49 results about "Sustained Release Capsule" patented technology

The invention provides a microbial slow-release porous composite material for sewage treatment as well as a preparation method and application thereof. The preparation method comprises the following steps: dropwise adding an organic ligand solution into a precursor solution consisting of a nanocellulose solution and a cobalt source solution; mixing the reaction solution with polyvinyl alcohol, injecting the mixture into a mold, and performing directional freezing to obtain an aerogel matrix; carrying out hydrophobic modification on the aerogel matrix to obtain a modified aerogel matrix; mixing the microbial suspension with sodium alginate, and homogenizing at high pressure to obtain a gel precursor emulsion; the preparation method comprises the following steps: dropwise adding a calcium chloride solution to gelatinize to obtain gel particles, and then cross-linking and drying by glutaraldehyde to obtain sustained-release capsule particles; dispersing the sustained-release capsule particles in deionized water to obtain dispersion liquid; and dipping the modified aerogel matrix in the dispersion liquid. An aerogel matrix with a hierarchical porous structure is compounded with a sustained-release capsule with a pH response mechanism, so that physical adsorption, chemical catalysis and biodegradation for sewage treatment are realized.

The invention relates to the field of hygienic products, in particular to a bacteriostatic non-menstrual-period panty liner based on a sustained-release capsule and a preparation method thereof.It is found through screening that matrine and lactein have the synergistic bacteriostatic effect, the bacteriostatic composition is prepared into a sustained-release microcapsule, long-acting sustained release of antibacterial components is achieved, and the antibacterial effect is good. The sustained-release capsule is prepared into the bacteriostatic non-menstrual period protection pad based on the sustained-release capsule. The air permeability and the moisture permeability of the protection pad are superior to those of the prior art, the comfort and the safety of non-menstrual female hygiene care are remarkably improved, and the protection pad is suitable for daily hygiene maintenance and infection prevention.

The invention discloses a CO2 sustained-release capsule and a preparation method thereof. The CO2 sustained-release capsule comprises sodium alginate, corn starch, amyloglucosidase, saccharomyces cerevisiae and anhydrous calcium chloride, and a solvent is ultrapure water. The saccharomyces cerevisiae is Saccharomyces cerevisiae BNCC185415, and the saccharomyces cerevisiae is Saccharomyces cerevisiae BNCC185415. The mass ratio of the sodium alginate in the capsule preparation is 2.00%-3.00%, the mass ratio of the corn starch in the capsule preparation is 10.00%-30.00%, the content of the amyloglucosidase in the capsule preparation is 1.0-3.0 U / g, and the mass ratio of the saccharomyces cerevisiae in the capsule preparation is 10.0%-30.0%. Based on the general taxis of underground pests to CO2, the invention creates a CO2 sustained-release capsule which has remarkable attraction activity on the pests, and the underground pests can be trapped, killed, prevented and controlled by combining physical prevention and control, biological prevention and control, chemical prevention and control and other measures in practical application.

The application discloses a foam displacement agent sustained-release capsule and a preparation method and application thereof. The foam displacement agent sustained-release capsule comprises a sustained-release film and a foam displacement agent coated in the sustained-release film; and the sustained-release film is a polymer film. The foam displacement agent sustained-release capsule has a sustained-release time of greater than 2 days under the gas well conditions of a temperature of 100-160 DEG C and a pH of 3-6, and the foamability, foam stability and liquid carrying capacity of a solution reach a peak value when the sustained-release time is 2-4 days, at which time, the liquid carrying capacity is greater than or equal to 120 mL, the foamability is greater than or equal to 140 mm, and the foam stability is greater than or equal to 120 mm. The foam displacement agent sustained-release capsule has good foamability, foam stability and liquid carrying capacity.

1. The name of the designed product: packing box (ibuprofen sustained-release capsule). 2. The use of the designed product: the designed product is used for medicine packing. 3. The design points of the designed product: the combination of shape, pattern and color. 4. The picture or photo that best shows the design points: perspective view. 5. The design contains color.

