standing for 18-24 hours, and filtering to obtain an extract; and smashing the donkey-hide gelatin, adding donkey-hide gelatin powder and non-cane-sugar auxiliary material powder into the extract, preparing into particles, drying and spraying volatile oil. The particle is a sugar-free preparation, and is suitable for people suffering from diabetes and other people with no sugar requirements; and the using amount of the auxiliary materials is lowered remarkably.

The invention provides an alginate dentifrice composition, belonging to the field of personal care products. The alginate dentifrice composition comprises alginate, a zinc ion source, a fluorine-releasing anti-caries agent provided by a nano-scale fluorine-doped zirconia powder, and a desensitizing material provided by a bioactive glass microsphere loading a catechinic acid substance. A method forpreparing the alginate dentifrice composition includes combining the liquid material and the powder material in the raw materials to prepare a mixture, and then combining a surfactant into the mixture, and mixing in a vacuum environment to obtain the dentifrice composition. The astringency of the dentifrice composition is neutralized, and the dentifrice composition can reduce hypersensitivity ofdentin, induce enamel regeneration and enhance porcelain gloss of the tooth surface, relieve oral mucosa, periodontal tissue and pulp damage, and promote formation of prothrombin to reduce bleeding time of gums. The preparation method can promote the phenomenon of agglomeration of anti-caries agent particles and generate tetragonal phase crystals, reduce system energy consumption, increase glass particle loading capacity and hydroxyapatite mineralization production, and improve resource utilization rate and effective yield.

A Chinese medicine for treating obstetrical diseases is prepared from 5 Chinese-medicinal materials including Chinese angelica root, Chuan-xiong rhizome, peach kernel, liquorice root, etc through slicing, pulverizing, proportionally mixing, preparing nanoparticles, microwave extracting, vacuum concentrating, and spray drying.

A temperature stable nanoparticle is provided comprising a core, a water soluble polymer and a peptide, the water soluble polymer attached to the core at a first terminus of the water soluble polymer, the peptide attached to a second terminus of the water soluble polymer, the peptide comprising an RGD amino acid sequence, the water soluble polymer of having sufficient length to allow binding of the peptide to glycoprotein lib / Ilia (GPIIb / llla). In one aspect, the nanoparticle has a melting temperature over 35° C. In various aspects, the nanoparticle has a spheroid shape and a diameter of less than 1 micron.

Isolated monoclonal antibodies that bind human tissue factor pathway inhibitor (TFPI) and the isolated nucleic acid molecules encoding them are provided. Pharmaceutical compositions comprising the anti-TFPI monoclonal antibodies and methods of treating deficiencies or defects in coagulation by administration of the antibodies are also provided. Methods of producing the antibodies are also provided.

The invention relates generally to the field of nucleic acids and more particularly to aptamers capable of binding to von Willebrand Factor useful as therapeutics in and diagnostics of thrombotic diseases and / or other diseases or disorders in which von Willebrand Factor mediated platelet aggregation has been implicated. The invention further relates to materials and methods for the administration of aptamers capable of binding to von Willebrand Factor.

The invention discloses a collagen aggregate based flocculent antibacterial hemostatic material and a preparation method thereof. The preparation method is characterized by comprising steps as follows: DCMC (dialdehyde carboxymethyl cellulose) and silver nitrate are blended, a mixed solution containing nano-silver is prepared through redox reaction, then certain amount of collagen aggregate and certain amount of polyvinylpyrrolidone are dissolved in the mixed solution sequentially, the mixture is subjected to processes including gradient dilution, dealcoholization, vacuum drying, impregnation, freeze-drying, moderate grinding, sterilization and the like, and the collagen aggregate based flocculent antibacterial hemostatic material is obtained finally. The material adopts the collagen aggregate more similar to a natural tissue collagen structure, and compared with common collagen materials, the prepared flocculent hemostatic material has excellent physical and chemical properties and biological properties such as structural stability, mechanical property, biological degradability, biocompatibility and the like, can promote wound healing and repair, has broad-spectrum antibacterial / antimicrobial activity of the nano-silver, has large contact surface with the wound surface, is high in hydrophilia and stickiness and can be used for hemostasis repair of body surface wound and general civil hemostasis emergency.

A blood vessel endothelium reaction measuring instrument comprises an avascularizing section (2) for avascularize an arterial vessel of an organism, a measuring section (4) for measuring the shape characteristic of the arterial vessel or the vessel wall, and a control section (3) for controlling the avascularizing section to repeat avascularization and its cancellation of the arterial vessel periodically two or more times. The measuring section (4) measures the shape characteristic during at least a part of the period for which the avascularization of the arterial vessel is canceled and processes the data on the shape characteristic during the part of the period using the cycle of the avascularization and its cancellation.

