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Dripping pills of meclozine hydrochloride and its preparation method

A technology of meclizine hydrochloride dripping pills and meclizine hydrochloride, applied in pill delivery, cardiovascular system diseases, drug combination, etc. The problem of long disintegration time of the pill is eliminated, and the effect of convenient carrying and taking, reduced amount of excipients, and small pill volume are achieved.

Inactive Publication Date: 2005-01-26
HONGYI SCI & TECH CO LTD NANCHANG
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Meclizine hydrochloride is tasteless, slightly smelly, very slightly soluble in water, its tablet disintegration time is long, absorption is poor, bioavailability is low, and the proportion of excipients is large. It is suitable for children, the elderly, bedridden patients and patients with dysphagia. Inconvenient, poor compliance, affecting the therapeutic effect of meclizine hydrochloride

Method used

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  • Dripping pills of meclozine hydrochloride and its preparation method

Examples

Experimental program
Comparison scheme
Effect test

example 1

[0023] prescription:

[0024] Meclizine Hydrochloride 5g

[0025] Macrogol 6000 15g

[0026] Makes 1000 capsules

[0027] Preparation method: Take the meclizine hydrochloride fine powder that has been ultrafinely pulverized and passed through a 200 mesh sieve, add it to the molten polyethylene glycol 6000 matrix, stir well, use simethicone as a coolant, make pellets by drop method, dry, Instantly.

example 2

[0029] prescription:

[0030] Meclizine Hydrochloride 5g

[0031] Macrogol 4000 15g

[0032] Makes 1000 capsules

[0033] Preparation method: Take the meclizine hydrochloride fine powder that has been ultrafinely pulverized and passed through a 200-mesh sieve, add it to the molten polyethylene glycol 4000 matrix, stir well, use simethicone as a coolant, make pellets by drop method, and dry. Instantly.

example 3

[0035] prescription:

[0036] Meclizine Hydrochloride 5g

[0037] Macrogol 6000 10g

[0038] Macrogol 4000 5g

[0039] Makes 1000 capsules

[0040] Preparation method: Take the meclizine hydrochloride fine powder that has been ultrafinely pulverized and passed through a 200-mesh sieve, add it to the molten polyethylene glycol 4000 and polyethylene glycol 6000 mixed matrix, stir well, use simethicone as the coolant, Drop system into legal pills, dry, and get it.

[0041] 4. Example 4

[0042] prescription:

[0043] Meclizine Hydrochloride 5g

[0044] Glyceryl monostearate 15g

[0045] Makes 1000 capsules

[0046] Preparation method: Take the meclizine hydrochloride fine powder that has been ultrafinely pulverized and passed through a 200 mesh sieve, add it to the molten glyceryl monostearate base, mix well, use ice water as the cooling agent, make pellets by drop method, dry, that is have to.

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PUM

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Abstract

The invention discloses am Imipramine Hydrochloride drop pill prepared through ultramicro disintegration and drop pills manufacturing technique, which has the advantages of improving collapse and dissolving speed, quick effect, increased medicament stability, reduced adjuvant consumption, lowered production costs, and easiness in carrying and use. It has good compliance, thus is especially suitable for children, the elderly, bedridden patients and dysphagia patients.

Description

technical field [0001] The invention relates to a pharmaceutical preparation and a preparation method thereof, in particular to meclizine hydrochloride dropping pills and a preparation method thereof. Background technique [0002] Meclizine hydrochloride is a histamine receptor antagonist, which can resist the hypotensive effect caused by histamine, and has a protective effect on animal death caused by lethal histamine. It has central inhibition and local anesthesia, and its anti-motion sickness and vertigo effects related to its anticholinergic effect. [0003] Meclizine hydrochloride takes effect 1 hour after oral administration, t 1 / 2 It lasts for 6 hours, and it can be maintained for 8 to 24 hours at a time. Only meclazine hydrochloride tablets are currently on the market, which are clinically used for the treatment and prevention of nausea, vomiting, and dizziness caused by motion sickness. It is also effective for vertigo caused by vestibular disease. [0004] Mecl...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/20A61K31/495A61P9/12
Inventor 钱进许军彭红李平朱丹刘孝乐
Owner HONGYI SCI & TECH CO LTD NANCHANG
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