82 results about "Terpyridine" patented technology

The invention discloses a flame-retardant corrosion-resistant coating and a preparation method thereof, and relates to the technical field of coatings. When the flame-retardant and corrosion-resistant coating is prepared, hexaaryl biimidazole and epoxy chloropropane are subjected to a reaction, and epoxidized hexaaryl biimidazole is prepared; the pre-modified mica sheet and 3-aminopropyltriethoxysilane are subjected to a reaction, and a modified mica sheet is prepared; the preparation method comprises the following steps: reacting allyl amine with 4 '-[4-(bromomethyl) phenyl]-2, 2': 6 ', 2' '-terpyridyl to obtain allyl terpyridyl; the preparation method comprises the following steps: reacting epoxy resin with allyl terpyridyl to obtain modified epoxy resin; and uniformly mixing the modified epoxy resin, epoxidized hexaaryl biimidazole, the modified mica sheet, isophorone diamine and acetone to prepare the flame-retardant corrosion-resistant coating. The flame-retardant corrosion-resistant coating prepared by the invention has excellent corrosion resistance, flame retardance and self-repairing performance.

The invention belongs to the technical field of preparation of transition metal organic photocatalysts, and particularly relates to design and a preparation method of a carbazole terpyridyl nickel catalyst. The invention aims to design and synthesize a carbazole terpyridyl nickel catalyst with light / nickel synergistic catalytic activity. The preparation method comprises the following specific synthesis steps: reacting different types of alpha-pyridone pyridinium and alpha, beta-unsaturated ketone in methanol, and carrying out suction filtration, washing, drying and other operations to obtain the corresponding carbazole terpyridyl ligand. The carbazole terpyridyl ligand and anhydrous nickel bromide are subjected to a heating reflux reaction in a tetrahydrofuran solution, and the corresponding carbazole terpyridyl nickel catalyst is obtained through methanol washing, suction filtration, drying and other operations. The terpyridyl nickel catalyst has high catalytic activity in a C-N, C-O and C-S coupling reaction promoted by visible light.

The invention discloses a reinforced flame-retardant PC composite material and a preparation method thereof, and relates to the technical field of composite materials. Comprising the following raw materials in parts by weight: 80 parts of PC resin, 10-20 parts of hydroxyl-terminated hyperbranched polycarbonate, 5-8 parts of a micro-crosslinking agent, 3-5 parts of a coupling agent, 25-35 parts of a filler, 5-8 parts of hyperbranched tripolyphosphazene terpyridyl CTP-TPY, 2-4 parts of a compatilizer, 0.3-0.6 part of an antioxidant, 0.3-0.6 part of a lubricant, 0.8-1.2 parts of an initiator and 1-3 parts of 9, 10-di-tert-butyl-4-methylphenol. The invention relates to a high-temperature-resistant anti-corrosion coating which is prepared from the following components in parts by weight: 2-6 parts of 2-acrylamido-2-methylpropanesulfonic acid, 2-4 parts of 1, 10-dihydro-9-oxa-10-phosphaphenanthrene-10-oxide, 1-3 parts of octaphenylcyclotetrasiloxane, 4-6 parts of 2-acrylamido-2-methylpropanesulfonic acid and 0.8-1.2 parts of a catalyst. The reinforced flame-retardant PC composite material is good in mechanical property and excellent in flame retardance, impact toughness and weather resistance.

The present invention relates to the field of optical material technology, and discloses a flexible organic room temperature phosphorescent material, its preparation method, and application. The preparation method comprises the following steps: dissolving a terpyridine phosphor and a polymer in water to obtain a precursor solution, annealing the precursor solution, and volatilizing the precursor solution to form a film to obtain the flexible organic room temperature phosphorescent material; the present invention uses a terpyridine compound as a phosphor and physically doping it into a polymer matrix to prepare an ultra-long organic room temperature phosphorescent material; and by regulating the doping concentration and type of phosphorescent molecules, the afterglow life and color can be regulated. The required raw materials are inexpensive and readily available, and the prepared material has the advantages of good flexibility, high transparency, and a long phosphorescence life, and has broad application prospects in the fields of afterglow display, information encryption, and anti-counterfeiting.

