15results about How to "Promote transdermal absorption" patented technology

The invention belongs to the technical field of cosmetics, and particularly relates to a skin-color-uniformizing whitening composition derived from plant extracts and application of the skin-color-uniformizing whitening composition. The whitening composition provided by the invention is prepared from the following components in parts by weight: 10 to 15 parts of saussurea involucrata extract, 1 to 8 parts of dendrobium officinale extract, 1 to 5 parts of wood apple extract and 0.5 to 5 parts of banana fruit extract. The four plant extracts are synergistically compounded, transdermal absorption of active ingredients can be promoted, the tyrosinase inhibition rate is effectively increased, and the skin glossiness and whiteness are improved, so that the effects of whitening, brightening and uniformizing the skin color are achieved, the whitening composition is mild and non-irritant, the preparation method is simple and convenient to operate, and the whitening composition has large-scale production capacity and industrial feasibility. When the whitening composition is applied to skin care products such as face cream, the whitening and brightening effects of the face cream can be effectively improved, and the whitening composition has wide market application value.

The invention belongs to the technical field of chemistry, and particularly relates to a water-based stable transdermal preparation based on a structural nanoemulsion and a preparation method of the water-based stable transdermal preparation. 1% to 10% of a polyether block copolymer; 5%-20% of a co-emulsion; 0.1% to 15% of an active ingredient; and the balance of deionized water. Through a compounding system of an amino acid surfactant and a gemini surfactant and in combination with the synergistic effect of a specific polyether block copolymer, a nanoemulsion drug delivery system with a stable structure is constructed. Through a compound system of the amino acid surfactant and the gemini surfactant and by combining the synergistic effect of the polyether block copolymer, a nano-emulsion drug delivery system with a stable structure is constructed, and the nano-emulsion drug delivery system has good long-term storage stability and temperature adaptability, is not easy to layer and is uniform in particle size distribution.

This invention relates to the field of cosmetics, specifically to a composition containing copper peptides for repairing photothermal damage and its application. The composition comprises a complex polypeptide, galactosomal yeast fermentation product filtrate, and cyanobacterial extract; wherein the complex polypeptide includes copper peptides, yeast polypeptides, and hexapeptide-11. This invention, by combining specific complex polypeptides with galactosomal yeast fermentation product filtrate and cyanobacterial extract, increases the expression level of heat shock proteins, thereby achieving excellent efficacy in repairing photothermal damage. Furthermore, this composition is mild and non-irritating, and can be widely used in cosmetics.

This invention discloses a liquid crystal cream with high penetration capability, its preparation method, and its application. The liquid crystal cream comprises: an oleophilic emulsifier, a hydrophilic emulsifier, long-chain fatty alcohols and esters, and the remainder being humectants, thickeners, chelating agents, emollients, preservatives, active ingredients, and deionized water. This invention's small liquid crystal moisturizing cream has an excellent skin feel, good absorption, is breathable and non-comedogenic, and can form a biomimetic moisturizing film with good skin affinity on the skin, enhancing skin hydration and moisturizing ability, effectively improving skin condition, and achieving the effect of protecting and repairing the skin barrier. The system exhibits good long-term stability and a complete liquid crystal structure. Furthermore, tests show that this small liquid crystal cream has a significant penetration effect on both oil-soluble and water-soluble active ingredients. It is expected to achieve better skincare effects by incorporating different active ingredients in the field of functional skincare cosmetics.

The application discloses an extraction method of sturgeon oil with skin repair function, which comprises the following steps: S1, preparation of crude fish oil of fish fat; S2, preparation of crude fish oil of fish liver; S3, preparation of crude fish oil of fish skin; S4, degumming and deacidification; and S5, refining. The fish oil extracted from different parts of sturgeon is mixed according to a specific proportion, the fish fat fish oil, the fish liver oil and the fish skin oil are mixed, and three kinds of functional components are added in the extraction process respectively, i.e. dihydroquercetin (providing antioxidant protection), phosphatidylserine (enhancing cell membrane repair and nutrient absorption) and curcumin (bringing anti-inflammatory and whitening effects), so that a multiple synergistic formula system is formed, and the prepared sturgeon oil is significantly enhanced in the repair function on the skin, and the bioavailability and stability of the product are improved.

