This invention relates to polymorphs of
metoprolol and its salts.
Crystal forms and combinations thereof of the
free base of
metoprolol selected from polymorphs A, B, C, D, E, F, and G are disclosed, as well as crystalline polymorphs of salts of
metoprolol. Pharmaceutical compositions containing one or more of these polymorphs and methods for preparing such polymorphs are also disclosed.
Metoprolol can be used to treat a variety of diseases associated with low
intracellular BH4 levels, such as phenylketonuria.