32 results about "Sustained Release Capsule" patented technology

The invention discloses a CO2 sustained-release capsule and a preparation method thereof. The CO2 sustained-release capsule comprises sodium alginate, corn starch, amyloglucosidase, saccharomyces cerevisiae and anhydrous calcium chloride, and a solvent is ultrapure water. The saccharomyces cerevisiae is Saccharomyces cerevisiae BNCC185415, and the saccharomyces cerevisiae is Saccharomyces cerevisiae BNCC185415. The mass ratio of the sodium alginate in the capsule preparation is 2.00%-3.00%, the mass ratio of the corn starch in the capsule preparation is 10.00%-30.00%, the content of the amyloglucosidase in the capsule preparation is 1.0-3.0 U / g, and the mass ratio of the saccharomyces cerevisiae in the capsule preparation is 10.0%-30.0%. Based on the general taxis of underground pests to CO2, the invention creates a CO2 sustained-release capsule which has remarkable attraction activity on the pests, and the underground pests can be trapped, killed, prevented and controlled by combining physical prevention and control, biological prevention and control, chemical prevention and control and other measures in practical application.

The application discloses a foam displacement agent sustained-release capsule and a preparation method and application thereof. The foam displacement agent sustained-release capsule comprises a sustained-release film and a foam displacement agent coated in the sustained-release film; and the sustained-release film is a polymer film. The foam displacement agent sustained-release capsule has a sustained-release time of greater than 2 days under the gas well conditions of a temperature of 100-160 DEG C and a pH of 3-6, and the foamability, foam stability and liquid carrying capacity of a solution reach a peak value when the sustained-release time is 2-4 days, at which time, the liquid carrying capacity is greater than or equal to 120 mL, the foamability is greater than or equal to 140 mm, and the foam stability is greater than or equal to 120 mm. The foam displacement agent sustained-release capsule has good foamability, foam stability and liquid carrying capacity.

1. The name of the designed product: packing box (ibuprofen sustained-release capsule). 2. The use of the designed product: the designed product is used for medicine packing. 3. The design points of the designed product: the combination of shape, pattern and color. 4. The picture or photo that best shows the design points: perspective view. 5. The design contains color.

The invention discloses a preparation method of a magnesium glycinate enteric-coated sustained-release capsule, and relates to the technical field of preparation of enteric-coated sustained-release capsules, and the preparation method is technically characterized by comprising the following steps: preparing a magnesium glycinate pellet: mixing magnesium glycinate with microcrystalline cellulose, starch and cane sugar to form uniform powder, adding the mixed powder into a centrifugal granulating and coating machine, and carrying out granulation and coating to obtain the magnesium glycinate pellet; taking hydroxypropyl methyl cellulose or a methyl cellulose solution as an adhesive, and performing centrifugal granulation at four stages of nucleation, coalescence, lamination and rolling compaction to obtain magnesium glycinate pellets; the nucleation is that the initial particles attract and are connected with one another due to the formation of a three-phase structure in the wetting process of the adhesive; the coalescence is that parent nuclei are combined to form larger particles due to random collision among the large particles; through a synergistic process of four-stage centrifugal granulation, specific-ratio slow-release coating and HPMCP enteric coating, efficient and accurate controlled release of magnesium glycinate is realized, and the problem of too fast release caused by insufficient weight gain of the slow-release coating is effectively avoided.

The invention relates to the field of aromatherapy wax, in particular to an environment-friendly aromatherapy candle capable of removing formaldehyde and a preparation process of the environment-friendly aromatherapy candle. Raw materials of the aromatherapy wax comprise the following components in parts by mass: 45-55 parts of modified vegetable wax, 3-8 parts of a plant essential oil mixture, 1-3 parts of a stabilizer, 2-3 parts of a dispersant and 6-10 parts of a sustained-release capsule, and the sustained-release capsule comprises a core material and a wall material, the core material is prepared from modified hydroxyapatite, tea polyphenol modified nano ZnO and a gynostemma pentaphyllum extract. The problems that aromatherapy formaldehyde removal efficiency is low, collapse is prone to occurring, fragrance release is too fast, fragrance is dissipated within a short time, and lasting fragrance cannot be achieved are solved. The environment-friendly aromatherapy candle capable of removing formaldehyde can efficiently remove indoor formaldehyde for a long time, can keep lasting faint scent, and is stable in structure and not prone to collapse.

