4 results about "DEPOSIT CALCIUM" patented technology

This application relates to biodegradable magnesium metal composite materials, their preparation methods, and medical devices. The preparation method of the biodegradable magnesium metal composite material includes the following steps: performing a first treatment on the surface of a magnesium metal matrix using an alkali agent to form a magnesium hydroxide passivation layer; performing a second treatment on the magnesium hydroxide passivation layer using phosphorylated amino acids to form a mineralization-inducing layer; and depositing a calcium-phosphorus coating on the surface of the mineralization-inducing layer to prepare the biodegradable magnesium metal composite material. The biodegradable magnesium metal composite material prepared by this method can meet the requirements of long-term corrosion resistance, strong interfacial bonding, and biocompatibility.

The invention relates to the technical field of composite microspheres, in particular to a porous composite microsphere for filling and repairing as well as preparation and application of the porous composite microsphere. The method comprises the following steps: firstly, performing calcium ion deposition on collagen by using a calcium source, and then performing phosphorus ion deposition on the treated collagen by using a phosphorus source to obtain mineralized collagen; uniformly mixing the mineralized collagen, a first emulsifier and a pore-forming agent to obtain a first water phase; dissolving the degradable polymer in a solvent to obtain an oil phase; uniformly mixing the mineralized collagen with a second emulsifier to obtain a second water phase; finally, uniformly mixing the oil phase with the first water phase to obtain primary emulsion; dropwise adding the second water phase into the primary emulsion until microspheres are formed, and performing post-treatment to obtain the porous composite microspheres. The porous composite microsphere provided by the invention has the characteristics of collagen, calcium phosphate and polylactic acid, and can be used in multiple fields of face, bone defect and cartilage defect filling and the like.

This invention discloses a mineralized body for bone repair, its preparation method, and its application. The preparation method includes the following steps: S1, osteogenic-associated cells are cultured in vitro and then subjected to osteogenic induction culture to induce the osteogenic-associated cells to secrete migration bodies and deposit calcium salts; S2, the culture system obtained in step S1 is decellularized to obtain mineralized bodies, wherein the mineralized bodies include the migration bodies and calcium salts. This invention, based on mineralized bodies composed of migration bodies and calcium nodules obtained from osteogenic-associated cells through osteogenic induction culture and decellularization, possesses the characteristics of high interface compatibility and stable binding with materials, and its osteogenic-associated activity remains stable after decellularization. It can induce osteogenic differentiation and promote bone regeneration in vivo, while avoiding the risks associated with live cell transplantation. This provides a novel and efficient cell-free strategy for bone defect repair, which is beneficial for clinical promotion and application.

The application discloses a composite coating and a preparation method thereof and a magnesium alloy product. The preparation method comprises the following steps: providing a deposition liquid, wherein the deposition liquid comprises a calcium salt, phosphoric acid and water; placing an electrically conductive substrate into the deposition liquid to deposit calcium hydrogen phosphate dihydrate on the surface of the electrically conductive substrate, so as to obtain a calcium hydrogen phosphate dihydrate layer; providing an organic coating, wherein the organic coating comprises an A component and a B component, the A component comprises a high-solid resin with a hindered secondary amine group, a filler, an additive and a solvent, and the B component comprises a curing agent; and placing the organic coating on the calcium hydrogen phosphate dihydrate layer to form an organic coating layer, so as to obtain the composite coating. The composite coating prepared by the preparation method has strong corrosion resistance.