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Tinidazole and spirolactone cream and preparation method thereof

A technology of tinidazole spiro and ester cream, which is applied in the directions of ointment delivery, pharmaceutical formulation, emulsion delivery, etc., can solve the problems of gastrointestinal reactions, lack of curative effect, small side effects, etc., to promote transdermal absorption, improve Clinical efficacy, the effect of reducing sebum secretion

Inactive Publication Date: 2014-09-24
南充市中心医院
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, after many years of clinical application and observation, it has been found that long-term oral administration of sex hormones can cause unavoidable systemic side effects, and retinoic acid can also cause dryness and teratogenicity, so that its application is greatly limited, and topical antibiotics are harmful to the following Papules and pus-based mild inflammatory acne have the best effect, but are ineffective for acne and cystic acne. Most oral antibiotics can cause gastrointestinal reactions, and long-term oral administration can cause severe liver and kidney damage and other adverse reactions. Therefore, Clinically, there is a lack of acne treatment drugs with definite curative effect and less side effects
[0003] Regarding the tinidazole spironolactone cream recorded in the paper "Preparation and Quality Control of Tinidazole Spironolactone Cream" in "China Pharmaceutical Industry", there is poor stability, and the cream base has moderate sensitization to guinea pig skin , still can not achieve the best effect

Method used

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  • Tinidazole and spirolactone cream and preparation method thereof
  • Tinidazole and spirolactone cream and preparation method thereof
  • Tinidazole and spirolactone cream and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] A kind of tinidazole spironolactone cream, in 1000g, concrete formula is as follows: tinidazole 20g, spironolactone 3g, laurocapram 10g, stearic acid 30g, white vaseline 60g, sorbitan monostearate 10g, Cetyl alcohol 90g, light liquid paraffin 60g, sodium lauryl sulfate 10g, polysorbate-80 15g, propylene glycol 120g, sodium benzoate 5g, purified water 567g.

[0032] Its preparation method is as follows:

[0033] (1) Add sodium lauryl sulfate, polysorbate-80, and sodium benzoate to purified water to dissolve according to the above weight parts, heat to 70-90°C, and then add tinidazole to dissolve; add spironolactone to propylene glycol , heating and dissolving in a water bath; mixing the aforementioned two solutions and heating to 70-90°C to obtain a water phase;

[0034] (2) Stearic acid, white petrolatum, sorbitan monostearate, cetyl alcohol, and light liquid paraffin were mixed according to the above parts by weight, and heated to 70-90°C to obtain an oil phase;

[0...

Embodiment 2

[0037] A kind of tinidazole spironolactone cream, in 1000g, concrete formula is as follows: tinidazole 22g, spironolactone 2g, laurocapram 13g, stearic acid 27g, white vaseline 67g, sorbitan monostearate 7g, Cetyl alcohol 103g, light liquid paraffin 58g, sodium lauryl sulfate 12g, polysorbate-80 18g, propylene glycol 115g, sodium benzoate 3g, purified water 553g.

[0038] Its preparation method is as follows:

[0039] (1) Add sodium lauryl sulfate, polysorbate-80, and sodium benzoate to purified water to dissolve according to the above weight parts, heat to 70-90°C, and then add tinidazole to dissolve; add spironolactone to propylene glycol , heating and dissolving in a water bath; mixing the aforementioned two solutions and heating to 70-90°C to obtain a water phase;

[0040] (2) Stearic acid, white petrolatum, sorbitan monostearate, cetyl alcohol, and light liquid paraffin were mixed according to the above parts by weight, and heated to 70-90°C to obtain an oil phase;

[0...

Embodiment 3

[0043] A kind of tinidazole spironolactone emulsifiable paste, in 1000g, described formula comprises following raw material: tinidazole 16g, spironolactone 5g, laurocaprolactone 7g, stearic acid 35g, white vaseline 52g, sorbitan monostearate Ester 13g, cetyl alcohol 80g, light liquid paraffin 70g, sodium lauryl sulfate 7g, polysorbate-80 11g, propylene glycol 137g, sodium benzoate 7g, purified water 560g.

[0044] Its preparation method is as follows:

[0045] (1) Add sodium lauryl sulfate, polysorbate-80, and sodium benzoate to purified water to dissolve according to the above weight parts, heat to 70-90°C, and then add tinidazole to dissolve; add spironolactone to propylene glycol , heating and dissolving in a water bath; mixing the aforementioned two solutions and heating to 70-90°C to obtain a water phase;

[0046] (2) Stearic acid, white petrolatum, sorbitan monostearate, cetyl alcohol, and light liquid paraffin were mixed according to the above parts by weight, and heat...

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PUM

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Abstract

The invention discloses tinidazole and spirolactone cream and a preparation method thereof, in order to solve problems of current tinidazole and spirolactone cream, such as poor stability and moderate sensitization. According to the formula, the cream comprises tinidazole, spirolactone, laurocapram, stearic acid, albolene, sorbitol anhydride monostearate, hexadecanol, light liquid paraffin, lauryl sodium sulfate, polysorbate-80, propylene glycol, sodium benzoate and purified water. The cream disclosed by the invention can inhibit formation of acne through such links as inhibiting bacteria, diminishing inflammation and reducing sebum secretion, and has an excellent curative effect on inflammatory skin lesion and non-inflammatory skin lesion caused by acne.

Description

technical field [0001] The invention specifically relates to a tinidazole spironolactone cream and a preparation method thereof. Background technique [0002] At present, the treatment of acne at home and abroad mainly adopts sex hormones, vitamin A acids, antibiotics, etc. However, after many years of clinical application and observation, it has been found that long-term oral administration of sex hormones can cause unavoidable systemic side effects, and retinoic acid can also cause dryness and teratogenicity, so that its application is greatly limited, and topical antibiotics are harmful to the following Papules and pus-based mild inflammatory acne have the best effect, but are ineffective for acne and cystic acne. Most oral antibiotics can cause gastrointestinal reactions, and long-term oral administration can cause severe liver and kidney damage and other adverse reactions. Therefore, Clinically, there is a lack of acne treatment drugs with definite curative effect and ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/585A61K9/06A61K47/34A61K47/20A61K47/16A61K47/10A61P17/10A61K31/4164
Inventor 彭贤东唐志立龙凤曾友志李勇邓长明张燕李林谢军潘良平郝伟迤王洁
Owner 南充市中心医院
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