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Epristeride dripping pills and its preparing method

A technology of Apulet and drop preparation method, which is applied in the field of Apulet dripping pills and its preparation, can solve the problems affecting the therapeutic effect of Apulet, long disintegration time of Apulet tablets, dissolution rate and dissolution rate. Low rate and other problems, to achieve the effect of convenient carrying and taking, good compliance, dissolution rate and dissolution rate

Inactive Publication Date: 2005-01-12
HONGYI SCI & TECH CO LTD NANCHANG
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The disintegration time of Apulet tablets is long, the dissolution rate and dissolution rate are low, the absorption is poor, the bioavailability is low, the proportion of excipients is large, the elderly, bedridden patients and patients with dysphagia are inconvenient to take, and the compliance is poor, which affects the quality of Aipulide tablets. The therapeutic effect of Liete

Method used

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  • Epristeride dripping pills and its preparing method

Examples

Experimental program
Comparison scheme
Effect test

example 1

[0065] prescription:

[0066] Applet 5g

[0067] Macrogol 6000 15g

[0068] Makes 1000 capsules

[0069] Preparation method: Take the ultra-finely pulverized and sieved through 200 mesh sieves and add it to the molten polyethylene glycol 6000 matrix, stir well, use simethicone as coolant, make pellets by drop method, dry, that is have to.

example 2

[0071] prescription:

[0072] Applet 5g

[0073] Macrogol 4000 15g

[0074] Makes 1000 capsules

[0075] Preparation method: Take the ultra-finely pulverized and sieved through 200 mesh sieve and add it into the molten polyethylene glycol 4000 matrix, stir well, use simethicone as coolant, make pellets by drop method, dry, that is have to.

example 3

[0077] prescription:

[0078] Applet 5g

[0079] Macrogol 6000 5g

[0080] Macrogol 4000 10g

[0081] Makes 1000 capsules

[0082] Preparation method: Take the fine powder of Apretide that has been ultrafinely pulverized and passed through a 200-mesh sieve, add it to the molten polyethylene glycol 4000 and polyethylene glycol 6000 mixed matrix, stir well, use simethicone as the coolant, drop The preparation method is to make pills, dry them, and obtain them.

[0083] 4. Example 4

[0084] prescription:

[0085] Applet 5g

[0086] Glyceryl monostearate 15g

[0087] Makes 1000 capsules

[0088] Preparation method: Take the ultra-finely pulverized 200-mesh sieve and add it into the melted glyceryl monostearate base, mix well, use ice water as the coolant, make pills by drop method, and dry to obtain .

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PUM

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Abstract

A dripping pill of Aipuliete is prepared through superfine pulverizing and the conventional steps for preparing dripping pills.

Description

technical field [0001] The invention relates to a pharmaceutical preparation and a preparation method thereof, in particular to Apret dripping pills and a preparation method thereof. Background technique [0002] Apretide is a selective non-competitive steroid type II 5α-reductase inhibitor for the treatment of benign prostatic hyperplasia, its mechanism of action is to reduce the production of dihydrotestosterone in the prostate by inhibiting the conversion of testosterone into dihydrotestosterone content, leading to atrophy of the prostatic body of hyperplasia. [0003] The pharmacokinetics of Apretide presents a two-compartment model, it is rapidly absorbed in the digestive tract, and the drug can be detected in the serum 0.25 hours after administration. The plasma concentration reaches the peak in 3 to 4 hours, and the half-life of the elimination phase (t 1 / 2 β) is 7.5 hours. On the 6th day of continuous administration (5 mg / time, twice a day), the blood drug concentr...

Claims

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Application Information

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IPC IPC(8): A61K9/20A61K31/56A61P13/08
Inventor 钱进许军彭红李平朱丹刘孝乐
Owner HONGYI SCI & TECH CO LTD NANCHANG
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