1. Name of the designed product: packing box (ibuprofen sustained-release capsule). 2. Use of the designed product: the designed product is used for packing. 3. Design points of the designed product: the pattern. 4. Picture or photo best indicating the design points: front view.

The invention provides a carvolevodopa sustained-release capsule and a preparation method thereof. The carvolevodopa sustained-release capsule comprises a cured hollow soft capsule, and the cured hollow soft capsule is sequentially coated with a drug-containing layer and a thin film layer; the cured hollow soft capsule is obtained by curing a hollow soft capsule with a curing agent; the drug-containing layer comprises carbidopa, levodopa, a sustained-release material and an adhesive. The cardopa-levodopa sustained-release capsule provided by the invention has a unique gastric floating mechanism, has better gastric floating performance, and also has an in-vitro dissolution curve similar to that of a reference preparation. Meanwhile, raw materials and auxiliary materials are easy to obtain in the preparation process of the Carbidopa-levodopa sustained-release capsule, the preparation process is simple, the cost is low, and continuous and commercialized production is facilitated.

The invention relates to the technical field of curing agents, in particular to a soil curing agent and a preparation method thereof.The soil curing agent is prepared from, by weight, 180-220 parts of fly ash, 160-180 parts of slag, 80-120 parts of calcium salt, 80-120 parts of potassium nitrate, 10-14 parts of microbial agents, 40-60 parts of sustained-release capsule particles and 20-30 parts of biological stimulants. Therefore, the soil structure is improved, and the content of large aggregates in the soil can be remarkably increased.

The present application relates to the technical field of pharmaceutical preparation, in particular to a sustained-release capsule for treating gastric ulcer and a preparation method thereof; the present application takes the traditional formula of Weike Ning as the basis and improves it, uses aluminum magnesium carbonate to replace the traditional white vitriol, the release amount of aluminum ions in the aluminum magnesium carbonate is much lower than that of the white vitriol, and most of the aluminum ions will form insoluble complexes in the intestinal tract and be discharged out of the body, so that the risk of accumulation in the body is extremely low, thereby reducing the side effects on the nervous system and the skeletal system; and the medicine is also subjected to gastric floating and sustained-release treatment, so that the medicine can float above the gastric juice, prolong the residence time of the medicine in the stomach and release slowly, thereby realizing the slow release of the medicine in the stomach and avoiding the defect that the medicine needs to be taken multiple times.

The invention relates to the technical field of pharmaceutical preparations. The invention provides a sustained-release capsule containing minoxidil and dutasteride and a preparation method of the sustained-release capsule, the sustained-release capsule is composed of a capsule shell and content, and the content comprises minoxidil, dutasteride, spirolactone, isovitamin A, a traditional Chinese medicine composition, a sustained-release material, a filling material, an adhesive, a lubricant, a traditional Chinese medicine solubilizing dispersant and a stabilizer. According to the sustained-release capsule, through the synergistic effect of chemical components and traditional Chinese medicine components, the medicine components are better and more stable, the duration time of the medicine effect is prolonged, and the side effects of hirsutism, edema and the like caused by minoxidil and the side effects of transaminase abnormality and the like caused by dutasteride are reduced; meanwhile, by means of the liver protecting and blood nourishing effects of the traditional Chinese medicine components, the liver metabolism pressure is better reduced, and the long-term medication safety is improved; the hair regeneration capability is enhanced, and a better alopecia prevention and treatment effect is achieved.

