57 results about "Promethazine" patented technology

A pharmaceutical dosage form which comprises promethazine and / or a pharmaceutically acceptable salt thereof and at least one second drug. The dosage form provides a plasma concentration within the therapeutic range of the at least one second drug over a period which is coextensive with a substantial part of the period over which the dosage form provides a plasma concentration within the therapeutic range of promethazine or salt thereof. This abstract is neither intended to define the invention disclosed in this specification nor intended to limit the scope of the invention in any way.

A pharmaceutical dosage form which comprises promethazine and / or a pharmaceutically acceptable salt thereof and at least one second drug. The dosage form provides a plasma concentration within the therapeutic range of the at least one second drug over a period which is coextensive with a substantial part of the period over which the dosage form provides a plasma concentration within the therapeutic range of promethazine or salt thereof. This Abstract is neither intended to define the invention disclosed in this specification nor intended to limit the scope of the invention in any way.

Described herein are pharmaceutical packaging systems which prevent oxidative degradation of morphine, hydromorphone, promethazine and other oxygen-sensitive drugs, such systems including a syringe with an oxygen permeable tip cap, a hermetically sealed oxygen barrier blister packaging with very low permeability to oxygen and comprises ethylene vinyl, and an oxygen absorber.

A pharmaceutical dosage form which comprises promethazine and / or a pharmaceutically acceptable salt thereof. The dosage form is capable of providing a promethazine plasma concentration within a therapeutic range for at least about 24 hours per single dose. This Abstract is neither intended to define the invention disclosed in this specification nor intended to limit the scope of the invention in any way.

Methods and compositions are provided which comprise effective amounts of one or more analgesics, such as hydrocodone or acetaminophen, and an antiemetic, such as promethazine, to treat a subject, including reducing or eliminating an adverse effect associated with the analgesics.

A topical pharmaceutical preparation suitable for use as an antihistamine or anti-nausea drug comprises an emu oil gel base and a therapeutic amount of promethazine.HCl. The preparation may further comprise an antioxidant. The preparation is preferably packaged as a single unit dose. A method for preparing the topical pharmaceutical preparation comprises the steps of combining a clear gel with an emu oil mixture and adding a therapeutic amount of promethazine.HCl solution.

The invention relates to a method for determining residual medicaments in mutton, and in particular relates to a method for determining multiple sedative type medicaments in mutton at the same time. The residual sedative type veterinary medicaments refer to zolpidem, haloperidol, chlordiazepoxide, promethazine, nitrazepam, chlorpromazine hydrochloride, perphenazine, fluphenazine hydrochloride, clonazepam, xylazine hydrochloride, propionylpromazine, carazolol, acepromazine, droperidol and azaperone. The method has the advantage that the residual amounts of 15 types of sedative type medicaments in mutton are determined through high-resolution liquid chromatography-tandem mass spectrometry. The method is high in sensitivity and high in recovery rate, and can meet the detection requirements on veterinary medicaments.

Relief or prophylaxis from nausea and / or emesis are provided by transdermal compositions comprising dexamethasone and promethazine. The transdermal compositions are in the form of transdermal solutions and / or suspensions, such as lotions, pastes, gels, ointments or transdermal patches.

The acne treating medicine composition consists of Ethinylestradiol, compound sulfamethoxazole, promethazine, chlorpheniramine, dexamethasone, isotretinoin, chloromycetin, vitamin E and vanishing cream. The present invention can heal acne radically according to the pathogenesis, has unique acne healing effect, and has the functions of eliminating scar, nourishing skin, beautifying, etc. when used regularly. The present invention has fast effect and no toxic side effect.

Disclosed is the unexpected finding that enantiomers of phenothiazines, preferably the (+) enantiomer of promethazine, are particularly effective in inhibiting the bone resorbing cells, osteoclasts, thus providing new uses and methods for reducing bone loss and, e.g., treating periodontitis and osteoporosis. The invention provides a range of such uses, methods, medicaments and associated compositions and kits.

The invention discloses a composite formulation for treating bronchial asthma, which is prepared from traditional Chinese medicinal material and western medicaments, wherein the Chinese medicinal material comprises (by weight ratio) ganoderma lucidum 5-20, root of large-flowered skullcap 5-15, radix salvia miltiorrhiza 8-30, banksia rose 6-12, perilla fruit 3-10, ash bark 3-15, the daily dosage of ammonia theophylline is 300-600mg, the daily dosage of promethazine hydrochloride is 37.5-75mg.