The invention discloses a preparation method of a magnesium glycinate enteric-coated sustained-release capsule, and relates to the technical field of preparation of enteric-coated sustained-release capsules, and the preparation method is technically characterized by comprising the following steps: preparing a magnesium glycinate pellet: mixing magnesium glycinate with microcrystalline cellulose, starch and cane sugar to form uniform powder, adding the mixed powder into a centrifugal granulating and coating machine, and carrying out granulation and coating to obtain the magnesium glycinate pellet; taking hydroxypropyl methyl cellulose or a methyl cellulose solution as an adhesive, and performing centrifugal granulation at four stages of nucleation, coalescence, lamination and rolling compaction to obtain magnesium glycinate pellets; the nucleation is that the initial particles attract and are connected with one another due to the formation of a three-phase structure in the wetting process of the adhesive; the coalescence is that parent nuclei are combined to form larger particles due to random collision among the large particles; through a synergistic process of four-stage centrifugal granulation, specific-ratio slow-release coating and HPMCP enteric coating, efficient and accurate controlled release of magnesium glycinate is realized, and the problem of too fast release caused by insufficient weight gain of the slow-release coating is effectively avoided.

The present invention provides a kind of ink with lasting fragrance and preparation method thereof, belong to the field of ink technology, the ink with lasting fragrance comprises the following raw materials in parts by weight: 20-40 parts of tripropylene glycol diacrylate, 10-20 parts of trimethylolpropane triacrylate, 20-50 parts of polyurethane acrylate, 1-5 parts of silicone acrylate, 4-6 parts of photoinitiator, 1-5 parts of active amine co-initiator, 3-5 parts of fragrance sustained-release capsule, 0.3-0.5 parts of defoamer, 5-15 parts of solvent; wherein, the fragrance sustained-release capsule is composed of an oil phase consisting of plant essential oil, polylactic acid-co-glycolic acid copolymer, PCL-PEG grafted cyclodextrin and ethyl acetate, and an aqueous phase consisting of polyvinyl alcohol in water, and is made by high-pressure homogenization, rotary evaporation and drying. The ink fragrance prepared by the present invention lasts for a long time and has the characteristics of good stability, strong adhesion, fast curing, scratch resistance, and green environmental protection.

The invention relates to the field of aromatherapy wax, in particular to an environment-friendly aromatherapy candle capable of removing formaldehyde and a preparation process of the environment-friendly aromatherapy candle. Raw materials of the aromatherapy wax comprise the following components in parts by mass: 45-55 parts of modified vegetable wax, 3-8 parts of a plant essential oil mixture, 1-3 parts of a stabilizer, 2-3 parts of a dispersant and 6-10 parts of a sustained-release capsule, and the sustained-release capsule comprises a core material and a wall material, the core material is prepared from modified hydroxyapatite, tea polyphenol modified nano ZnO and a gynostemma pentaphyllum extract. The problems that aromatherapy formaldehyde removal efficiency is low, collapse is prone to occurring, fragrance release is too fast, fragrance is dissipated within a short time, and lasting fragrance cannot be achieved are solved. The environment-friendly aromatherapy candle capable of removing formaldehyde can efficiently remove indoor formaldehyde for a long time, can keep lasting faint scent, and is stable in structure and not prone to collapse.

1. Name of the designed product: packing box (ibuprofen sustained-release capsule). 2. Use of the designed product: the designed product is used for packing. 3. Design points of the designed product: the pattern. 4. Picture or photo best indicating the design points: front view.

The invention provides a carvolevodopa sustained-release capsule and a preparation method thereof. The carvolevodopa sustained-release capsule comprises a cured hollow soft capsule, and the cured hollow soft capsule is sequentially coated with a drug-containing layer and a thin film layer; the cured hollow soft capsule is obtained by curing a hollow soft capsule with a curing agent; the drug-containing layer comprises carbidopa, levodopa, a sustained-release material and an adhesive. The cardopa-levodopa sustained-release capsule provided by the invention has a unique gastric floating mechanism, has better gastric floating performance, and also has an in-vitro dissolution curve similar to that of a reference preparation. Meanwhile, raw materials and auxiliary materials are easy to obtain in the preparation process of the Carbidopa-levodopa sustained-release capsule, the preparation process is simple, the cost is low, and continuous and commercialized production is facilitated.