This invention belongs to the field of organic synthesis and relates to a method for synthesizing monofluoroalkenyl silicon. Using terpyridine ruthenium chloride hexahydrate as a catalyst, triethylenediamine as a base, tert-butyl peroxybenzoate as an initiator, and dimethyl sulfoxide as a solvent, the following reaction formula is carried out to produce a class of E-configuration monofluoroalkenyl silicon compounds. The starting materials are readily available and inexpensive, with high selectivity. The reaction requires only a single step, resulting in a short route and no pre-prepared special reagents, resulting in high economic value. This provides an efficient, practical, and convenient method for synthesizing E-configuration monofluoroalkenyl silicon compounds. #imgabs0#

The application discloses an organic-inorganic composite modified concrete external curing agent and a preparation method thereof. The organic-inorganic composite modified concrete external curing agent is prepared by mixing 100-150 parts by weight of polyvinyl ether terpyridine modified styrene-acrylic emulsion, 8-16 parts by weight of sodium silicate nonahydrate, 15-30 parts by weight of polyethylene glycol, 1-1.5 parts by weight of a defoaming agent, 1-1.5 parts by weight of a leveling agent and 20-50 parts by weight of deionized water. The application is sprayed or coated on the surface of concrete, can quickly form a thin layer of dense film on the surface, has good environmental adaptability, can effectively work under various climate conditions, ensures that the internal moisture of concrete is retained, promotes the full hydration of cement, and thus improves the overall performance of concrete and prolongs the service life of concrete. Meanwhile, the cost effectiveness and environmental friendliness of the application are good, which is helpful to realize the sustainable development goal of concrete construction and maintenance.

The invention discloses injectable copper ion mediated antibacterial hydrogel and a preparation method and application thereof, and relates to the technical field of medicinal chemistry, the injectable copper ion mediated antibacterial hydrogel is formed by self-assembly of 4 '-[(4-(4-morpholinyl butoxy) phenyl)]-2, 2': 6 '2 ''-terpyridyl ligand L and copper ions, and the antibacterial hydrogel has a porous structure; the preparation method comprises the following steps: mixing a 4 '-[(4-(4-morpholinyl butoxy) phenyl)]-2, 2': 6 '2 ''-terpyridyl ligand L with a copper bromide aqueous solution to prepare hydrogel; the invention also provides an application of the antibacterial hydrogel in preparation of antibacterial drugs. The process for preparing the hydrogel is simple, the prepared hydrogel is excellent in antibacterial performance and has good biocompatibility, in-vivo greater wax moth larva infection treatment tests also prove that the hydrogel has a good in-vivo antibacterial effect, and the survival rate of greater wax moth larvae can be increased.

The invention discloses a transition metal catalyst based on a terpyridine ligand, a preparation method and application thereof, and particularly relates to application of the transition metal catalyst in the field of catalyzing copolymerization of olefin and polar monomers, the structural formula of the metal catalyst is shown in the specification, and R1 is selected from any one of a hydrogen atom electron-donating group or a fluorine atom electron-withdrawing group; and R2 is selected from a hydrogen atom electron-donating group. According to the scheme, terpyridyl with excellent coordination capability is used as a ligand to prepare the transition metal catalyst, and the electronic effect of the ligand is regulated and controlled, so that the catalytic performance of the catalyst is optimized, and favorable regulation and control on the catalytic activity, the relative molecular mass and distribution of a polymer, the copolymerization performance and the like are realized.

The present invention discloses an N^N^N type terpyridine platinum complex, its preparation method, and application. The present invention relates to the technical field of fluorescent probe material preparation, and specifically to an N^N^N type terpyridine platinum complex, its preparation method, and application. The present invention mixes 4'-(3,4-bisethoxyphenyl)-2,2':6',2''-terpyridine (S1) with K2PtCl4, adds a halogenated hydrocarbon solvent and an alcohol solvent, and conducts a heating reaction. After the reaction, the solvent is removed by reduced pressure distillation, and column chromatography is used for purification to obtain an N^N^N type terpyridine platinum complex. The preparation method of the N^N^N type terpyridine platinum complex of the present invention has readily available raw materials, a simple reaction process, and can be industrially produced. It has specific targeting to lysosomes, low cytotoxicity, and good two-photon absorption activity, and has good application prospects in lysosomal analysis and imaging products.