The invention belongs to the technical field of organic synthesis and provides a polymerization inhibitor for acrylic acid monomer refining. The polymerization inhibitor comprises, by mass, 94-95% of hydroquinone, 4.0-5.0% of chlorpromazine and 1.0-2.0% of promethazine. Through use of two common chemical products in the original polymerization inhibitor, the modified polymerization inhibitor does not need change of original reaction conditions of the production device. The novel polymerization inhibitor can be prepared through simple and easy processes. The modified polymerization inhibitor can substantially prolong a rectifying tower continuous production period to 200 days in acrylic acid monomer production.

The invention discloses an external ointment for treating internal and external hemorrhoids as well as burns and scalds. The ointment is prepared from the following Chinese and western medicines and auxiliary materials, and obtained by crushing subprostrate sophora, typhonium giganteum, fructus cnidii, fructus kochiae, caesalpinia cucullata, cyproheptadine, promethazine, borneol and B2, adding powdery vanishing cream, and stirring. The ointment has the functions of diminishing inflammation, easing pain, killing bacteria, stopping bleeding, astringing, and resisting irritability, acts on the effects of dispersing blood stasis and promoting granulation, and accelerates wound healing, as well as is wide in adaptation diseases, convenient to use, safe and free from side effects. The ointment is capable of curing burns and scalds, malignant sores and anabrosis, internal and external hemorrhoids, wound joint swelling, perianal abscess, allergic dermatitis, mosquito bite, herpes zoster, dankness tinea and dental ulcer.

A method for anesthetizing a patient undergoing a cosmetic surgical procedure comprising: providing an antibiotic medication at least from about 12 hours to about 24 hours prior to the cosmetic surgical procedure; providing a first dosage of oxycodone and a first dosage of promethazine to be taken by the patient prior to arrival at a surgical facility where the cosmetic surgical procedure is to occur; and providing a dosage of lorazepam, a dosage of zolpidem, and a dosage of hydroxyzine just prior to the cosmetic surgical procedure, wherein the zolpidem comprises a dosage of AMBIEN. In one embodiment, the method further comprises: preparing an anesthetizing solution comprising lidocaine, epinephrine, and sodium bicarbonate; and infiltrating the anesthetizing solution in a targeted area of the patient. In another embodiment, the method further comprises: providing one or more reversing agents to the patient after the cosmetic surgical procedure.

The invention relates to a medicament injection for curing strawberry and cavernous hemangioma, wherein the medicament injection is made by the preparation of beautyberry, cape jasmine, pyridoxine and phenergan. The medicament injection cures strawberry and cavernous hemangioma without any special apparatus, the technical operation is simple and easy to learn, the medicament is easy to obtain, and the invention is economic and convenient. The invention cures the thrombus, the connected, the hyperplasia and the fiberized tissues happened in the patients with hemangioma effectively, and the invention avoids the complicate treatment methods with side effects just like radiation, laser, hormone, isotope and the like, further the pain and the fatalness of the surgery operation are relieved. According to the experimental verification, after using the medicament injection of the invention, the intergrown of the external form of the patient is good without any scar, and thereby the satisfactory effect is achieved without the plastic operation.

The invention discloses a specific monoclonal antibody for detecting various promethazine drugs such as anti-chlorpromazine, anti-promazine, anti-perphenazine drugs and an enzyme linked immunosorbent assay and kit for detecting the promethazine drugs. The monoclonal antibody disclosed by the invention is secreted from a hybridoma 3A5 with the preservation number of CCTCC NO: 201354. Compared with the prior art, the monoclonal antibody disclosed by the invention can be used for identifying various promethazine drugs simultaneously. The enzyme linked immunosorbent assay and kit disclosed by the invention have the advantages of being high in detection efficiency and sensitivity, good in precision and accuracy and the like.

The current invention provides formulations for transdermal delivery of promethazine which achieve delivery of the drug with consistent plasma levels. The topical formulations of the invention are superior to both rectal suppositories and oral dosage forms in that variable blood levels, first-pass metabolism, unpredictable peaks in blood levels, and variable bioavailability are minimized. Formulations of the invention provide antiemetic and antipruritic relief to patients in need of treatment while minimizing side effects and adverse reactions known to occur with other routes of administration and other formulations.

