412 results about "Tricarboxylic acid" patented technology

The invention discloses a low-cost neutral aqueous organic iron-cerium flow battery, and belongs to the field of electrochemical energy storage. The positive electrode electrolyte and the negative electrode electrolyte both adopt organic phosphine ligand chelating metals in a water system, and organic phosphine ligands are selected from 2-hydroxyphosphonoacetic acid, etidronic acid, diethylenetriaminepenta (methylene phosphonic acid), 2-phosphonobutane-1, 2, 4-tricarboxylic acid, polyhydric alcohol phosphate ester, hexamethylenediamine tetra (methylene phosphonic acid), polyamino polyether methylene phosphonic acid and bis (1, 2, 4-tricarboxylic acid. And one or more of 2, 6-hexylidene triamine penta (methylene phosphonic acid) and lithium, sodium, potassium and ammonium salt derivatives thereof. And the supporting electrolyte is used for adjusting and stabilizing the pH environment of the electrolyte. According to the invention, no additional auxiliary electrolyte is needed, high conductivity and stable performance can be achieved, and a new possibility is developed for development and application of a flow battery technology. The material has the characteristics of stable performance, low cost, wide raw material source and environmental friendliness, and is suitable for automobile power supplies, household energy storage, standby power supplies, large-scale energy storage devices and the like.

The invention belongs to the technical field of concrete, and particularly relates to a concrete hydration temperature rise inhibitor and a preparation method and application thereof. The concrete hydration temperature rise inhibitor is of a core-shell structure composed of an inner core and a shell layer. Wherein the core comprises a porous material and a hydration temperature rise inhibition material loaded on the porous material, and the hydration temperature rise inhibition material comprises 2-phosphonobutane-1, 2, 4-tricarboxylic acid, modified starch, 1-hydroxyethylidene-1, 1-diphosphonic acid, sodium polyacrylate and cellulose ether. The concrete hydration temperature rise inhibitor has an efficient hydration heat inhibition effect, the proportion of a hydration temperature rise inhibition material in the inhibitor is large, meanwhile, an exothermic temperature peak can be accurately inhibited, and no negative influence is caused to a hydration induction period.

The invention discloses an aconitic acid-based polyester plasticizer and a preparation method thereof, and relates to the technical field of plasticizer composite materials, the molecular structure of the plasticizer is as follows: # imgabs0 #, R1 and R2 are independently selected from alkyl groups containing 1-4 carbon atoms, and the number n of structural units is 1-20. The aconitic acid-based polyester plasticizer provided by the technical scheme of the invention avoids the cross-linking phenomenon in the process of preparing a polyester material from tricarboxylic acid, so that the aconitic acid-based polyester plasticizer has good flowability and plastification performance when plastifying a plastic matrix, meanwhile, the reaction raw materials are derived from biomass, the preparation process conditions are mild, the equipment requirement is low, and the yield is high.

The invention provides a reverse osmosis high-silicon-resistant scale inhibitor for coal chemical wastewater and application of the reverse osmosis high-silicon-resistant scale inhibitor. The reverse osmosis high-silicon-resistant scale inhibitor for the coal chemical industry wastewater comprises an acrylic acid-sulfonate copolymer, 1, 2, 4-tricarboxylic acid-2-phosphonic acid butane, polyacrylic acid and hydrolytic polymaleic acid, and the weight ratio of the acrylic acid-sulfonate copolymer to the 1, 2, 4-tricarboxylic acid-2-phosphonic acid butane to the polyacrylic acid to the hydrolytic polymaleic acid is (15-25): (10-20): (2-8): (1-5).

The invention relates to construction of a Ralstonia strain capable of producing isobutanol by utilizing fructose and carbon dioxide and application of the Ralstonia strain. The construction method comprises the following steps: firstly, knocking out bkdA and bkdB genes in tricarboxylic acid cycle of the Ralstonia H16 to obtain a recombinant strain H1601; then, a PHB operator phaCAB in the H1601 is knocked out, and an alsS gene of bacillus subtilis and ilvC and ilvD genes of Ralstonia are introduced into the site, so that a recombinant strain H1602 is obtained. And finally, introducing yqhD and kivD gene expression cassettes of escherichia coli into the H1602, and constructing a recombinant strain H1603 capable of synthesizing isobutanol by using fructose and carbon dioxide. The strain can be used for synthesizing isobutanol through heterotrophic or autotrophic fermentation by taking carbon dioxide and fructose as carbon sources, the operation is simple and convenient, and higher yield can be obtained.

