Tablet of isosorbide mononitrate

A technology of isosorbide dinitrate and tablet, applied in the directions of pill delivery, active ingredients of heterocyclic compounds, cardiovascular system diseases, etc., can solve problems such as incomplete release of active ingredients of medicines, and achieve good drug release rate and complete drug release. , good safety effect
CN101732276AActive Publication Date: 2010-06-16LUNAN BETTER PHARMA
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
LUNAN BETTER PHARMA
Publication Date
2010-06-16

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Abstract

The invention relates to a tablet of isosorbide mononitrate, in particular to a double-layer osmotic pump controlled release tablet of isosorbide mononitrate, which belongs to the field of medicine preparation. A single-chamber double-layer osmotic pump tablet of the isosorbide mononitrate is characterized in that a semi-transparent coating film cover a double-layer core body consisting of a medicine-containing layer and a boosting layer; and the coating film is provided with a medicine releasing pore on the surface of the medicine-containing layer. The gastrointestinal tract water enters a double-layer tablet chip through the semi-transparent film; the medicines forms a mixed suspension liquid or solution when contacting water in the medicine-containing layer; a penetration enhancer enables the solution of the medicine-containing layer to be hypertonic so that an osmotic pressure difference exists between the inner side and the outer side of the film, which is beneficial to pumping the medicines out; and the pressure is generated in the boosting layer through water absorption, dissolution and expansion of a penetrating agent so as to further boost a medicine liquid to eject the pore.
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Description

technical field The invention relates to a tablet of isosorbide mononitrate, in particular to a double-layer osmotic pump controlled-release tablet of isosorbide mononitrate, which belongs to the field of pharmaceutical preparations. Background technique Isosorbide mononitrate is the main biologically active metabolite of isosorbide dinitrate. It is a long-acting nitrate drug for the treatment of coronary heart disease and angina pectoris. It was discovered in the metabolites of isosorbide dinitrate in the 1960s . In the 1980s, Boehringer Mannheim GmbH.h of Germany first introduced it to the market, and then it was launched in more than ten countries in Europe and America, and has been widely used in clinical practice. my country imported the drug in 1988, and it was widely welcomed by patients. Its main mechanism of action is to expand venous volume vessels and peripheral resistance vessels, reduce cardiac preload and postload, and reduce myocardial oxygen consumption. T...

Claims

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