3 results about "Ivabradine" patented technology

The invention discloses a sinoatrial node If channel inhibitor floating type gastric retention sustained-release tablet and a preparation method thereof, the floating type gastric retention sustained-release tablet is prepared from a sinoatrial node If channel inhibitor, a framework material, a floating aid, an expanding agent, a diluent, a lubricant and a film coating material, the sinoatrial node If channel inhibitor is ivabradine or a pharmaceutical salt thereof, and the framework material is a filler. The floating type gastric retention sustained release tablet is prepared through the steps of mixing, tabletting, film coating and the like. The floating type gastric retention sustained-release tablet for the sinus node If channel inhibitor can quickly float in a gastric environment, the gastric retention time is prolonged, so that the absorption time is prolonged, the bioavailability of active ingredients is improved, the preparation process is simple, and the technical effect of slow release can be realized.

Process for the synthesis of ivabradine of 141296 formula (I): and addition salts thereof with a pharmaceutically acceptable acid.

Provided herein are methods of treating or preventing an arrhythmia in a cardiac graft patient, wherein the method comprises administering combinations of anti-arrhythmic agents (e.g., amiodarone, metoprolol, ivabradine, and / or mexiletine) to the subject in need thereof.