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Coumarin acetate drip pill and its preparation method

A technology of coumarin and acetic acid, which is applied in pill delivery, active ingredients of heterocyclic compounds, blood diseases, etc., can solve problems affecting the therapeutic effect of coumarin acetate, slow disintegration of tablets, and large amount of excipients, etc. And the effect of convenient taking, fast disintegration and dissolution, and reduced dosage of excipients

Inactive Publication Date: 2004-05-05
HONGYI SCI & TECH CO LTD NANCHANG
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Coumarin acetate has a bitter taste and is almost insoluble in water. Its tablets disintegrate slowly, and the amount of excipients is large. It is inconvenient for children, the elderly, bedridden patients and patients with dysphagia to take it, and the compliance is poor, which affects the therapeutic effect of coumarin acetate. to play

Method used

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  • Coumarin acetate drip pill and its preparation method

Examples

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Comparison scheme
Effect test

example 1

[0022] prescription:

[0023] Coumarin Acetate 1g

[0024] Macrogol 6000 19g

[0025] Makes 1000 capsules

[0026] Preparation method: Take coumarin acetate fine powder that has been ultrafinely pulverized and passed through a 200-mesh sieve, add it to the molten polyethylene glycol 6000 matrix, stir well, use simethicone oil as a coolant, make pellets by dropping, dry, and have to.

example 2

[0028] prescription:

[0029] Coumarin Acetate 1g

[0030] Macrogol 4000 19g

[0031] Makes 1000 capsules

[0032] Preparation method: Take coumarin acetate fine powder that has been ultrafinely pulverized and passed through a 200-mesh sieve, add it to the molten polyethylene glycol 4000 matrix, stir well, use simethicone oil as a coolant, make pellets by dropping, dry, and have to.

example 3

[0034] prescription:

[0035] Coumarin Acetate 1g

[0036] Macrogol 6000 9g

[0037] Macrogol 4000 10g

[0038] Makes 1000 capsules

[0039] Preparation method: Take the coumarin acetate fine powder that has been ultrafinely pulverized and passed through a 200-mesh sieve, add it to the molten polyethylene glycol 4000 and polyethylene glycol 6000 matrix, stir well, and use simethicone oil as a coolant. Drop system into legal pills, dry, and get it.

[0040] 4. Example 4

[0041] prescription:

[0042] Coumarin Acetate 1g

[0043] Glyceryl monostearate 19g

[0044] Makes 1000 capsules

[0045] Preparation method: Take the coumarin acetate fine powder that has been ultrafinely pulverized and passed through a 200-mesh sieve, add it to the molten glyceryl monostearate base, mix well, use ice water as the coolant, make pellets by drop method, and dry to obtain .

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PUM

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Abstract

A dripping pill of cumarin acetate and its superfine pulverizing process for preparing it are disclosed. Its advantages are high dissolving and disintegrating speed, high stability and low cost.

Description

technical field [0001] The invention relates to a medicine preparation and a preparation method thereof, in particular to coumarin acetate dripping pills and a preparation method thereof. Background technique [0002] Coumarin acetate can inhibit the coagulation process of blood, and as an anticoagulant drug, it is clinically used for the prevention and treatment of thromboembolic diseases. Only coumarin acetate tablets are currently on the market. [0003] Coumarin acetate has a bitter taste and is almost insoluble in water. Its tablets disintegrate slowly, and the amount of excipients is large. Children, the elderly, bedridden patients and patients with dysphagia are inconvenient to take and have poor compliance, which affects the therapeutic effect of coumarin acetate. play. [0004] The present invention is exactly to make the coumarin acetate drop pill by applying the superfine pulverization technology and the drop pill preparation technology, thereby overcomes the ab...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/20A61K31/37A61P7/02
Inventor 钱进许军彭红李平刘孝乐
Owner HONGYI SCI & TECH CO LTD NANCHANG
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