839results about How to "Promote transdermal absorption" patented technology

A phototherapy light cap is a flexible, generally hemispherical cap having a light source to supply suitable dosage requirements of current and future light therapies. The phototherapy light cap may also include a rechargeable battery source, a light source or an array of light sources, a light diffuser and an interface to a recharging source that may be a docking station. A phototherapy light cap may alternatively be an insert for any commercial head dressing, preferably adapted for convenient recharging. Combining the use of a phototherapy light cap with gelatinized therapeutic agents provides a suitable treatment technique for a scalp utilizing phototherapy, heat and any suitable combination of active ingredients such as minoxidil.

Disclosed is an external preparation composition having good transdermal absorbability. An external preparation composition having excellent transdermal absorbability can be produced by dissolving a medicinal substance or a salt thereof in a fatty acid-based ionic liquid to form a composite ionic composition of the medicinal substance. The external preparation composition can be used as a liquid preparation, an ointment, a cream, a plaster or the like, and enables to provide a preparation having excellent transdermal absorbability.

The problem of the invention is to provide a drug-containing patch which is very favorable in percutaneous absorbability and is excellent in sustainability of the drug efficacy, that is, the drug-containing patch having a sufficient percutaneous absorbability and effect sustainability in a degree to be actually used for therapy of patients. The problem is solved by a patch comprising a drug, a melting point lowering agent and an adhesive base.

The invention provides a special private care wet tissue for women. The private care wet tissue is produced through the following steps of: preparing a wet tissue stock solution from a nanosilver solution, water soluble vitamin E, hyaluronic acid, lauric acid modified superoxide dismutase, chamomile flower water, a hydrolyzed pearl solution, a saponin extract, 1,2-propylene glycol, isothiazolinone and deionized water at a certain ratio; evenly and dropwise adding the wet tissue stock solution on a nonwoven spunlace membrane; then hermetically packaging the nonwoven spunlace membrane. For use, the special private care wet tissue for women provided by the invention only needs to be put to flatly cover the private part of a woman, and after a short wait, the wet tissue is used for wiping the private part of the women back and forth a plurality of times. The private care wet tissue special for women provided by the invention is capable of sterilizing and disinfecting the private part of the woman, and also capable of moisturizing and cleaning the skin of the private part; the private care wet tissue has no any side effect and no any irritation.

The present invention provides a transdermal patch having excellent preservation stability and transdermal absorbency of DMAEs. The patch has a support and a plaster layer integrally laminated on one surface of the support, and the plaster layer includes: DMAEs; an acrylic adhesive prepared by copolymerizing monomers respectively containing 30 to 99% by weight of alkyl methacrylate having an alkyl group with a carbon number of 6 to 22 and 1 to 70% by weight of alkyl acrylate having an alkyl group with a carbon number of 2 to 20; and fatty acid ester prepared by dehydro-condensing saturated fatty acid having an alkyl group with a carbon number of 10 to 20 and saturated aliphatic monohydric alcohol having an alkyl group with a carbon number of 2 to 20, wherein solubility of the DMAEs is 0.05 to 5 g at 25° C. with respect to the fatty acid ester.

The invention provides a multi-moisturizing double-layer makeup remover. The multi-moisturizing double-layer makeup remover is characterized by being prepared from, by weight, 20%-35% of grease, 1%-15% of alcohol moisturizer, 0.25%-2.5% of sugar moisturizer, 0.01%-0.25% of macromolecular moisturizer, 5%-20% of surfactant, 0.25%-2.5% of natural moisturizing factors (NMF), 0.1%-0.6% of preservative, 0.1%-0.4% of anti-allergic agent and the balance deionized water. The double-layer makeup remover greatly integrates cleansing oil and cleansing water and adopts an oil-water separation structure, the bottom layer is water, and the upper layer is oil. Before the makeup remover is used, the makeup remover is needed to be shaken to be uniform, the water-oil proportion is adjusted to reach the state that the makeup remover is non-irritant to the skin, the advantage of string makeup removing capability of the cleansing oil is played, and a mild and non-irritant effect is also achieved. In addition, the composite moisturizing system formed by four different types of moisturizing components serves as a whole, the defect that single moisturizing components are not comprehensive and not remarkable in effect is greatly overcome. Furthermore, the invention further provides a preparation method of the multi-moisturizing double-layer makeup remover.

