Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Compound Norfloxacin slow-release capsules and preparing method thereof

A technology of norfloxacin and sustained-release capsules, which is applied in the field of compound norfloxacin sustained-release capsules and its preparation, can solve problems such as poor patient compliance, frequent administration of immediate-release preparations, diarrhea, nausea or vomiting, and achieve maintenance Effects of medicine, enhancement of body immunity, and improvement of compliance

Inactive Publication Date: 2015-11-18
QINGDAO HAIZHIYUAN INTELLIGENT TECH
View PDF2 Cites 3 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] However, oral administration of norfloxacin can easily lead to abdominal discomfort or pain, diarrhea, nausea or vomiting, and may also cause dizziness, headache, drowsiness or insomnia, and the frequent use of immediate-release preparations leads to poor patient compliance

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Compound Norfloxacin slow-release capsules and preparing method thereof
  • Compound Norfloxacin slow-release capsules and preparing method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] A compound norfloxacin sustained-release capsule, the components and parts by weight of the sustained-release capsule include 4 parts of norfloxacin, 33 parts of frankincense, 38 parts of Guya, 35 parts of divine music, 27 parts of dried ginger, Lu Ying 12 parts, 18 parts of Atractylodes macrocephala, 13 parts of Morinda officinalis, 35 parts of red dates, 6 parts of Magnolia officinalis leaves, 19 parts of Citrus aurantii, 2 parts of microcrystalline cellulose, 1.5 parts of polyvinylpyrrolidone, 0.8 parts of talcum powder, 4 parts of polypropylene , 0.15 parts of glycerides, and 0.3 parts of polyethylene glycol.

[0026] A preparation method of compound norfloxacin sustained-release capsules, comprising the following steps:

[0027]1) preparing materials, preparing materials according to the components and parts by weight of a kind of compound norfloxacin sustained-release capsule, wherein the pharmaceutical adjuvant is pulverized through a 100 mesh sieve, and norfloxa...

Embodiment 2

[0034] A compound norfloxacin sustained-release capsule, the components and parts by weight of the sustained-release capsule include 3 parts of norfloxacin, 30 parts of frankincense, 35 parts of grain buds, 30 parts of divine music, 25 parts of dried ginger, Lu Ying 10 parts, 15 parts of Atractylodes macrocephala, 10 parts of Morinda officinalis, 30 parts of red dates, 5 parts of Magnolia officinalis leaves, 15 parts of Citrus aurantii, 1 part of microcrystalline cellulose, 1 part of polyvinylpyrrolidone, 0.5 parts of talcum powder, 3 parts of polypropylene , 0.1 part of glyceride, and 0.2 part of polyethylene glycol.

[0035] A preparation method of compound norfloxacin sustained-release capsules, comprising the following steps:

[0036] 1) preparing materials, preparing materials according to the components and parts by weight of a kind of compound norfloxacin sustained-release capsule, wherein the pharmaceutical adjuvant is pulverized through a 100 mesh sieve, and norfloxac...

Embodiment 3

[0043] A compound norfloxacin sustained-release capsule. The components and parts by weight of the sustained-release capsule include 5 parts of norfloxacin, 35 parts of frankincense, 40 parts of grain buds, 40 parts of divine music, 30 parts of dried ginger, Lu Ying 15 parts, 20 parts of Atractylodes macrocephala, 15 parts of Morinda officinalis, 40 parts of red dates, 10 parts of Magnolia officinalis leaves, 20 parts of Citrus aurantii, 3 parts of microcrystalline cellulose, 2 parts of polyvinylpyrrolidone, 1 part of talcum powder, 5 parts of polypropylene , 0.2 parts of glycerides, and 0.4 parts of polyethylene glycol.

[0044] A preparation method of compound norfloxacin sustained-release capsules, comprising the following steps:

[0045] 1) preparing materials, preparing materials according to the components and parts by weight of a kind of compound norfloxacin sustained-release capsule, wherein the pharmaceutical adjuvant is pulverized through a 100 mesh sieve, and norflo...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses compound Norfloxacin slow-release capsules and a preparing method thereof. The compound Norfloxacin slow-release capsules comprises Norfloxacin, mastic, rice sprout, medicated leaven, dried ginger, Chinese elder herb, white atractylodes rhizome, medicinal Indian mulberry root, red jujube, officinal magnolia leaf, bitter orange, microcrystalline cellulose, polyvinylpyrrolidone, talcum powder, polypropylene, glyceride, and polyethylene glycol. The preparing method includes preparing materials, extracting effective components from herbal materials, preparing compound Norfloxacin pellets, preparing compound Norfloxacin slow-release pellets, and performing capsulizing. The herbal materials are significant in synergistic effect, the function of Norfloxacin to sterilize skin and diminish inflammation is improved, the side effects of Norfloxacin upon gastrointestinal tracts are overcome, the capsules are effective in strengthening the spleen and stomach, patient compliance is improved. The effect of the capsules is maintained by controlling concentration of drugs in blood, drug release peaks fewer times, and organs of a patient can be further partly protected.

Description

technical field [0001] The invention belongs to the field of quinolone antibacterial drugs, in particular to a compound norfloxacin sustained-release capsule and a preparation method thereof. Background technique [0002] Norfloxacin is a third-generation quinolone antibacterial drug, its chemical name is 1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinolone Phyloline carboxylic acid can hinder the action of DNA gyrase (DNAGyrase) of pathogenic bacteria, hinder bacterial DNA replication, and have an inhibitory effect on bacteria. It has broad-spectrum antibacterial effect, especially high antibacterial activity against aerobic Gram-negative bacilli, and is suitable for urinary tract infection, gonorrhea, prostatitis, intestinal infection, typhoid fever and other Salmonella infections caused by sensitive bacteria. [0003] Oral absorption of norfloxacin on an empty stomach is rapid but incomplete, about 30% to 40% of the dose; it is widely distributed in various t...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/9068A61K9/52A61K47/34A61K47/38A61K47/04A61P31/04A61P29/00A61K31/496
Inventor 袁国防赵秀霞李明孙梅梅
Owner QINGDAO HAIZHIYUAN INTELLIGENT TECH
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com