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Tramadol hydrochloride drops and their preparation

A technology of tramadol hydrochloride and dropping pills, applied in the directions of pill delivery, nervous system diseases, non-central analgesics, etc., can solve the problems affecting the therapeutic effect of tramadol hydrochloride, low dissolution rate and dissolution rate, and large proportion of excipients and other problems, to achieve the effects of convenience in carrying and taking, improvement in dissolution rate and dissolution rate, and reduction in the amount of excipients

Inactive Publication Date: 2005-02-23
HONGYI SCI & TECH CO LTD NANCHANG
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Tramadol hydrochloride is odorless, bitter, hygroscopic, and easily soluble in water, but its tablet disintegration time is long, the dissolution rate and dissolution rate are low, the absorption is poor, the bioavailability is low, and the proportion of excipients is large. , the elderly, bedridden patients and patients with dysphagia are inconvenient to take and have poor compliance, which affects the therapeutic effect of tramadol hydrochloride

Method used

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Examples

Experimental program
Comparison scheme
Effect test

example 1

[0051] prescription:

[0052] Tramadol Hydrochloride 5g

[0053] Macrogol 6000 15g

[0054] Makes 1000 capsules

[0055] Preparation method: Take tramadol hydrochloride fine powder that has been ultrafinely pulverized and passed through a 200-mesh sieve, add it to the molten polyethylene glycol 6000 matrix, stir well, use simethicone as a coolant, make pellets by drop method, and dry. have to.

example 2

[0057] prescription:

[0058] Tramadol Hydrochloride 5g

[0059] Macrogol 4000 15g

[0060] Makes 1000 capsules

[0061] Preparation method: Take the tramadol hydrochloride fine powder that has been ultrafinely pulverized and passed through a 200-mesh sieve, add it to the molten polyethylene glycol 4000 matrix, stir well, use simethicone as a coolant, make pellets by dropping, dry, and have to.

example 3

[0063] prescription:

[0064] Tramadol Hydrochloride 5g

[0065]Macrogol 6000 10g

[0066] Macrogol 4000 5g

[0067] Makes 1000 capsules

[0068] Preparation method: Take tramadol hydrochloride fine powder that has been ultrafinely pulverized and passed through a 200-mesh sieve, add it to the molten polyethylene glycol 4000 and polyethylene glycol 6000 mixed matrix, stir well, use simethicone as the coolant, drop The preparation method is to make pills, dry them, and obtain them.

[0069] 4. Example 4

[0070] prescription:

[0071] Tramadol Hydrochloride 5g

[0072] Glyceryl monostearate 15g

[0073] Makes 1000 capsules

[0074] Preparation method: Take tramadol hydrochloride fine powder that has been ultrafinely pulverized and passed through a 200-mesh sieve, add it to the molten glyceryl monostearate matrix, mix well, use ice water as a coolant, make pellets by drop method, and dry to obtain .

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PUM

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Abstract

A dripping pill of tramadol hydrochloride is prepared by ultrafine pulverizing and conventional process for preparing dripping pills.

Description

technical field [0001] The invention relates to a medicine preparation and a preparation method thereof, in particular to tramadol hydrochloride dripping pills and a preparation method thereof. Background technique [0002] Tramadol hydrochloride is a non-opioid central analgesic. Although it can also bind to opioid receptors, its affinity is very weak. The affinity for μ receptors is equivalent to 1 / 6000 of morphine, and the affinity for κ and δ receptors The affinity is only 1 / 25 of the μ receptor. Tramadol is a racemate, the (+) enantiomer acts on opioid receptors, while the (-) enantiomer inhibits the reuptake of norepinephrine at neuronal synapses and increases extraneuronal 5- The concentration of serotonin affects the transmission of pain and produces analgesic effect, and its strength is 1 / 8 to 1 / 10 of that of morphine. Tramadol hydrochloride has no respiratory depressant effect, has little dependence on long-term application, has antitussive effect, and its streng...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/20A61K31/137A61P25/04A61P29/00
Inventor 钱进许军彭红李平朱丹刘孝乐
Owner HONGYI SCI & TECH CO LTD NANCHANG
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