The invention relates to the technical field of curing agents, in particular to a soil curing agent and a preparation method thereof.The soil curing agent is prepared from, by weight, 180-220 parts of fly ash, 160-180 parts of slag, 80-120 parts of calcium salt, 80-120 parts of potassium nitrate, 10-14 parts of microbial agents, 40-60 parts of sustained-release capsule particles and 20-30 parts of biological stimulants. Therefore, the soil structure is improved, and the content of large aggregates in the soil can be remarkably increased.

The invention relates to the field of pharmaceutical preparations, and discloses a tamsulosin hydrochloride sustained-release capsule and a preparation method thereof.The sustained-release capsule is prepared from, by mass, 0.1%-0.2% of tamsulosin hydrochloride, 5%-20% of sustained-release framework material and 80%-95% of filler, the sustained-release framework material is methacrylic acid-ethyl acrylate copolymer, and the filler is a filler. The filling agent comprises starch and microcrystalline cellulose; the dissolution behavior of the sustained-release capsule is consistent with that of an original development agent; the starch in the sustained-release capsule can remarkably reduce the dosage of the methacrylic acid-ethyl acrylate copolymer, and the production cost is remarkably reduced while the weight and the sustained-release effect of the sustained-release capsule are not changed; according to the preparation method of the tamsulosin hydrochloride sustained-release capsule, water with the water temperature being greater than or equal to 50 DEG C is selected as a solvent of tamsulosin hydrochloride, so that the pill preparation yield is remarkably improved, the production efficiency is remarkably improved, and the pill uniformity is remarkably improved.

The invention relates to the technical field of pharmaceutical preparations, in particular to a mannitol-starch ester bond conjugate colon-targeted sustained-release capsule and a preparation method and application thereof, and the capsule is composed of a mannitol-starch ester bond conjugate pellet, an enteric coating layer, an electrolyte compensation agent and a taste regulator; 90% of drugs of the sustained-release capsule can be accurately released in the colon, animal experiments show that compared with PEG-ELS, the Boston score of the capsule is 3-4 (vs 1-2), the dehydration risk of the capsule is reduced, the survival rate of the capsule is high, all the raw materials are medicinal, the process can be amplified to 10 kg batch, equipment is a conventional fluidized bed and a capsule filling machine, and the production process and equipment are simple.

The present application relates to the technical field of pharmaceutical preparation, in particular to a sustained-release capsule for treating gastric ulcer and a preparation method thereof; the present application takes the traditional formula of Weike Ning as the basis and improves it, uses aluminum magnesium carbonate to replace the traditional white vitriol, the release amount of aluminum ions in the aluminum magnesium carbonate is much lower than that of the white vitriol, and most of the aluminum ions will form insoluble complexes in the intestinal tract and be discharged out of the body, so that the risk of accumulation in the body is extremely low, thereby reducing the side effects on the nervous system and the skeletal system; and the medicine is also subjected to gastric floating and sustained-release treatment, so that the medicine can float above the gastric juice, prolong the residence time of the medicine in the stomach and release slowly, thereby realizing the slow release of the medicine in the stomach and avoiding the defect that the medicine needs to be taken multiple times.

The invention relates to the technical field of pharmaceutical preparations. The invention provides a sustained-release capsule containing minoxidil and dutasteride and a preparation method of the sustained-release capsule, the sustained-release capsule is composed of a capsule shell and content, and the content comprises minoxidil, dutasteride, spirolactone, isovitamin A, a traditional Chinese medicine composition, a sustained-release material, a filling material, an adhesive, a lubricant, a traditional Chinese medicine solubilizing dispersant and a stabilizer. According to the sustained-release capsule, through the synergistic effect of chemical components and traditional Chinese medicine components, the medicine components are better and more stable, the duration time of the medicine effect is prolonged, and the side effects of hirsutism, edema and the like caused by minoxidil and the side effects of transaminase abnormality and the like caused by dutasteride are reduced; meanwhile, by means of the liver protecting and blood nourishing effects of the traditional Chinese medicine components, the liver metabolism pressure is better reduced, and the long-term medication safety is improved; the hair regeneration capability is enhanced, and a better alopecia prevention and treatment effect is achieved.