The invention relates to a novel passive targeting nano emulsion with skin whitening effect and a preparation method thereof. The invention uses a novel passive targeting transdermal delivery dosing system TDDS-nano emulsion as a carrier of a function component for whitening or lighting the skin, uses different physical and chemical properties, action mechanism and actual effect of each skin whitening function component, especially the action advantages of certain novel skin whitening function components, and provides skin whitening effect nano emulsion systems with two joint applications in morning and evening matched with each other. The two joint applied nano emulsion systems not only have minimum spherical grains, extremely even distribution of nano-scale grains, remarkable passive targeting function, good transdermal absorption and strong penetrability, but also have extremely even, exquisite, smooth and glossy texture of the nano emulsion, is quite comfortable after coating on the face or the skin, has no stimulus and good stability; and the nano is light yellow, beautiful in appearance, bright and transparent, clear and crystalline, has light opalescence, and is adhesive but not sticky, thick but not heavy, oily but not greasy.

Disclosed is an antifungal agent for external use, which is characterized by containing a compound represented by the general formula (1), 50 to 95 mass % of an alcohol such as ethanol, 0.1 to 35 mass % of water or the like, and 0.01 to 5 mass % of a cellulose thickening agent. X is a halogen or H.

The invention relates to a traumatic injury analgesic cataplasm and a preparation method thereof, the traumatic injury analgesic cataplasm is produced by formula raw materials of traumatic injury analgesic paste according to the process of the cataplasm and comprises a hydrophilic gel matrix, a non-woven fabric back-up material and a traumatic injury analgesic paste drug, and the traumatic injury analgesic paste drug consists of ground beetle, crude kusnezoff monkshood, nux vomica (stir-fried), rhubarb, rosewood heart wood, shinyleaf pricklyash root, baical skullcap root, amur corktree bark, giant knotweed rhizome, borneol, camphor, menthol, peppermint oil and methyl salicylate. The soluble matrix of the cataplasm has good compatibility with water-soluble and fat-soluble drugs, and the drug loading of the matrix is great, thereby being very applicable to medication features of multiple components and large dose of traditional Chinese medicine; compared with an adhesive plaster agent, the cataplasm is easier to soften the horny layer of skin, is conductive to transdermal absorption of the drug and has better air permeability, adhesion to the skin and moisture retention, thereby having the advantages of comfortable use, small irritation to the skin, repeated tearing and pasting, no pollution of clothes, no residue, no pain when tearing after the use and the like.

The invention discloses a method for preparing ultra-low molecular weight hyaluronic acid oligosaccharides and a salt thereof through combination of solid-liquid biphasic enzymolysis and ultrafiltration. The method comprises the following steps: degrading hyaluronic acid and a salt thereof by utilizing hyaluronidase produced by bacilli; preparing high-concentration hyaluronic acid enzymatic hydrolysate by adopting the method of combining a solid-liquid biphasic enzymolysis system and an ultrafiltration system, and then performing inactivating, activated carbon adsorption and impurity removal,filtering and spray-drying to obtain the ultra-low molecular weight hyaluronic acid oligosaccharides and the salt thereof with the molecular weight of less than or equal to 3 kDa. The product preparedby the method is high in stability, ultra-low in molecular weight, good in inflammation resistance and percutaneous absorptivity, high in purity, strong in oxidation resistance, does not have cytotoxicity, has the advantages of repairing skin cell damage and the like, and can be widely applied to the fields of cosmetics, food and medicines. According to the method, the process flow is easy to operate; conditions are mild; various alcohols are not used; the energy consumption is relatively low; the method does not have damage to a product structure, does not have environmental pollution, and is suitable for large-scale industrial production.

