57 results about "Promethazine" patented technology

A pharmaceutical dosage form which comprises promethazine and/or a pharmaceutically acceptable salt thereof and at least one second drug. The dosage form provides a plasma concentration within the therapeutic range of the at least one second drug over a period which is coextensive with a substantial part of the period over which the dosage form provides a plasma concentration within the therapeutic range of promethazine or salt thereof. This Abstract is neither intended to define the invention disclosed in this specification nor intended to limit the scope of the invention in any way.

A pharmaceutical dosage form which comprises promethazine and/or a pharmaceutically acceptable salt thereof. The dosage form is capable of providing a promethazine plasma concentration within a therapeutic range for at least about 24 hours per single dose. This Abstract is neither intended to define the invention disclosed in this specification nor intended to limit the scope of the invention in any way.

A topical pharmaceutical preparation suitable for use as an antihistamine or anti-nausea drug comprises an emu oil gel base and a therapeutic amount of promethazine.HCl. The preparation may further comprise an antioxidant. The preparation is preferably packaged as a single unit dose. A method for preparing the topical pharmaceutical preparation comprises the steps of combining a clear gel with an emu oil mixture and adding a therapeutic amount of promethazine.HCl solution.

The invention relates to a method for determining residual medicaments in mutton, and in particular relates to a method for determining multiple sedative type medicaments in mutton at the same time. The residual sedative type veterinary medicaments refer to zolpidem, haloperidol, chlordiazepoxide, promethazine, nitrazepam, chlorpromazine hydrochloride, perphenazine, fluphenazine hydrochloride, clonazepam, xylazine hydrochloride, propionylpromazine, carazolol, acepromazine, droperidol and azaperone. The method has the advantage that the residual amounts of 15 types of sedative type medicaments in mutton are determined through high-resolution liquid chromatography-tandem mass spectrometry. The method is high in sensitivity and high in recovery rate, and can meet the detection requirements on veterinary medicaments.

Relief or prophylaxis from nausea and/or emesis are provided by transdermal compositions comprising dexamethasone and promethazine. The transdermal compositions are in the form of transdermal solutions and/or suspensions, such as lotions, pastes, gels, ointments or transdermal patches.

The acne treating medicine composition consists of Ethinylestradiol, compound sulfamethoxazole, promethazine, chlorpheniramine, dexamethasone, isotretinoin, chloromycetin, vitamin E and vanishing cream. The present invention can heal acne radically according to the pathogenesis, has unique acne healing effect, and has the functions of eliminating scar, nourishing skin, beautifying, etc. when used regularly. The present invention has fast effect and no toxic side effect.

Disclosed is the unexpected finding that enantiomers of phenothiazines, preferably the (+) enantiomer of promethazine, are particularly effective in inhibiting the bone resorbing cells, osteoclasts, thus providing new uses and methods for reducing bone loss and, e.g., treating periodontitis and osteoporosis. The invention provides a range of such uses, methods, medicaments and associated compositions and kits.

The invention discloses a composite formulation for treating bronchial asthma, which is prepared from traditional Chinese medicinal material and western medicaments, wherein the Chinese medicinal material comprises (by weight ratio) ganoderma lucidum 5-20, root of large-flowered skullcap 5-15, radix salvia miltiorrhiza 8-30, banksia rose 6-12, perilla fruit 3-10, ash bark 3-15, the daily dosage of ammonia theophylline is 300-600mg, the daily dosage of promethazine hydrochloride is 37.5-75mg.

The invention discloses an external ointment for treating internal and external hemorrhoids as well as burns and scalds. The ointment is prepared from the following Chinese and western medicines and auxiliary materials, and obtained by crushing subprostrate sophora, typhonium giganteum, fructus cnidii, fructus kochiae, caesalpinia cucullata, cyproheptadine, promethazine, borneol and B2, adding powdery vanishing cream, and stirring. The ointment has the functions of diminishing inflammation, easing pain, killing bacteria, stopping bleeding, astringing, and resisting irritability, acts on the effects of dispersing blood stasis and promoting granulation, and accelerates wound healing, as well as is wide in adaptation diseases, convenient to use, safe and free from side effects. The ointment is capable of curing burns and scalds, malignant sores and anabrosis, internal and external hemorrhoids, wound joint swelling, perianal abscess, allergic dermatitis, mosquito bite, herpes zoster, dankness tinea and dental ulcer.