The invention provides a verapamil hydrochloride sustained-release capsule with stable release rate during storage, the sustained-release capsule content comprises a sustained-release coated pellet, and the sustained-release coated pellet comprises (a) a blank pellet core, (b) a drug coating layer wrapping the blank pellet core, and (c) a sustained-release coating layer wrapping the drug coating layer; the drug coating layer comprises verapamil hydrochloride and a release stabilizer, and the in-vitro release degree similarity factor f2 of the sustained-release capsule after being placed for a long time under the conditions of 40 DEG C and RH of 75% and the sustained-release capsule before being placed is greater than 50. The verapamil hydrochloride sustained-release capsule effectively solves the problem that the in-vitro release degree is unstable in the storage process of the verapamil hydrochloride sustained-release capsule, and the clinical medication safety of the preparation within the storage validity period is greatly improved.

The invention discloses a lavender essential oil sustained-release capsule for air purification and a preparation method of the lavender essential oil sustained-release capsule, relates to the field of microcapsules, and aims to solve the problems that existing lavender essential oil is easy to volatilize quickly and poor in function synergy when being used for air purification. The preparation method comprises the following steps: firstly, preparing modified mesoporous silica and modified bamboo charcoal powder, wherein the modified mesoporous silica is prepared by vinyl modification, hydrophobic grafting and epoxy introduction; the modified bamboo charcoal powder is prepared by activation, oxidation and polyethyleneimine grafting. And combining lavender essential oil with the modified mesoporous silica to form an essential oil-mesoporous compound, preparing chitosan and the modified bamboo charcoal powder into a bamboo charcoal composite solution, mixing the essential oil-mesoporous compound and the bamboo charcoal composite solution, adding glutaraldehyde for crosslinking, and drying to obtain the sustained-release capsule. The capsule prepared by the invention can realize long-term stable slow release of essential oil and high-efficiency degradation of harmful gases such as formaldehyde, the process is environment-friendly and controllable, large-scale production is easy, and the capsule is suitable for indoor air purification scenes such as families and offices.

The invention relates to a fluvoxamine maleate sustained-release capsule with stable release degree, the sustained-release capsule content comprises a sustained-release coated pellet, and the sustained-release coated pellet comprises (a) a blank pellet core, (b) a drug coating layer wrapping the blank pellet core, and (c) a sustained-release coating layer wrapping the drug coating layer. (c) a stable release coating layer wrapping the drug coating layer; and (d) a slow release coating layer wrapping the stable release coating layer. The stable release coating layer comprises a first stable release material and a second stable release material, and the first stable release material is selected from one or more of hydroxypropyl methylcellulose, hydroxy propyl cellulose and povidone. The fluvoxamine maleate sustained-release capsule disclosed by the invention has high-stability in-vitro release degree, small in-batch release degree variation, high in-batch release degree reproducibility and excellent clinical use safety and robustness.

The invention discloses a collagen composite soft capsule with a three-layer structure as well as a preparation method and application of the collagen composite soft capsule, and belongs to the technical field of composite sustained-release capsules. The capsule contains an outer collagen peptide-gelatin composite rubber layer, a middle Pickering emulsion layer and an inner sustained-release pellet. A compact network is formed on the outer layer under the action of molecules, so that the mechanical strength and the biocompatibility are improved; the middle layer stably loads active ingredients; and the inner-layer sustained-release pellet fixes collagen peptide and integrates various components, so that controlled release is realized. During preparation, a three-layer structure is constructed step by step, physical mixing avoids damage to activity, step-by-step injection keeps each layer independent, and sealing does not need an additional adhesive. The process enhances the strength of the capsule skin, ensures the structural stability, accurately controls the sustained-release structure of the pellet, and improves the gastric acid tolerance and active ingredient stability of the capsule.

1. The name of the design product: sustained-release capsules (ectopic ossification treatment). 2. The use of the design product: the sustained-release capsules for treating ectopic ossification treatment. 3. The design points of the design product: in shape. 4. The picture or photo that best indicates the design points: perspective view.

