59results about How to "Promote transdermal absorption" patented technology

The invention belongs to the technical field of cosmetics, and particularly relates to a skin-color-uniformizing whitening composition derived from plant extracts and application of the skin-color-uniformizing whitening composition. The whitening composition provided by the invention is prepared from the following components in parts by weight: 10 to 15 parts of saussurea involucrata extract, 1 to 8 parts of dendrobium officinale extract, 1 to 5 parts of wood apple extract and 0.5 to 5 parts of banana fruit extract. The four plant extracts are synergistically compounded, transdermal absorption of active ingredients can be promoted, the tyrosinase inhibition rate is effectively increased, and the skin glossiness and whiteness are improved, so that the effects of whitening, brightening and uniformizing the skin color are achieved, the whitening composition is mild and non-irritant, the preparation method is simple and convenient to operate, and the whitening composition has large-scale production capacity and industrial feasibility. When the whitening composition is applied to skin care products such as face cream, the whitening and brightening effects of the face cream can be effectively improved, and the whitening composition has wide market application value.

The invention belongs to the technical field of functional foods and health foods, and particularly relates to an anti-saccharification and anti-aging aronia melanocarpa fruit composition and a preparation method thereof. The composition is prepared from the following raw materials in parts by weight: 150 to 400 parts of aronia melanocarpa fruit fermentation liquor, 10 to 80 parts of lycium ruthenicum, 10 to 80 parts of ginseng, 0.5 to 2.5 parts of grape seed extract, 10 to 70 parts of collagen peptide, 0.5 to 4 parts of sodium hyaluronate, 0.1 to 0.8 part of resveratrol and 0.03 to 0.3 part of yeast extract. The content of type I collagen peptide in the skin is increased, the generation of in-vitro anti-glycation end products is inhibited, and the anti-glycation and anti-aging effects are achieved.

The invention discloses a compound traditional Chinese medicine patch for conditioning hyperplasia of mammary glands and a preparation method thereof, and relates to the technical field of traditional Chinese medicine preparations. The compound traditional Chinese medicine patch for conditioning hyperplasia of mammary glands is prepared from an iron-based metal organic framework composite drug carrying system, dopamine hydrochloride, a blank gel matrix, ethyl oleate, menthol, a solubilizer, a wetting agent and water, the iron-based metal organic framework composite drug loading system is composed of traditional Chinese medicine dihydric alcohol plastid, iron-based metal organic framework nanoparticles and cinnamomum camphora essential oil. The traditional Chinese medicine dihydric alcohol plastid and the cinnamomum camphora essential oil are loaded in the iron-based metal organic framework nano particles, so that the transdermal absorption of the medicine is improved, the pH response release property is realized, the dosage of active ingredients permeating into a focus part and the lasting action time are effectively increased, and then a coating layer is formed by polydopamine, so that the anti-inflammatory effect is improved. The dispersibility and compatibility of the drug loading system in vivo are further enhanced, the drug effect can be fully exerted, and the treatment effect on the hyperplasia of mammary glands is remarkably improved.

The invention belongs to the technical field of cosmetic preparations, and particularly relates to a microcapsule emulsion containing collagen and a preparation method thereof. According to the invention, tranexamic acid is utilized to adjust the pH value and Zeta potential value of a collagen solution system, so that the collagen shows the characteristics of lowest solubility and lowest conductivity in a state close to an isoelectric point, the microcapsule preparation containing the collagen is successfully prepared, and the purposes of improving the stability and transdermal absorbability of the collagen and improving the bioavailability of the collagen are achieved. And the skin state is improved in a slow-release manner.