The invention provides a verapamil hydrochloride sustained-release capsule with stable release rate during storage, the sustained-release capsule content comprises a sustained-release coated pellet, and the sustained-release coated pellet comprises (a) a blank pellet core, (b) a drug coating layer wrapping the blank pellet core, and (c) a sustained-release coating layer wrapping the drug coating layer; the drug coating layer comprises verapamil hydrochloride and a release stabilizer, and the in-vitro release degree similarity factor f2 of the sustained-release capsule after being placed for a long time under the conditions of 40 DEG C and RH of 75% and the sustained-release capsule before being placed is greater than 50. The verapamil hydrochloride sustained-release capsule effectively solves the problem that the in-vitro release degree is unstable in the storage process of the verapamil hydrochloride sustained-release capsule, and the clinical medication safety of the preparation within the storage validity period is greatly improved.

The present invention relates to a high expansion rate algae dietary fiber sustained-release capsule and its preparation method and application, the sustained-release capsule, including a core material and a wall material, the mass ratio of the core material to the wall material is 1: (1-3); in parts by mass, the core material includes 15-25 parts of probiotics, 5-15 parts of carboxymethyl cellulose, and 5-10 parts of chitosan; the wall material includes 20-30 parts of algae dietary fiber and 10-20 parts of resistant dextrin, and the core material forms a self-assembled coating on the surface of the probiotics through the electrostatic adsorption of carboxymethyl cellulose and chitosan; the expansion force of the algae dietary fiber is greater than 100mL / g, and the water holding capacity is greater than 10000%; the core material and the wall material are prepared by a negative pressure low-temperature spray drying method to obtain the sustained-release capsule. The wall material algae dietary fiber and the resistant dextrin of the sustained-release capsule of the present invention have a good taste, increase satiety, and are combined with the core material probiotics released by intestinal positioning to contribute to intestinal peristalsis and promote intestinal health.

The present invention provides a highly permeable concrete protective coating and a preparation method thereof. The raw materials for preparing the concrete protective coating include a powder and a liquid. The powder comprises, by weight, 40 to 60 parts of Portland cement, 2 to 4 parts of nano-silica, 30 to 40 parts of quartz sand, and 8 to 12 parts of silicate. The liquid comprises, by weight, 15 to 20 parts of siloxane oligomers, 20 to 30 parts of acrylic emulsion, and 4 to 6 parts of sustained-release capsules. The sustained-release capsules use graphene oxide as the capsule wall and zirconium silicone as the capsule core. In the present invention, siloxane oligomers are introduced to replace traditional volatile, non-environmentally friendly solvents. Nano-silica and silicate are combined to react with concrete to hydrate and fill the micropores of the mortar, synergistically enhancing the density and impermeability of the concrete and improving the permeability of the coating. The introduction of sustained-release capsules can enhance the compressive strength of the concrete and extend its service life.

The invention relates to the field of medical materials, in particular to a Sannine patch with combined moxibustion and traditional Chinese medicine application functions and a use method.The Sannine patch comprises a backing layer, a medicine function layer and an anti-sticking release layer which are arranged in a stacked mode, and (a) the backing layer is a carbon black photo-thermal layer; (b) the medicine functional layer comprises the following components in percentage by mass: (i) 40-50% of a sustained-release capsule matrix; (ii) 20-30% of self-heating functional powder; (iii) 30 to 40% of a medical adhesive matrix; and (c) the anti-sticking release layer is silicone oil coated paper. The microcapsule technology is utilized, the reaction process of spontaneous heating powder is combined, the heating temperature is regulated and controlled through phase change, scalding is prevented, meanwhile, the transdermal effect is improved, and the slow release effect is guaranteed; by combining with the moxibustion technology, the synergistic interaction of moxibustion thermal therapy and traditional Chinese medicine transdermal absorption is realized.

