The invention discloses a compound norfloxacin composition and a preparation method. The composition comprises the following components: norfloxacin, frankincense, fructus setariae germinatus, medicated leaven, dried ginger, Luying, largehead atractylodes rhizome, morinda root, red dates, leaves of officinal magnolia bark, bitter orange, sodium carboxymethyl starch, low-substituted hydroxypropyl cellulose, starch, sucrose ester and aerosil. The preparation method comprises the steps of material preparation, extraction of active ingredients of active pharmaceutical ingredients of traditional Chinese medicines, granulation, drying, granule integration and tabletting/encapsulation. The composition has the beneficial effects that the medicines have obvious synergistic effects, not only have the effect of improving the bacteriostatic and antiphlogistic effects of norfloxacin but also have the effect of overcoming the side effects of norfloxacin on gastrointestinal tracts and have the effects of tonifying the spleen and nourishing the stomach, thus improving the compliance of patients; the composition is reasonable in usage amount of the medicinal auxiliary materials and usage amount selection and is simple in formula; the preparation process is reasonable and stable, has good reproducibility and easily achieves industrial production; the cost is low, thus being beneficial to reducing the product price.