The invention relates to an aromatic soluble polymer microneedle as well as a preparation method and application thereof. The preparation method comprises the following steps: adding a zinc acetate hexahydrate aqueous solution and a Tris buffer solution into a eugenol-curcumin mixed ethanol solution to obtain self-assembled carrier-free nanoparticles containing eugenol and curcumin; and dissolving the nano-particles in a soluble hyaluronic acid solution, drying in a microneedle mold, and demolding to obtain the aromatic soluble polymer microneedle. The structure of the aromatic soluble polymer microneedle is that self-assembled carrier-free nanoparticles are wrapped in a soluble hyaluronic acid microneedle. Compared with the prior art, the aromatic soluble polymer microneedle prepared by the invention can overcome skin barrier and quickly absorb moisture and dissolve so as to promote the transdermal absorption effect of active substances; a perfume delivery system is constructed by using the soluble polymer microneedle, so that the biocompatibility is improved, the slow release control capability of the perfume can be effectively enhanced, and a new path is opened up for clinical application of inflammatory diseases.

The invention discloses glabridin liposome, a whitening product, a preparation method and application, and relates to the technical field of cosmetics. The glabridin liposome is prepared from the following components in percentage by mass: 0.5%-2.5% of glabridin, 1%-8% of phospholipid, 0%-1% of cholesterol, 10%-15% of liquid grease, 0.5%-1.5% of an emulsifier, 0.5%-1.5% of an antioxidant, 0.2%-1% of trehalose, 10%-30% of glycerol and the balance of water. Through innovation of the process and formula, the problems of instability of glabridin, non-uniformity of lipidosome and the like are solved, the encapsulation efficiency can be improved, the transdermal absorption capacity and stability can be improved, and the inhibitory activity on cell tyrosinase and melanin can be improved.

The invention relates to a preparation method of a cannabidiol nano-lipid carrier, in particular to a preparation method of a cannabidiol nano-lipid carrier with a transdermal absorption function. The invention aims to solve the problem that the existing cannabidiol lipid carrier cannot have high water solubility and high transdermal absorption function at the same time, and is poor in stability and easy to irritate skin. The method comprises the following steps: 1, weighing raw materials; 2, preparing an oil phase; 3, preparing a water phase; 4, mixing; 5, performing ultrasonic homogenization; 6, cooling; and 7, removing impurities. The preparation method is used for preparing the cannabidiol nano-lipid carrier with the transdermal absorption function.

The invention belongs to the field of cosmetics, and discloses a ceramide E-containing polypeptide composition and application thereof. The polypeptide composition containing ceramide E is prepared from the following components in parts by mass: 5 to 10 parts of ceramide E, 3 to 6 parts of fibronectin, 3 to 6 parts of palmitoyl pentapeptide-4, 1.5 to 3.5 parts of ergothioneine, 20 to 40 parts of oil-phase solvent, 1.5 to 4.5 parts of caprylic / capric triglyceride, 0.5 to 2.5 parts of soybean lecithin, 0.5 to 1.5 parts of polysorbate-80, 0.1 to 0.5 part of cholesterol and the balance of water, wherein the total mass part of the water is 100. In the polypeptide composition disclosed by the invention, ceramide E, fibronectin, ergothioneine and palmitoyl pentapeptide-4 are mutually promoted and have synergistic interaction, and a final product shows very good repairing and antioxidant effects.

The invention belongs to the technical field of medicines, provides an in-situ bubble generation hyaluronic acid composition for ultrasonic introduction and a patch thereof, and relates to the hyaluronic acid composition, a method for preparing and introducing the patch from the composition and an ultrasonic introduction method. The hyaluronic acid composition comprises the following raw materials: hyaluronic acid, a foaming agent and a penetration enhancer, the preparation method of the lead-in patch comprises the steps of mixing the components and applying. The ultrasonic leading-in method comprises the steps of setting ultrasonic leading-in instrument parameters and leading-in time, and carrying out specific ultrasonic leading-in operation. According to the ultrasonic introduction mode, bubbles are generated in situ, the efficiency is higher than that of pure ultrasonic introduction, and the concentration of hyaluronic acid in the articular cavity can be rapidly increased. Compared with hyaluronic acid injection administration, the administration technology is noninvasive, painless, good in clinical compliance, simple and convenient to operate and low in cost; compared with oral administration of hyaluronic acid, the composition has the advantages of good directionality, accurate and controllable action range and small gastrointestinal irritation.

