Collagen aggregate based flocculent antibacterial hemostatic material and preparation method thereof

Abstract

The invention discloses a collagen aggregate based flocculent antibacterial hemostatic material and a preparation method thereof. The preparation method is characterized by comprising steps as follows: DCMC (dialdehyde carboxymethyl cellulose) and silver nitrate are blended, a mixed solution containing nano-silver is prepared through redox reaction, then certain amount of collagen aggregate and certain amount of polyvinylpyrrolidone are dissolved in the mixed solution sequentially, the mixture is subjected to processes including gradient dilution, dealcoholization, vacuum drying, impregnation, freeze-drying, moderate grinding, sterilization and the like, and the collagen aggregate based flocculent antibacterial hemostatic material is obtained finally. The material adopts the collagen aggregate more similar to a natural tissue collagen structure, and compared with common collagen materials, the prepared flocculent hemostatic material has excellent physical and chemical properties and biological properties such as structural stability, mechanical property, biological degradability, biocompatibility and the like, can promote wound healing and repair, has broad-spectrum antibacterial/antimicrobial activity of the nano-silver, has large contact surface with the wound surface, is high in hydrophilia and stickiness and can be used for hemostasis repair of body surface wound and general civil hemostasis emergency.

Description

technical field [0001] The invention relates to a flocculent antibacterial and hemostatic material based on collagen aggregates and a preparation method thereof, belonging to the field of preparation of biomedical materials. Background technique [0002] In various surgical operations or trauma treatments, wound bleeding and isolation from the outside world to avoid infection have a great impact on the patient's wound healing. If the wound loses too much blood, the wounded will go into shock, coma, or even face great danger of life. The autologous physiological hemostasis cannot make the wound hemostasis quickly and effectively. In actual surgery and trauma operation, exogenous hemostatic drugs or hemostatic materials are often used to promote the rapid hemostasis of wounds and wounds. Collagen-based hemostatic materials have been widely concerned by people for a long time. As early as 1953, some researchers discovered that collagen has a hemostatic effect [Jiang Tingda. Col...

AI Technical Summary

Problems solved by technology

[0003] 1. Collagen itself has insufficient mechanical properties and poor adhesion, especially its sponge products, which are not easy to stick to the wound surface;

[0004] 2. Collagen itself has general hemostatic performance and single function