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Swelling medical biogel filler based on portulaca oleracea polysaccharide and flavone extract

A technology of purslane flavonoids and biogel, which is applied in the field of medical materials, can solve the problems of poor molding toughness and antibacterial properties.

Inactive Publication Date: 2019-08-16
NANJING XIAOZHUANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0019] The purpose of the present invention is to overcome the disadvantages of poor molding toughness and antibacterial properties of traditional Chinese medicine gel fillers in the prior art, and provide a swelling medical biogel filler based on purslane polysaccharides and flavonoid extracts and a preparation method thereof. The gel filler has high formability after absorbing water and swelling, and has good anticoagulation and excellent antibacterial activity

Method used

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  • Swelling medical biogel filler based on portulaca oleracea polysaccharide and flavone extract
  • Swelling medical biogel filler based on portulaca oleracea polysaccharide and flavone extract
  • Swelling medical biogel filler based on portulaca oleracea polysaccharide and flavone extract

Examples

Experimental program
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Effect test

Embodiment 1

[0075] Extraction of high-purity polysaccharides and total flavonoids from purslane

[0076] 1) Dry 1 kg of dried purslane stems and leaves, grind them through a 60-mesh sieve to obtain purslane powder; soak the obtained purslane powder in ethanol with 95% volume fraction for 3 hours, and place them in a Soxhlet extractor in batches Soxhlet extraction was performed at 55°C for 2h.

[0077] 2) The obtained extract is distilled and concentrated under reduced pressure to obtain about 460ml of the concentrate; after the concentrate is diluted with an equal volume of 75% ethanol, it is extracted and degreased with petroleum ether; the degreased extract is subjected to a gradient with a macroporous adsorption resin column Elution, followed by elution with deionized water, 50% ethanol, 75% ethanol, during the elution process, ultraviolet detection scans the absorption peak, collects the eluate containing flavonoids; evaporates, concentrates and crystallizes, and precipitates the tota...

Embodiment 2

[0084] Preparation of Modified Collagen Gel Fractions

[0085] (1) Preparation of low hydroxyethyl substituted purslane polysaccharides

[0086] Weigh 20.8g of the purified polysaccharide, dissolve it in 1.6kg mixed solution containing 1wt% sodium hydroxide and 3wt% sodium chloride at 4°C, slowly add 2.5ml of 2-chloroethanol dropwise, react at room temperature for 5 hours, then heat up Continue the reaction at 60°C for 2 hours. After the reaction is completed, cool the reaction liquid to room temperature and adjust it to neutral with 1M hydrochloric acid. Suction filtration. The filtrate is dialyzed with a dialysis bag with a molecular weight cut-off of 10,000. After dialysis, it is separated and purified by ultrafiltration, and the product is concentrated. to 110ml, add 500ml of 95% ethanol precipitation concentrate, centrifuge the obtained precipitate, then wash with acetone and ether successively, and vacuum dry to obtain a polysaccharide powder modified by low hydroxyethyl...

Embodiment 3

[0089] Preparation of swellable complex polysaccharide gel components

[0090] (1) Weigh 50.4 g of sodium hyaluronate and purified purslane polysaccharide in equal weight, stir and dissolve with 3.5L konjac glucomannan solution (glucomannan concentration 0.45wt%) to obtain a complex polysaccharide solution , drop acetic acid therein to adjust the pH value of the solution to 4.5; then slowly add 2wt% carbodiimide solution dropwise to the solution as a cross-linking agent at room temperature and under stirring, and the dropping amount is 28ml in total;

[0091] (2) Continue to stir and react for 16 hours after the dropwise addition is completed. After the reaction is completed, it is evaporated and concentrated to 380ml. 5 times the mass of 95% ethanol solution is added to the concentrated solution to carry out alcohol precipitation, suction filtration, and the solids are washed with absolute ethanol. Dry, grind and pulverize to obtain about 65 g of powdery swellable complex pol...

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Abstract

The invention relates to swelling medical biogel filler based on portulaca oleracea polysaccharide and flavone extract. The swelling medical biogel filler comprises a collagen gel component modified by compound polysaccharide, a swelling compound polysaccharide gel component and a nano hydroxy phosphorite component loaded with portulaca oleracea flavone extract and calcium ion. The swelling medical biogel filler is a framework supporting polysaccharide filling material integrating effects of absorbing seepage, stopping bleeding, filling and promoting healing and has antibacterial and antipyrotic characteristics. Portulaca oleracea is rich in source, and polysaccharide is low in preparation cost, so that the swelling medical biogel filler is suitable for industrial production.

Description

technical field [0001] The invention belongs to the field of medical materials, and in particular relates to a swelling medical biogel filler based on biological macromolecules such as purslane polysaccharides and flavonoid extracts and a preparation method thereof. Background technique [0002] Purslane belongs to the plant of Portulaca oleracea. It is widely distributed in my country, easy to cultivate, edible, and has medicinal value. It has the functions of clearing away heat, detoxification and cooling blood. Studies have reported that purslane extracts have anti-inflammatory effects and can be used to prepare anti-inflammatory drugs. Further studies have shown that purslane extracts contain polysaccharides, alkaloids, flavonoids and other components, which have a contraction effect on blood vessels and can promote epithelial cells. Growth, is conducive to ulcer healing. Although there are reports on the extraction of purslane polysaccharides and flavonoids in the prio...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L15/28A61L15/40A61L15/32A61L15/18A61L15/42A61L15/44A61L15/46A61L31/04A61L31/00A61L31/02A61L31/14A61L31/16
CPCA61L15/18A61L15/28A61L15/325A61L15/40A61L15/42A61L15/44A61L15/46A61L31/005A61L31/028A61L31/042A61L31/044A61L31/14A61L31/145A61L31/16A61L2300/30A61L2300/404A61L2300/41A61L2300/412A61L2300/602A61L2400/04A61L2400/12C08L5/00C08L5/08
Inventor 唐宁张边江陈全战王立科杨平
Owner NANJING XIAOZHUANG UNIV
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