92results about How to "Disintegration and dissolution fast" patented technology

The invention relates to an oral solid pharmaceutical composition comprising pharmacologically effective amounts of entacapone, levodopa and carbidopa, or a pharmaceutically acceptable salt or hydrate thereof, and one or more pharmaceutically acceptable excipients, wherein the excipients are long-chain polymers having an equilibrium moisture content of at least 2%, and to a preparation method thereof. The compositions can be used for the treatment of Parkinson's disease.

A provided (-)-pantoprazole sodium enteric coated tablet consists of a tablet core containing (-)-pantoprazole sodium, a separation layer and an enteric layer, the increased weight of the separation layer accounts for 2-9%, and the increased weight of the enteric layer accounts for 7-15%. In dissolution tests using a system with pH of 5.5 or more, 85% or more of the main drug is dissolved in 30 min. The prepared (-)-pantoprazole sodium enteric coated tablet is an oral preparation with stable quality and high bioavailability.

This invention relates to a dripping pill of diacetyl rhein. the pill is characterised in that it is prepared from diacetyl rhein and dripping pill substrate at a weight ratio of 1:1-5. the preparation method comprises pulverizing diacetyl rhein, adding substrate, heating, stirring to fusion, moving to a dripping pill engine with the temperature of materials and dripper at 75-85deg.C, stirring, dripping into coolant at 0-6deg.C and speed of 40+-10 pill / min, separating the dripping pill and coolant through a separating unit, and dripping to obtain the final product. The invention has the advantages of few air contact, uneasy oxidation, no hydrolysis, increase medicine stability, and improved shelf life.

The invention discloses a berberine hydrochloride medicinal composition and a preparation method thereof, which are used for increasing the dissolution rate of berberine hydrochloride in water and enhance the in-vivo absorption of berberine hydrochloride. According to the specific technical scheme, berberine hydrochloride serves as a medicinal active ingredient of the composition; and a filling agent, a disintegrating agent, a flavoring agent and a lubricating agent in the weight ratio (1-50):(25-60):(3-15):(1.5-3):(0.4-1.2) serve as auxiliary materials. The method for preparing the berberine hydrochloride medicinal composition comprises the following steps of: (1) dissolving; (2) drying; (3) screening; and (4) tableting. The berberine hydrochloride medicinal composition prepared with the method has high disintegrating and dissolving speeds and a good medicament effect, and the problems of low solubility and unstable absorption of berberine hydrochloride are solved. The berberine hydrochloride medicinal composition is effective to enteral infection caused by dysentery bacillus and colon bacillus, and is used for treating enteral infection and diarrhea.

The present invention is slow released diacetyl rheinic acid preparation and its preparation process. The slow released diacetyl rheinic acid preparation, which may be granule, tablet or capsule, is prepared with diacetyl rheinic acid as main material and other supplementary material. The slow released diacetyl rheinic acid preparation of the present invention has excellent slow releasing effect and simple preparation process.

The present invention discloses a kind of berberine hydrochloride dispersing tablet and its preparation process. The berberine hydrochloride dispersing tablet contains berberine hydrochloride in recipe amount, microcrystalline cellulose in 10-40 wt%, sodium carboxymethyl starch 6-35 wt%, silicon dioxide in 1-20 wt% and magnesium stearate in 0.5-20 wt%. The preparation process includes 100 mesh sieving berberine hydrochloride and supplementary material; mixing berberine hydrochloride, microcrystalline cellulose and sodium carboxymethyl starch while adding proper amount of 95 % concentration alcohol solution to form soft material; 30 mesh sieving, palletizing, drying at 65 deg.c, 20 mesh sieving, adding silicon dioxide and magnesium stearate; tabletting, coating and packing. The dispersing tablet has the advantages of fast disintegration and leaching, and high medicinal effect.

The present invention utilizes ultramicropulverization and dripping pill preparation production process to make aniosidine hydrobromide dripping pills, and can attain the goal of raising disintegration and dissolution speed, quickly obtaining therapeutic effect, raising stability of medicine, reducing dose of auxiliary material, reducing production cost and convenient administration. Said pill not noly can be sucket, but also can be swallowed, and its compliance is good.

A dripping pill of ginseng stem and leaf's common saponin and its superfine pulverizing process for preparing it are disclosed. Its advantages are high dissolving and disintegrating speed, high stripping percentage, quickly taking its effect, high stability and low cost.

