189 results about "Calcium phosphorus" patented technology

The invention provides a biomimetic calcium phosphate fiber composite bracket material and a preparation method thereof. The bracket material has similar component and structure as natural reticulated bone and consists of nanometer/micron calcium phosphate fiber substrate and biological polymer coating on the surface, wherein the calcium phosphate fiber is lapped on each other to form a three-dimensional reticulated bone structure, the porosity is not lower than 80% and thickness of the polymer coating is from 100 to 1000 nm. The preparation method comprises the following steps of: dripping solution containing calcium ions into hydrolyzed phosphate solution; adjusting the PH value of the phosphate solution between 1 and 10 and the calcium-phosphorus ratio between 1.0 and 1.6; aging at low temperature to obtain precursor collosol and adding polymer spinning improver into the collosol to perform electrostatic spinning to obtain continuous three-dimensional nanometer/micron fiber; post-processing for shaping, sintering at high temperature, soaking and drying to obtain the biomimetic calcium phosphate fiber composite bracket material.

The invention provides a preparation method of crisp Tilapia middle vertebrae leisure food. The Tilapia middle vertebrae is adopted as the raw material, the raw material is undertaken the high-temperature acidizing cooking treatment after the pretreatment and then is undertaken the seasoning composite treatment to obtain the fishbone leisure food. The efficiency for adopting the high-temperature acidizing cooking treatment to soften the tilapia fishbone is high, and the time can be reduced by 50 to 83 percent compared with the pure high-temperature cooking treatment. The fishbone leftovers in the aquatic processing is adequately used; the bone mass of the product is uniformly crisp, so the product is easy to chew up, the flavor is good, and no bone residue exists. The calcium-phosphorus ration of the product is about 2.5:1, thereby favoring the absorption and utilization of the calcium in the human body.

The invention relates to an ejected aquagel of sodium alginate crosslink dope, with dual-phase calcium-phosphorus particle, wherein it is prepard from aldehyde group sodium alginate, dope, and dual-phase calcium-phosphorus particles; the mass percentages of each material are: aldehyde group sodium alginate at 5-20%; dope at 10-30%; and dual-phase calcium-phosphorus particles at 50-70%. The invention also discloses a relative preparation and application, wherein said inventive product is characterized in that: (1), the materials are safe and innocuous; (2), it can provide best physical chemical environment for regenerating and rebuilding skelton, with better biological compatibility and adjustable physical property and biological degrade function; (3), the material can stuff the skeleton damage in any shape, to contact the around organism, with simple operation.

The invention discloses a production method of an attapulgite loaded hydroxyapatite composite defluorination filter bulb, which comprises the following steps: preparing attapulgite loaded hydroxyapatite powder from industrial-grade calcium hydroxide, phosphoric acid, acetic acid and attapulgite as raw materials, regulating the solubility of calcium hydroxide using acetic acid, and controlling calcium-phosphorus ratio and pH value of the solution so as to ensure the purity and the defluorination capacity of the products; and fabricating the attapulgite loaded hydroxyapatite powder into pelletsof diameters 0.5-1.5mm, and drying and molding the pellets at a temperature ranging from 350 to 450 DEG C so as to obtain attapulgite loaded hydroxyapatite composite defluorination filter bulb. The composition of attapulgite and hydroxyapatite reduces cost, is helpful for pellet formation, and enhances defluorination of hydroxyapatite. The method of the invention uses cheap and easily-accessible raw materials, high capacity of defluorination filter bulbs, long service life and small fluent water resistance, , and is simple in preparation, easy for control and regeneration, and easy for large-scale industrial production and promotion.

