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Functional chitosan microsphere as well as preparation method and application thereof

A technology of chitosan microspheres and chitosan, which is applied in applications, pharmaceutical formulations, surgery, etc., can solve the problem of unsatisfactory hemostasis speed and effect, unable to meet the high clinical standard requirements, and the hemostasis time of hydrophobic chitosan Shorten the problem, to achieve the effect of improving hemostasis, improving the effect of flocculation and adsorption, and shortening the bleeding time

Active Publication Date: 2022-02-08
江苏西宏生物医药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Chitosan-related products are also the most potential first-aid hemostatic agent due to their high biocompatibility, biodegradability and safety, antibacterial properties and low cost; but pure chitosan hemostatic The application effect of the material is only good for mild bleeding wounds, but the hemostatic effect for severe bleeding is unstable, and the speed and effect of hemostasis are not ideal, and it is difficult to fully meet the requirements of ideal rapid hemostatic materials
[0005] Patent CN108276506B discloses a hydrophobic chitosan used to prepare hemostatic materials, which is obtained by adding a substrate containing a hydrophobic group (polyvinyl alcohol, etc.) shortened, but the amount of bleeding is still large, unable to meet the high clinical standards

Method used

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  • Functional chitosan microsphere as well as preparation method and application thereof
  • Functional chitosan microsphere as well as preparation method and application thereof

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Embodiment 1

[0031] A preparation method of functionalized chitosan microspheres, the concrete steps are as follows:

[0032] (1) 2g of high molecular weight chitosan (viscosity average molecular weight greater than 1.0×10 5 Da, degree of deacetylation greater than 70%) was dissolved in 80g mass concentration 2% acetic acid solution, stirred and mixed to obtain chitosan acetic acid solution, then ozone was passed into the chitosan acetic acid solution, and in a magnetic field environment, carried out Ultrasonic degradation treatment and post-treatment to obtain low molecular weight chitosan (viscosity average molecular weight less than 1.0×10 3 Da) solution;

[0033] (2) Dissolve 3g of lactobionic acid in 40g of water to obtain a lactobionic acid solution, then dissolve 1g of N,N'-dicyclohexylcarbodiimide in 30g of tetramethylethylenediamine to obtain N,N'-bicyclic Hexyl carbodiimide solution, and then lactobionic acid solution and N,N'-dicyclohexyl carbodiimide solution were dropped int...

Embodiment 2

[0041]A preparation method of functionalized chitosan microspheres, the concrete steps are as follows:

[0042] (1) 4g of high molecular weight chitosan (viscosity average molecular weight greater than 1.0×10 5 Da, degree of deacetylation greater than 70%) was dissolved in 70g mass concentration 4% acetic acid solution, stirred and mixed to obtain chitosan acetic acid solution, then ozone was introduced into the chitosan acetic acid solution, and in a magnetic field environment, carried out Ultrasonic degradation treatment and post-treatment to obtain low molecular weight chitosan (viscosity average molecular weight less than 1.0×10 3 Da) solution;

[0043] (2) Dissolve 2g of lactobionic acid in 50g of water to obtain lactobionic acid solution, then dissolve 0.8g of N,N'-dicyclohexylcarbodiimide in 40g of tetramethylethylenediamine to obtain N,N'-dicyclodiimide Cyclohexylcarbodiimide solution, and then lactobionic acid solution and N,N'-dicyclohexylcarbodiimide solution are ...

Embodiment 3

[0051] A preparation method of functionalized chitosan microspheres, the concrete steps are as follows:

[0052] (1) 3g of high molecular weight chitosan (viscosity average molecular weight greater than 1.0×10 5 Da, degree of deacetylation greater than 70%) was dissolved in 75g mass concentration 3% acetic acid solution, stirred and mixed to obtain chitosan acetic acid solution, then ozone was introduced into the chitosan acetic acid solution, and in a magnetic field environment, carried out Ultrasonic degradation treatment and post-treatment to obtain low molecular weight chitosan (viscosity average molecular weight less than 1.0×10 3 Da) solution;

[0053] (2) Dissolve 2.5g of lactobionic acid in 45g of water to obtain lactobionic acid solution, then dissolve 0.9g of N,N'-dicyclohexylcarbodiimide in 35g of tetramethylethylenediamine to obtain N,N'- Dicyclohexylcarbodiimide solution, then lactobionic acid solution and N,N'-dicyclohexylcarbodiimide solution are dropped into ...

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Abstract

The invention belongs to the technical field of chitosan derivative preparation, and particularly provides a functionalized chitosan microsphere and a preparation method and application thereof. The method comprises the steps that high-molecular-weight chitosan is degraded to obtain a low-molecular-weight chitosan solution, then chitosan is subjected to functional modification through lactobionic acid and ammonium ferrous sulfate, and finally, under the action of sodium polyphosphate, cross-linking reaction is conducted to obtain the functional chitosan microsphere. The functional chitosan microsphere can be used for preparing hemostatic materials, the bleeding time is greatly shortened, the bleeding amount is reduced, and the hemostatic effect is good.

Description

technical field [0001] The invention belongs to the technical field of preparation of chitosan derivatives, in particular to a functionalized chitosan microsphere and its preparation method and application. Background technique [0002] In various accidents, excessive blood loss due to injury is the most important factor leading to traumatic death. In addition, after puncture and extubation of various arteries and veins in the hospital, various bleeding conditions will also be faced. Clinical medicine points out that if the human body does not take effective first aid measures due to acute bleeding, the patient will die within 6 to 20 minutes. If the blood loss of the human body exceeds 20% of the whole body's blood volume, shock will occur; if the blood loss exceeds 40% of the whole body's blood volume, it will be on the verge of death. Early control of bleeding is the main method to reduce mortality. [0003] At present, there are two most widely used methods of hemostas...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08B37/08C08J3/24C08J3/12C08L5/08C08K3/32A61L24/08A61L24/00
CPCC08B37/003C08J3/24C08J3/12A61L24/08A61L24/0015A61L24/001A61L2400/04C08J2305/08C08K2003/324C08L5/08
Inventor 王志强张新明付劼徐增松何伟
Owner 江苏西宏生物医药有限公司
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