5results about How to "Promote transdermal absorption" patented technology

This invention discloses a liquid crystal cream with high penetration capability, its preparation method, and its application. The liquid crystal cream comprises: an oleophilic emulsifier, a hydrophilic emulsifier, long-chain fatty alcohols and esters, and the remainder being humectants, thickeners, chelating agents, emollients, preservatives, active ingredients, and deionized water. This invention's small liquid crystal moisturizing cream has an excellent skin feel, good absorption, is breathable and non-comedogenic, and can form a biomimetic moisturizing film with good skin affinity on the skin, enhancing skin hydration and moisturizing ability, effectively improving skin condition, and achieving the effect of protecting and repairing the skin barrier. The system exhibits good long-term stability and a complete liquid crystal structure. Furthermore, tests show that this small liquid crystal cream has a significant penetration effect on both oil-soluble and water-soluble active ingredients. It is expected to achieve better skincare effects by incorporating different active ingredients in the field of functional skincare cosmetics.

The application relates to a preparation method and application of a ginsenoside-loaded triple-assembled Pickering emulsion, and belongs to the biomedical technology field. In order to solve the problems that the Pickering emulsion constructed by natural active ingredients in the prior art has insufficient mechanical strength of an interface film, is easy to break and lose stability, has passive release behavior, lacks controllability and environmental responsiveness, and is difficult to realize precise release, a ginsenoside-loaded triple-assembled Pickering emulsion is provided. Through a three-step cascade strategy of "molecule-interface-function", a stable "metal-phenol coordination network" interface layer is constructed on the surface of oil droplets, the physical and chemical stability of the emulsion is fundamentally improved, a Pickering emulsion which is all-natural, highly stable and has a pH response intelligent release function is successfully constructed, and the triple-assembled Pickering emulsion has significant advantages in stability, controllable release and function integration, and provides a feasible technical strategy for a response type delivery system design based on natural products.

The present application relates to the technical field of supramolecular, in particular to a collagen supramolecule, a preparation method and application thereof, the collagen supramolecule is prepared by taking collagen, a stabilizer, an alcohol solvent, glycerol, an ionic liquid and water as raw materials, the preparation method of the collagen supramolecule is simple and easy to operate, and the prepared collagen supramolecule has high stability. Meanwhile, in the collagen supramolecule, the collagen can not only be used as one of active ingredients to improve the skin condition, but also be used as a carrier of active ingredients to improve the solubility and transdermal performance of various active ingredients including the collagen itself, so as to solve the defects in the prior art.

This invention discloses an anti-aging composition and its application in skincare products. The composition comprises lentil seed extract and β-nicotinamide mononucleotide; the anti-aging composition is prepared by a two-step process: aerobic fermentation with *Aspergillus oryzae* followed by anaerobic fermentation with *Bifidobacterium*. This invention achieves synergistic anti-aging effects by significantly inhibiting matrix metalloproteinase activity and promoting type I collagen synthesis through a multi-pathway synergistic effect of "anti-inflammatory, anti-oxidative, repair-energy-supply." The composition has high bioavailability, is mild and safe, and its preparation process is green and stable, making it suitable for skincare products such as creams and serums.

This invention discloses a plant essential oil microemulsion hydrogel fever-reducing patch and its preparation method. The fever-reducing patch comprises, by weight, phase A, phase B, an alkyl glycoside green surfactant system, and a hydrogel matrix; phase A consists of lavender essential oil, melaleucalyptus essential oil, cardamom essential oil, Roman chamomile essential oil, pine needle essential oil, and α-bisabolol; phase B consists of peony bark extract and peony root extract; the alkyl glycoside green surfactant system consists of alkyl glucoside, lecithin, and glycerol. This invention prepares phases A and B, along with the green surfactant system, into a microemulsion with a particle size of 20-60 nm, which is then mixed with the hydrogel matrix and coated onto a non-woven fabric backing layer to form the fever-reducing patch. This fever-reducing patch achieves a rapid, safe, and comfortable auxiliary fever-reducing effect through a synergistic effect of antiviral, anti-inflammatory, sedative, antispasmodic, and antipyretic mechanisms.