The invention provides a nanogel hemostatic material modified with modified glucan as well as preparation and an application of the nanogel hemostatic material. The nanogel hemostatic material is formed by polymerizing modified glucose and monomers containing vinyl, wherein the modified glucose is glucose modified with glycidyl methacrylate. The nanogel hemostatic material has excellent water absorption and good biocompatibility, the size is increased after the nanogel hemostatic material absorbs water to expand, a polymer hydrogel layer is formed and can block a wound to stop bleeding, modified glucan nonogel has an excellent hemostatic effect on traumatic hemorrhage such as venous hemorrhage, arterial hemorrhage, body surface hemorrhage as well as internal organ hemorrhage such as liver hemorrhage, is a good and novel hemostatic and has good application prospects in clinical trauma. The invention further provides a preparation method of the modified polysaccharide modified nanogel hemostatic material. The raw materials are cheap and easy to obtain, the reaction condition is mild, the reaction operation is simple, and post-treatment is convenient.

The invention relates to swelling medical biogel filler based on portulaca oleracea polysaccharide and flavone extract. The swelling medical biogel filler comprises a collagen gel component modified by compound polysaccharide, a swelling compound polysaccharide gel component and a nano hydroxy phosphorite component loaded with portulaca oleracea flavone extract and calcium ion. The swelling medical biogel filler is a framework supporting polysaccharide filling material integrating effects of absorbing seepage, stopping bleeding, filling and promoting healing and has antibacterial and antipyrotic characteristics. Portulaca oleracea is rich in source, and polysaccharide is low in preparation cost, so that the swelling medical biogel filler is suitable for industrial production.

The invention belongs to the technical field of chitosan derivative preparation, and particularly provides a functionalized chitosan microsphere and a preparation method and application thereof. The method comprises the steps that high-molecular-weight chitosan is degraded to obtain a low-molecular-weight chitosan solution, then chitosan is subjected to functional modification through lactobionic acid and ammonium ferrous sulfate, and finally, under the action of sodium polyphosphate, cross-linking reaction is conducted to obtain the functional chitosan microsphere. The functional chitosan microsphere can be used for preparing hemostatic materials, the bleeding time is greatly shortened, the bleeding amount is reduced, and the hemostatic effect is good.

The invention provides antibacterial medical hemostasis absorbent cotton gauze, which consists of medicine dressing and a tissue material carrying the medicine dressing, wherein the medicine dressingis prepared from traditional Chinese medicine and western medicine; the tissue material carrying the medicine dressing is blended by scleroprotein fiber and cotton fiber. The hemostasis and the antibacterial effects are integrated; the obvious effects are achieved on abnormal bleeding in operations of lung, liver, pancreas, adrenal gland and the like, the bleeding except for obstetrics departmentand postpartum hemorrhage, urinary tract bleeding and the like; in addition, the antibacterial medical hemostasis absorbent cotton gauze can be used under the conditions of great and deep wound and great bleeding quantity; the hemostasis is fast; the wound surface wound recovery is facilitated; meanwhile, the antibacterial spectrum is wide; the sterilization power is strong; the action is fast; the effectiveness can also be achieved on pseudomonas aeruginosa, klebsiella, escherichia coli, enterobacter, staphylococcus, mycoplasma and chlamydia; in addition, good effects are achieved on trimethoprim drug resistant bacteria, penicillin drug resistant staphylococcus aureus andtylosin or tiamulin drug resistant mycoplasma.

The invention relates to the use of adeno-associated virus (AAV) vectors to achieve long term expression of a transgene in the liver of a juvenile subject. The invention includes the stable long-term amelioration of disease symptoms of the subjection following a single administration of an AAV vector to a juvenile subject, wherein the AAV vector delivers the transgene to the subject's liver.

The invention discloses an oligopeptide containing an Hyp-Gly sequence and having antiplatelet and antithrombotic functions. The invention provides the oligopeptide containing the Hyp-Gly sequence orsalt forms thereof. The oligopeptide containing an OG sequence can be prepared through artificial synthesis as well as enzymolysis of fish skin. The molecular weight of the oligopeptide containing theOG sequence is smaller than 1,000 Da, the mass ratio of the oligopeptide to total enzyme-digested products is 65%-95%, and the oligopeptide has a specific inhibition effect on ADP-induced platelet aggregation, can inhibit thrombosis, does not affect the blood coagulation function, does not prolong the bleeding time and is very small in bleeding risk; and the oligopeptide has the characteristics of resistance to gastrointestinal tract digestive enzyme enzymolysis and easiness in absorption.

