99 results about "Nanoparticle coating" patented technology

A medical device comprising radiopaque water-dispersible metallic nanoparticles, wherein the nanoparticles are released from the medical device upon implantation of the device. The medical device of the present invention is sufficiently radiopaque for x-ray visualization during implantation, but loses its radiopacity after implantation to allow for subsequent visualization using more sensitive imaging modalities such as CT or MRI.

The nanoparticles are formed of a metallic material and have surface modifications that impart water-dispersibility to the nanoparticles. The nanoparticles may be any of the various types of radiopaque water-dispersible metallic nanoparticles that are known in the art. The nanoparticles may be adapted to facilitate clearance through renal filtration or biliary excretion. The nanoparticles may be adapted to reduce tissue accumulation and have reduced toxicity in the human body. The nanoparticles may be applied directly onto the medical device, e.g., as a coating, or be carried on the surface of or within a carrier coating on the medical device, or be dispersed within the pores of a porous layer or porous surface on the medical device. The medical device itself may be biodegradable and may have the nanoparticles embedded within the medical device itself or applied as or within a coating on the biodegradable medical device. The nanoparticles may be released by diffusion through the carrier coating, disruption of hydrogen bonds between the nanoparticles and the carrier coating, degradation of the nanoparticle coating, degradation of the carrier coating, diffusion of the nanoparticles from the medical device, or degradation of the medical device carrying the nanoparticles.

Implantable medical devices having a nanoparticle coating applied thereon. The nanoparticle coating comprises nanopulverized antiproliferative compounds. More specifically, the nanoparticulate antiproliferative compounds comprise particles less than 500 nm in size. The nanoparticle size of the compounds improves compounds' solubility. In addition to improving the solubility of otherwise insoluable antiproliferative compounds, the nanoparticle size minimizes the preparation and formulation required to prepare a dose of the antiproliferative compounds.

Coatings for drug delivery. In particular, coatings comprising nanoparticles loaded with at least one drug, on implants such as stents, to deliver drugs at the sites of implantation.

The present invention relates to a system and method for cleaning and/or treating a surface, preferably surfaces such as ceramic, steel, plastic, glass and/or painted surfaces such as the exterior surface of a vehicle. In one embodiment, the method forms a transparent, hydrophilic coating on the surface of a vehicle. This embodiment of the method includes the steps of: (a) providing a vehicle having at least some surfaces that are at least one of the following: cured painted surfaces, cured clearcoat surfaces, and glass surfaces; (b) applying a non-photoactive nanoparticle coating composition to such surfaces; and (c) allowing the coating composition to dry on such surfaces before the surfaces are contacted by water.

A colorimetric reagent in the form of nanoparticles, composite nanoparticles, and nanoparticle coatings, including methods of use, methods of preparation, deposition, and assembly of related devices and specific applications. The colorimetric reagent comprises cerium oxide nanoparticles which are used in solution or immobilized on a solid support, either alone or in conjunction with oxidase enzymes, to form an active colorimetric component that reacts with an analyte to form a colored complex. The rate of color change and the intensity of the color are proportional to the amount of analyte present in the sample. Also described is the use of ceria and doped ceria nanoparticles as an oxygen storage/delivery vehicle for oxidase enzymes and applications in biocatalytic processes in anaerobic conditions of interest in biomedicine and bioanalysis. Further described are a variety of related applications of the disclosed technology including clinical diagnosis, in vivo implantable devices, food safety, and fermentation control.

The disclosure is directed to nanoparticles used in creating nanostructure complexes in the presence of divalent cations. In particular, the disclosure is directed to nanoparticles that are coated with zwitterions and linker portions in a manner that facilitates nanostructure complex assembly while reducing or preventing non-specific spontaneous aggregation of nanoparticle in the presence of divalent cations. The disclosure also provides a method for preparing a nanoparticle coating of the present invention. Furthermore, the disclosure provides a method for assembling nanostructure complexes using coated nanoparticles with a scaffold.

Embodiments of the invention relate to functionalized nanoparticle coating compositions. These coating can improve the light extraction efficiency of light emitting devices, including LEDs and OLEDs. In some embodiments, the coating can improve other properties such as anti-staining, abrasion and/or scratch resistance.

