Ambroxol hydrochloride drop pills and its preparation method

A technology of ambroxol hydrochloride dropping pills and ambroxol hydrochloride, which is applied in the directions of pill delivery, respiratory system diseases, drug combination, etc. Problems such as low dissolution rate and dissolution rate, to achieve the effects of convenient carrying and taking, small pill volume, and improved dissolution rate and dissolution rate

Inactive Publication Date: 2005-04-06
HONGYI SCI & TECH CO LTD NANCHANG
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Amoxorbromide hydrochloride is odorless, tasteless, and slightly soluble in water. Its tablet or capsule disintegrates for a long time, has low dissolution rate and dissolution rate, poor absorption, low bioavailability, and a large proportion of auxiliary materials. Children, the elderly, Bedridden patients and patients with dysphagia are inconvenient to take and have poor compliance, which affects the therapeutic effect of Amoxorbromide Hydrochloride

Method used

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Examples

Experimental program
Comparison scheme
Effect test

example 1

[0051] prescription:

[0052] Amoxorium Hydrochloride 5g

[0053] Macrogol 6000 15g

[0054] Makes 1000 capsules

[0055] Preparation method: Take the ultrafinely pulverized 200-mesh sieve and add it into the melted polyethylene glycol 6000 matrix, stir well, use simethicone as coolant, make pellets by drop method, dry, that is have to.

example 2

[0057] prescription:

[0058] Amoxorium Hydrochloride 5g

[0059] Macrogol 4000 15g

[0060] Makes 1000 capsules

[0061] Preparation method: Take the ultrafinely pulverized 200-mesh sieve and add it into the melted polyethylene glycol 4000 matrix, stir well, use simethicone as coolant, make pellets by drop method, dry, that is have to.

example 3

[0063] prescription:

[0064] Amoxorium Hydrochloride 5g

[0065] Macrogol 6000 5g

[0066] Macrogol 4000 10g

[0067] Makes 1000 capsules

[0068] Preparation method: Take the ultrafinely pulverized 200-mesh sieve of methoxol bromide hydrochloride powder and add it to the molten mixed matrix of polyethylene glycol 4000 and polyethylene glycol 6000, stir well, use simethicone as coolant, drop The preparation method is to make pills, dry them, and obtain them.

[0069] 4. Example 4

[0070] prescription:

[0071] Amoxorium Hydrochloride 5g

[0072] Glyceryl monostearate 15g

[0073] Makes 1000 capsules

[0074] Preparation method: Take the ultrafinely pulverized 200-mesh sieve of thorol bromide hydrochloride and add it into the melted glyceryl monostearate matrix, mix well, use ice water as the cooling agent, make pellets by drop method, and dry to obtain .

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PUM

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Abstract

The invention uses super micro shattering and drop pills producing the technology to produce fenfluramine drop pills, reaching the purposes such as increasing speed, and dissolution of disintegration, increasing the medicine stability, reducing the dose of auxiliary materials and decreasing cost, with rapid effect and convenient use. It can be buccal as well as deglutition, has remarkable conformity, and is especially suitable for children, older man, sicker in bed or with difficulty of swallowing.

Description

technical field [0001] The invention relates to a medicine preparation and a preparation method thereof, in particular to amethorbromide hydrochloride dripping pills and a preparation method thereof. Background technique [0002] Amoxorbromide hydrochloride is a mucolytic agent, which can increase the secretion of serous glands in the respiratory mucosa and reduce the secretion of mucus glands, thereby reducing the viscosity of sputum. It can also promote the secretion of pulmonary surfactant, increase the movement of bronchial cilia, and make sputum easy to cough up. . [0003] Amoxorbromide hydrochloride is rapidly absorbed after oral administration, and the blood concentration reaches the peak value in about 1 hour, and is rapidly distributed from the blood to the tissues, with more distribution in the lung, liver, and kidney, mainly through liver metabolism, and the serum half-life (t 1 / 2 ) is about 7 hours, mainly excreted in urine, and the plasma protein binding rate ...

Claims

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Application Information

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IPC IPC(8): A61K9/20A61K31/137A61P11/10
Inventor 钱进许军彭红李平朱丹刘孝乐
Owner HONGYI SCI & TECH CO LTD NANCHANG
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