The invention relates to the technical field of ion acceleration equipment, in particular to a mixed ion acceleration device. The device comprises a cavity, a radio frequency quadrupole field and a drift tube are arranged on the same center line in the cavity, a foundation plate is correspondingly arranged on the joint of the radio frequency quadrupole field and the drift tube, two T-shaped plates are symmetrically arranged in the cavity in an up-down mode, the two ends of the cavity are provided with end plates, the radio frequency quadrupole field comprises two bar type electrodes, the two adjacent bar type electrodes are installed on the T-shaped plates through an electrode support and an electrode support supporting rod, and electrode supporting contact parts are arranged between the electrode support and the bar type electrodes. The drift tube is of a multi-segment structure, each segment of drift tube is installed on the corresponding T-shaped plate through a drift tube supporting rod, the gap between every two adjacent drift tubes is of an interactive phase bunching structure, and the drift tube supporting rods are designed in an interdigitated H type. By means of the device, a lot of space and cost are saved, and the device is more economical and practical and has high transmission efficiency, high gradient acceleration ability and high power acceleration efficiency.