The present invention relates to the technical field of luminescent materials, and discloses an organic room-temperature phosphorescent material with controllable afterglow performance, a preparation method thereof, and an application thereof. The method includes the following steps: Step 1, dissolving a terpyridine derivative and a polymer in water to obtain a precursor solution; removing water by volatilization to obtain an organic room-temperature phosphorescent material; Step 2, soaking the organic room-temperature phosphorescent material in an aqueous solution containing lanthanide ions, and removing water by volatilization to obtain the organic room-temperature phosphorescent material with controllable afterglow performance; by regulating the concentration of lanthanide ions in the aqueous solution containing lanthanide ions, the afterglow performance of the organic room-temperature phosphorescent material is regulated, and the prepared material still has the advantage of transparency. On the other hand, the organic room-temperature phosphorescent material with controllable afterglow performance exhibits long-wavelength fluorescence emission and short-wavelength afterglow emission, greatly expanding the scope of practical applications.

The present invention discloses a preparation method of a terpyridine functional chain extender. The terpyridine functional chain extender is a terpyridine functional chain extender capped with dihydroxy groups. The preparation method is as follows: Under an anhydrous and anaerobic environment, 4'-bromo-2,2':6,2'-terpyridine and triethanolamine are mixed, and then cuprous iodide and cesium carbonate are added as catalysts. The reaction is carried out under reflux in a sealed environment, cooled to room temperature, the organic phase is extracted, and purified by column chromatography. At the same time, the present invention also discloses the application of the terpyridine functional chain extender in the preparation of a self-healing conductive polyurethane elastomer. When preparing the self-healing conductive polyurethane elastomer of the present invention, no solvent is required, pollution is reduced, and a polyurethane material with good conductivity, mechanical properties and room temperature self-healing properties can be prepared.

The invention belongs to the technical field of fluorescent probes, and particularly relates to a fluorescent probe for detecting pyrophosphoric acid or pyrophosphate based on ratiometric fluorescence, a preparation method and application. According to the fluorescent probe, cyclotriphosphazene is taken as a core platform, a naphthalimide-triphenylamine luminophore and a terpyridine recognition unit are introduced, a multi-arm fluorescent probe is integrally formed, coordination terpyridine interacts with metal ions Zn < 2 + >, fluorescence signals are induced to change, and therefore sensitive detection on PPi is achieved. The fluorescent probe has the advantages of quick response, high selectivity, interference resistance and low cost, and has important application value in the fields of environmental science, biological science and the like.

The application discloses a terpyridine zinc complex and a preparation method and application thereof, and belongs to the technical field of materials. The terpyridine zinc complex has the following molecular structure: wherein X is a counter anion; R1 and R2 are independently selected from a nitrogen heterocyclic unit, a benzene ring unit or a triphenylamine unit. The terpyridine zinc complex has a semiconductor property, can generate hydrogen peroxide under sunlight together with water and oxygen, and can be applied as a photosensitizer or a photocatalyst.

The invention discloses a programmable singlet-triplet exciton regulated molecular platform as well as a preparation method and application thereof, and belongs to the technical field of organic photoelectric materials. The molecular platform comprises a D-sigma-A ligand formed by connecting a carbazole donor unit with a terpyridine receptor unit through a flexible alkyl spacer chain, and a zinc salt complex coordinated with the ligand. By cooperatively regulating and controlling the alkyl spacer chain length and the zinc salt counter ion type, the full-range and continuous accurate modulation of the solution phase singlet state and triplet state exciton population ratio from nearly 0% to about 100% can be realized in a single molecule platform. A series of dissolved oxygen probes can be constructed based on the platform: when an alkyl chain is relatively short, a turn-off probe based on luminous intensity change is formed; when the alkyl chain is long, a self-calibration ratio-type probe based on a characteristic peak intensity ratio is formed. The invention provides a brand new programmable material tool for excited state dynamics research and high-precision optical sensing.

The present invention relates to a method for recovering lithium from natural or artificial brines that comprises preparing a terpyridine-functionalised composite, contacting the brine with the functionalised composite inside a filtering bag in a column, maintaining contact until a functionalised composite-lithium complex is formed, controlling the process until the saturation of the functionalised composite-lithium complex is reached, acidifying the complex with a strong acid to release the lithium and recovering the lithium. The composite formed with mesoporous materials on a nano- or micrometre scale is capable of extracting and concentrating the lithium after initial contact with said composite for at least 48 hours at room temperature. The formed composites exhibit a high lithium-bonding capacity based on brines with lithium concentrations as low as 2 ppm, in addition to being very strong. This lithium can be easily released by means of a change in pH, with a strong acid.