A formulation provides a unique synergistic composition for the treatment of the novel Coronavirus (COVID-19). Due to multiple mechanisms and synergy of action of the ingredients involved, using drug and nutrient therapy to support the body's natural immune response, it can provide a significant advantage to currently used therapies and may also be administered prophylactically. In its optimal embodiment the composition can be prepared in solid (tablet or capsule) or liquid form, containing Aspirin or any natural salicinoid, Phenylephrine, Promethazine, Vitamin D, Vitamin C, Niacinamide, Iodine Zinc and Selenium.

Pharmaceutical compositions are provided, which comprise effective amounts of an opioid analgesic such as oxycodone, and an antiemetic, such as promethazine, to treat a subject for conditions, including for reducing or eliminating an adverse effect associated with the opioid analgesic.

The invention relates to an acne treatment, itching relieving liniment which comprises the following components in parts by weight: 9-15 parts of polygonum cuspidatum, 8-12 parts of oriental wormwood, 8-12 parts of bolbostemma paniculatum, 8-12 parts of edible tulip, 8-12 parts of gentian 0.08-0.12 part of borax, 0.2-0.3 part of chloramphenicol, 0.08-0.12 part of diphenhydramine, 0.04-0.06 part of chlortrimeton, 0.12-0.18 part of promethazine and 0.16-0.24 part of spirolactone. The acne treatment, itching relieving liniment has the functions of enriching yin and nourishing kidney, promoting blood circulation to remove blood stasis, clearing heat and expelling toxicity; a plurality of traditional Chinese components supplement each other to cool blood, eliminate spots, clear internal heat, dispel wind and dissipate heat; the body internal secretion is adjusted, the in vivo hormonal balance is maintained, sebum metabolism is prompted, and bacterial growth is inhibited; the acne treatment, itching relieving liniment is remarkable in curative effect and free of toxic and side effect.

A method for anesthetizing a patient undergoing a cosmetic surgical procedure comprising: providing an antibiotic medication at least from about 12 hours to about 24 hours prior to the cosmetic surgical procedure; providing a first dosage of oxycodone and a first dosage of promethazine to be taken by the patient prior to arrival at a surgical facility where the cosmetic surgical procedure is to occur; and providing a dosage of lorazepam, a dosage of zolpidem, and a dosage of hydroxyzine just prior to the cosmetic surgical procedure, wherein the zolpidem comprises a dosage of AMBIEN. In one embodiment, the method further comprises: preparing an anesthetizing solution comprising lidocaine, epinephrine, and sodium bicarbonate; and infiltrating the anesthetizing solution in a targeted area of the patient. In another embodiment, the method further comprises: providing one or more reversing agents to the patient after the cosmetic surgical procedure.

The invention discloses a drug for treating a cancer as well as a preparation method and application thereof. The drug is prepared from the following raw materials in parts by weight: 3-7 parts of prednisone, 5-12 parts of aminophylline, 6-10 parts of butylphthalide, 1-3 parts of promethazine and 11-19 parts of maltotriitol. The preparation method comprises the following steps: mixing the prednisone and aminophylline, then adding deionized water, and carrying out ultrasonic treatment for 20min at the temperature of 45 DEG C to prepare a mixture A; mixing the butylphthalide and the promethazine, then adding the deionized water, and carrying out microwave treatment for 5min to prepare a mixture B; and mixing the maltotriitol, the mixture A and the mixture B, carrying out ultrasonic treatment for 10min at the temperature of 65 DEG C, and then stirring the mixture at the temperature of 60 DEG C to dry to obtain the drug. The drug is used for treating the cancer, particularly has a unique curative effect on treating leukemia, is simple and available in raw materials, simple in preparation technology and low in production cost, does not have side and toxic effects and is suitable for large-scale popularization.

The invention discloses a method for detecting sedative drug metabolism residues in animal tissues, which adopts a dispersive solid-phase extraction-high performance liquid chromatography triple quadrupole mass spectrometry method to simultaneously determine chlorpromazine, promethazine, methylthiazine and metabolites thereof such as chlorpromazine sulfoxide, 2-chlorophenothiazine, promethazine sulfoxide, 2, 6-dimethylaniline in pork, pork liver, pig kidney, pig heart and pig lung. The method optimizes the detection conditions, can accurately detect the sedative drugs in animal tissues, has accurate and reliable detection results, provides reliable data for the measurement of sedative drug metabolic residues, has significant economic benefits, and has wide market prospects. The method has a good reference value for guiding the measurement of drug residues.

