17results about How to "Long-lasting effect" patented technology

The invention discloses a pesticide microcapsule and its application, belonging to the technical field of pesticides. The pesticide microcapsule is prepared by the following method: adding the pesticide active ingredient to ethyl acetate, and then adding polylactic acid, stirring evenly, and obtaining an organic phase; the pesticide active ingredient is composed of a bifenthrin-thiamethoxam complex and piperine in a mass ratio of 1: (1-3); polyvinyl alcohol is dissolved in water to obtain an aqueous phase; under ice-water bath conditions, the organic phase is added dropwise to the aqueous phase, and stirred at the same time to form an emulsion; the emulsion is stirred and evaporated, centrifuged, washed, and dried to obtain a pesticide microcapsule. The present invention prepares pesticide microcapsules by compounding bifenthrin, clothianidin and piperine, effectively avoiding the drug resistance of pests caused by the action of a single agent, and piperine not only directly produces a toxic effect on pests, but also can enhance the insecticidal effect of bifenthrin and clothianidin, and achieves a synergistic effect of 1+1>2.

This solution relates to the coatings field and proposes an aqueous nano-dispersion of far-infrared negative oxygen ion material. By weight, it comprises: 300-350 parts water; 35-45 parts wetting agent; 40-60 parts dispersant; 25-35 parts defoamer; 35-45 parts multifunctional additive; 5-7 parts thickener; 400-600 parts activated far-infrared negative oxygen ion material; 1-3 parts accelerator; and 3-5 parts shielding agent. This solution designs a multi-component synergistically promoting activated far-infrared negative oxygen ion material, which can improve the hemispherical spectral emissivity in the 4-14μm band, even reaching above 0.95 in the key 8-12μm band, effectively promoting formaldehyde decomposition with a long-lasting effect, while also improving antibacterial properties.

The invention provides a spirotetramat polyurethane / polyurea microcapsule suspending agent as well as a preparation method and application thereof, and belongs to the technical field of pesticide preparations. The preparation method comprises the following steps: mixing an oil-phase solution containing spirotetramat raw medicine and polyisocyanate with a water-phase solution containing an emulsifier and a dispersant, carrying out shear emulsification, adding a water-soluble wall material monomer water solution containing polyamine and / or polyol, and carrying out an interfacial polymerization reaction; after the polymerization is finished, sequentially carrying out curing treatment and cooling, then adding an auxiliary agent, and blending to obtain the spirotetramat polyurethane / polyurea microcapsule suspending agent. The spirotetramat microcapsule suspending agent is prepared through an interfacial polymerization method, spirotetramat is coated in a polyurethane or polyurea capsule wall, and the spirotetramat microcapsule suspending agent has the advantages of being high in encapsulation efficiency, good in physical and chemical stability, long in pesticide effect lasting period, safer to non-target organisms (such as bees) and the environment and the like. The preparation method is stable in process, easy for industrial production and excellent in product performance.

The utility model belongs to sleep aid technical field, concretely is a kind of intermittent type enhancement electric pulse rhythm stimulation manufacturing circulatory tension to relax sleep aid device. Including control module, for setting and adjusting current parameter;Micro-current release module, the micro-current release module connection control module, and with positive / negative pole piece connection;Acquisition module, including heart rate module, acceleration sensor and electromyography module;Charging module, with control module circuit connection;Storage module, and sleep analysis model are stored with 9 grades current parameter;The control module is configured as: according to acquisition module data, sleep stage is judged by sleep analysis model, and the output waveform of micro-current release module is dynamically adjusted. The utility model formed safe and effective, simple method, fast effect and applicable to most sleepless user's device, specific performance is sleep length is greatly shortened, night wake frequency reduces, and sleep efficiency is greatly improved.

The invention relates to siRNA (small interfering Ribonucleic Acid) for regulating expression of angiotensinogen AGT, a conjugate and a pharmaceutical composition of the siRNA and application of the siRNA. The siRNA comprises a positive-sense strand and an antisense strand, each nucleotide in the siRNA is independently modified or unmodified nucleotide, the positive-sense strand contains a nucleotide sequence I, the antisense strand contains a nucleotide sequence II, and the nucleotide sequence I and the nucleotide sequence II are at least partially reversely complementary to form a double-strand region. The siRNA, the conjugate thereof and the pharmaceutical composition provided by the invention can effectively regulate the expression of angiotensinogen AGT.

The invention belongs to the field of tablet candy preparation, and particularly relates to an edible mushroom extract-containing tablet candy and a preparation method thereof. The preparation method comprises the following steps: mixing polyvinyl alcohol and distarch phosphate to form distarch phosphate gel, performing frozen nano spray drying, and fully adsorbing the caries-preventing mixture, so that the prepared caries-preventing and blood sugar-reducing colloid particles have the effects of preventing caries and reducing blood sugar; a porous enzymolysis product obtained through enzymolysis is mixed with polyglycerol fatty acid ester and a plant extracting solution, and the prepared composition capable of accelerating disintegration and maintaining activity can rapidly absorb saliva and expand and disintegrate; the surface of the candy tablet is sprayed with an anti-oxidation anti-cracking solution, the tabletted candy containing the edible mushroom extract after film formation does not cause caries after being eaten for a long time, the disintegration speed is not affected after long-time storage, and tablet cracking is avoided.