The application discloses a modified gelatin sustained-release capsule and a preparation method and application thereof, and the preparation method of the sustained-release capsule is as follows: S1, calcium magnesium phosphate fertilizer powder is added into deionized water, and stirring is conducted until the water solution is uniform; S2, gelatin particles are mixed with the water solution, and the gelatin particles are absorbed and swelled into gelatin gel; S3, glycerol is added into the gelatin gel, and the gelatin liquid is obtained by stirring and heating; S4, the gelatin liquid is prepared into a capsule film body, the capsule film body is immersed into a crosslinking agent solution for crosslinking; and S5, the crosslinked capsule film body is taken out, and the gelatin capsule is obtained after water drying. The gelatin, water, glycerol and calcium magnesium phosphate fertilizer are uniformly mixed into a solution by heating, and the solution is crosslinked into a shell by glutaraldehyde, and the crosslinking and the filling of the calcium magnesium phosphate fertilizer significantly enhance the mechanical property and the hydrophobic property of the gelatin, and better sustained-release effect is obtained. The fertilizer is packaged into the sustained-release capsule, so that the utilization rate of the fertilizer is improved, and the environment is not polluted.

This invention discloses a method for preparing nattokinase enteric-coated sustained-release capsules and sustained-release gel spheres, belonging to the field of sustained-release microcapsules. This invention improves the selection of wall materials and the preparation process, encapsulating nattokinase using a mixture of food-grade enteric-coating shellac and whey protein isolate as the wall material. After spray drying, food-grade enteric-coated microcapsules are obtained. These microcapsules are then embedded in calcium alginate gel, forming enteric-coated gel spheres through stepwise encapsulation. The gel spheres prepared by this invention are safe for consumption, have a high encapsulation rate, are resistant to gastric acid, can be released into the intestines, are easy to store and transport, and can be mass-produced industrially.

The invention relates to the crossing field of biological materials and agricultural technologies, in particular to an immune protein sustained-release capsule based on a metal polyphenol network as well as a preparation method and application of the immune protein sustained-release capsule. The method comprises the following steps: (1) separating and purifying RxLR23 immune protein, and stabilizing by using a PBS (Phosphate Buffer Solution); (2) preparing a FeCl3 solution and a tannic acid solution; (3) combining the RxLR23 protein with a metal polyphenol network; and (4) dropwise adding the RxLR23-metal polyphenol compound solution into an oil phase, adding a cross-linking agent, stirring, and curing to form the sustained-release capsule. By adopting an emulsification cross-linking method, the effective concentration maintaining time of the immune protein in a plant body is prolonged by 3 times, the lasting period of the immune protein is prolonged, and the utilization rate of foliage spraying is increased. A metal polyphenol network is used as a raw material, the problem that plant immune protein is easy to degrade is solved, meanwhile, tannic acid in the metal polyphenol network has good biocompatibility and oxidation resistance, and the problem that a traditional pesticide sustained-release agent cannot be compatible with protein activity is avoided.

The utility model provides an urapidil hydrochloride sustained-release capsule medicament oscillating granulator, belongs to the technical field of granulation equipment, and aims to solve the problem that the mounting effect of a screen is relatively low due to the fact that two ends of the screen need to be clamped independently in the prior art. Comprising a granulator base, a granulator main body, a feeding hopper, a granulation driving roller, a screen clamping pipe, a discharging fixing mechanism and an auxiliary mounting mechanism, the granulator main body is fixedly connected to the upper part of the granulator base; the feeding hopper is fixedly connected to the upper end of the front part of the granulator main body; the granulation driving roller is rotationally connected to the middle position of the inner side of the feeding hopper; the number of the screen clamping pipes is two, the two screen clamping pipes are connected to the inner side of the feeding hopper in an inserted mode, and spline structures are arranged at the front ends of the peripheries of the two screen clamping pipes; the blanking fixing mechanism is arranged above the granulator base; the installation auxiliary mechanism is arranged on the inner side of the feeding hopper, operation of workers is facilitated, operation steps of the workers are reduced, and the installation efficiency of the screen is improved.

The application provides a hydrophobic slow-release capsule and a rheology-adjusted high-performance accelerator, wherein the hydrophobic slow-release capsule can release hydrophobic components in time sequence under the dual response of pH / time, solves the problems of the existing shotcrete technology, such as contradiction between the accelerating function and the hydrophobic function, high rebound rate, large late strength loss, poor anti-permeation and anti-corrosion capacity, and has good application effect in wet shotcrete construction.

