New application of composition containing isosorbide mononitrate and ivabradine

A technology of isosorbide dinitrate and ivabrax, applied in the field of medicine, can solve the problems of large toxic and side effects of drugs, lack of effective therapeutic drugs, etc., and achieve the effects of convenient taking, reducing the occurrence of adverse reactions and good therapeutic effect

Active Publication Date: 2016-12-07
LUNAN PHARMA GROUP CORPORATION
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] In view of the lack of effective therapeutic drugs in the treatment process of existing diastolic heart failure, and the defects of the existing therapeutic drugs with large toxic and side effects, the present invention provides a safe and effective drug for the treatment of diastolic heart failure, further increasing the number of patients with diastolic heart failure. The choice of clinical medication, the pharmaceutical composition with isosorbide mononitrate and ivabradine as the active ingredients of the drug, which has a good therapeutic effect on diastolic heart failure, less toxic and side effects, and has a good clinical application prospect

Method used

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  • New application of composition containing isosorbide mononitrate and ivabradine
  • New application of composition containing isosorbide mononitrate and ivabradine
  • New application of composition containing isosorbide mononitrate and ivabradine

Examples

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Comparison scheme
Effect test

Embodiment 1

[0021] Embodiment 1 pharmaceutical composition common tablet of the present invention

[0022]

[0023] Preparation process: Weigh the prescription amount of isosorbide mononitrate, ivabradine, starch and dextrin and mix evenly. In addition, add an appropriate amount of 50% ethanol to the mixed powder, mix evenly, make soft material, pass through a 18-mesh nylon sieve to make wet granules, and dry at about 60°C. The moisture content of the dry granules should be controlled below 1.5%. Sieve through a 20-mesh sieve, mix with magnesium stearate, and press into tablets.

Embodiment 2

[0024] Embodiment 2 pharmaceutical composition capsule of the present invention

[0025]

[0026]

[0027] Preparation process: crush isosorbide mononitrate, ivabradine, microcrystalline cellulose, and micropowder silica gel through a 100-mesh sieve, mix well, and directly fill capsules.

Embodiment 3

[0028] Embodiment 3 pharmaceutical composition bilayer tablet of the present invention

[0029]

[0030] Preparation process of isosorbide mononitrate granules: Isosorbide mononitrate is passed through a 100-mesh sieve, mannitol, lactose, and microcrystalline cellulose are passed through a 80-mesh sieve, and the prescribed amount of isosorbide mononitrate and mannitol, lactose, and microcrystalline cellulose are weighed. The crystalline cellulose is mixed evenly, and an appropriate amount of 95% ethanol solution of 6% PVP is added to granulate, dried at 60° C., and the dry granules are sieved with a 16-mesh sieve, and the prescribed amount of magnesium stearate is added to the dry granules.

[0031]

[0032] Preparation process of ivabradine granules: pass through 100 sieves for ivabradine, pass through 80 mesh sieves for pregelatinized starch and mannitol, weigh the prescribed amount of ivabradine, pregelatinized starch and mannitol and mix evenly, add 6 The 95% ethanol s...

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Abstract

The invention belongs to the field of medicine and particularly relates to an application of a pharmaceutical composition taking isosorbide mononitrate and ivabradine as active pharmaceutical ingredients in preparation of medicine for treating diastolic heart failure. By conformation through a lot of pharmacology experiment, the isosorbide mononitrate and the ivabradine can obviously improving heart diastolic function of patients with diastolic heart failure, and remarkable synergistic effect is achieved in the aspect of treating the diastolic heart failure. The pharmaceutical composition is obvious in treating effect and little in side effects in treating the diastolic heart failure, and is quite good in medical application prospect.

Description

technical field [0001] The invention belongs to the field of medicine, and relates to a new application of a composition comprising isosorbide mononitrate and ivabradine, in particular to the preparation of a composition comprising isosorbide mononitrate and ivabradine for the treatment of diastolic cardiomyopathy Use in depletion medicines. Background technique [0002] The traditional concept of heart failure is that the systolic function of the heart is reduced, and the venous return blood cannot be effectively discharged, resulting in venous system congestion and peripheral tissue ischemia. The separation of diastolic heart failure (diastolic heart failure, DHF) from the traditional concept of heart failure is a great progress in heart failure research in the past 20 years. The concept of diastolic heart failure was first proposed by Kessle in 1988 to describe a clinical syndrome characterized by abnormal diastolic function with symptoms and signs of heart failure and n...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/55A61P9/04A61K31/34
Inventor 张贵民姚景春李晓梅赵涛李红华张金霞
Owner LUNAN PHARMA GROUP CORPORATION
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