The invention relates to a carboxylic acid ligand-copper metal organic framework nano material, a preparation method thereof and an injection. The carboxylic acid ligand-copper metal organic framework nano material is of a polycrystal MOF structure formed by connecting carboxylic acid ligands and copper ions through coordinate bonds; the carboxylic acid ligand comprises at least one of dicarboxylic acid and tricarboxylic acid; preferably, the dicarboxylic acid comprises at least one of itaconic acid and fumaric acid, and the tricarboxylic acid comprises at least one of aconitic acid and citric acid; the valence states of the copper ions comprise zero valence, + 1 valence and + 2 valence; preferably, based on the total amount of the copper ions being 100 at%, the total content of Cu0 and Cu + is 85-90 at%, and the content of Cu2 + is 10-15 at%.

The invention relates to the field of bioengineering, in particular to a construction method and application of recombinant yarrowia lipolytica with high succinic acid yield. The recombinant yarrowia lipolytica disclosed by the invention simultaneously expresses a reduced tricarboxylic acid pathway related gene, a glyoxylic acid circulation pathway related group, a heterologous dicarboxylic acid transport related gene and a mitochondrial transport related gene, and an endogenous dicarboxylic acid transport protein coding gene is also knocked out; and a natural promoter of an isocitrate dehydrogenase coding gene IDH1 is replaced. The recombinant yarrowia lipolytica constructed by the invention can produce 112.85 g / L of succinic acid after fed-batch fermentation under the condition of not controlling pH, and efficient synthesis of succinic acid in the yarrowia lipolytica is realized.

The invention discloses a tear-resistant fluororubber material and a preparation method thereof, and belongs to the technical field of fluororubber production, and the tear-resistant fluororubber material comprises the following raw materials: tetrafluoroethylene-propylene rubber, modified carbon nanotubes, a vulcanizing agent, an accelerant, a plasticizer and an anti-aging agent. The modified carbon nanotube is prepared by the following steps: adding a multi-walled carbon nanotube into 2-phosphonobutane-1, 2, 4-tricarboxylic acid, vacuumizing, heating and stirring, cooling, discharging, washing and drying to obtain a phosphonic acid modified carbon nanotube, adding the phosphonic acid modified carbon nanotube and thioacetamide into pure water, ultrasonically stirring, adding a metal nitride, and stirring to obtain the phosphonic acid modified carbon nanotube. And heating to 80-90 DEG C, stirring at a constant temperature for 8-10 hours, cooling to room temperature after the stirring is finished, and carrying out suction filtration, washing and drying to obtain the modified carbon nanotube. Through detection, the fluororubber prepared by the invention has excellent tear resistance, mechanical property and flame retardant property.

The invention belongs to the technical field of bioengineering, and relates to a yarrowia lipolytica strain with high squalene yield, a construction method of the yarrowia lipolytica strain and an application method of the yarrowia lipolytica strain in squalane synthesis. Specifically, a DGA1 gene is knocked out on the basis of constructed recombinant yarrowia lipolytica by utilizing a gene editing means, and then a squalene synthetase gene is integrated on a genome, so that a series of recombinant yarrowia lipolytica strains with high squalene yield are constructed; the high-yield strain is subjected to fermentation culture optimization, tricarboxylic acid circulation metabolism is strengthened, alkane is added into a culture solution for extraction to promote discharge of products, and the final squalene yield reaches 42.1 g / L; the squalene extracted and separated from the fermentation broth is subjected to hydrogenation reduction by taking Reshaki nickel as a catalyst to obtain squalene. The constructed recombinant yarrowia lipolytica strain has the advantages of high yield, simple product extraction, separation and conversion, low production cost, and good industrial application prospects.

The invention belongs to the technical field of polyester polyol preparation, and particularly relates to phosphorus-nitrogen synergistic flame-retardant polyester polyol and a preparation method thereof.The phosphorus-nitrogen synergistic flame-retardant polyester polyol is obtained by conducting condensation polymerization on a phosphate carboxylic acid compound I, a phosphate carboxylic acid compound II, micromolecular polyol and micromolecular polybasic acid under the action of a catalyst; wherein the phosphate carboxylic acid compound I is obtained by carrying out esterification reaction on 2-phosphonobutane-1, 2, 4-tricarboxylic acid and coniferyl alcohol under the action of concentrated sulfuric acid; the phosphate carboxylic acid compound II is obtained by carrying out esterification reaction on 2-phosphonobutane-1, 2, 4-tricarboxylic acid and 1H-imidazole-5-propanol under the action of concentrated sulfuric acid. The flame retardant property is improved through phosphorus-nitrogen synergism, and meanwhile, the aging resistance is improved. The invention also provides a preparation method thereof.