The invention provides a double-fermentation thick skin factor liposome, a preparation method thereof and a cosmetic, and relates to the technical field of biomedical materials. The double-fermentation thick skin factor liposome comprises alkaloid, a double-fermentation thick skin factor, phospholipid and short-chain fatty alcohol, the dual-fermentation skinning factor comprises galactose yeast fermentation liquor, lactic acid bacteria NP and glycyrrhetinic acid. According to the double-fermentation thick-skin factor liposome provided by the invention, the double-fermentation thick-skin factor has excellent anti-aging and anti-aging effects, can remarkably improve the cell activity and enhance the skin barrier, and is prepared into a liposome form, and glycyrrhetinic acid in the double-fermentation thick-skin factor and sophocarpidine are utilized to form a supramolecular eutectic. The double-fermentation thick skin factor liposome has double advantages of the supramolecular eutectic solvent and the liposome, the double-fermentation thick skin factor is efficiently promoted to enter the skin, the skin residence rate is increased, and the local treatment effect is effectively improved to play the anti-aging effect of the double-fermentation thick skin factor liposome.

The invention belongs to the field of medical biology, and relates to a medical preparation, in particular to a nano supramolecular drug-loaded liposome and a preparation method thereof. The nano supramolecular drug-loaded liposome is prepared from the following raw materials in percentage by weight: 1 to 20 percent of active ingredient, 5 to 15 percent of lecithin, 20 to 40 percent of eutectic solvent, 0.1 to 10 percent of grease, 0.1 to 0.5 percent of cholesterol, 0.1 to 5 percent of emulsifier, 0.1 to 1.5 percent of stabilizer and the balance of deionized water, and the active ingredient is water-soluble VC (prototype VC). According to the invention, the active ingredients and the deep eutectic solvent are subjected to ultrasonic treatment to form a ternary supramolecular VC structure, and then the ternary supramolecular VC structure is wrapped, so that the stability of VC molecules in a solution state is greatly improved by virtue of dual clamping of supramolecules and lipidosome, the problem of oxidation discoloration of the VC molecules in a long-term storage process is improved, and the effect of VC in the cosmetic industry is better played.

The invention belongs to the technical field of chemistry, and particularly relates to a water-based stable transdermal preparation based on a structural nanoemulsion and a preparation method of the water-based stable transdermal preparation. 1% to 10% of a polyether block copolymer; 5%-20% of a co-emulsion; 0.1% to 15% of an active ingredient; and the balance of deionized water. Through a compounding system of an amino acid surfactant and a gemini surfactant and in combination with the synergistic effect of a specific polyether block copolymer, a nanoemulsion drug delivery system with a stable structure is constructed. Through a compound system of the amino acid surfactant and the gemini surfactant and by combining the synergistic effect of the polyether block copolymer, a nano-emulsion drug delivery system with a stable structure is constructed, and the nano-emulsion drug delivery system has good long-term storage stability and temperature adaptability, is not easy to layer and is uniform in particle size distribution.

The invention discloses a lifting, tightening and exfoliating composition as well as a soluble microcrystal and a preparation method thereof. According to the technical scheme, the skin care product is prepared from 0.2 to 1.2 parts of fructus perillae extract, 0.2 to 1.2 parts of rhizoma curcumae longae extract, 0.2 to 4 parts of XVII type collagen, 0.1 to 0.5 part of vitriol, 0.2 to 1.2 parts of gardenia extract, 5 to 20 parts of oxidized hyaluronic acid, 3 to 10 parts of algal polysaccharide, 3 to 10 parts of glycerol and 51.9 to 88.1 parts of ultrapure water. According to the microcrystal provided by the invention, the lifting, tightening and exfoliating composition is embedded in the oxidized hyaluronic acid soluble microcrystal needle body, so that the effects of improving the transdermal absorbability and slow release property of active components and reducing irritation are achieved, and the lifting, tightening and exfoliating effects are further improved; belongs to the technical field of daily chemicals.