The invention discloses a medical gel, which is composed of the following components and their weight ratio: 10%-60% magnesium sulfate, 0.01%-5% plant extract, 0.5%-15% glycerin, 0.1%-5% ethanol , 0.5%-20% hydrophilic polymer material, 0.5%-15% PEG40-hydrogenated castor oil, 0.001%-5% antibacterial agent, and the balance is purified water; Antibacterial, anti-inflammatory and analgesic plant extracts. The invention also discloses a gel wet compress prepared by using the medical gel and a preparation method thereof. The medical gel of the invention has the effects of removing edema, reducing inflammation, relieving pain, inhibiting bacteria, protecting skin, etc., is non-irritating to human body, is safe to use, has quick onset and good curative effect.

The invention belongs to the fields of enzymology and pharmaceutical chemistry, and relates to the low molecular hyaluronate, preparation method and purpose thereof. Concretely, the preparation method comprises a degradation step of hyaluronic acid or salt thereof whose molecular weight is greater than 1000 kDa by hyaluronidase prepared by Bacillus spp whose preservation number is CGMCC No. 5744 or SEQ ID No:2 coded hyaluronidase. The preparation of low molecular hyaluronic acid or salts thereof by using hyaluronidase produced by Bacillus spp of the present invention has the advantages of simple operation, mild condition, non-destroy of the product structure and low cost. The product is suitable for large scale industrialized production. The low molecular hyaluronate prepared by the invention has the advantages of good transdermal absorbency, good purity, non-cytotoxicity, good antioxidation, etc., and can be used in the fields of cosmetic, foodstuff and medicine.

[Summary] An external preparation formulation superior in the transdermal absorbability has been desired as a new administration route of aripiprazole. Transdermal absorption of aripiprazole has been enabled for the first time by appropriately combining aripiprazole and an organic acid (particularly fatty acid with low lipophilicity). That is, it has been found that more superior transdermal absorbability can be achieved by forming a salt by using a compound showing lipophilicity within the range of −1.5-2, such as fatty acid and the like. It has been further found that the transdermal absorbability is remarkable improved by appropriately selecting the solvent composition. As a result, since a new dosage form of aripiprazole other than oral preparation has been developed, a new transdermal absorption preparation of aripiprazole can be provided.

A remote treatment delivery system comprising a substantially non-skin piercing dosage projectile containing a biologically active agent and a transdermal carrier.

The invention belongs to the technical field of medicinal preparations and relates to a tripterygium glycoside-containing micro-emulsified gel transdermal preparation and a preparation method thereof. The preparation method is characterized in that a gel matrix is added into microemulsion and the mixture is further processed into the tripterygium glycoside-containing micro-emulsified gel transdermal preparation. The tripterygium glycoside-containing micro-emulsified gel transdermal preparation comprises: by mass, 0.1 to 15% of tripterygium glycoside, 15 to 20% of one or more surfactants, 30 to 40% of one or more auxiliary surfactants, 15 to 25% of oil phases, 15 to 25% of water, 0.5 to 2% of one or more transdermal absorption promoters, and 0.5 to 5% of one or more gel base materials. Thetripterygium glycoside-containing micro-emulsified gel transdermal preparation is semitransparent or transparent, has nattier blue opalescence and a pH value of 6 to 10 and can form micro-emulsion having particle sizes of 10 to 100nm, can be processed into pasters so that drug transdermal delivery is realized, has low skin irritation, can be prepared by the simple preparation method, and has stable quality and good drug transdermal absorption promotion performances.