A dripping pile of corydalis B hydrochloride is prepared through superfine pulverizing and the conventional steps for preparing dripping pills. Its advantages are high disintegrating and dissolving speed, quickly taking its effect and low cost.

A dripping pill of trihexyphenidyl is prepared by superfine pulverizing and conventional process for preparing dripping pills.

The invention relates to a Nefopam Hydrochloride drop pill prepared by utilizing ultramicro disintegration and drop pill manufacturing process, which has the advantages of improving collapse and dissolving speed, quick effect, increased medicament stability, reduced adjuvant consumption, lowered production costs, and easiness in carrying and use. It has good compliance, thus is especially suitable for children, the elderly, bedridden patients and dysphagia patients.

The invention relates to a pharmaceutical composition containing valsartan and amlodipine besylate and a preparation method. The composition takes valsartan and amlodipine besylate as raw materials, and comprises pharmaceutically acceptable excipients of microcrystalline cellulose, crosslinked sodium carboxymethyl cellulose, silica and sodium stearyl fumarate. The preparation method comprises following steps: carrying out dry granulation on the raw materials and part of the excipients firstly, and adding the sodium stearyl fumarate to carry out tabletting and coating to be produced into film-coated tablets. The preparation method is characterized in that the dry granulation is adopted to avoid the influence of moisture on main ingredients during wet granulation, and the sodium stearyl fumarate serves as a lubricant instead of commonly used magnesium stearate to prevent the influence of the magnesium stearate on the main ingredients, therefore on the premise of disintegrating and dissolving the product better, the product quality is further stabilized and the drug safety is enhanced.

A dripping pill of Aipuliete is prepared through superfine pulverizing and the conventional steps for preparing dripping pills.

A dripping pill of isosorbide mononitrate is prepared through superfine pulverizing and conventional steps for preparing dripping pill. Its advantages are high disintegration speed, high stripping rate, quickly taking its effect, and low cost.

The invention relates to a meloxicam drop pill prepared by utilizing ultramicro disintegration and drop pill manufacturing process, which has the advantages of improving collapse and dissolving speed, quick effect, increased medicament stability, reduced adjuvant consumption, lowered production costs, and easiness in carrying and use. It has good compliance, thus is especially suitable for children, the elderly, bedridden patients and dysphagia patients.

The invention relates to the technical field of medicines, in particular to a chitosan oligosaccharide drop pill and a method for preparing the same. The chitosan oligosaccharide drop pill is preparedfrom chitosan oligosaccharides and drop pill matrixes. A weight ratio of the chitosan oligosaccharides to the drop pill matrixes is 1:1-1:6. The chitosan oligosaccharides and the drop pill matrixes are components in the chitosan oligosaccharide drop pill. The chitosan oligosaccharide drop pill and the method have the advantages that the prescription for the chitosan oligosaccharide drop pill which is a drop pill preparation is determined by means of scientific screening tests; the dissolution rate of the chitosan oligosaccharides can be obviously increased, the bioavailability of the chitosanoligosaccharides can be obviously improved, and accordingly the chitosan oligosaccharide drop pill and the method have obvious technical superiority; processes for preparing the chitosan oligosaccharide drop pill are simple, and the chitosan oligosaccharide drop pill and the method are low in cost and have excellent application prospects.

A dripping pile of berberine or its salts is prepared through superfine pulverizing and the conventional steps for preparing dripping pill. Its advantages are high disintegrating and dissolving speed, quickly taking its effect and low cost.

The invention relates to a formula and a process of an isosorbide mononitrate orally disintegrating tablet produced with a direct powder tabletting method and a novel powder feed device for a tabletting machine. Compared with the conventional technology of the direct powder tabletting, the isosorbide mononitrate orally disintegrating tablet produced by the invention has cool and fine mouth feelings, small difference in tablet weight, favorable uniformity of content, fast disintegration and dissolution, high dissolution rate and dissolubility, strong rigidity and favorable compressibility.

The invention uses super micro shattering and drop pills producing the technology to produce fenfluramine drop pills, reaching the purposes such as increasing speed, and dissolution of disintegration, increasing the medicine stability, reducing the dose of auxiliary materials and decreasing cost, with rapid effect and convenient use. It can be buccal as well as deglutition, has remarkable conformity, and is especially suitable for children, older man, sicker in bed or with difficulty of swallowing.