The application provides a preparation method of an ion complex and a supramolecular framework assembly, an artificial solid electrolyte interface phase and a zinc metal anode, and belongs to the field of supramolecular framework assemblies. The ion complex is prepared through ion interaction of a polyoxometalate cluster, coordination of zinc ions and cationic terpyridine and hydrogen bonding of grafted carboxyl groups, so that the three-dimensional SF is constructed in a good crystalline state. The three-dimensional growth of the framework of the ion complex is beneficial to improving the structural stability, while the unique performance is maintained. The ion complex can grow in situ on the zinc surface and further extend laterally to form a defect-free full coverage layer. Through dissolution and post-coordination effect, the 3D SF layer is used as an artificial solid electrolyte interface to improve the performance of the zinc anode. The clusters uniformly distributed in the nanopores of the ion complex form negatively charged nanochannels, which can accelerate the transfer of zinc ions and make the zinc deposition uniform.

The invention relates to the field of underground engineering, in particular to a waterproof corrosion-resistant anti-cracking plugging material for underground engineering as well as a preparation method and application of the waterproof corrosion-resistant anti-cracking plugging material. The problems that an existing plugging material is poor in corrosion resistance and insufficient in anti-cracking capacity are solved. A polyethylene glycol grafted terpyridyl benzotriazole copolymer is added into the plugging material, and the preparation method of the polyethylene glycol grafted terpyridyl benzotriazole copolymer comprises the following steps: firstly, reacting 2, 4-dinitrobenzaldehyde with 2-acetylpyridine, and then reducing with stannous chloride dehydrate to obtain diaminophenyl terpyridyl; the preparation method comprises the following steps: carrying out a series of reactions on 2, 5-methyl benzotriazole to obtain epoxy benzotriazolyl oxadiazole, and carrying out a cross-linking reaction on diaminophenyl terpyridyl, polyethylene glycol diglycidyl ether and epoxy benzotriazolyl oxadiazole to obtain a polyethylene glycol grafted terpyridyl benzotriazole copolymer. The corrosion resistance, crack resistance and impermeability of the material are improved, and the long-term stability and reliability of the material are improved.

The invention belongs to the technical field of organic synthesis, and discloses a ketene derivative as well as a preparation method and application thereof. A novel synthesis method is researched and developed, a strategy of catalytic reduction coupling reaction of cheap metal cobalt is adopted, cobalt bromide is used as a catalyst, terpyridyl is used as a ligand, zinc powder is used as a reducing agent, and dimethyl sulfoxide is used as a solvent to realize coupling addition. Aiming at the reaction conditions of the reaction, the four aspects of the catalyst, the reaction solvent, the ligand and the reaction temperature are confirmed and optimized. By researching and developing the novel synthesis method, the synthesis of the ketene derivative has wider universality, reaction conditions are milder, the reaction process is easier to operate and control, and the method is energy-saving, environment-friendly, economical and efficient. In addition, an intermediate of a medicine rosuvastatin calcium for treating cardiovascular diseases is synthesized by using the method, so that the intermediate has potential significance in industrial production. # imgabs0 #

The invention belongs to the technical field of functional materials, and particularly relates to color-changing ink for anti-drilling identification of a wine bottle body as well as a preparation method and application of the color-changing ink. The color-changing ink provided by the invention is prepared by taking a novel terpyridyl diyne compound as a raw material; the terpyridyl diyne compound is formed by connecting diyne compounds with different chain lengths and terpyridyl with different structures through amido bonds, has excellent color change performance, can improve the change temperature, and is good in color change stability; the color-changing performance of the paint is not influenced when the paint is dispersed in various paints; the method has sensitive responsiveness to the temperature and has potential application prospects in the aspects of temperature warning, safety protection and the like. The material is used for preparing the color-changing ink, the bottle body of the wine bottle is coated with the color-changing ink, and anti-drilling identification can be effectively carried out.