The invention provides herbal ointment for relieving limpness, numbness and swelling pain and a preparation method thereof, and belongs to the technical field of medicines. The traditional Chinese medicine composition is prepared from the following raw materials: codonopsis pilosula, cinnamon, angelica sinensis, corydalis serrate, paeonia lactiflora, peony root bark, ligusticum chuanxiong hort, liquorice, fructus evodiae, caulis spatholobi, leonurus, rhizoma corydalis, garden balsam stem, radix aconiti carmichaeli, rhizoma atractylodis, lycopodium clavatum, cortex dictamni, ramulus mori, radix clematidis, rhizoma arisaematis, semen brassicae and notopterygium root. The herbal ointment for relieving limp, numb and swelling pain has the effects of promoting blood circulation to remove blood stasis, expelling wind and removing cold, relieving pain and clearing damp, expelling toxin and enhancing immunity, is good in transdermal absorption promoting effect, long in contact time with skin and lasting in acting effect, can well improve toothache and arthralgia caused by shoulder pain, cervical vertebra pain, waist soreness and back pain, stiff neck, dizziness, headache and excessive internal heat, and has the effects of relieving pain, relieving swelling pain, relieving pain and relieving swelling pain. , varicosity, sprain, bruise, limpness, numbness and swelling pain of limbs, and the like, and has a wide application prospect.

The invention relates to the field of biological medicines, in particular to application of [1, 1 '-biphenyl]-2, 4-diol in drugs for inhibiting melanoma cell proliferation. The invention proposes that the [1, 1 '-biphenyl]-2, 4-diol can inhibit the proliferation of melanoma cells for the first time, and the product is low in price, has a very good inhibition effect on the proliferation of the melanoma cells, has a very good transdermal absorption effect, can deeply inhibit the melanoma cells, and can inhibit the proliferation of the melanoma cells within the concentration range of inhibiting the melanoma cells. No irritation or injury is caused to the skin. The invention provides a theoretical basis for research and development of drugs for treating melanoma cell proliferation.

The invention belongs to the field of microneedle transdermal drug delivery, and particularly relates to an acupoint drug delivery soluble evodia rutaecarpa microneedle as well as a preparation method and application thereof in treatment of oral ulcer. The preparation method comprises the following steps: modifying effective biological components in fructus evodiae to obtain a solid dispersion, and then mixing the solid dispersion with a needle tip matrix to prepare the drug-loaded microneedle. Wherein the effective biological component in the fructus evodiae is evodiamine (EVO) or rutaecarpin (RUT). The medicinal evodia soluble drug-loaded microneedle is prepared, and the medicinal evodia soluble drug-loaded microneedle is attached to the pelma Yongquan acupoint to treat oral ulcer through matching of the medicinal evodia and the acupoint.

The invention relates to an extraction method of a transdermally absorbable tremella extract, and belongs to the technical field of fungus extraction. The tremella extract is obtained through warm water soaking, hydrogen peroxide pretreatment, two-stage fermentation, two times of extraction, composite enzymolysis and final ultrafiltration, the molecular weight of the tremella extract is gradually reduced through layer-by-layer treatment, and the tremella extract can be effectively applied to the fields of cosmetics and the like and has a good transdermal absorption effect.

