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Formulation of calcium phosphate coating deposit solution for bone implantation material, and coating method

A technology of bone implant material and calcium phosphate salt, which is applied in the field of bionic preparation of calcium phosphate salt coating, which can solve the problems of complicated process, complex preparation of coating solution, and long time-consuming coating process, etc.

Inactive Publication Date: 2003-03-12
TSINGHUA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] In summary, the traditional coating process takes a long time, the preparation of the coating solution is complicated, and the process is complex

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] Use titanium alloy (Ti-6Al-4V) as the coating base material. Before deposition, all samples were polished with 600# sandpaper, and then ultrasonically cleaned in absolute ethanol, acetone and deionized water for 5 minutes, 15 minutes, and 5 minutes.

[0017] Dissolve 0.24g NaOH in 100ml deionized water to prepare 0.6M NaOH pretreatment solution in the reactor. Put the polished and cleaned titanium sheet into a reaction kettle for surface pretreatment, the treatment temperature is 160°C, and the treatment time is 48 hours.

[0018] The titanium sheet after surface pretreatment was taken out of the reactor, washed with deionized water, and put into a 150ml beaker. 100ml of deionized water, 0.0555g of calcium chloride, 0.06g of sodium dihydrogen phosphate and 0.0126g of sodium bicarbonate were sequentially added, and placed in a water bath shaker for deposition. The water bath was kept at a constant temperature of 37°C and the deposition time was 24 hours.

[0019] After the d...

Embodiment 2

[0021] Use titanium alloy (Ti-6Al-4V) as the coating base material. Before deposition, all samples were polished with 600# sandpaper, and then ultrasonically cleaned in absolute ethanol, acetone and deionized water for 10 minutes, 10 minutes, and 10 minutes.

[0022] Dissolve 2g of NaOH in 100ml of deionized water to prepare a 5M NaOH pretreatment solution and put it into the reactor. Put the polished and cleaned titanium sheet into a reaction kettle for surface pretreatment, the treatment temperature is 25°C, and the treatment time is 48 hours.

[0023] The titanium sheet after surface pretreatment was taken out of the reactor, washed with deionized water, and put into a 250ml beaker. 100ml of deionized water, 0.111g of calcium chloride, 0.03g of sodium dihydrogen phosphate and 0.0126g of sodium bicarbonate were added sequentially. Cover the beaker with plastic wrap and place it in a water bath shaker for deposition. The water bath has a constant temperature of 37°C and the depos...

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PUM

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Abstract

A solution for depositing calcium phosphate layer on bone implantation material is a deionized one containing calcium chloride, sodium dihydrogen phosphate and sodium hydrogen carbonate. Its depositing process includes grinding and washing Ti matrix, surface treating in NaOH solution at 20-200 deg.C for 24-48 hr, washing, and depositing in said solution at 30-40 deg.C for 20-24 hr. Its advantage is short period.

Description

Technical field [0001] The invention relates to a method for biomimetic preparation of calcium phosphate salt coatings of bone implant materials, and belongs to the field of biomedical materials. Background technique [0002] In 1990, Japan’s T. Kokubo et al. first proposed a method for biomimetic preparation of calcium phosphate salt coatings, and obtained coatings similar to apatite in bones on the surfaces of ceramics, metals and organics. The coating process is completed in simulated body fluid (SBF). When configuring SBF, you can add an appropriate amount of NaCl, NaHCO 3 , KCl, K 2 HPO 4 ·3H 2 O, MgCl 2 ·6H 2 O, CaCl 2 , And Na 2 SO 4 Dissolve in deionized water, adjust the ion concentration, temperature and pH of the solution to be basically consistent with the corresponding values ​​in human plasma. [0003] In the study of Barrere F et al., they added more Mg to the simulated body fluids. 2+ And HCO 3 - , Obtained calcium phosphate salt coatings with different compositi...

Claims

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Application Information

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IPC IPC(8): A61L27/12
Inventor 冯庆玲李帆崔福斋
Owner TSINGHUA UNIV
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