The invention relates to an electrochemiluminescence sensor based on an intelligent controlled release-interface capture-self-enhancement mechanism and application of the electrochemiluminescence sensor in procalcitonin detection, and belongs to the technical field of electrochemiluminescence detection. Controllable release of signal molecules is achieved by packaging terpyridyl ruthenium through ZIF-8, meanwhile, a DNA layer rich in guanine is modified on an electrode interface, and the layer can serve as a nano trap to efficiently capture the signal molecules and can also serve as a co-reactant to achieve signal amplification. A DNA strand displacement reaction is utilized to regulate and control a target response release process, and detection is realized according to a quantitative relationship between the concentration of procalcitonin and an electrochemical luminescence signal. A labeling recovery method verifies that the recovery rate of the sensor in a human serum sample reaches 100.6-103.6%, good accuracy and precision are shown, and a reliable platform is provided for clinical detection of inflammatory markers.

The invention belongs to the technical field of fluorescent probes, and particularly relates to application of a triphenylamine-terpyridyl fluorescent probe to detection of nucleotide and / or chain-shaped polyphosphoric acid. The fluorescent ligand TPA-3TPY provided by the invention is chelated with # imgabs0 # ions in situ to successfully prepare the metal complex, so that the fluorescence emission wavelength moves towards the long wave direction. When the nucleotide and the derivative thereof are detected, the # imgabs 1 # ion is separated from the fluorescent ligand, and the fluorescence emission wavelength is recovered, so that the effective detection of the nucleotide and the derivative thereof is realized. The method has the advantages of quick response, high selectivity, interference resistance and low cost, and has important application value in the fields of food science, environmental science, biological science and the like.

The invention belongs to the technical field of organic synthesis, and particularly discloses a terpyridine derivative synthesis method, which comprises: carrying out a hydrolysis / carboxylation reaction on a 2-cyanopyridine derivative under the catalysis of an acidifying agent, the method comprises the following steps: adding a catalyst into a pyridine-2-carboxylic acid derivative in an aprotic polar solvent, and carrying out intermolecular condensation cyclization on the pyridine-2-carboxylic acid derivative; the preparation method comprises the following steps: in the presence of an ammonium salt, constructing a terpyridine skeleton through a dehydration ring-closing reaction of a 1, 5-di (2-pyridyl) pentane-1, 3, 5-triketone derivative; a chlorination reagent is adopted to carry out selective chlorination reaction on a terpyridyl skeleton. According to the synthesis method of the terpyridyl derivative, the economical efficiency, the safety, the environmental protection property and the industrial feasibility are considered, a new path is provided for efficient, green and low-cost preparation of terpyridyl compounds, and the synthesis method has important practical application value and market prospects.

The application belongs to the technical field of chemical medicines and relates to a crystal form of a terpyridine diketone compound shown in formula (I), which is a p38 / MK2 inhibitor, can inhibit the production of a cytokine TNF alpha and is used for treating diseases such as arthritis.

The present invention relates to the field of organic light-emitting materials, and specifically to a heat-induced delayed fluorescence complex, a preparation method thereof, and an organic electroluminescent device. The present invention provides a heat-induced delayed fluorescence complex, a preparation method thereof, and an organic electroluminescent device. The heat-induced delayed fluorescence complex provided by the present invention has TADF characteristics, good stability, short delayed fluorescence lifetime, and high fluorescence efficiency; it utilizes the strong coordination ability of nitrogen-containing aromatic heterocyclic groups such as dipyridine and terpyridine, and after coordinating them with metal cations, increases their receptor strength and improves the rigidity of their derivatives, and utilizes the coordination effect to induce organic molecules that originally do not have TADF to form a complex with TADF characteristics after coordination and has a high luminescence efficiency. Experiments show that the complex provided by the present invention achieves an external quantum efficiency of 11.7% in the performance test of the electroluminescent device, breaking through the external quantum efficiency limit of 5% of traditional fluorescent materials.

The application belongs to the technical field of biology and specifically relates to a kind of fluorescent compound with aggregation-induced emission characteristics and a preparation method and application thereof.A new kind of terpyridine fluorescent compound with aggregation-induced emission characteristics is synthesized, which has the characteristics of easy preparation, high fluorescence intensity, low fluorescence background, high biological safety and the like.The compound prepared by the application can be used as a fluorescent dye and photosensitizer for bacterial membrane and DNA double targeting, and has the advantages of good light stability, good biocompatibility, short time consumption and simple operation in dyeing imaging effect, and can be used for bacterial imaging, distinguishing gram-positive bacteria and gram-negative bacteria.The compound of the application can also be used for antibacterial treatment of drug-resistant bacteria, mainly by targeted binding to destroy the structure of bacterial membrane and DNA, to achieve high-efficiency bacterial killing effect, and has broad spectrum.