The invention relates to the technical field of medicines, in particular to application of alpha-ketoglutaric acid in preparation of a medicine for preventing and / or treating myopia. The invention provides application of alpha-ketoglutaric acid or pharmaceutically acceptable salt thereof in preparation of products for preventing and / or treating myopia, and the alpha-ketoglutaric acid is taken as an important intermediate metabolite of tricarboxylic acid cycle in mitochondrial aerobic respiration and has oral safety; researches show that alpha-ketoglutaric acid can inhibit myopia progress and ocular axis elongation by improving sclera fibroblast phenotype transformation and extracellular matrix remodeling, and a new idea is provided for preparation of myopia intervention drugs.

The invention relates to the technical field of biological materials and tissue engineering, in particular to a three-dimensional scaffold with biological energy activity and a preparation method of the three-dimensional scaffold. The preparation method comprises the following steps: carrying out prepolymerization reaction on an intermediate product of tricarboxylic acid circulation and trihydric alcohol to obtain a prepolymerization product; mixing a polar solvent and the prepolymer to obtain a prepolymer solution; the sacrificial template, isocyanate and the prepolymer solution are mixed to remove the polar solvent, and printing slurry is obtained; carrying out 3D printing on the printing slurry under a preset printing condition so as to carry out primary cross-linking molding to obtain a crude three-dimensional bracket; carrying out secondary cross-linking molding on the crude three-dimensional bracket to obtain the three-dimensional bracket; wherein the weight m1 of the sacrificial template and the weight m2 of the prepolymer product in the prepolymer solution meet the relational expression: m1: m2 = 2: 1. According to the preparation method, the adjustability and uniformity of the pore structure of the three-dimensional scaffold with the biological energy activity can be improved at the same time, and a new material can be provided for clinical treatment of the orthopedics department.

There is provided an aqueous coating liquid having excellent storage stability and capable of forming a coating film with excellent water resistance. The aqueous coating liquid is an aqueous coating liquid for forming a coating film to be provided between a collector and an active material layer in an electrode for an electricity storage apparatus. This aqueous coating liquid contains: a water-based medium containing water; at least one polyvinyl alcohol (PVA)-based resin selected from the group consisting of unmodified polyvinyl alcohols and modified polyvinyl alcohols; an electrically conductive material; and 2-phosphonobutane-1,2,4-tricarboxylic acid (PBTC). In addition, the aqueous coating liquid satisfies a condition that the aqueous coating liquid is free of polyacrylic acid, or that even when the aqueous coating liquid contains polyacrylic acid, the content of polyacrylic acid is less than 9% by mass based on the total mass of the aqueous coating liquid. Further, the ratio of the content of the PVA-based resin in the aqueous coating liquid to the content of PBTC in the aqueous coating liquid is 2 to 100.

The invention relates to a method for recycling high-purity graphite from a negative electrode of a waste lithium battery by using a fine washing agent. The method comprises the following steps: preliminarily disassembling the waste lithium battery negative electrode to separate out a negative electrode plate; crushing and screening the negative plate by adopting a machine crusher, and collecting screened fine powder; carrying out heat treatment to remove the binder and other organic matters; stirring and soaking the graphite powder subjected to heat treatment, inorganic acid, sodium carbonate and a fine washing agent; filtering, washing a filter cake with deionized water, and drying to obtain high-purity graphite; the fine cleaning agent is prepared by the following steps: continuously irradiating acrylamide-beta-cyclodextrin, tetramercapto porphyrin, 1-butylene-2, 3, 4-tricarboxylic acid, dimethyl sulfoxide and a photoinitiator at room temperature for 30-80 minutes by keeping ultraviolet light of 365 nm and 10 mW / cm < 2 >, and distilling to remove dimethyl sulfoxide. The fixed carbon content of the recovered graphite can reach 99.98%.