The invention relates to the technical field of supramolecules, in particular to a ginsenoside CK-aescin supramolecule, in the supramolecule, ginsenoside CK and aescin are formed through a non-covalent bond, the mass ratio of ginsenoside CK to aescin is 1: (1-25), and a preparation method comprises the following steps: dispersing aescin in an organic solvent aqueous solution to prepare a suspension A, dissolving ginsenoside CK in ethanol to prepare a solution D for later use; stirring the suspension A to obtain a suspension B; performing ultrasonic treatment on the suspension B to obtain emulsion C; slowly adding the emulsion C into the solution D while stirring, stirring to obtain a ginsenoside CK-aescin supramolecular solution crude product, and dialyzing. According to the ginsenoside CK-aescin supramolecule prepared by the invention, an IVPT test shows that the transdermal absorption capacity of the ginsenoside CK-aescin supramolecule is remarkably improved, so that the ginsenoside CK-aescin supramolecule can be better absorbed by human skin, and the efficacy of the ginsenoside CK-aescin supramolecule is favorably exerted.

The application relates to a preparation method and application of a ginsenoside-loaded triple-assembled Pickering emulsion, and belongs to the biomedical technology field. In order to solve the problems that the Pickering emulsion constructed by natural active ingredients in the prior art has insufficient mechanical strength of an interface film, is easy to break and lose stability, has passive release behavior, lacks controllability and environmental responsiveness, and is difficult to realize precise release, a ginsenoside-loaded triple-assembled Pickering emulsion is provided. Through a three-step cascade strategy of "molecule-interface-function", a stable "metal-phenol coordination network" interface layer is constructed on the surface of oil droplets, the physical and chemical stability of the emulsion is fundamentally improved, a Pickering emulsion which is all-natural, highly stable and has a pH response intelligent release function is successfully constructed, and the triple-assembled Pickering emulsion has significant advantages in stability, controllable release and function integration, and provides a feasible technical strategy for a response type delivery system design based on natural products.

The present application relates to the technical field of supramolecular, in particular to a collagen supramolecule, a preparation method and application thereof, the collagen supramolecule is prepared by taking collagen, a stabilizer, an alcohol solvent, glycerol, an ionic liquid and water as raw materials, the preparation method of the collagen supramolecule is simple and easy to operate, and the prepared collagen supramolecule has high stability. Meanwhile, in the collagen supramolecule, the collagen can not only be used as one of active ingredients to improve the skin condition, but also be used as a carrier of active ingredients to improve the solubility and transdermal performance of various active ingredients including the collagen itself, so as to solve the defects in the prior art.

The invention discloses a high-permeability rose collagen compound for deeply repairing and whitening and tendering lip color and application thereof, the compound takes recombinant collagen, rose hip oil ceramide, rose PDRN and grape flower cell extract as functional components, and a penetration enhancer is used for improving the transdermal absorption of the collagen and other components and improving the bioavailability of the active components. The rose collagen compound disclosed by the invention has the effects of relieving, deeply repairing, whitening and tendering the lip color, resisting wrinkles, fullness and the like, and can be applied to lip cosmetics such as lipsticks, lip masks and the like.

The invention belongs to the technical field of cosmetics, and particularly relates to a soothing composition based on milk exosomes and rose exosomes and a preparation method of the soothing composition. The soothing composition based on the milk exosome and the rose exosome comprises the following components: the milk exosome, the rose exosome, composite polypeptide, a salmon egg extract and PDRN, the preparation method of the soothing composition comprises the following steps: uniformly mixing the milk exosome, the rose exosome, the WKPepSRM polypeptide, the salmon egg extract and the PDRN to obtain the soothing composition based on the milk exosome and the rose exosome. The soothing composition disclosed by the invention can simultaneously exert an excellent soothing effect and an excellent water locking effect.

