Bionic preparing method for depositing calcium and phosphor active layer on memory alloy of nickel and titanium for medical use

A nickel-titanium memory alloy, surface deposition technology, applied in coatings, medical science, prosthesis, etc., can solve the problem of low biological activity, achieve high bonding strength, easy promotion, and improved surface biocompatibility

Inactive Publication Date: 2004-12-29
SOUTHEAST UNIV +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Technical problem: the purpose of the present invention is to propose a method that is beneficial to the adhesion, growth and proliferation of cells on its surface, calcium phosphorus The bonding strength between the active coating and the nickel-titanium substrate is high, and it is suitable for the bionic preparation method of depositing a calcium-phosphorus active layer on the surface of the medical nickel-titanium memory alloy outside the human body

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] Adopt the method of the present invention to prepare by calcium phosphate amorphous transition layer and doped CO 3 2- The calcium-phosphorous bioactive layer is composed of the ionic bone-like apatite crystal phase surface layer. Its preparation process is as follows:

[0023] Step 1. Nickel-titanium alloy surface activation treatment

[0024] Select medical grade NiTi shape memory alloy with 50% Ni atomic percentage, and process it into 10×10×0.3mm 3 thin ribbon. After the nickel-titanium alloy was ultrasonically cleaned with acetone, 70% alcohol, and distilled water in sequence, it was cleaned in boiling H at a concentration of 20%. 2 o 2 Treat in aqueous solution for 30 minutes, take it out and rinse with distilled water; then soak in 50°C, 4M NaOH aqueous solution for 24 hours, take out distilled water to rinse, and dry at 70°C.

[0025] Step 2. "Two-step biomimetic deposition process" of calcium-phosphorus active coating

[0026] (1) Preparation of biomimet...

Embodiment 2

[0033] The method of the invention is used to prepare a calcium phosphorus biologically active layer composed of a calcium phosphate amorphous transition layer and an octacalcium phosphate crystal phase surface layer on the surface of the tubular medical nickel-titanium memory alloy. Its preparation process is as follows:

[0034] Step 1. Nickel-titanium alloy surface activation treatment

[0035] A medical-grade NiTi shape-memory alloy pipe material with an atomic percentage of Ni of 50% is selected, and its inner diameter is 5 mm, its thickness is 1 mm, and its length is 10 mm. After the nickel-titanium alloy pipe was ultrasonically cleaned with acetone, 70% alcohol, and distilled water in sequence, it was cleaned in boiling H at a concentration of 20%. 2 o 2 Treat in aqueous solution for 45 minutes, take it out and rinse with distilled water; then soak in 60°C, 3M NaOH aqueous solution for 12 hours, take out distilled water and rinse, and dry at 100°C.

[0036] Step 2. "...

Embodiment 3

[0044] The method of the present invention is used to prepare an amorphous transition layer made of calcium phosphate and doped CO on the surface of the tubular medical nickel-titanium memory alloy. 3 2- The calcium-phosphorous bioactive layer is composed of the ionic bone-like apatite crystal phase surface layer. Its preparation process is as follows:

[0045] Step 1. Nickel-titanium alloy surface activation treatment

[0046] A medical-grade NiTi shape-memory alloy pipe material with an atomic percentage of Ni of 50% is selected, and its inner diameter is 5 mm, its thickness is 1 mm, and its length is 10 mm. After the nickel-titanium alloy pipe was ultrasonically cleaned with acetone, 70% alcohol, and distilled water in sequence, it was cleaned in boiling H at a concentration of 20%. 2 o 2 Treat in aqueous solution for 30 minutes, take it out and rinse with distilled water: then soak in 50°C, 4M NaOH aqueous solution for 24 hours, take out distilled water and rinse, and ...

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Abstract

The present invention is the bionic process of preparing bioactive calcium phosphate layer on the surface of medical Ni-Ti memory alloy. The preparation process includes ultrasonic cleaning of medical Ni-Ti alloy with acetone, alcohol and distilled water successively; surface activation, and two-step bionic deposition of active calcium phosphate layer to form active calcium phosphate layer in two-layer structure on the surface of Ni-Ti alloy. The active calcium phosphate layer comprises transitional compact non-crystalline calcium phosphate layer of 1-10 micron thickness and porous octacalcium phosphate or surface bone-like crystalline apatite layer of 10-100 micron thickness. During the surface activation, boiling H2O2 aqua of 10-60 concentration is first used for treatment of 10-90 min, and NaOH aqua of 1-10 M concentration at 30-80 deg.c is then used for soaking after flushing for 6-48 hr.

Description

technical field [0001] The invention relates to a bionic preparation method for depositing a calcium-phosphorus active layer on the surface of a medical nickel-titanium memory alloy, more precisely, it relates to a bionic method for preparing a calcium-phosphorus bioactive layer on the surface of a medical nickel-titanium memory alloy, which belongs to the surface of biological materials modification technology field. Background technique [0002] At present, nickel-titanium (NiTi) alloys have been successfully used in clinical medicine such as dentistry, orthopedics, and interventional radiology because of their excellent properties such as shape memory effect, superelasticity, and corrosion resistance. Nevertheless, because nickel-titanium memory alloys contain nearly 50 atomic percent of the carcinogenic Ni element, there is general concern in the medical community about the safety of nickel-titanium alloys as human implants, and nickel-titanium ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/04A61L27/32
Inventor 储成林浦跃朴林萍华尹立红周俊沈刚
Owner SOUTHEAST UNIV
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