This invention belongs to the field of biomedical materials technology, specifically relating to a
chitosan hemostatic
sponge and its preparation method. This patent addresses the problems of residual
acetic acid and side reactions, low strength, and low absorbency caused by cross-linking methods during the preparation of
chitosan hemostatic sponges. It innovatively proposes a method for physically cross-linking
chitosan hemostatic sponges using
hydrogen bonding-electrostatic synergistic superabsorbency based on
alcohol-regulated substances. By introducing alcohols to regulate the
electrostatic interaction between chitosan amino groups and
acetic acid, while simultaneously adjusting the
hydrogen bonding interaction between chitosan molecules, and introducing other
polymer materials to construct a semi-interpenetrating network, the overall material properties are enhanced. The chitosan hemostatic material prepared by this process, although without the addition of cross-linking agents, still exhibits an insoluble
sponge-like structure, good flexibility, and excellent absorbency and hemostatic effect.