Combined combination drug for resisting heart failure and application of combined combination drug in preparation of drug for resisting heart failure

A heart failure and drug technology, applied in the field of biomedicine, can solve the problems of large side effects and insufficient curative effect, and achieve the effect of reducing ROS content, increasing cell survival rate, and improving the effect of anti-heart failure
CN112089843AActive Publication Date: 2020-12-18HEFEI UNIV OF TECH
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
HEFEI UNIV OF TECH
Publication Date
2020-12-18

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Abstract

The invention discloses a combined combination drug for resisting heart failure and application of a steroid aldosterone receptor antagonist and beta-cyclodextrin in preparation of a drug for resisting heart failure. The combined drug contains a diluent, an adhesive, a disintegrating agent, an antioxidant, an emulsifier, a solubilizer, the steroid aldosterone receptor antagonist and beta-cyclodextrin. According to the combined combination drug for resisting heart failure, compared with drugs such as spirolactone, beta-cyclodextrin, nebivolol and amlodipine which are independently used, the combined combination drug of the steroid aldosterone receptor antagonist and beta-cyclodextrin can significantly increase the cell survival rate, can reduce the ROS content in cells treated by adriamycin, can significantly improve the antioxidant ability of the cells, and can further greatly improve the anti-heart failure effect of the drug.
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Description

technical field

[0001] The invention belongs to the technical field of biomedicine. More specifically, it relates to an anti-heart failure combined drug and the application of the combination of steroidal aldosterone receptor antagonist and β-cyclodextrin in the preparation of anti-heart failure drugs. Background technique

[0002] Heart failure (heart failure), referred to as heart failure, refers to the failure of the venous blood to fully discharge the heart due to cardiac systolic and / or diastolic dysfunction, resulting in blood stasis in the venous system and insufficient blood perfusion in the arterial system. Cardiac circulatory disorder syndrome, which is characterized by pulmonary congestion and vena cava congestion. The morbidity and mortality of heart failure among adults remains high worldwide, which may be due to the accelerated aging of the world-wide population and the increase in the number of acute cardiovascular events.

[0003] At present, combined drugs...

Claims

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