The present invention discloses a combined flotation regulator for high-mud lead-zinc oxide ores and its application method. The combined regulator consists of regulator A and regulator B in a mass ratio of 1:(3-10); regulator A is a high-molecular polysaccharide substance; regulator B consists of B1 and B2, with B1 being 80-90 parts by mass and B2 being 10-20 parts by mass; B1 is sodium silicate, and B2 is at least one of polyaminopolyether methylene phosphonic acid, polyepoxysuccinic acid, and 2-butanephosphonate-1,2,4-tricarboxylic acid. The application method is as follows: grinding the raw ore, sequentially adding sodium carbonate, regulator A, regulator B, and sodium sulfide for slurry mixing, and finally adding a collector for zinc oxide mineral flotation to obtain a zinc oxide coarse concentrate. The present invention can effectively recover zinc oxide minerals in high-mud lead-zinc oxide ores, the reagent components are non-toxic and harmless, the application method is simple, and it is convenient for large-scale production management.

The invention relates to the technical field of sensor preparation and antibiotic detection, in particular to a preparation method of a dual-emission fluorescence sensor, a product and application of the dual-emission fluorescence sensor. The preparation method of the dual-emission fluorescence sensor comprises the following steps: dissolving 1, 3, 5-benzene tricarboxylic acid and melamine in an organic solvent to prepare a suspension; the suspension liquid is subjected to a first heating reaction and then mixed with zinc salt to be subjected to a second heating reaction, and Zn-MBTC is obtained; the preparation method comprises the following steps: dissolving Zn-MBTC and Ru (bpy) 3 < 2 + > in water, carrying out ultrasonic treatment and oscillation, and then washing, centrifuging and drying to obtain the dual-emission fluorescence sensor. The dual-emission fluorescence sensor prepared by the method has the advantages of high sensitivity and high detection speed when being used for detecting four tetracycline antibiotics, namely doxycycline, tetracycline, oxytetracycline and gold tetracycline, and the detection limit is as low as 0.013 mu mol / L.

The invention discloses application of a Cpeb3 gene inhibitor and a copper death inhibitor in preparation of a medicine for treating myocardial ischemia-reperfusion injury, and relates to the technical field of myocardial ischemia-reperfusion injury. By specifically reducing or knocking out Cpeb3 expression, myocardial repair can be remarkably promoted, action potential stability is improved, and the death rate is reduced. Therefore, Cpeb3 is a specific intervention target spot of copper death in Gpc6 + CMs. The small molecule inhibitor of Cpeb3 can remarkably reverse changes of copper death, aerobic respiration and / or glycolysis caused by Cpeb3 activation. In addition, the copper death inhibitor can improve the survival rate of myocardial cells, reverse the change of aerobic respiration and / or glycolysis induced by Cu, and reverse the change of glycolysis, pentose phosphate pathway and tricarboxylic acid cycle metabolites caused by Cu stimulation. Therefore, the invention provides a new solution for prevention and treatment of myocardial ischemia reperfusion injury, and has a good application prospect.

The invention relates to an electrochemical sensor for detecting xanthine, the electrochemical sensor is a three-electrode system, a working electrode of the electrochemical sensor is prepared by preparing a modification solution from Cu-BTC-HHTP-HCG and dispensing the modification solution on the surface of a glassy carbon electrode, and the Cu-BTC-HHTP-HCG is synthesized from copper nitrate trihydrate, 1, 3, 5-benzene tricarboxylic acid, 2, 3, 6, 7, 10, 11-hexahydroxy triphenylene hydrate and high-conductivity graphene. According to the electrochemical sensor for xanthine detection, Cu-BTC-HHTP has high electrocatalytic activity, specific surface area and porosity, the enrichment efficiency and electron transfer capability of xanthine can be effectively improved, meanwhile, the conductivity and stability of the electrochemical sensor can be further enhanced through compounding of high-conductivity graphene, and the electrochemical sensor can be applied to xanthine detection. Therefore, the electrochemical sensor is endowed with excellent electrochemical response performance. The electrochemical sensor is high in sensitivity, low in detection limit, good in stability and interference resistance and suitable for detecting xanthine in actual fish and shrimp products.