The invention belongs to the field of pharmaceutical preparations, and provides a drug sustained-release capsule for treating liver diseases as well as a preparation method and application of the drug sustained-release capsule. The sustained-release capsule provided by the invention is prepared by filling a capsule with sustained-release pellets. The drug carried by the sustained release pellet is IMM-H014 (Immunoglobulin M-H014). The sustained-release pellet is prepared by coating a sustained-release layer on a drug-loaded pellet, and the drug-loaded pellet has the characteristic of delayed release, and is stable in dissolution rate and good in bioavailability. The traditional Chinese medicine composition is used for treating non-alcoholic fatty liver, hepatitis and drug-induced liver diseases.

The invention provides an application of a sustained-release material loaded with a water-soluble aroma substance in cigar maintenance. The sustained-release material comprises at least one of sustained-release emulsifiable paste and sustained-release capsules, the sustained-release emulsifiable paste comprises an oil phase and a water phase, and the oil phase wraps the water phase; the water phase comprises a solution containing a water-soluble aroma substance and a water-soluble cationic polymer, the oil phase comprises silicon dioxide, wax, a gel and base oil, and the addition amount of the gel is 2-7 wt% based on the mass of the base oil; the sustained-release capsule comprises a core and a capsule wall material wrapping the core, and the core comprises the sustained-release cream. The slow-release material can prevent rapid volatilization of water-soluble aroma substances, and further provides better slow-release performance, thereby promoting quality improvement and aroma enhancement of cigars.

The invention discloses a sustained-release capsule as well as a preparation method and application thereof. The sustained-release capsule is of a core-shell structure, the sustained-release capsule comprises a capsule core and a composite capsule wall, the composite capsule wall wraps the outer side of the capsule core, and the composite capsule wall comprises an inert isolation layer, an inner capsule wall and an outer capsule wall which sequentially wrap the outer side of the capsule core from inside to outside; wherein the capsule core comprises a carbonate ion source; the inert isolation layer is made of a hydrophobic high polymer material with chemical inertness; the inner capsule wall is formed by carrying out hydration pretreatment and carbonization pretreatment on a cement-based material; and the outer capsule wall is made of an alkali-activated degradable high polymer material. Through collaborative design of the core-shell structure and the multiple layers of capsule walls, delayed release of the carbonate ion source in the cement-based material service process is achieved, and the problem that carbonate ions are insufficient in supply in the carbonization reaction process is solved.

This invention belongs to the field of oral solid dosage form technology and relates to a loratadine sustained-release capsule and its preparation method. This application provides a loratadine-containing sustained-release capsule, wherein loratadine is melt-mixed with citric acid and salicylic acid to prepare a drug-containing core, and the core is coated with a sustained-release layer, an immediate-release layer, and a protective layer. This not only effectively solves the problem of slow dissolution of loratadine in the presence of insufficient gastric acid, but also ensures uniform drug release, achieving long-lasting effects and increased efficacy.

The present application provides a kind of isosorbide mononitrate sustained-release capsules and its preparation method, the isosorbide mononitrate sustained-release capsule of the present application, characterized in that, the drug loading layer, sustained-release layer, immediate-release layer and protective layer of the isosorbide mononitrate sustained-release capsule are respectively coated by fluidized bed granulation coating machine.The granular preparation has good stability, small side effect;The preparation process of the isosorbide mononitrate sustained-release capsule of the present application is simple, the equipment is simple and easy to operate, the labor intensity is small, and it is economic and safe.At the same time, the prescription and preparation method are more economical, and are suitable for industrial production.