This application discloses a method for preparing Nutmeg and Schisandra pills to improve depression-induced arrhythmia, including the following steps: S1, take nutmeg, costus root, aucklandia root, and long pepper, in parts by weight, 20-30 parts of nutmeg, 15-25 parts of costus root, 15-25 parts of aucklandia root, and 10-20 parts of long pepper, add water for distillation extraction, and collect the obtained volatile oil. This application uses extrusion spheroidization combined with fluidized bed coating technology to prepare sustained-release microcapsules, prolonging the duration of efficacy, reducing the frequency of medication, and avoiding excessive fluctuations in blood drug concentration, thus reducing the risk of adverse reactions. The volatile oil is fully extracted by sufficient steam distillation, combined with an appropriate ratio of β-cyclodextrin inclusion and spray drying process to reduce the loss of volatile oil and ensure the stability of the formulation efficacy. The high-dose ratio of medicinal materials can not only effectively regulate the patient's mood and improve the depressive state, but also improve myocardial blood supply, stabilize cardiac electrophysiology, and break the vicious cycle between depression and arrhythmia.

The invention relates to the technical field of high polymer materials, and particularly discloses anti-yellowing polyester resin for an MDF plate and a preparation method of the anti-yellowing polyester resin. An antioxidant unit and a formaldehyde reactive unit are simultaneously bonded on a molecular chain of the polyester resin through covalent bonds, and the two functional units are connected to a polyester main chain through flexible chain segments. The preparation method comprises the following steps: firstly, synthesizing a difunctional linking agent of which one end contains an antioxidant group, the other end contains a formaldehyde reactive group and the middle is connected by a flexible chain segment; and carrying out melt polycondensation reaction on the coupling agent serving as an end-capping reagent or a comonomer, polyhydric alcohol and polybasic acid to obtain the target resin. The problems of migration, loss and failure caused by traditional physical addition of small-molecule auxiliaries are fundamentally solved, so that when the obtained polyester resin is used for an MDF plate facing coating, lasting and efficient hot-pressing yellowing resistance and weather yellowing resistance can be provided, the free formaldehyde release amount of a plate can be continuously captured and reduced, and the service life of the plate is prolonged. The decorative property and the environment-friendly property are both improved.

The application discloses a preparation method of water-soluble hydrogen-containing siloxane and application of the water-soluble hydrogen-containing siloxane in the field of cosmetics, and belongs to the technical field of cosmetic raw material preparation and application. The preparation method comprises the following steps: 1) preparation of a catalyst solution; 2) mixing of raw materials; 3) catalytic reaction; and 4) post-treatment and purification. In the application, water-soluble groups such as polyethylene glycol, polypropylene glycol and polyglycerol are used to modify siloxanes with Si-H bonds such as cyclosiloxane and polymethyl hydrogen siloxane, so as to prepare water-soluble hydrogen-containing siloxane. The water-soluble hydrogen-containing siloxane prepared in the application has excellent water solubility, good compatibility with a water phase system of cosmetics, can stably and continuously release hydrogen molecules in a water-based proton solvent, and the hydrogen molecules can effectively reduce high-activity free radicals in skin, reduce damage of the free radicals to skin cells, and realize antioxidant and anti-wrinkle effects. The product prepared in the application has high purity and good safety, raw materials are easy to obtain, the process is easy to industrialize, and the product can be widely applied to various water-based or water-oil compound cosmetics.

The invention provides a sustained-release fluorocalcitriol tablet and a preparation method thereof, and relates to the technical field of pharmaceutical preparations, the preparation raw materials comprise a sustained-release skeleton layer prepared from a fluorocalcitriol-containing drug core particle and a controlled-release film coating solution containing a methacrylate copolymer, the preparation method comprises the following steps: preparing the medicine core, preparing the controlled-release film coating solution and coating, preparing the controlled-release skeleton layer, and drying and packaging.

The invention discloses an application of benzalkonium bromide and chlorhexidine in prevention and treatment of plant diseases, and discloses a benzalkonium bromide and chlorhexidine compound composition which has a relatively good synergistic effect in prevention and treatment of the plant diseases and has a very good application prospect.

The invention belongs to the field of medicaments, and provides a method for preparing an ibuprofen-containing composition as well as a corresponding product and application thereof, the method comprises the following steps: (1) in the presence of an organic solvent, mixing ibuprofen and a matrix; (2) in the presence of an emulsifier, adding the mixed product obtained in the step (1) into water, and sealing; and (3) blowing the sealed product in the step (2). The ibuprofen-containing composition prepared by the method not only can be quickly released to achieve the effect of quickly taking effect, but also can last for a long time to achieve the effect of longer drug effect duration, and meanwhile, better drug absorption is provided.

