Dripping pills of cyproheptadine hydrochloride and its preparation method

A technology of cyproheptadine hydrochloride and dropping pills, which is applied in the field of pharmaceutical preparations and its preparation, can solve the problems affecting the therapeutic effect of cyproheptadine hydrochloride, the large proportion of excipients used, and the long disintegration time of tablets, etc., and achieve the goal of carrying and taking Convenience, reduced amount of excipients, small pill size

Inactive Publication Date: 2005-01-26
HONGYI SCI & TECH CO LTD NANCHANG
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Cyproheptadine hydrochloride has a slightly bitter taste and is slightly soluble in water. The disintegration time of the tablet is long, the absorption is poor, the bioavailability is low, and the proportion of excipients is large. It is inconvenient to take for children, the elderly, bedridden patients and patients with dysphagia. Poor compliance, affecting the therapeutic effect of cyproheptadine hydrochloride

Method used

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Examples

Experimental program
Comparison scheme
Effect test

example 1

[0022] prescription:

[0023] Cyproheptadine Hydrochloride 2g

[0024] Macrogol 6000 18g

[0025] Makes 1000 capsules

[0026] Preparation method: Take the fine powder of cyproheptadine hydrochloride that has been ultrafinely pulverized and passed through a 200-mesh sieve, add it to the molten polyethylene glycol 6000 matrix, stir well, use simethicone as a coolant, make pellets by drop method, and dry. have to.

example 2

[0028] prescription:

[0029] Cyproheptadine Hydrochloride 2g

[0030] Macrogol 4000 18g

[0031] Makes 1000 capsules

[0032] Preparation method: Take the fine powder of cyproheptadine hydrochloride that has been ultrafinely pulverized and passed through a 200-mesh sieve, add it to the molten polyethylene glycol 4000 matrix, stir well, use simethicone as a coolant, make pellets by drop method, and dry. have to.

example 3

[0034] prescription:

[0035] Cyproheptadine Hydrochloride 2g

[0036] Macrogol 6000 12g

[0037] Macrogol 4000 6g

[0038] Makes 1000 capsules

[0039] Preparation method: Take the fine powder of cyproheptadine hydrochloride that has been ultrafinely pulverized and passed through a 200-mesh sieve, add it to the molten polyethylene glycol 4000 and polyethylene glycol 6000 mixed matrix, stir well, use simethicone as the coolant, drop The preparation method is to make pills, dry them, and obtain them.

[0040] 4. Example 4

[0041] prescription:

[0042] Cyproheptadine Hydrochloride 2g

[0043] Glyceryl monostearate 18g

[0044] Makes 1000 capsules

[0045] Preparation method: Take the fine powder of cyproheptadine hydrochloride that has been ultrafinely pulverized and passed through a 200 mesh sieve, add it to the molten glyceryl monostearate matrix, mix well, use ice water as the cooling agent, make pellets by drop method, and ...

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PUM

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Abstract

The invention discloses a cyproheptadine hydrochloride drop pill prepared through ultramicro disintegration and drop pills manufacturing technique, which has the advantages of improving collapse and dissolving speed, quick effect, increased medicament stability, reduced adjuvant consumption, lowered production costs, and easiness in carrying and use. It has good compliance, thus is especially suitable for children, the elderly, bedridden patients and dysphagia patients.

Description

technical field [0001] The invention relates to a pharmaceutical preparation and a preparation method thereof, in particular to cyproheptadine hydrochloride dropping pills and a preparation method thereof. Background technique [0002] Cyproheptadine hydrochloride is H 1 Receptor antagonist, stronger than chlorpheniramine and promethazine, and has mild to moderate anti-serotonin and anticholinergic effects, so it can block serotonin’s effect on blood vessels, intestines and other Smooth muscle effect, can be used as an inhibitor of vascular headache. [0003] Cyproheptadine hydrochloride is well absorbed orally, and the duration of action is about 8 hours. Most of the products of drug metabolism in the body are combined with glucuronic acid, and are mainly excreted in urine, and a small amount of original drugs and metabolites are excreted in feces. The rate of elimination of the drug is slowed in renal impairment. Currently, only tablets are available on the market, and...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/20A61K31/445A61P37/08
Inventor 钱进许军彭红李平朱丹刘孝乐
Owner HONGYI SCI & TECH CO LTD NANCHANG
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