The invention discloses a method for efficiently synthesizing D-psicose from cane sugar by escherichia coli through double PTS transfer. E.coliJM109 (DE3) is used as a chassis host bacterium, and a D-psicose synthesis path based on a sucrose PTS transport system is established through co-expression of alsE, a6PP, scrA and scrB genes; by introducing the glpX [K29A] gene, a carbon source is driven to flow from a D-fructose PTS transport system to a D-psicose synthesis path; through knockout of pfkA and rpiA genes and inhibition of expression of fbaA genes, an endogenous glycolysis pathway and a phosphopentose pathway are adjusted, and the carbon flow entering tricarboxylic acid circulation is adjusted, and finally, the purpose that the D-psicose is efficiently synthesized from sucrose by escherichia coli through double PTS transport is finally achieved. Genetic engineering modification is carried out on wild escherichia coli, D-psicose is efficiently synthesized from sucrose by using a sucrose PTS and fructose PTS system, and a new scheme is provided for synthesis of D-psicose.

The invention discloses a corrosion and scale inhibitor for green circulating cooling water and a preparation method of the corrosion and scale inhibitor, and the scale inhibitor is prepared from the following components in parts by weight: 3 to 6 parts of acrylic acid-2-acrylamide-2-methylpropanesulfonic acid copolymer, 6 to 12 parts of 1-hydroxyethylidene-1, 1-diphosphonic acid, 6 to 15 parts of 2-phosphonobutane-1, 2, 4-tricarboxylic acid, 6 to 12 parts of polyepoxysuccinic acid and 6 to 12 parts of polyaspartic acid. The method comprises the following steps: adding an acrylic acid-2-acrylamide-2-methylpropanesulfonic acid copolymer, 1-hydroxyethylidene-1, 1-diphosphonic acid, 2-phosphonobutane-1, 2, 4-tricarboxylic acid, polyepoxysuccinic acid, polyaspartic acid and water into a stirrer, and stirring at room temperature for 10 minutes to obtain the corrosion and scale inhibitor for the green circulating cooling water. The efficient corrosion and scale inhibition performance can be guaranteed, meanwhile, the phosphorus content in cooling circulating water is greatly reduced, and breeding of algae in the circulating water is effectively restrained.

Oral care compositions including tin, monodentate ligand, and polydentate ligand with an optimized molar ratio of tin to monodentate ligand to polydentate ligand. Oral care compositions with a tin to monodentate ligand to polydentate molar ratio of from about 1:0.5:0.5 to about 1:5:5. Oral care compositions including tin, monocarboxylic acid, and tricarboxylic acid.

Oral care compositions including tin, monodentate ligand, and polydentate ligand with an optimized molar ratio of tin to monodentate ligand to polydentate ligand. Oral care compositions with a tin to monodentate ligand to polydentate molar ratio of from about 1:0.5:0.5 to about 1:5:5. Oral care compositions including tin, monocarboxylic acid, and tricarboxylic acid.

The invention relates to the technical field of scale inhibitors, and particularly discloses a scale inhibitor for a reverse osmosis membrane as well as a preparation method and application of the scale inhibitor. The scale inhibitor for the reverse osmosis membrane, provided by the invention, is obtained by carrying out dehydration condensation reaction on carboxylated chitosan and 2-phosphonobutane-1, 2, 4-tricarboxylic acid serving as raw materials. The scale inhibitor for the reverse osmosis membrane has excellent scale inhibition performance, the scale inhibition rate can reach 95% or above, meanwhile, the scale inhibitor has the advantages of being low in cost, easy to operate, safe, efficient and the like, scale can be effectively inhibited in the long-term use process, meanwhile, the structural integrity and performance stability of the reverse osmosis membrane can be kept, and the service life of the reverse osmosis membrane is prolonged. And the reverse osmosis system can be efficiently, continuously and stably operated, can be applied to reverse osmosis systems with different water source characteristics, is particularly suitable for reverse osmosis systems for advanced treatment of municipal wastewater secondary discharge water, reuse of reclaimed water, seawater desalination and the like, and has a relatively high engineering practical value.

The present invention relates to a method for producing higher titers and / or a higher quality of recombinant viruses and / or less or reduced impurities in virus like particle (VLP) production in respective production processes in mammalian cell lines, the method comprising the step of supplementing a suitable mammalian cell line culture media with at least one intermediate substrate of the tricarboxylic acid (TCA) cycle and optionally supplementing the suitable mammalian cell line culture media with further additives and / or further adjusting the conditions of the mammalian cell line culture media. Furthermore, the present invention relates to the balanced suitable mammalian cell line culture media and the use of this balanced suitable mammalian cell line culture media for producing higher titers and / or a higher quality of recombinant viruses and / or less or reduced impurities in virus like particle (VLP) production in respective production processes for producing higher titers and / or quality of recombinant viruses.