The invention relates to traditional Chinese medicine gel for treating thyroid nodules from liver as well as a preparation method and application of the traditional Chinese medicine gel. The traditional Chinese medicine gel takes an extracting solution of a traditional Chinese medicine composition as an effective component in parts by weight, the traditional Chinese medicine composition comprises the following raw materials: 15-25 parts of selfheal, 10-20 parts of radix bupleuri, 8-15 parts of vinegar-processed curcuma zedoary, 8-15 parts of fructus forsythiae, 5-15 parts of thunberg fritillary bulb, 5-15 parts of moutan bark, 5-8 parts of scutellaria baicalensis, 5-10 parts of oyster, 3-8 parts of mint and 3-8 parts of borneol. From the perspective of soothing liver-qi stagnation, the thyroid nodules are treated by firstly soothing liver-qi stagnation and cooperating with phlegm reducing, stagnation resolving, blood circulation promoting and blood stasis removing, mint and borneol are added in the formula, and the overall improvement effect of the external medicine on unhealthy emotions such as depression and anxiety and the dissipation effect on the nodules are enhanced. Meanwhile, all the medicinal materials in the formula are classified, extracted and refined, all the effective components are reserved to the maximum extent, transdermal absorption is good, and the effects of reducing swelling, removing stasis and improving the depressive emotion are improved.

This invention relates to the field of cosmetics, specifically to a composition containing copper peptides for repairing photothermal damage and its application. The composition comprises a complex polypeptide, galactosomal yeast fermentation product filtrate, and cyanobacterial extract; wherein the complex polypeptide includes copper peptides, yeast polypeptides, and hexapeptide-11. This invention, by combining specific complex polypeptides with galactosomal yeast fermentation product filtrate and cyanobacterial extract, increases the expression level of heat shock proteins, thereby achieving excellent efficacy in repairing photothermal damage. Furthermore, this composition is mild and non-irritating, and can be widely used in cosmetics.

This invention discloses a liquid crystal cream with high penetration capability, its preparation method, and its application. The liquid crystal cream comprises: an oleophilic emulsifier, a hydrophilic emulsifier, long-chain fatty alcohols and esters, and the remainder being humectants, thickeners, chelating agents, emollients, preservatives, active ingredients, and deionized water. This invention's small liquid crystal moisturizing cream has an excellent skin feel, good absorption, is breathable and non-comedogenic, and can form a biomimetic moisturizing film with good skin affinity on the skin, enhancing skin hydration and moisturizing ability, effectively improving skin condition, and achieving the effect of protecting and repairing the skin barrier. The system exhibits good long-term stability and a complete liquid crystal structure. Furthermore, tests show that this small liquid crystal cream has a significant penetration effect on both oil-soluble and water-soluble active ingredients. It is expected to achieve better skincare effects by incorporating different active ingredients in the field of functional skincare cosmetics.

The present invention relates to a method for preparing quercetin liposomes, comprising the following steps: (1) adding quercetin, lecithin, ceramide and cholesterol to a solvent for mixing, and performing vacuum rotary evaporation to obtain an oil phase; (2) preparing a PBS buffer, adding polyethylene glycol, and mixing uniformly to obtain a PBS-PEG solution, i.e., an aqueous phase; (3) adding the aqueous phase to the oil phase, heating in a water bath, and then emulsifying to obtain quercetin liposomes. The quercetin liposomes obtained by the present invention have a small particle size and uniform distribution, a high encapsulation rate, are conducive to transdermal absorption, and have good market application prospects.

The present application belongs to the technical field of cosmetic production, and discloses an acid-free acne-removing composition, comprising 10-20% of dipeptide-15, 1-5% of olive leaf extract, 5-10% of acetyl glucosamine, 0.1-1% of 10-hydroxydecanoic acid, 5-10% of yeast / zinc fermentation product, 1-5% of bisabolol, 5-10% of tetrahydromethylpyrimidine carboxylic acid, 1-10% of capryloyl glycine, 0.01-1% of polylysine, 28-32% of polyol and the balance of deionized water. Through the synergistic effect among the above multiple components, the antibacterial ability of the composition and the inhibitory effect on inflammatory factors 1L-1α and 5α-reductase are further improved. Moreover, the composition disclosed in the present application also has good anti-allergic ability. In addition, the present application also discloses the application of the acid-free acne-removing composition and a daily chemical product.