A method for anesthetizing a patient undergoing a cosmetic surgical procedure comprising: providing an antibiotic medication at least from about 12 hours to about 24 hours prior to the cosmetic surgical procedure; providing a first dosage of oxycodone and a first dosage of promethazine to be taken by the patient prior to arrival at a surgical facility where the cosmetic surgical procedure is to occur; and providing a dosage of lorazepam, a dosage of zolpidem, and a dosage of hydroxyzine just prior to the cosmetic surgical procedure, wherein the zolpidem comprises a dosage of AMBIEN. In one embodiment, the method further comprises: preparing an anesthetizing solution comprising lidocaine, epinephrine, and sodium bicarbonate; and infiltrating the anesthetizing solution in a targeted area of the patient. In another embodiment, the method further comprises: providing one or more reversing agents to the patient after the cosmetic surgical procedure.

The invention discloses a specific monoclonal antibody for detecting various promethazine drugs such as anti-chlorpromazine, anti-promazine, anti-perphenazine drugs and an enzyme linked immunosorbent assay and kit for detecting the promethazine drugs. The monoclonal antibody disclosed by the invention is secreted from a hybridoma 3A5 with the preservation number of CCTCC NO: 201354. Compared with the prior art, the monoclonal antibody disclosed by the invention can be used for identifying various promethazine drugs simultaneously. The enzyme linked immunosorbent assay and kit disclosed by the invention have the advantages of being high in detection efficiency and sensitivity, good in precision and accuracy and the like.

The current invention provides formulations for transdermal delivery of promethazine which achieve delivery of the drug with consistent plasma levels. The topical formulations of the invention are superior to both rectal suppositories and oral dosage forms in that variable blood levels, first-pass metabolism, unpredictable peaks in blood levels, and variable bioavailability are minimized. Formulations of the invention provide antiemetic and antipruritic relief to patients in need of treatment while minimizing side effects and adverse reactions known to occur with other routes of administration and other formulations.

Pharmaceutical compositions are provided, which comprise effective amounts of an opioid analgesic such as oxycodone, and an antiemetic, such as promethazine, to treat a subject for conditions, including for reducing or eliminating an adverse effect associated with the opioid analgesic.

The invention discloses a drug for treating a cancer as well as a preparation method and application thereof. The drug is prepared from the following raw materials in parts by weight: 3-7 parts of prednisone, 5-12 parts of aminophylline, 6-10 parts of butylphthalide, 1-3 parts of promethazine and 11-19 parts of maltotriitol. The preparation method comprises the following steps: mixing the prednisone and aminophylline, then adding deionized water, and carrying out ultrasonic treatment for 20min at the temperature of 45 DEG C to prepare a mixture A; mixing the butylphthalide and the promethazine, then adding the deionized water, and carrying out microwave treatment for 5min to prepare a mixture B; and mixing the maltotriitol, the mixture A and the mixture B, carrying out ultrasonic treatment for 10min at the temperature of 65 DEG C, and then stirring the mixture at the temperature of 60 DEG C to dry to obtain the drug. The drug is used for treating the cancer, particularly has a unique curative effect on treating leukemia, is simple and available in raw materials, simple in preparation technology and low in production cost, does not have side and toxic effects and is suitable for large-scale popularization.

The invention discloses a method for detecting sedative drug metabolism residues in animal tissues, which adopts a dispersive solid-phase extraction-high performance liquid chromatography triple quadrupole mass spectrometry method to simultaneously determine chlorpromazine, promethazine, methylthiazine and metabolites thereof such as chlorpromazine sulfoxide, 2-chlorophenothiazine, promethazine sulfoxide, 2, 6-dimethylaniline in pork, pork liver, pig kidney, pig heart and pig lung. The method optimizes the detection conditions, can accurately detect the sedative drugs in animal tissues, has accurate and reliable detection results, provides reliable data for the measurement of sedative drug metabolic residues, has significant economic benefits, and has wide market prospects. The method has a good reference value for guiding the measurement of drug residues.

The invention discloses a western medicine for curing a cold of a bamboo rat and a preparation method of the western medicine. The western medicine for curing the cold of the bamboo rat comprises the following components by weight: 5-8 parts of chlortrimeton, 20-25 parts of calcium gluconate, 4-8 parts of cetirizine, 10-15 parts of ephedrine, 2-8 parts of acetylspiramycin, 4-10 parts of roxithromycin, 15-20 parts of promethazine, 8-15 parts of omeprazole, 10-15 parts of etamsylate, 8-10 parts of cedilanid, 2-6 parts of bromhexine, and 2-8 parts of aminophylline. Compared with the prior art, the western medicine is mixed into a feed to feed the bamboo rat and has good effects of preventing and treating the cold of the bamboo rat, the marked effective rates of the prevention and the treatment are up to 99% and 95%, and in addition, the western medicine has no strong flavor of the western medicine, is mixed into the feed to feed the bamboo rat, does not affect the feeding of the bamboo rat, and is convenient to use.