The invention discloses a water-phase visible light catalytic reduction coupling synthesized polysubstituted olefin and a preparation method thereof. The method aims to overcome the dependence on toxic organic solvents, harsh conditions or noble metal catalysts in traditional synthesis. According to the method, a terpyridyl ruthenium complex is used as a photocatalyst, sodium ascorbate is used as a reducing agent, and the method is carried out in a water-phase micelle micro-reaction system formed by a surfactant under mild blue light irradiation and inert atmosphere. According to the system, the synergistic effect of solubilization and enrichment effects of micelles on reactants and catalysts and photocatalytic circulation is utilized, so that the reaction efficiency and selectivity are remarkably improved. The method is mild in condition, environment-friendly and simple and convenient to operate, and a new way is provided for green synthesis of high-added-value fine chemicals and functional molecules.

This invention discloses a dual-site heterovalent metal MOF material for NO adsorption, its preparation method, and its application, belonging to the field of gas adsorption materials. The chemical formula of this material is [Cu]. Ⅰ (Cu Ⅱ )4(2-TPY)2(IA ‑ )3(NO3 ‑ )2I ‑ O 2‑ ]·(NO3 ‑ The material was prepared by a solvothermal method using the reaction of bis(terpyridine), isonicotinic acid, and cuprous iodide. This material possesses a three-dimensional structure and Cu... Ⅰ / Cu Ⅱ The bimetallic active sites exhibit excellent thermal stability, high specific surface area, and highly selective adsorption capacity for NO. This invention solves the problems of low NO adsorption capacity and poor selectivity of traditional adsorbents in complex flue gas, and can efficiently achieve NO / CO separation. It is suitable for the deep removal and resource utilization of NO in industrial waste gas, and has good cycle stability and application prospects.

The application discloses a kind of probe with terpyridine as recognition group and containing three electron donors and a preparation method and application thereof.The para position of the three pyridine nitrogens of the compound simultaneously contains a carbazole, 3,6-di-tert-butyl carbazole, diphenylamine, 4,4'-dimethoxytriphenylamine or 10-phenylphenothiazine electron donor;In the preparation method, with tris(dibenzylideneacetone) dipalladium, palladium catalyst such as tetra(triphenylphosphine) palladium or cuprous iodide as catalyst, with 4,4',4"-tribromo-2,2':6',2"-terpyridine or 4,4"-dibromo-[2,2':6',2"-terpyridine]-4'-yl trifluoromethanesulfonate as intermediate, the probe is prepared.The application realizes rapid visual sensitive detection of copper ions.

The invention discloses a preparation method of dynamic metal double coordinate bond cross-linked ethylene propylene diene monomer rubber. Amino-terminated terpyridine and maleic anhydride grafted ethylene propylene diene monomer are subjected to a reaction, terpyridine and carboxyl generated by the reaction are coordinated with ferrous ions, and the double-coordination-bond cross-linked ethylene propylene diene monomer is prepared. On one hand, strong coordinate bonds formed by ferrous ions and terpyridyl effectively improve the mechanical strength and toughness of the elastomer; on the other hand, weak coordination bonds of ferrous ions and carboxyl can accelerate dissociation and recombination of dynamic bonds, and can be used as sacrificial bonds to improve the energy dissipation capability of the material. According to the present invention, the mechanical property, the self-repairing property and the remolding and recycling property of the ethylene propylene diene monomer are regulated and controlled through the synergy of the two metal coordinate bonds, and the preparation method is simple, and has potential application prospects in the fields of aerospace, electronics, buildings and the like.

The present invention discloses a micro electrochemiluminescent biosensor for measuring thrombin activity, a preparation method and its application, which belong to the field of electrochemiluminescent biosensors. A micro electrochemiluminescent biosensor is constructed using a thrombin-specific peptide as an activity recognition unit and a terpyridine ruthenium-tri-n-propylamine-ferrocene system as a luminescence quenching system. Only 10 μL of whole blood or serum is needed to achieve rapid and accurate measurement of thrombin activity. Combining the micro electrochemiluminescent biosensor with a portable device for thrombin activity detection can greatly improve the convenience and timeliness of the detection, and is expected to achieve real-time monitoring at the bedside, providing a fast and accurate diagnostic basis for the clinic and optimizing patient treatment management.