The invention relates to the field of aromatherapy wax, in particular to antibacterial acarus killing type aromatherapy wax and a preparation process thereof. Raw materials of the aroma wax comprise the following components in parts by mass: 45-55 parts of vegetable wax, 1-8 parts of plant essential oil, 1-3 parts of a stabilizer, 2-3 parts of a dispersant and 5-10 parts of a sustained-release capsule, the sustained-release capsule comprises a core material and a wall material, the core material comprises an antibacterial and anti-mite mixture, gamma-cyclodextrin and zinc nitrate, and the wall material comprises an antibacterial and anti-mite mixture, gamma-cyclodextrin and zinc nitrate. And the wall material is a seaweed silk fibroin film. The problem that an existing aromatherapy product is poor in long-acting antibacterial and acarus killing performance is solved. The aromatherapy wax has antibacterial, acarus-killing and long-term stable slow-release effects while releasing fragrance, so that the stable and uniform combustion texture of the aromatherapy wax is guaranteed, the air quality is improved, and the human health is guaranteed.

The utility model provides a metal detector for urapidil hydrochloride sustained-release capsule production, belongs to the technical field of pharmaceutical detection, and aims to solve the problems that an existing metal detector for urapidil hydrochloride sustained-release capsule production is large in capsule collecting box gap, low in space utilization rate and low in compatibility between a material conveying machine pipeline and a feeding port. Comprising a mounting base, a supporting rod, a metal detector body, a controller body, a connecting disc, a placement table, a limiting assembly and a vibration assembly, and the supporting rod is fixedly mounted on the upper portion of the mounting base; the metal detector main body is slidably connected to the outer side of the supporting rod; the controller main body is fixedly mounted at the top of the metal detector main body; the connecting disc is arranged on the outer side of the metal detector main body; the placing table is arranged at the upper part of the mounting base; the limiting assembly is arranged in the connecting disc; and the vibration assembly is arranged in the mounting base. The utility model has the advantages of high adaptability, convenience in use, improved space utilization rate and the like.

The invention belongs to the technical field of pharmaceutical preparations, and particularly relates to a sustained-release stable diltiazem capsule and a preparation method thereof. The capsule content comprises diltiazem hydrochloride sustained-release particles, and the sustained-release particles are obtained by adsorbing diltiazem hydrochloride through mesoporous silica, adsorbing a waxy material, wrapping with the waxy material, mixing with a sustained-release material and a plasticizer, and granulating through an adhesive. The sustained-release capsule is stable in release, good in stability, capable of being completely released within 24 hours, simple in preparation process and suitable for industrial production.

The invention relates to the technical field of pharmaceutical preparations, in particular to a sustained-release capsule for treating gastric ulcer and a preparation method of the sustained-release capsule. According to the traditional formula of the Weishenning, improvement is carried out on the basis, the hydrotalcite is used for replacing traditional alum, the release amount of aluminum ions in the hydrotalcite is far lower than that of the alum, most of the aluminum ions can form insoluble compounds in intestinal tracts to be discharged out of the body, the in-vivo accumulation risk is extremely low, and the effect of improving the bioavailability of the Weishenning is achieved. Therefore, side effects on a nervous system and a skeletal system are reduced; the medicine is subjected to gastric floating and slow release treatment, so that the medicine can float above gastric juice, the retention time of the medicine in the stomach is prolonged, and the medicine is slowly released, so that the slow release of the medicine in the stomach is realized, and the defect that the medicine needs to be taken for multiple times is avoided.

The invention provides a mesalazine-containing slow-release solid dispersion and a preparation method thereof, and provides a mesalazine-containing slow-release solid dispersion in order to solve the problems that the existing mesalazine solid dispersion is poor in stability, free of targeting and easy to degrade in the preparation process. The solubility is high (the solubility is improved by 25-30 times compared with that of an original drug), the sustained release within 12 hours is controllable (accurate release in a colon segment, and the cumulative release rate within 12 hours reaches 85-90%), and the accelerated storage stability is high (the crystallization rate lt in 6 months; 3%, and the drug content gt; 98% and the ethanol residue 1t; 0.3%) and the like. The sustained-release solid dispersion provided by the invention and pharmaceutically acceptable auxiliary materials are prepared into sustained-release tablets or sustained-release capsules, and the sustained-release solid dispersion can be used for preparing oral preparations for treating inflammatory bowel diseases, can improve the drug concentration of diseased regions of intestinal tracts and reduce untoward effects of the whole body, and has remarkable clinical application value.