There is provided an aqueous coating liquid having excellent storage stability and capable of forming a coating film with excellent water resistance. The aqueous coating liquid is an aqueous coating liquid for forming a coating film to be provided between a collector and an active material layer in an electrode for an electricity storage apparatus. This aqueous coating liquid contains: a water-based medium containing water; at least one polyvinyl alcohol (PVA)-based resin selected from the group consisting of unmodified polyvinyl alcohols and modified polyvinyl alcohols; an electrically conductive material; and 2-phosphonobutane-1,2,4-tricarboxylic acid (PBTC). In addition, the aqueous coating liquid satisfies a condition that the aqueous coating liquid is free of polyacrylic acid, or that even when the aqueous coating liquid contains polyacrylic acid, the content of polyacrylic acid is less than 9′% by mass based on the total mass of the aqueous coating liquid. Further, the ratio of the content of the PVA-based resin in the aqueous coating liquid to the content of PBTC in the aqueous coating liquid is 2 to 100.

The present invention is directed to a method of generating hydrogen. The method comprises the steps of: combining aluminum or an aluminum alloy with gallium or a gallium eutectic to form a compound; placing the compound in contact with a solution comprising an aliphatic diprotic or triprotic carboxylic acid to corrode the aluminum or aluminum alloy, and generating hydrogen and hydrolyzed aluminum as a byproduct; collecting the generated hydrogen; and recovering the solution for reuse. The present method is an environmentally sound, highly efficient method, which generates useful quantities of hydrogen in a scalable system.

The invention relates to the technical field of synthesis of natural dyes by a biological method, in particular to an antibiotic-demand-free ornamental blue high-yield strain as well as construction and application of the antibiotic-demand-free ornamental blue high-yield strain. Corynebacterium glutamicum is used as an initial strain, a tricarboxylic acid circulating gene is regulated and interfered, and the copy number of exogenous blue pigment synthetase BpsA in a genome is adjusted, so that the ornamental blue high-yield strain is obtained. The strain does not need to use antibiotics in the fermentation process, the yield is stable, the product production capacity equivalent to the level when antibiotics are used can still be achieved through fermentation under the antibiotic-free condition, and the growth performance of the strain is kept. The method for producing the ornamental blue by using the strain provided by the invention ensures that the ornamental blue product is natural and green, also improves the efficient production capacity of the strain, solves the contradiction between green environmental protection and stable high yield of the ornamental blue dye, is green and environment-friendly, and has a remarkable industrial application prospect.

The invention relates to the field of acetylene purification and new materials, and particularly provides a double-interspersed MOF (Metal Organic Framework) and a preparation method and application thereof in acetylene purification, and the specific synthesis method comprises the following steps: reacting a tricarboxylic acid ligand 1, 3, 5-tris (4-carboxylphenyl) benzene (H3btb) with a nitrogen-containing methyl-containing ligand 3-methyl-1H-1, 2, 3, 4-tetramethyl-1, 3, 4-tetramethyl-1, 3, 4-tetramethyl-1, 3, 4-tetramethyl-1, 3, 4-tetramethyl-1, 3, 4-tetramethyl-1, 3-tetramethyl-1 The MOF (Zn-btb-fmtrz) with ultrahigh stability performance is synthesized from 2, 3, 4-triazole (fmtrz) and a zinc-containing compound, and the material can be used as an adsorbent, has strong acetylene adsorption action force, high selectivity and good stability, is suitable for industrial production, and shows a more excellent separation effect on low-concentration acetylene compared with a traditional method. The synthesized material is stable and has good acetylene adsorption capacity, and a new direction is provided for using MOF as an acetylene purification material.

This disclosure features methods to treat viral diseases and / or hypercytokinemia using compounds that disrupt the tricarboxylic acid (TCA) cycle and / or compounds that activate the unfolded protein response (UPR) in immune cells such as plasmacytoid dendritic cells. In some embodiments, the immune cells are dendritic cells, macrophages, T cells, B cells, natural killer cells, and / or neutrophils.

Oral care compositions including tin, monodentate ligand, and polydentate ligand with an optimized molar ratio of tin to monodentate ligand to polydentate ligand. Oral care compositions with a tin to monodentate ligand to polydentate molar ratio of from about 1:0.5:0.5 to about 1:5:5. Oral care compositions including tin, monocarboxylic acid, and tricarboxylic acid.