The invention discloses a method for preparing a nanoparticle coating with the bone induction and antibiosis functions on the surface of a medical metal. According to the method, nanoparticles with different electric properties as used as a carrier, the nanoparticles are formed by mutual crosslinking of high-molecular polymers, and growth factors and antibiotics are respectively loaded in the process of preparing the nanoparticles with dissimilar electric properties, wherein factors and factor-friendly polyanions are sufficiently mixed to react first and are then immobilized into the nanoparticles through ionic crosslinking; and amino-containing antibiotics are grafted to a polyaldehyde anionic polymer through chemical crosslinking first and are then loaded into the nanoparticles through ionic crosslinking. The two types of nanoparticles are alternately assembled on the surface of the medical metal through electrostatic adsorption, covalent crosslinking is also formed among the particles, and the stability of the coating is enhanced. The coating prepared by using the method has the function of controlling adsorption and release of the growth factors and the antibiotics under the normal physiological environment, the activity of the growth factors are keep well and a strong bone induction function is achieved; and in addition, the antibiotics can be slowly released for a long time, and a good antibiosis effect is achieved.

Coatings for implantable medical devices including nanoparticles incorporating an active agent, and methods for fabricating the coatings.

A preparation method of core-shell composite material wrapped in a titanium dioxide nanoparticle coating includes: firstly, acquiring nanoparticle carrier; and secondly, wrapping the surface of the metal or metal oxide nanoparticle carrier with a titanium dioxide nanoparticle coating. The second step includes dissolving titanium isobutoxide in glycol, mixing at room temperature for 4-8 hours to obtain titanium dioxide precursor mixed solution A, dispersing the nanoparticle carrier in acetone, mixing well to obtain even mixed solution B, adding the titanium dioxide precursor mixed solution A into the mixed solution B, allowing for obtained solution to stand at room temperature to form precipitate mixed solution, and subjecting the precipitate mixed solution to centrifugal separation, and heating in water bath at 80-100 DEG C. The preparation method of the core-shell composite material wrapped in the titanium dioxide nanoparticle coating allows for increasing of photocatalysis efficiency and is low in cost.

The invention discloses a three-dimensional graphene-based combined electrode with a MnO2 and Au nanoparticle-coating surface. By taking three-dimensional porous foam nickel as a matrix, graphene directly grows on the matrix, and flower-shaped delta-MnO2 directly grows on the graphene and loaded with Au nanoparticles. The invention further discloses a preparation method and applications of the three-dimensional graphene-based combined electrode with the MnO2 and Au nanoparticle-coating surface. The preparation method has the advantages of being simple in preparation technology, low in cost, short in period, low in energy consumption and the like, and is suitable for industrial mass production; the prepared three-dimensional graphene-based combined electrode does not contain any conductive agent and binder, and due to the synergistic catalytic action of a special three-dimensional porous structure and the flower-shaped delta-MnO2, Au nanoparticles and graphene, the three-dimensional graphene-based combined electrode shows low polarization and better cycling stability when being used as a lithium-air battery cathode.

The invention discloses mesoporous carbon prepared by using a manganese compound, and a preparation method thereof. According to the method, manganese oxide crystal nanoparticles formed by decomposinga manganese compound during pyrolysis carbonization of a carbon precursor have mesoporous size characteristic, the manganese compound can catalyze the carbon precursor to form carbon, and the manganese compound is used as a template agent precursor so as to prepare mesoporous carbon. The method specifically comprises: 1, uniformly mixing a thermoplastic carbon precursor and a manganese compound through solid phase powder or a liquid phase solution; 2, carrying out high-temperature carbonizing on the mixture in an inert atmosphere to obtain a MnO-nanoparticle-coating carbide; and 3, uniformlymixing the carbide and a dilute acid solution, and removing MnO to obtain mesoporous carbon. According to the present invention, the prepared mesoporous carbon has characteristics of high specific surface area, high mesoporosity, large mesopore volume, easily-controlled pore structure and easily-controlled pore size distribution, can greatly reduce the carbonization temperature of the carbon precursor, and can be widely used in the fields of adsorption, catalysis and separation.