The invention discloses a spontaneous heating moxibustion patch. The spontaneous heating moxibustion patch comprises a back lining layer, a spontaneous heating iron powder bag, a traditional Chinese medicine cataplasm layer and anti-adherent membranes, wherein the two end portions of the back lining layer are each provided with a medical pressure-sensitive adhesive in an adherent mode, and the spontaneous heating iron powder bag is attached to a middle position of the back lining layer; the spontaneous heating iron powder bag generates heat once in contact with air; the Chinese medicine cataplasm layer is attached to the spontaneous heating iron powder bag; the medical pressure-sensitive adhesives and the Chinese medicine cataplasm layer are each provided with an anti-adherent membrane with an adherent mode; the Chinese medicine cataplasm layer is composed of a substrate and a hydrogel layer smeared on the substrate; the substrate is attached to the spontaneous heating iron powder bag; the hydrogel layer is composed of a hydrogel matrix and a medicament; and the two end portions of the back lining layer, after being folded, wrap the middle position of the back lining layer, and thus the spontaneous heating moxibustion patch is obtained. According to the spontaneous heating moxibustion patch, the traditional Chinese medicine cataplasm layer comprises an Artemisia leaf pure dew emulsion with micromolecule terpenoids as its main components, and the micromolecule terpenoids can penetrate human skin quite easily and can penetrate the human skin more successfully under the effect of the spontaneous heating iron powder bag and a penetration enhancer so as to be absorbed by a human body.

An externally-applied skin pasting film is composed of a water-soluble polymer material, a function additive and distilled water, and concretely comprises sodium polyacrylate, cross-linked polyacrylate, polyvinyl alcohol, sodium alginate, sorbitol, citric acid, glycerin, the function additive and distilled water, wherein the function additive is anyone of or a mixture comprising several of a skin humectants, a skin whitening agent, a cutin softener, a skin anti-wrinkling agent and a skin reparing agent; the skin humectant is anyone of or a mixture comprising several of chondroitin sulfate, allantoin, elastin, lactic acid, hyaluronic acid, sodium alginate, chitosan, chitin, casein, soybean protein, wheat gluten protein and lactalbumin; and the function additive is processed to prepare a water-soluble polymer system, has the characteristics of large drug loading, good biocompatibility with skins, no excitation, no allergy, comfortable application and the like, simultaneously enhances the hydration of the skins and the percutaneous absorption of functional substances, and improves the percutaneous absorption effect.

An exterior-applied ointment for treating thyroidism is prepared from glucocorticoid, thyroidism-resistant medicines, percutaneous promoter, oily matrix, water-soluble matrix, and distilled water.

The invention relates to a high skin retention ceramide nano composition, and a preparation method and applications thereof. The high skin retention ceramide nano composition is composed of, by mass, 0.5 to 8.0% of ceramide, 3.0 to 10.0% of phospholipid, 0.5 to 5.0% of cholesterol, 0.5 to 5.0% of octyldodecanol, 0.5 to 5.0% of D-alpha-tocopheryl polyethylene glycol 1000 succinate, 10.0 to 30.0% of a polyalcohol, and the balance purified water. According to the preparation method, an oil phase prepared from ceramide, phospholipid, cholesterol, and octyldodecanol is added into a water phase prepared from D-alpha-tocopheryl polyethylene glycol 1000 succinate, the polyalcohol, and purified water dropwise; and an obtained mixture is subjected to high speed shear emulsification and high pressure homogenization or high pressure microfluidic equipment treatment. Drug loading capacity of the high skin retention ceramide nano composition is large; transdermal delivery of ceramide, and high concentration long time retention are promoted; stability and safety are high; the preparation method is simple, and is convenient to control; and the preparation method is suitable for industrialized production.

The invention relates to the technical field of medicines, in particular to a novel electret microneedle transdermal drug delivery system. The system comprises an isolation layer and a drug-containing pressure-sensitive adhesive layer arranged on the inner side of the isolation layer, wherein an electret layer made from an electret material is arranged on the outer side of the isolation layer; a controlled-release membrane layer is arranged on the inner side of the drug-containing pressure-sensitive adhesive layer; the electret layer, the isolation layer, the drug-containing pressure-sensitive adhesive layer and the controlled-release membrane layer are arranged in sequence from outside to inside to form a reservoir type patch; a microneedle array layer is arranged on the inner side of the reservoir type patch and comprises a microneedle array formed by a plurality of microneedles; each microneedle is 20-50 microns in diameter; and the spacing between every two adjacent microneedles is 1-1.5mm. According to the system, a drug can conveniently penetrate the skin by optimizing microneedle structure and arrangement; and when the system is used, the microneedles act on the skin firstly, the drug quickly penetrates the skin through the needle holes of the microneedles, and the electret layer accelerates drug penetration to achieve a treatment effect.

