51 results about "Spirolactone" patented technology

The invention discloses an antihypertensive medicine synergist. The antihypertensive medicine synergist is composed of the medicine constituents in the following parts by mass: 0.5-15 parts of spirolactone and 0.25-13 parts of hydrochlorothiazide. The synergist disclosed by the invention is capable of creating a high-potassium low-sodium antihypertensive internal environment with moderate serum. The synergist is capable of increasing the pressure-reducing standard-reaching rate of an antihypertensive medicine and improving the stability and safety of the pressure-reducing effect of the antihypertensive medicine, stable in curative effect, few in adverse reactions and high in patient compliance.

The invention discloses a preparation method and application of near-infrared emission xanthene fluorescent dye with large Stokes shift. The preparation method has the advantages that xanthene fluorescent dye with maximum absorption wavelength exceeding 600 nm, maximum fluorescent emission wavelength exceeding 730 nm and Stokes shift exceeding 100 nm is designed and synthesized through a strategy of prolonging a xanthene conjugated system linearly, and the xanthene fluorescent dye is one of the fluorescent dyes with largest Stokes shift in the existing known rhodamine fluorescent dyes. According to a cell imaging experiment, the dye has good water solubility, biocompatibility, small biotoxicity and is used for positioning lysosome in a targeted mode. Besides, the dye structurally contains a spirolactone structure, and can be used as a near-infrared emission dye fluorescence reporter group to design various near-infrared emission fluorescence opening type biological fluorescent probes. In a word, the invention provides a design and synthesis method for the novel near-infrared emission xanthene fluorescent dye with large Stokes shift, and the novel near-infrared emission xanthene fluorescent dye is used for novel fluorescence probe design and development.

The invention pertains to a near-infrared fluorescent dye that is cell permeable and can be attached to selected proteins in living cells. The dye has the general formulaor its corresponding spirolactonewhereinY is chosen from the group consisting of Si, Ge and Sn;R0 is —COO− or COOH;R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, R12, R13, R14, R15 and R16 are substituents, including hydrogen, independently from each other.The dye (i) absorbs and emits light at wavelengths above 600 nm; (ii) possesses high photostability; (iii) has high extinction coefficients and high quantum yields; (iv) can be derivatized with different molecules; and (v) is membrane-permeable and shows minimal background binding to biomolecules and biomolecular structures.

A composite medicine for treating hypertension contains diuretic, a Ca-contained component and accessory which is acceptable in pharmacy, wherein the weight ratio between the diuretic and the Ca-contained component is in the range of 1:10-2000. The diuretic is chosen from furosemidum, ethacrynic acid, bumetanide, torasemide, hydrochlorothiazinde, chlorothiazide, hygroton, metolazone, quinethazone, triamterene, amiloride, spirolactone or acetazolamide, the Ca-contained component is chosen from shell, keel, inorganic Ca salt, organic Ca salt, etc, wherein the shell comprises concha margaritiferallsta, oyster, concha haliotidis or activative product calcium oxide; inorganic Ca salt and organic Ca salt comprise calcium chloride, Ca carbonate, Ca phosphate, Ca citrate, Ca lactate, Ca gluconate or Ca L-threonate .The composite medicine is capable of decreasing blood pressure by rapidly reducing blood volume, wherein the Ca-contained component can restrain the level of booster factors in body to enhance depressurization effects of the diuretic.

The invention relates to processes for obtaining steroids with a spirolactone group in position 17, particularly to industrially obtaining 6β,7β; 15β,16β-dimethylene-3-oxo-17α-pregn-4-ene-21,17-carbolactone, commonly known as Drospirenone, as well as to intermediates useful in said process.