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Absorbable and hemostatic multifunctional particle with tissue induction and preparation and application of multifunctional particle

A particle and functional technology, applied in absorbent pads, medical science, bandages, etc., can solve the problems of toxic side effects, adhesion, insufficient liquid absorption, etc., and achieve good usability, convenient preparation method, and good biocompatibility. Effect

Active Publication Date: 2012-11-14
SUZHOU BOCHUANG TONGKANG PHARM TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

"Arista" hemostatic microporous starch granules have a definite degradation mechanism in the body and also have certain adsorption properties, which have recently attracted a lot of research. The use of chlorohydrin cross-linking agents may bring about the risk of toxic and side effects; "Avistop" hemostatic collagen and fibrin are both macromolecular proteins derived from humans or animals, and there are inevitably risks of allergic and immunogenic reactions. Heparinized patients are not effective

Method used

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  • Absorbable and hemostatic multifunctional particle with tissue induction and preparation and application of multifunctional particle
  • Absorbable and hemostatic multifunctional particle with tissue induction and preparation and application of multifunctional particle
  • Absorbable and hemostatic multifunctional particle with tissue induction and preparation and application of multifunctional particle

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0044] Weigh carboxymethyl chitosan, chitosan, hyaluronic acid (molecular weight: 10,000) and RGD polypeptide 2.5g, 1.5g, 0.01g and 0.005g, respectively, and place them in a beaker; electric stirring for 10min until uniform; Take 45ml of water for injection, add acetic acid dropwise to adjust pH=2.0, pour it into a beaker; use a stirrer at 3000rmp to stir for 2h until uniform, add NaOH dropwise to adjust pH=7.0; measure 10ml of the stirred solution, pour it into a small culture Then put it into a freezer at -80°C for 2 hours, then put it into a freeze dryer, and freeze it completely after 52 hours; put the freeze-dried block into an electric grinder and crush it, and sieve the retained particles Particles with a diameter of 0.01 mm to 1.0 mm; Weigh a certain amount of particles and carefully put them into aluminum-plastic packaging bags, seal them at high temperature with a sealing machine, and sterilize them with cobalt 60 radiation to obtain the absorbable and Granular mater...

Embodiment 2

[0061] Weigh carboxymethyl chitosan, hyaluronic acid (molecular weight: 1.2 million), calcium chloride, hyaluronic acid (molecular weight: 10,000) and RGD polypeptide 3g, 1g, 0.6g, 0.01g and 0.005g respectively, and set in a beaker; electric stirring for 10min until uniform; measure 46ml of water for injection and pour it into the beaker; use a stirrer at 3000rmp to stir for 2h until uniform; measure 10ml of the stirred solution and pour them into small Petri dishes; Pre-freeze the small petri dish in a -80°C refrigerator for 2 hours, then put it in a freeze dryer, and freeze-dry it completely after 52 hours; put the freeze-dried sample into EDC (1-ethyl-3-(3-di Methylaminopropyl)-carbodiimide) solution, (where the EDC concentration is 2g / L, NHS (N-hydroxysuccinimide) is 0.5g / L, MES (2-(N-morphine ) ethylenesulfonic acid) as a buffer, adjust the pH value to 5.5), place it at 4°C for 24h, and then use 0.1mol / L Na 2 HPO 4 The solution was soaked for 1 h, then washed with deion...

Embodiment 3

[0064] Weigh carboxymethyl starch, hyaluronic acid (molecular weight: 1.2 million), CaCl 2 , Hyaluronic acid (molecular weight 10,000) 2.0g, 2.0g, 0.5g and 0.005g, put in a beaker; electric stirring for 10min until uniform; measure 45ml of water for injection, pour into the beaker; use a stirrer 3000rmp to stir for 2h to Evenly; take 10ml of the stirred solution and pour them into small petri dishes respectively; put the small petri dishes into -80℃ refrigerator for 2 hours, then put them into a freeze dryer, and freeze them completely after 52 hours Dry; put the freeze-dried lumps into an electric grinder and crush them, and sieve and intercept particles with a particle size of 0.01mm to 1.0mm; weigh a certain amount of particles and carefully put them into aluminum-plastic packaging bags, and seal them with Machine high-temperature sealing, using cobalt 60 irradiation sterilization, to obtain the absorbable granular material sample of this embodiment, which has the functions...

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Abstract

The invention relates to a multifunctional particle used for stopping human body wounds bleeding, filling, absorbing fluid, preventing adhesion and inducing tissue regeneration and repair. The absorbable particle with multiple functions of stopping bleeding, filling, absorbing the fluid, preventing the adhesion and inducing the tissue regeneration and repair comprises the following raw materials in weight percentage: 30-98.95 percent of polyanionic substance, 1-70 percent of cationic substance and / or polycationic substance, 0.05-2 percent of hyaluronic acid and / or functional factor polypeptide and 0-68.95 percent of pharmaceutical excipient. The particle is 0.01-1.0mm in particle size, and the particle is irregular in shape. The absorbable particle material with the multiple functions of stopping bleeding, filling, absorbing the fluid, preventing the adhesion and inducing the tissue regeneration and repair can be used for stopping the human body wounds bleeding, filling, absorbing fluid, preventing the adhesion and inducing the tissue regeneration and repair and is especially suitable for the wounds and defective tissues during minimally invasive surgery.

Description

technical field [0001] The invention relates to a multifunctional particle used for hemostasis, filling, liquid absorption, anti-adhesion and inducing tissue regeneration and repair of human trauma wounds or defective tissues, and is especially suitable for minimally invasive surgery. Background technique [0002] Bleeding is a common problem encountered in surgical operations, injury wounds and accidents, and sometimes even threatens life. Therefore, research on fast and effective hemostatic materials and methods has always been a subject of interest. With the improvement of people's material living conditions, people pay more attention to their own health, so higher requirements are placed on the applicability and functionality of medical materials. As an excellent medical hemostatic material, it not only needs to have the usual short hemostatic time, Good effect, can not increase the infection of the wound, and should not cause secondary trauma, and the implanted material...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L15/42A61L15/50A61L15/32A61L15/28
Inventor 吴昌琳
Owner SUZHOU BOCHUANG TONGKANG PHARM TECH CO LTD
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