The invention discloses a lavender essential oil sustained-release capsule for air purification and a preparation method of the lavender essential oil sustained-release capsule, relates to the field of microcapsules, and aims to solve the problems that existing lavender essential oil is easy to volatilize quickly and poor in function synergy when being used for air purification. The preparation method comprises the following steps: firstly, preparing modified mesoporous silica and modified bamboo charcoal powder, wherein the modified mesoporous silica is prepared by vinyl modification, hydrophobic grafting and epoxy introduction; the modified bamboo charcoal powder is prepared by activation, oxidation and polyethyleneimine grafting. And combining lavender essential oil with the modified mesoporous silica to form an essential oil-mesoporous compound, preparing chitosan and the modified bamboo charcoal powder into a bamboo charcoal composite solution, mixing the essential oil-mesoporous compound and the bamboo charcoal composite solution, adding glutaraldehyde for crosslinking, and drying to obtain the sustained-release capsule. The capsule prepared by the invention can realize long-term stable slow release of essential oil and high-efficiency degradation of harmful gases such as formaldehyde, the process is environment-friendly and controllable, large-scale production is easy, and the capsule is suitable for indoor air purification scenes such as families and offices.

The invention relates to a fluvoxamine maleate sustained-release capsule with stable release degree, the sustained-release capsule content comprises a sustained-release coated pellet, and the sustained-release coated pellet comprises (a) a blank pellet core, (b) a drug coating layer wrapping the blank pellet core, and (c) a sustained-release coating layer wrapping the drug coating layer. (c) a stable release coating layer wrapping the drug coating layer; and (d) a slow release coating layer wrapping the stable release coating layer. The stable release coating layer comprises a first stable release material and a second stable release material, and the first stable release material is selected from one or more of hydroxypropyl methylcellulose, hydroxy propyl cellulose and povidone. The fluvoxamine maleate sustained-release capsule disclosed by the invention has high-stability in-vitro release degree, small in-batch release degree variation, high in-batch release degree reproducibility and excellent clinical use safety and robustness.

The invention discloses a collagen composite soft capsule with a three-layer structure as well as a preparation method and application of the collagen composite soft capsule, and belongs to the technical field of composite sustained-release capsules. The capsule contains an outer collagen peptide-gelatin composite rubber layer, a middle Pickering emulsion layer and an inner sustained-release pellet. A compact network is formed on the outer layer under the action of molecules, so that the mechanical strength and the biocompatibility are improved; the middle layer stably loads active ingredients; and the inner-layer sustained-release pellet fixes collagen peptide and integrates various components, so that controlled release is realized. During preparation, a three-layer structure is constructed step by step, physical mixing avoids damage to activity, step-by-step injection keeps each layer independent, and sealing does not need an additional adhesive. The process enhances the strength of the capsule skin, ensures the structural stability, accurately controls the sustained-release structure of the pellet, and improves the gastric acid tolerance and active ingredient stability of the capsule.

1. The name of the design product: sustained-release capsules (ectopic ossification treatment). 2. The use of the design product: the sustained-release capsules for treating ectopic ossification treatment. 3. The design points of the design product: in shape. 4. The picture or photo that best indicates the design points: perspective view.

The application discloses a modified gelatin sustained-release capsule and a preparation method and application thereof, and the preparation method of the sustained-release capsule is as follows: S1, calcium magnesium phosphate fertilizer powder is added into deionized water, and stirring is conducted until the water solution is uniform; S2, gelatin particles are mixed with the water solution, and the gelatin particles are absorbed and swelled into gelatin gel; S3, glycerol is added into the gelatin gel, and the gelatin liquid is obtained by stirring and heating; S4, the gelatin liquid is prepared into a capsule film body, the capsule film body is immersed into a crosslinking agent solution for crosslinking; and S5, the crosslinked capsule film body is taken out, and the gelatin capsule is obtained after water drying. The gelatin, water, glycerol and calcium magnesium phosphate fertilizer are uniformly mixed into a solution by heating, and the solution is crosslinked into a shell by glutaraldehyde, and the crosslinking and the filling of the calcium magnesium phosphate fertilizer significantly enhance the mechanical property and the hydrophobic property of the gelatin, and better sustained-release effect is obtained. The fertilizer is packaged into the sustained-release capsule, so that the utilization rate of the fertilizer is improved, and the environment is not polluted.