The invention discloses a western medicine for curing a cold of a bamboo rat and a preparation method of the western medicine. The western medicine for curing the cold of the bamboo rat comprises the following components by weight: 5-8 parts of chlortrimeton, 20-25 parts of calcium gluconate, 4-8 parts of cetirizine, 10-15 parts of ephedrine, 2-8 parts of acetylspiramycin, 4-10 parts of roxithromycin, 15-20 parts of promethazine, 8-15 parts of omeprazole, 10-15 parts of etamsylate, 8-10 parts of cedilanid, 2-6 parts of bromhexine, and 2-8 parts of aminophylline. Compared with the prior art, the western medicine is mixed into a feed to feed the bamboo rat and has good effects of preventing and treating the cold of the bamboo rat, the marked effective rates of the prevention and the treatment are up to 99% and 95%, and in addition, the western medicine has no strong flavor of the western medicine, is mixed into the feed to feed the bamboo rat, does not affect the feeding of the bamboo rat, and is convenient to use.

The invention provides a mixed herbicide containing propyrisulfuron and dichloroquinolone and an application thereof. The mixed herbicide contains active components of the propyrisulfuron and the dichloroquinolone; the weight ratio of the propyrisulfuron to the dichloroquinolone is 1-10:1-40. The mixed herbicide provided by the invention can be used for controlling broadleaf weeds, gramineous weeds and nutgrass flatsedge.

Pharmaceutical compositions are provided, which comprise effective amounts of an opioid analgesic such as oxycodone, and an antiemetic, such as promethazine, to treat a subject for conditions, including for reducing or eliminating an adverse effect associated with the opioid analgesic.

This invention provides uses for promethazine in the preparation of products to treat liver cancer and / or colon cancer and / or lung cancer. From carrying out cancer drug repositioning for the FDA- and CFDA-approved drug promethazine, experiments for this invention show, based on screening of non-anti-cancer drugs for various cancer cell lines (tissue types) and mutation sites, that promethazine has a new use as an anti-liver cancer and / or colon cancer and / or lung cancer medication, thus achieving a new purpose for an old drug.

The invention discloses medicine for treating acne and a preparation method of the medicine. The medicine comprises the following components of, in parts by weight, 60-90 parts of alcohol, 5-10 partsof chloramphenicol, 5-10 parts of metronidazole, 10-15 parts of taraxacum mongolicum, 20-30 parts of aloe, 100-150 parts of dementholized peppermint oil, 110-140 parts of methyl salicylate, 5-15 partsof cinnamon oil, 1-2 parts of borneol, 10-16 parts of menthol, 15-20 parts of eucalyptus oil, 20-60 parts of tea oil extract, 2-3 parts of ethinylestradiol, 8-12 parts of compound sulfamethoxazole, 1-2 parts of promethazine, 0.5-1 part of chlorpheniramine maleate, 0.5-1 part of dexamethasone, 0.5-1 part of isotretinoin, and 3-5 parts of vitamin E. According to the medicine, by adopting the alcohol, chloramphenicol, metronidazole, taraxacum mongolicum, aloe, dementholized peppermint oil, methyl salicylate, cinnamon oil, borneol, menthol, eucalyptus oil, tea oil extract, ethinylestradiol, compound sulfamethoxazole, promethazine, chlorpheniramine malate, dexamethasone, isotretinoin and vitamin E, the prepared medicine has a sterilization function, and also has good detumescence and acne removal effects; and the whole preparation method is simple and easy to operate.

The invention belongs to the field of medicine preparation, in particular to a preparation method of promethazine hydrochloride tablet. Firstly, poloxamer and PEG6000 were weighed to prepare an auxiliary material solution, then the active ingredient promethazine hydrochloride was formulated as a main drug solution, and the auxiliary material solution and the main drug solution were mixed uniformly to obtain a mixed solution; the mixed solution was vacuum-dried; the obtained solid The material is crushed, and other excipients are added into the granulator to shear and granulate, and then put into the boiling dryer for drying; the dried granules are sieved and granulated, and the obtained granules are mixed with the lubricant in the prescription and then compressed into tablets .