6 results about "Isosorbide mononitrate" patented technology

The present invention relates to a docosahexaenoic acid ester with an alcohol chosen among the group-B vitamins or provitamins, advantageously comprised by: nicotinyl alcohol of the following formula: 1 pantthenol of the following formula:2 and inositol of the following formula:3 or with isosorbide of the following formula:4 or isosorbide mononitrate of the following formula:5 It also relates to a method of preparation of same, a pharmaceutical composition same and the of same in the treatment or prevention of cardiovascular disease, in particular auricular fibrillation.

The present invention belongs to the field of pharmaceuticals. Disclosed in the present invention are a class of salt compounds of isosorbide mononitrate derivatives and the use thereof. Salts formed by the isosorbide mononitrate derivatives of the present invention and D-cycloserine exhibit dual activities as a nitric oxide donor and a partial NMDA receptor agonist. The present invention further relates to the use of the salts formed by the isosorbide mononitrate derivatives and D-cycloserine in a drug for treating cerebral stroke or the recovery period of cerebral stroke.

The application belongs to the technical field of direct compression of pharmaceutical preparations, and particularly relates to a sustained-release isosorbide mononitrate tablet and a preparation method thereof. The sustained-release tablet is composed of a sustained-release tablet core and a coating layer. After isosorbide mononitrate, hydroxypropyl cellulose, palm wax, silicon dioxide, microcrystalline cellulose-lactose and talc powder are mixed, the powder is directly compressed into a tablet. The obtained tablet is coated into a film-coated tablet by using a moisture-proof coating material (AMB). The powder direct compression technology is adopted, so that the technical complexity is greatly reduced, and the wet heat unit operation is avoided. The preparation process is simple, and the quality is stable.

The application belongs to the technical field of pharmaceutical preparations, and particularly relates to a mononitrate isosorbide oral dissolving film and a preparation method thereof. The mononitrate isosorbide oral dissolving film preparation is composed of a drug-containing layer and isolation layers which are compounded on the upper and lower surfaces of the drug-containing layer. The drug-containing layer comprises the following raw materials in percentage by mass: cyclodextrin-encapsulated mononitrate isosorbide 10-60%, film-forming material 20-80%, plasticizer 0-20% and auxiliary material 0-10%. The isolation layer comprises the following raw materials in percentage by mass: film-forming material 70-100%, plasticizer 0-30% and auxiliary material 0-10%. The mononitrate isosorbide oral dissolving film prepared by the application has the advantages of smooth appearance, good taste, uniform drug content, rapid dissolution under the action of saliva after entering the mouth, and further release and absorption, which greatly improves the drug administration compliance and solves the problem of surface crystallization of mononitrate isosorbide after long-term storage.

The utility model provides a high-speed rotary tablet press for isosorbide mononitrate sustained-release capsule medicaments, belongs to the technical field of pharmaceutical production, and aims to solve the problem that a rotary processing part is easy to hurt people when the rotary processing part is operated by the people at present. Comprising a tabletting main body, a tabletting rotating plate, an operation panel, an emergency stop switch, a protective rotating shaft, a shutdown pressing block, a protective plate switching mechanism and a maintenance shutdown mechanism, the tablet pressing part is arranged in the tablet pressing main body; the operation panel is fixedly connected to the right end face of the pressing piece body. The emergency stop switch is fixedly connected to the front side of the operation panel; the protective rotating shaft is rotationally connected to the interior of the pressing sheet main body; the shutdown pressing block is connected to the interior of the pressing sheet main body in a sliding manner; the protective plate switching mechanism is arranged in the tablet pressing main body; and the maintenance shutdown mechanism is arranged on the right side in the tabletting main body. By means of the protection plate opening and closing mechanism, personnel can maintain the tablet pressing part conveniently, and by means of the maintenance stopping mechanism, the safety of the personnel for maintaining the tablet press is guaranteed.

The present application provides a kind of isosorbide mononitrate sustained-release capsules and its preparation method, the isosorbide mononitrate sustained-release capsule of the present application, characterized in that, the drug loading layer, sustained-release layer, immediate-release layer and protective layer of the isosorbide mononitrate sustained-release capsule are respectively coated by fluidized bed granulation coating machine.The granular preparation has good stability, small side effect;The preparation process of the isosorbide mononitrate sustained-release capsule of the present application is simple, the equipment is simple and easy to operate, the labor intensity is small, and it is economic and safe.At the same time, the prescription and preparation method are more economical, and are suitable for industrial production.