This invention discloses a method for preparing nattokinase enteric-coated sustained-release capsules and sustained-release gel spheres, belonging to the field of sustained-release microcapsules. This invention improves the selection of wall materials and the preparation process, encapsulating nattokinase using a mixture of food-grade enteric-coating shellac and whey protein isolate as the wall material. After spray drying, food-grade enteric-coated microcapsules are obtained. These microcapsules are then embedded in calcium alginate gel, forming enteric-coated gel spheres through stepwise encapsulation. The gel spheres prepared by this invention are safe for consumption, have a high encapsulation rate, are resistant to gastric acid, can be released into the intestines, are easy to store and transport, and can be mass-produced industrially.

The invention discloses a hydrogen-tea polyphenol supramolecular composite composition, and belongs to the technical field of large health products. The composition comprises: 0.5%-1.2% of a hydrogen-tea polyphenol supramolecular compound, wherein electrolytic hydrogen and tea polyphenol form a supramolecular structure under a high pressure of 300-500 MPa; oSA is used for modifying a tea polyphenol steady-state carrier (0.05%-0.15%), and octenyl succinic anhydride is used for grafting to improve the stability; the hydrogen molecule sustained-release capsule (0.1%-0.3%) is used for realizing in-situ hydrogen production by using beta-cyclodextrin to include hydrogen and containing IrO2 and CeO2 as a catalyst; and the balance is a medicinal or edible carrier. Through triple technologies of supramolecular compounding, chemical modification and catalytic hydrogen production, the problems that hydrogen is easy to escape and tea polyphenol is easy to degrade are synergistically solved, efficient, stable and long-acting slow release of double active components is realized, the antioxidant synergistic effect and bioavailability are remarkably improved, and the tea polyphenol-modified supramolecular composite material is suitable for the fields of functional beverages, skin care products, health care products and the like.

The invention relates to the crossing field of biological materials and agricultural technologies, in particular to an immune protein sustained-release capsule based on a metal polyphenol network as well as a preparation method and application of the immune protein sustained-release capsule. The method comprises the following steps: (1) separating and purifying RxLR23 immune protein, and stabilizing by using a PBS (Phosphate Buffer Solution); (2) preparing a FeCl3 solution and a tannic acid solution; (3) combining the RxLR23 protein with a metal polyphenol network; and (4) dropwise adding the RxLR23-metal polyphenol compound solution into an oil phase, adding a cross-linking agent, stirring, and curing to form the sustained-release capsule. By adopting an emulsification cross-linking method, the effective concentration maintaining time of the immune protein in a plant body is prolonged by 3 times, the lasting period of the immune protein is prolonged, and the utilization rate of foliage spraying is increased. A metal polyphenol network is used as a raw material, the problem that plant immune protein is easy to degrade is solved, meanwhile, tannic acid in the metal polyphenol network has good biocompatibility and oxidation resistance, and the problem that a traditional pesticide sustained-release agent cannot be compatible with protein activity is avoided.

The utility model provides an urapidil hydrochloride sustained-release capsule medicament oscillating granulator, belongs to the technical field of granulation equipment, and aims to solve the problem that the mounting effect of a screen is relatively low due to the fact that two ends of the screen need to be clamped independently in the prior art. Comprising a granulator base, a granulator main body, a feeding hopper, a granulation driving roller, a screen clamping pipe, a discharging fixing mechanism and an auxiliary mounting mechanism, the granulator main body is fixedly connected to the upper part of the granulator base; the feeding hopper is fixedly connected to the upper end of the front part of the granulator main body; the granulation driving roller is rotationally connected to the middle position of the inner side of the feeding hopper; the number of the screen clamping pipes is two, the two screen clamping pipes are connected to the inner side of the feeding hopper in an inserted mode, and spline structures are arranged at the front ends of the peripheries of the two screen clamping pipes; the blanking fixing mechanism is arranged above the granulator base; the installation auxiliary mechanism is arranged on the inner side of the feeding hopper, operation of workers is facilitated, operation steps of the workers are reduced, and the installation efficiency of the screen is improved.

The application provides a hydrophobic slow-release capsule and a rheology-adjusted high-performance accelerator, wherein the hydrophobic slow-release capsule can release hydrophobic components in time sequence under the dual response of pH / time, solves the problems of the existing shotcrete technology, such as contradiction between the accelerating function and the hydrophobic function, high rebound rate, large late strength loss, poor anti-permeation and anti-corrosion capacity, and has good application effect in wet shotcrete construction.