The application discloses a TAT peptide modified photoredox enzyme liposome and a preparation method and application thereof, and the method comprises the following steps: S1: mixing and dispersing phosphatidylserine, dipalmitoyl phosphatidylglycerol, phosphatidic acid and glycerol to obtain a phospholipid-glycerol mixed phase; S2: dissolving photoredox enzyme and carboxymethyl chitosan, and adding the photoredox enzyme and carboxymethyl chitosan into the phospholipid-glycerol mixed phase to obtain photoredox enzyme liposomes; and S3: mixing and dispersing TAT peptides and the photoredox enzyme liposomes to obtain the TAT peptide modified photoredox enzyme liposomes; the TAT peptide modified photoredox enzyme liposomes have the advantages of mildness, non-stimulation and low cost, are non-toxic and have biological safety, have a storage stability of more than 90 days, and can effectively promote transdermal absorption of active substances in biological drugs, and thus the application range is widened.

The application relates to the technical field of liposome preparation, in particular to a lipoic acid liposome as well as a preparation method and application thereof. The raw materials of the lipoic acid liposome of the application include lipoic acid, a mixed solvent, mixed lipids and a stabilizer; wherein the mixed lipids include hydrogenated lecithin, camellia seed oil and tocopherol acetate. Through improvement of the raw material formula and the preparation process of the lipoic acid liposome, the product stability and the use safety are remarkably improved, the transdermal absorption performance is remarkably improved, long-acting release is realized, multiple components are loaded, and the whitening and anti-wrinkle effects of the product are remarkably improved.

The invention relates to the technical field of supramolecule preparation, in particular to a ginsenoside CK-resveratrol supramolecule which comprises ginsenoside CK and resveratrol which are connected through a hydrogen bond, and in an XRD (X-Ray Diffraction) spectrum of the supramolecule, a characteristic peak exists at the position where a 2theta angle is 15.89 degrees; the preparation method comprises the following steps: mixing ginsenoside CK and resveratrol powder, and dissolving the mixture in a DMSO or ethanol solvent to obtain a solution A; dropwise adding the solution A into purified water; then carrying out magnetic stirring to obtain a ginsenoside CK-resveratrol supramolecular crude product; and dialyzing the supermolecule crude product to obtain the ginsenoside CK-resveratrol supermolecule aqueous solution. The transdermal absorption capacity of the ginsenoside CK-resveratrol supramolecule prepared by the preparation method disclosed by the invention is remarkably improved.

This invention discloses an anti-aging composition and its application in skincare products. The composition comprises lentil seed extract and β-nicotinamide mononucleotide; the anti-aging composition is prepared by a two-step process: aerobic fermentation with *Aspergillus oryzae* followed by anaerobic fermentation with *Bifidobacterium*. This invention achieves synergistic anti-aging effects by significantly inhibiting matrix metalloproteinase activity and promoting type I collagen synthesis through a multi-pathway synergistic effect of "anti-inflammatory, anti-oxidative, repair-energy-supply." The composition has high bioavailability, is mild and safe, and its preparation process is green and stable, making it suitable for skincare products such as creams and serums.

This invention discloses a plant essential oil microemulsion hydrogel fever-reducing patch and its preparation method. The fever-reducing patch comprises, by weight, phase A, phase B, an alkyl glycoside green surfactant system, and a hydrogel matrix; phase A consists of lavender essential oil, melaleucalyptus essential oil, cardamom essential oil, Roman chamomile essential oil, pine needle essential oil, and α-bisabolol; phase B consists of peony bark extract and peony root extract; the alkyl glycoside green surfactant system consists of alkyl glucoside, lecithin, and glycerol. This invention prepares phases A and B, along with the green surfactant system, into a microemulsion with a particle size of 20-60 nm, which is then mixed with the hydrogel matrix and coated onto a non-woven fabric backing layer to form the fever-reducing patch. This fever-reducing patch achieves a rapid, safe, and comfortable auxiliary fever-reducing effect through a synergistic effect of antiviral, anti-inflammatory, sedative, antispasmodic, and antipyretic mechanisms.