The present invention provides a natural skin care hydrogel for pet wounds and a preparation method and application thereof, wherein the raw materials for preparing the hydrogel include: a gel forming agent, a moisturizing agent, aloe polysaccharide, zinc hyaluronate, saccharic acid, laurocapron, zinc gluconate, vitamin E, vitamin B, PEG-40 castor oil, polyethylene glycol, triethanolamine, mint essence, ethyl hydroxybenzoate and deionized water. The natural hydrogel matrix screened out by the present invention can absorb and retain a large amount of water to form a soft, elastic and transparent gel-like substance; the gel has a uniform appearance and has the dual effects of hydration and absorption, and has good gel network mechanical properties, density, apparent viscosity, water absorption and moisturizing air permeability, can keep the wound surface moist and have the dual effects of hydration and absorption, autonomously moisturize the wound surface to promote epidermal growth and epithelial regeneration, prolong the contact time with the skin, and improve the absorption of effective substances; the physicochemical properties are stable, and it is a very ideal skin dressing for external use.

The invention belongs to the technical field of traditional Chinese medicine patches, and particularly relates to a traditional Chinese medicine transdermal patch for treating radiation enteritis and a preparation method thereof. Traditional Chinese medicines such as radix paeoniae alba, radix scutellariae, radix angelicae sinensis, cortex cinnamomi, areca nuts, radix glycyrrhizae preparata, radix et rhizoma rhei, rhizoma coptidis, radix aucklandiae, herba andrographitis, red clover and caulis polygoni multiflori are firstly subjected to water bath and ultrasonic extraction and then are subjected to secondary fermentation, lactobacillus reuteri and streptococcus thermophilus are probiotics, and the probiotics are added so that intestinal flora balance can be adjusted; by combining the penetration enhancer and the cosolvent, the transdermal absorption performance of the medicine can be improved, so that the medicine can more easily penetrate through the skin barrier and reach the treatment part, the bioavailability is improved, the synergistic interaction effect is generated, and the treatment effect is improved through multi-target treatment. The traditional Chinese medicine composition has the functions of comprehensively improving the symptoms of radiation enteritis, improving the treatment effect, effectively improving intestinal microcirculation, regulating intestines and viscera and the like.

The present invention belongs to the field of pharmaceutical preparations, and in particular to a loxoprofen sodium gel patch and a preparation method thereof. The loxoprofen sodium gel patch comprises a backing layer, a drug storage layer and a protective layer from top to bottom in sequence; wherein, the raw materials of the drug storage layer include: loxoprofen sodium emulsion, a gel matrix and a pH regulator; by weight, the raw materials of the gel matrix include: 20-30 parts of sodium polyacrylate, 5-10 parts of acrylic acid grafted starch 300, 0.5-1 parts of triethanolamine, 15-20 parts of gelatin, 0.5-5 parts of sodium edetate, 0.5-2.5 parts of a cross-linking agent, 1-5 parts of a filler, 25-35 parts of a moisturizer, 0.05-1 parts of an antibacterial agent, 0.005-1 parts of an antioxidant and 40-50 parts of water. The loxoprofen sodium gel patch prepared by the prescription and process of the present invention not only ensures constant release and transdermal absorption of the drug, but also has excellent stability.

A far-infrared weak-magnetic hot compress instrument comprises a control host and a far-infrared weak-magnetic heating bag, the control host is provided with a timing control circuit and a voltage control circuit group, the voltage control circuit group comprises at least two voltage control circuits which are electrically connected with the far-infrared weak-magnetic heating bag respectively, and the far-infrared weak-magnetic heating bag is electrically connected with the timing control circuit. The timing control circuit controls voltage output within set time, the far infrared weak magnetic heating bag comprises an outer cloth bag and a heating inner container sewn in the outer cloth bag, and the heating inner container comprises an eddy current heating coil, far infrared carbon fiber cloth, heat reflection tin cloth, a weak magnetic heat conduction piece and soaking cotton cloth. The outer cloth pocket is provided with a first hook-and-loop fastener bonding position used for fixing the herbal medicine bag. According to the utility model, a far infrared heat source is applied to stimulate the medicine property of Chinese herbal medicine, and meanwhile, cells at an affected part are activated through a uniform low-intensity magnetic field fully covering the affected part, so that different requirements and diversified fusion of different affected parts when a plurality of elderly people at home use herbal medicine bags for hot compress physiotherapy at home are met.