The invention relates to a triad integration freckle-removing functional nano cream for skin external use and a method for preparing the same. The three types (night use type, daytime use type and auxiliary type) freckle-removing nano creams improve and optimize a novel international passive target transdermal drug delivery system (TDDS) as a carrier, and organically combine and solubilize freckle-removing functional components with different biological efficacies, action ways and physical and chemical properties to form a good mutual aid synergic function system which has remarkable effect of controlling and relieving colored patches (such as chloasma, inflammatory pigmentation, sunburn, and the like) caused by abnormal facial metabolism of pigment. The product has the advantages of tiny particle sizes of spherical particles, obvious passive target function, excellent adaptability, homodromous property, fluidity and dispersion, strong penetrability, even texture, subtleness, lubricity and luster, is simple and convenient to use, and is comfortable without pungency and side effects; besides, the appearance is light yellow with slight opalescence, is glittering and translucent, clear and transparent, sticky but not viscous, thick but not dense, and oily but not greasy, has good stability, excellent curative effect, short industrialization cycle and high production efficiency, saves time, materials and energy sources, dose not need special devices and heat energy, and is easy for popularization and application.

The invention discloses a cosmetic composition containing gold collagen. The cosmetic composition consists of nano-gold particles, collagen hydrolysate, phospholipids, 1,3-butanediol, hexanediol, pentanediol, ethylhexyl glycerin and a skin conditioning component. On one hand, nano-gold plays roles of activating superoxide dismutase, eliminating hydroxyl free radicals, promoting the proliferation of human epidermal cells and resisting decrepitude; on the other hand, the nano-gold particles, collagen hydrolysate and phospholipids are uniformly dispersed according to a microjet technology, interact and are combined through a charge or other ways; the nano-gold particles and the phospholipids have excellent affinity on skin cells and interact to promote the percutaneous absorption of small-molecule collagen hydrolysate, replenish collagen as well as related polypeptides and amino acids, promote skin repairing and collagen synthesis, so as to achieve skin repair effects of delaying skin aging and improving skin health.

The invention relates to an antioxidant network efficacy nanoemulsion externally used for skin and a preparation method thereof. The nanoemulsion consists of the following raw materials according to weight mixture ratio: 1.0-1.5 of vitamin E, 2.0-3.0 of glutathione, 2.0-2.5 of L-ascorbic acid-2-heteroside, 1.0-1.8 of seabuckthorn oil, 1.0-1.6 of coenzyme Q10, 0.5-0.6 of alpha-lipoic acid, 8.0-10 of isopropyl myristate, 20-25 of caprylic acid capric acid polyethylene glycol glyceride, 7.0-9.0 of polyglyceryl fatty acid ester, 0.5-1.0 of azone, 46-50 of triple distilled water, 0.05-0.25 of citric acid and 1.0-1.6 of sodium citrate. The functional ingredients in the formula can form an antioxidant network system with cooperative interaction, synergy and regeneration, and the penetrating function of a nanoemulsion carrier system greatly enhances the antioxidant function and effect of the functional ingredients. The preparation method can enhance the stability and effectiveness of antioxidant, is simple in preparation technology and easy for scale production, needs no extra energy, saves time, energy and raw materials and is beneficial to environment protection.

The invention discloses a method for preparing a hyaluronate oligomer according to a digestion method, a prepared hyaluronate oligomer and an application thereof. Bacillussp. A50 CGMCC NO.5744 is fermented and cultured, thereby obtaining Bacillussp hyaluronidase for degrading hyaluronic acid or salt solution thereof. The method comprises the following steps of: preparing a solution of the hyaluronic acid or salt solution thereof; performing enzymolysis; inactivating; filtering; depositing; and dewatering and drying. According to the invention, the Bacillussp hyaluronidase generated by the Bacillussp is utilized to degrade the hyaluronic acid or salt thereof; the hyaluronate oligomer is prepared according to the steps of dezymotizing, ethanol precipitation, dewatering and drying; the method is simple in operation, mild in condition, free from damage to product structure and free from environmental pollution; the cost of the hyaluronidase as a fermentation source is low; the method is suitable for large-scale industrial production; the prepared hyaluronate oligomer has the advantages of excellent transdermal absorption property, high purity, zero cytotoxicity, strong oxidation resistance, and the like; and the hyaluronate oligomer can be applied to the fields of cosmetics, food and medicines.

