Fluorescent probe for detecting sarin and analogue thereof as well as synthesis method and application of fluorescent probe

A technology of fluorescent probe and synthesis method, which is applied in the field of fluorescent sensing, can solve the problem of inability to detect sarin poison and its simulants, and achieve excellent sensing performance, easy mass preparation, and fast response
CN106748976AActive Publication Date: 2017-05-31SHANGHAI INST OF MICROSYSTEM & INFORMATION TECH CHINESE ACAD OF SCI
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
SHANGHAI INST OF MICROSYSTEM & INFORMATION TECH CHINESE ACAD OF SCI
Publication Date
2017-05-31

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Abstract

The invention relates to a fluorescent probe for detecting sarin and an analogue thereof. The fluorescent probe comprises a compound which is loaded on a substrate and has a structure shown as a formula I, wherein the formula I is shown in the description. The invention further provides a synthesis method and application of the fluorescent probe for detecting the sarin and the analogue thereof. According to the application provided by the invention, when a compound with the structure shown as the formula I in the fluorescent probe is in contact with the sarin or the DCP (Diethyl Chlorophosphate) in air, the fluorescence intensity and the emission wavelength are both changed, and gas-phase detection of the sarin and the DCP can be realized. The compound with the structure shown as the formula I can have one or more terpyridines; when the sarin or the DCP reacts with one certain pyridine in one certain terpyridine in a molecule, charge transferring from the fluorescent probe to the sarin or the DCP occurs; meanwhile, energy transferring from a polymer core to a peripheral radical occurs, and fluorescent quenching of the whole molecule is caused, so that the fluorescent probe has excellent sensing performance.
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Description

technical field

[0001] The present invention relates to the technical field of fluorescent sensing, and more specifically relates to a fluorescent probe for detection of sarin poison and its simulant, its synthesis method and application. Background technique

[0002] Sarin, whose scientific name is isopropyl meflodronate, is a commonly used military nerve gas. Sarin can inhibit the activity of acetylcholinesterase in organisms, make acetylcholine accumulate in the body, and cause cholinergic nervous system dysfunction. All voluntary and involuntary muscle movements of organisms are a balance between acetylcholine and acetylcholinesterase. After this balance is disrupted, the muscles will only contract but not expand, which will cause paralysis of respiratory function, miosis, gastrointestinal spasm and severe pain, and tear secretion The ducts of blood, sweat and saliva will also discharge a large amount of secretions due to contraction, which makes people die very painful...

Claims

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