A series of multicoordinating and multifunctional ligands optimized for the surface-functionalization of luminescent quantum dots (QDs) and gold nanoparticles (AuNPs) alike is disclosed. An L-aspartic acid precursor is modified with functionality, through simple peptide coupling chemistry, one or two lipoic acid (LA) groups and poly(ethylene glycol) (PEG) moieties in the same ligand. These ligands were combined with a new photoligation strategy to yield hydrophilic and reactive QDs that are colloidally stable over a broad range of conditions, including storage at nanomolar concentration and under ambient conditions.

The invention discloses a method for constructing a nano coating on the surface of a micro-nano structure and application of the nano coating on antireflection. In the method, a nano-particle coatingis adopted and comprises a solution a and a solution b; the solution a comprises a silane coupling agent and a solvent; the solution b comprises nano-particle dispersion liquid and a solvent; the solution a is dropwise added in the solution b to obtain the nano-particle coating; and the silane coupling agent in the solution a has positive electricity, and nano-particles in the solution b has negative electricity or is improved by substances which have negative electricity. By the method, the conformal nano coating with the uniform thickness is constructed on the surface with an irregular micro-nano structure, and furthermore, the thickness of the coating can be regulated and controlled according to time of immersion in the nano-particle coating. In addition, the method for constructing thenano coating is applied to antireflection, and thus, a transmittance value of a substrate is increased to a certain extent on the original.

The invention relates to a platinum-based nanoparticle coating and tin dioxide covering carbon nanotube and a preparation method thereof, wherein the carbon nanometer tube is a multi-wall carbon nanotube; a layer of tin dioxide is loaded on the carbon nanotube; a layer of platinum-based metal is loaded on the tin dioxide layer; the platinum-based metal exists in a nanometer particle form, and is connected into a network structure. The catalyst provided by the invention has the advantages that the noble metal utilization rate is high; the catalytic activity and the carbon monoxide poisoning resistance performance of the catalyst are high; the service life of the catalyst is long; the methanol catalytic oxidation activity is more than 6.2 times of the commercial Pt/C catalyst; the oxygen reduction mass activity at the hydrogen scale potential being 0.9V is 9.6 times of that of the commercial Pt/C catalyst; the granularity is preferably between 1.0 to 10.0nm, and is also preferably between 2.0 to 4.0nm.

The invention discloses a construction method of an enzyme-reponsive multifunctional nano-coating. The construction method comprises the following steps: firstly, immobilizing avidin molecules to the surface of dopamine-coated stainless steel; then, on the basis of specific recognition and binding effects between avidin and biotin, immobilizing biotinylated heparin/PEI nanoparticles to the surface of a material, and further binding high-concentration avidin molecules to residual biotin on the surface of a nanoparticle coating, so that a novel biotin binding site is introduced; then, continuing to assemble biotinylated enzyme-responsive polypeptide to the surfaces of the nanoparticles on the basis of an interaction between the biotin and the avidin; and finally, by virtue of an EDC/NHS/MES coupling agent, immobilizing SDF-1[alpha] to an amino terminal of the polypeptide in a covalent mode, so that the multifunctional nano-coating, which has a matrix metalloproteinase 9 responsive characteristic, is constructed. According to the construction method provided by the invention, by constructing a multifunctional layer, which has anti-coagulating and endothelial regeneration inducing capacities, on a titanium surface, blood compatibility and a damaged endothelial repair capacity of the material can be obviously improved.

The invention relates to a preparation method of a seawater electrolytic reaction anode IrO2-RuO2-SnO2-TiO2 nanoparticle coating. The seawater electrolytic reaction anode IrO2-RuO2-SnO2-TiO2 nanoparticle coating is prepared by the following improved thermal decomposition method: mixing soluble SnIV, RuIII and IrIV salt solution and titanium dioxide, adding high molecular polymer, and stirring or carrying out supersonic oscillation to form a suspension, thereby obtaining the anode coating liquid; and brushing the suspension on a Ti matrix, drying, calcining, cooling, and repeating many times until the coating reaches the required thickness. The anode coating prepared by the method provided by the invention has the advantages of uniform metallic oxide particle distribution, small microcrystal particle size, large specific area, increased electrode conductivity, excellent electrocatalytic activity and high stability, and has a mud crack appearance on the surface. The preparation method provided by the invention is simple, and suitable for industrial large-scale production.