The invention discloses a bisoprolol fumarate dispersible tablet for the treatment of essential hypertension and angina pectoris diseases and preparation process for same. The tablet is obtained by pelletizing at least part of accessories by wet method, mixing the accessories with bisoprolol fumarate, and tabletting the mixture. Inventive medicament has high bioavailability, good stability, quickdisintegration and dissolution, quick action, and good compliance for patient.

The present invention discloses an instant tea capsule, which comprises a tea concentrate and a capsule shell according to a mass ratio of the tea concentrate to the capsule shell of 70:30, wherein the tea capsule shell comprises, by weight, 70-80% of glutinous rice starch, 5-10% of an organic acid, and 10-20% of sodium bicarbonate, and the tea concentrate is screened with a 80-100 mesh sieve. According to the present invention, the tea concentrate retains most of the water-soluble components of the tea raw leaf, wherein the sodium bicarbonate and the organic acid in the capsule shell can be quickly subjected to the effervescent reaction and the produced gas bubbles are attached to the tea concentrate powder after the instant tea capsule is put into the infusion container and the capsule shell contacts the water, such that the tea concentrate can be promoted to be rapidly dispersed and dissolved so as to form the clarified and uniform tea beverage, wherein the tea aroma is rich; and the instant tea capsule has characteristics of easy carrying and easy infusion, can achieve the infusion with room temperature water, has advantages of rapid disintegration and rapid dissolution, and can achieve the good taste tea beverage.

The invention discloses a betahistine hydrochloride drop pill prepared through ultramicro disintegration and drop pills manufacturing technique, which has the advantages of improving collapse and dissolving speed, dissolving out speed and degree, quick effect, increased medicament stability, reduced adjuvant consumption, lowered production costs, and easiness in carrying and use. It has good compliance, thus is especially suitable for children, the elderly, bedridden patients and dysphagia patients.

The invention uses super micro shattering and propranolol drop pills producing the technology to produce fenfluramine drop pills, reaching the purposes such as increasing speed, and dissolution of disintegration, increasing the medicine stability, reducing the dose of auxiliary materials and decreasing cost, with rapid effect and convenient use. It can be buccal as well as deglutition, has remarkable conformity, and is especially suitable for children, older man, sicker in bed or with difficulty of swallowing.

The invention relates to a maleic acid perhexiline drop pill prepared by utilizing ultramicro disintegration and drop pill manufacturing process, which has the advantages of improving collapse and dissolving speed, quick effect, increased medicament stability, reduced adjuvant consumption, lowered production costs, and easiness in carrying and use. It has good compliance, thus is especially suitable for children, the elderly, bedridden patients and dysphagia patients.

The invention discloses am Imipramine Hydrochloride drop pill prepared through ultramicro disintegration and drop pills manufacturing technique, which has the advantages of improving collapse and dissolving speed, quick effect, increased medicament stability, reduced adjuvant consumption, lowered production costs, and easiness in carrying and use. It has good compliance, thus is especially suitable for children, the elderly, bedridden patients and dysphagia patients.

A dripping pill containing (R)-3-[(S)-(5-oxy-2-pyrrolidine) carboxyl]-thiazolidine-4-carboxyl (Piduomode) is prepared from (R)-3-[(S)-(5-oxy-2-pyrrolidine) carboxyl]-thiazolidine-4-carboxyl (Piduomode) and matrix through proportional mixing, dripping into cooling liquid and drying.

A dripping pill of cumarin acetate and its superfine pulverizing process for preparing it are disclosed. Its advantages are high dissolving and disintegrating speed, high stability and low cost.

The invention uses super micro shattering and drop pills producing the technology to produce fenfluramine drop pills, reaching the purposes such as increasing speed, and dissolution of disintegration, increasing the medicine stability, reducing the dose of auxiliary materials and decreasing cost, with rapid effect and convenient use. It can be buccal as well as deglutition, has remarkable conformity, and is especially suitable for children, older man, sicker in bed or with difficulty of swallowing.

The invention discloses a cyproheptadine hydrochloride drop pill prepared through ultramicro disintegration and drop pills manufacturing technique, which has the advantages of improving collapse and dissolving speed, quick effect, increased medicament stability, reduced adjuvant consumption, lowered production costs, and easiness in carrying and use. It has good compliance, thus is especially suitable for children, the elderly, bedridden patients and dysphagia patients.

A dripping pill of tramadol hydrochloride is prepared by ultrafine pulverizing and conventional process for preparing dripping pills.