The invention provides for dry spray compositions comprising co-polymers comprising a core, water-soluble polymer and a peptide.

The present invention relates to a dengue vaccine, a pharmaceutical composition comprising the same, a nucleotide sequence, and an antibody composition. The dengue vaccine of the present invention includes chimeric nonstructural protein 1, which comprises N-terminus of DV NS1 from amino-acid residues 1 to 270 and C-terminus of JEV NS1 from amino-acid residues 271 to 352 (designated DJ NS1). Therefore, the dengue vaccine without autoimmunity according to the present invention is able to avoid cross-reactions with endothelial cells and platelets, and is able to shorten the bleeding time.

Disclosed are methods for treating bleeding disorders, such as hemophilia, in subjects in need thereof by administering an antibody that specifically binds CD73. The methods reduce production of adenosine, increase platelet activation and / or enhance the level of coagulation on the platelet surface to reduce and / or stop bleeding. In some embodiments, the methods can further include co-administering Factor VIII to treat the bleeding disorder.

The invention belongs to the technical field of traditional Chinese medicines, and discloses a Shenghua decoction added with Radix Codonopsis for preventing intrauterine adhesion after artificial abortion and a preparation method of the Shenghua decoction. The Shenghua decoction added with Radix Codonopsis for preventing intrauterine adhesion after artificial abortion consists of Radix Codonopsis,Radix Astragali, Semen Persicae, Radix Angelicae Sinensis, Rhizoma Chuanxiong, Rhizoma Zingiberis Preparatum, Herba Leonuri, Pollen Tyjphae (parched), Fructus Aurantii (parched), Herba Taraxaci, Radix Cyathulae and Radix Glycyrrhizae Preparata. Medicines are added or reduced on the basis of the formula. By the Shenghua decoction added with Radix Codonopsis for preventing intrauterine adhesion after artificial abortion, the time of vaginal bleeding after induced abortion can be shortened; first menstrual resurgence after induced abortion is improved; postoperative periodic abdominal pain is improved; and uterine cavity adhesion rate is reduced. The medicine taking types of patients are reduced, and the cost of the patients is saved; the medicine taking period and the visiting times of thepatients are reduced, and the cost of the patients is reduced; the postoperative uterine cavity adhesion rate is reduced, the possibility of secondary operation is reduced, and the hospitalization frequency of the patients is reduced, so that the expenditure of the patients and national medical insurance can be reduced; The formula has a remarkable curative effect, the influence of traditional Chinese medicines is expanded, and the propaganda cost of traditional Chinese medicine culture is indirectly saved. The new medicine provided by the invention can effectively reduce adverse reaction after induced abortion; and the influence of the traditional Chinese medicine is expanded, and Chinese cultural legacy is promoted.

The invention relates to a pharmaceutical composition for treating hemorrhoid and process for preparation, wherein the composition comprises pagodatree fruit 385.5g, red peony root 193g, bark of peony root 193g, ledebouriella root 193g, Chinese angelica root 193g, bitter orange 193g, baikal skullcap root 193g and processed radix aconiti 8g.

The invention relates to a high-efficiency beef cattle slaughtering line. The high-efficiency beef cattle slaughtering line is characterized by comprising two overturning and slaughtering boxes, wherein a blood baffle is arranged on the outer side of a blood collecting groove; the height of the blood baffle exceeds the neck of each beef cattle body during hanging; a peeling workshop section is provided with two peeling machines, and the two peeling machines are respectively arranged on two sides of the peeling workshop section; a distributor mechanism is arranged between a railway and the twopeeling machines; and the tail end of the peeling workshop section is integrated into the railway. The high-efficiency beef cattle slaughtering line disclosed by the invention has the beneficial effects that the blood baffle is arranged on the outer side of the blood collecting groove, so that the situation that cattle blood pollutes ground of a slaughtering chamber can be avoided, the cleanlinessand the recovery yield of the cattle blood are improved, and civilized production level is improved; besides, the time that the slaughtered cattle bodies occupy the overturning and slaughtering boxescan also be shortened; in addition, hanging is performed in advance, so that blood draining is convenient, and bloodletting time is substantially shortened; the overturning and slaughtering boxes andthe peeling machines are additionally arranged, so that the running of time-consuming working procedures and other working procedures is more coordinated, the efficiency of the slaughtering line is substantially increased; and the distributor mechanism of the two peeling machines uses dead weight of the cattle bodies as power, so that the structure is simple, and energy resources are saved.