The present invention discloses a method for preparing a polysaccharide extract of Dendrobium officinale. The specific steps include: after the Dendrobium officinale is roughly crushed, it is firstly extracted with water, filtered and separated, extracted 1 to 3 times, the drug residue collected after filtration is crushed and then extracted with water for the second time, centrifuged and separated, extracted 1 to 2 times, and the centrifuge liquid is collected; then dried to obtain a polysaccharide extract B of Dendrobium officinale; the polysaccharide extract B of Dendrobium officinale is an extract containing polysaccharides with a molecular weight of 1.5 million to 2.5 million. The method of the present invention solves the technical defects of the existing water extraction technology, realizes the simultaneous extraction of polysaccharides of Dendrobium officinale with different molecular weights, solves the technical defects of difficult extraction of fine powder and high energy consumption, and also solves the technical defect of low extraction rate of coarse powder. The method of the present invention is simple to operate, easy to be applied in industrial production, and has a very high market application prospect.

The application discloses an extraction method of sturgeon oil with skin repair function, which comprises the following steps: S1, preparation of crude fish oil of fish fat; S2, preparation of crude fish oil of fish liver; S3, preparation of crude fish oil of fish skin; S4, degumming and deacidification; and S5, refining. The fish oil extracted from different parts of sturgeon is mixed according to a specific proportion, the fish fat fish oil, the fish liver oil and the fish skin oil are mixed, and three kinds of functional components are added in the extraction process respectively, i.e. dihydroquercetin (providing antioxidant protection), phosphatidylserine (enhancing cell membrane repair and nutrient absorption) and curcumin (bringing anti-inflammatory and whitening effects), so that a multiple synergistic formula system is formed, and the prepared sturgeon oil is significantly enhanced in the repair function on the skin, and the bioavailability and stability of the product are improved.

The invention relates to the technical field of supramolecules, in particular to a ginsenoside CK-aescin supramolecule, in the supramolecule, ginsenoside CK and aescin are formed through a non-covalent bond, the mass ratio of ginsenoside CK to aescin is 1: (1-25), and a preparation method comprises the following steps: dispersing aescin in an organic solvent aqueous solution to prepare a suspension A, dissolving ginsenoside CK in ethanol to prepare a solution D for later use; stirring the suspension A to obtain a suspension B; performing ultrasonic treatment on the suspension B to obtain emulsion C; slowly adding the emulsion C into the solution D while stirring, stirring to obtain a ginsenoside CK-aescin supramolecular solution crude product, and dialyzing. According to the ginsenoside CK-aescin supramolecule prepared by the invention, an IVPT test shows that the transdermal absorption capacity of the ginsenoside CK-aescin supramolecule is remarkably improved, so that the ginsenoside CK-aescin supramolecule can be better absorbed by human skin, and the efficacy of the ginsenoside CK-aescin supramolecule is favorably exerted.

The application relates to a preparation method and application of a ginsenoside-loaded triple-assembled Pickering emulsion, and belongs to the biomedical technology field. In order to solve the problems that the Pickering emulsion constructed by natural active ingredients in the prior art has insufficient mechanical strength of an interface film, is easy to break and lose stability, has passive release behavior, lacks controllability and environmental responsiveness, and is difficult to realize precise release, a ginsenoside-loaded triple-assembled Pickering emulsion is provided. Through a three-step cascade strategy of "molecule-interface-function", a stable "metal-phenol coordination network" interface layer is constructed on the surface of oil droplets, the physical and chemical stability of the emulsion is fundamentally improved, a Pickering emulsion which is all-natural, highly stable and has a pH response intelligent release function is successfully constructed, and the triple-assembled Pickering emulsion has significant advantages in stability, controllable release and function integration, and provides a feasible technical strategy for a response type delivery system design based on natural products.