The invention relates to the technical field of medical health care products, and particularly discloses a beewax wax therapy product and a preparation method thereof. The beeswax wax therapy product comprises the following components in parts by weight: 60-80 parts of beeswax, 10-16 parts of a propolis extract, 10-30 parts of a traditional Chinese medicine extract, 5-10 parts of a plasticizer, 1-3 parts of an absorption enhancer and 0.8-2.2 parts of a compatilizer, the absorption enhancer is prepared by mixing mannitol, azone and protein peptide according to the weight ratio of (1-5): (1-5): (0.2-0.6); the compatilizer is formed by mixing squalene and a surfactant according to the weight ratio of (1-3): (0.2-0.8); the preparation method of the traditional Chinese medicine extract comprises the following steps: respectively weighing corresponding parts by weight of traditional Chinese medicine raw materials, mixing, and then carrying out alcohol extraction and vacuum concentration. The beeswax wax therapy product prescription provided by the invention has the effects of warming and activating meridians, dispelling wind and eliminating dampness, promoting blood circulation to arrest pain, easing pain and resisting inflammation, and the beeswax wax therapy product provided by the invention has good safety and stability.

The present application provides a kind of aceclofenac enteric microcapsule and its preparation method, the microcapsule includes core and coating, the core includes pill core, aceclofenac, adhesive;The coating includes enteric coating material, plasticizer, anti-adhesive. By screening and optimizing the type and proportion of adhesive and enteric material, optimizing and controlling the preparation process parameters, effectively improve the stability and long-term stability of aceclofenac sustained-release microcapsule, block the release of drug in mouth and stomach, direct the drug to small intestine and slowly release, and the release effect is long-acting and durable.

The invention discloses a composite reducing agent for reducing substances in low-yield rice field soil, which comprises 30-40 parts of lime, 20-40 parts of medical stone, 20-30 parts of magnesium-based hydrotalcite, 5-15 parts of calcium peroxide, 1-5 parts of a metal organic framework material MOF-5 and 0.5-2 parts of carboxymethyl cellulose, and the proper dosage of the composite reducing agent is selected according to the type of main obstacles of the soil. And turning and pressing the composite reducing agent and straws into soil, irrigating and steeping the field for 3 days, and then fertilizing and transplanting rice. When the composite reducing agent is applied to the rice field, the content of dissolved oxygen can be increased through a synergistic effect, the pH value and the oxidation-reduction potential are improved, accumulation of reducing substances is reduced, straw decomposition can be accelerated, the problem of accumulation of the reducing substances for rice field straw decomposition is solved, and the rice field straw decomposition effect is improved. The fertilizer can also effectively relieve the fertilizer efficiency loss, provide necessary nutrient elements such as silicon, zinc and magnesium for rice, promote the growth and development of rice and comprehensively improve the productivity.

This invention discloses a black hot spring bath concentrate, its preparation method, and its application, relating to the field of personal care products technology. It comprises component A, an active black hot spring concentrate, and component C, a sulfide and humic acid composite stabilization system. Component A must contain humic acid with a content of ≥500 mg / L metasilicic acid, 5-15 mg / L fluoride ions, ≥10 mg / L total hydrogen sulfide, ≥20 mg / L metaboric acid, and ≥100 mg / L total organic carbon. Component C consists of selenite, polyphenolic antioxidants, and metal ion chelating agents. This invention utilizes a low-temperature membrane enrichment-bioenzymatic hydrolysis coupling-nano-stabilization integrated technology to fully preserve the quaternary characteristic component spectrum of black hot springs ("metasilicic acid-fluoride-sulfide-humic acid"), and uniquely employs a composite stabilization technology targeting the dual-active system of "sulfide-humic acid." It can be stored for a long time at room temperature and pressure, exhibiting excellent physical stability and long-lasting efficacy, and demonstrating a clearly targeted therapeutic effect of black hot springs.

This invention provides a dense honeycomb structure cross-linked sodium hyaluronate gel and its preparation method, comprising the following steps: S1. Preparing a chloride ion solution, adding a cross-linking agent, slowly adding sodium hyaluronate under stirring conditions, adjusting the pH to alkaline, and stirring evenly under vacuum conditions to obtain a mixture; S2. Maintaining vacuum conditions, heating the mixture in a water bath, cutting it to obtain a block gel, cross-linking it in a water bath to obtain a cross-linked sodium hyaluronate gel; S3. Adjusting the pH of the cross-linked sodium hyaluronate gel to neutral, performing a first vortex-shear composite grinding treatment to obtain a homogeneous paste-like gel, dialysis, then a second vortex-shear composite grinding treatment, adding non-cross-linked sodium hyaluronate and PBS solution, performing a third vortex-shear composite grinding treatment, filling, and sterilizing to obtain the dense honeycomb structure cross-linked sodium hyaluronate gel. The dense honeycomb structure cross-linked sodium hyaluronate gel obtained by this invention has smooth injection, strong support, long-lasting effect, and low adverse reaction rate.