An epidermal needle device for beautifying skin is composed of a sheet-type bearing body and a needle array on said bearing body. Said needles can pass through the horny layer of skin but not in dermis layer, and are prepared from monosilicon material through etching, or from high-molecular material or other materials. With said device, the skin-beautifying nutrients, such as collagen, elastin, coenzyme Q10, etc, can be percutaneously absorbed by skin.

An external preparation containing the following components (A), (B), (C), and (D):(A) a non-steroidal analgesic / anti-inflammatory agent,(B) a terpene and / or an essential oil containing a terpene,(C) a higher alcohol, and(D) a polyoxyalkylene alkyl ether and / or a polyoxyalkylene alkenyl ether. The external preparation of the present invention has improved skin permeation, and can thus be effective at a low concentration, and also has excellent appearance.

The invention discloses a composition for improving skin color and a whitening cosmetic. The composition comprises tranexamic acid, acetyl chitosamine and beta-nicotinamide mononucleotide. The tranexamic acid, the acetyl chitosamine and the beta-nicotinamide mononucleotide are compounded, the beta-nicotinamide mononucleotide is combined with the tranexamic acid and the acetyl chitosamine, pigmentation caused by ultraviolet rays or other skin irritation can be inhibited, and skin pigmented spots related to pigmentation are effectively prevented or improved. The acetyl chitosamine can improve transdermal absorption of effective components such as the tranexamic acid and the beta-nicotinamide mononucleotide, has a whitening effect, and can achieve a synergistic whitening effect when being used together with the tranexamic acid and the beta-nicotinamide mononucleotide, so that the tranexamic acid, the acetyl chitosamine and the beta-nicotinamide mononucleotide can achieve whitening and brightening effects at a low concentration, and are stable, safe and non-irritant.

The invention provides a moisturizing co-transportation nano composition and a preparation method and application thereof, and belongs to the technical field of cosmetics. The moisturizing co-transportation nano composition contains the following components in mass percentage: 0.1-10% of physiological lipid, 0.2-10% of an emollient, 0.5-25% of a moisture absorbent, 0.1-6% of biomacromolecules combined with water, 1-20% of liquid grease, 10-50% of emulsifier, 5-30% of co-emulsifier, 0.01-1% of preservative and the balance of water; and the particle size of the moisturizing co-transportation nano composition is 10-500nm. According to the invention, multiple active components with different moisturizing mechanisms are enveloped in a same nano carrier, and therefore, the transdermal co-transportation and cooperated moisturizing effect of multi-target multi-mechanism moisturizing active components is realized, and the dual effects of skin moisturizing and cutin barrier repair are achieved.

The invention relates to the technical field of medicaments and discloses desensitizing composite nano emulsion for sensitive skin repair. The emulsion is prepared from the following raw materials in preferable part by weight: 12.956 parts of isopropyl myristate, 29.4 parts of polyethylene glyceryl caprylate / caprate, 9.8 parts of polyglycerol-3-dioleate, 39.3475 parts of distilled water, 0.495 part of citric acid, 0.6525 part of sodium citrate, 0.005 part of metallothionein, 2.25 parts of daisy extract, 2.25 parts of oxymatrine, 1.246 parts of vitamin E, 0.79 part of chamomile, and 0.79 part of lavender oil. The average particle size of the emulsion is no more than 100 nm. The method greatly improves the skin penetration performance and dispersibility of active ingredients and the extensibility of the product on skin, thereby greatly improving the desensitizing effect of the product. The composite nano emulsion of the invention can be widely used for desensitizing sensitive skins.