A high-strength, biodegradable, organic polymer/inorganic particle composite material for bone fixation, which is prepared by mixing and dispersing a biocompatible, inorganic fine or ultrafine particle in an organic monomer and then polymerizing the organic monomer and thus exhibits remarkably improved mechanical strength, and also to a high-strength, biodegradable, organic polymer/inorganic particle composite material prepared thereby is disclosed. More particularly, the a high-strength, biodegradable, organic polymer/inorganic particle composite material for bone fixation is prepared by mixing and dispersing a calcium phosphorus compound or a calcium aluminate compound in a biodegradable organic monomer, at the amount of 0.5 to 60% by weight; and polymerizing the biodegradable organic monomer; and then forming the polymerized material into a desired shape. The synergistic, reinforcing effect of the inorganic fine particle is increased, so that the high-strength material for bone fixation can be prepared. Also, the biocompatible fine particle is used, so that a long-term side effect can be reduced.

The invention discloses a preparation technology of a hydroxyapatite-containing composite biological film on a titanium or titanium alloy surface. Firstly, a calcium-phosphorus-containing micro-arc oxidation biological film is prepared on the titanium or titanium alloy surface by means of micro-arc oxidation, then titanium or titanium alloy with the calcium-phosphorus-enriched biological film on the surface is subjected to microwave hydrothermal treatment through a microwave technique, and accordingly the hydroxyapatite-containing composite biological film can be generated on the titanium-base surface. The composite biological film is of a three-layer structure, the inner layer is dense titanium dioxide, the middle is a porous structure, and the surface layer is nano-fibrous hydroxyapatite. The hydroxyapatite-containing composite biological film is prepared on the titanium-base surface by the aid of a two-step method, so that bioactivity of the titanium or titanium alloy is improved obviously; besides, the hydroxyapatite-containing composite biological film has high bonding strength since the film grows in situ from the titanium-base surface and is bonded with a titanium base in an indented manner; more importantly, by the adopted microwave technique, hydrothermal temperature is lowered remarkably, reaction time is shortened greatly, and the preparation technology is suitable for industrial processing and production.

The present application provides dental compositions, and methods of making and using dental compositions that include a calcium and phosphorus releasing glass. Such dental compositions can be useful for delivering ions to the oral environment.

The invention relates to a preparation method of an efficient calcium-based sepiolite phosphorus adsorbent. The preparation method comprises the following steps of mechanically pulverizing natural calcium-enriched sepiolite ore into powder, drying the powder at constant temperature, and then directly heating and modifying the powder to obtain the calcium-based sepiolite phosphorus adsorbent. According to the preparation method provided by the invention, inertia calcium in the natural calcium-enriched sepiolite is activated through a heating and modification method, a part of active calcium enters into a sepiolite lattice system, and the alcium-based sepiolite adsorbent having high absorption capacity to phosphorus is generated by the original ore through recombination and reaction. The calcium-based sepiolite phosphorus adsorbent provided by the invention is used for eliminating phosphorus in polluted water or bottom sediment, and is capable of efficiently and rapidly eliminating phosphate in the water and efficiently translating labile phosphorus in the polluted bottom sediment into inert calcium phosphorus, thereby achieving the aim of controlling nutrition enrichment of lakes. The calcium-based sepiolite phosphorus adsorbent prepared by the preparation method has the advantages of wide raw material distribution, low cost, simple preparation process, obvious phosphorus fixation effect, and wide application prospect and use value.

The invention discloses a degradable magnesium-based bone implant drug-loaded high molecular/calcium-phosphorus composite coating and a preparation method. From inside to outside, the composite coating comprises a fluorinated film on the surface layer of a bone implant, a biodegradable high molecular coating and a bioactive calcium-phosphorus coating; and the preparation method comprises the following steps: soaking a magnesium or magnesium alloy bone implant in hydrofluoric acid at constant temperature, so as to form a fluorinated protective layer; dissolving a biodegradable high molecular material in an organic solvent, coating the dissolved biodegradable high molecular material on the surface of the fluorinated bone implant by virtue of an extracting method, and conducting vacuum drying so as to obtain a polymer coating; and conducting ultraviolet ozone or plasma surface pre-treatment on the bone implant coated with the polymer coating, and soaking the bone implant in phosphate mixed liquid at constant temperature. According to the composite coating prepared by the invention, the surface bio-activity of magnesium or magnesium alloy which serves as a base is enhanced and the corrosion rate of the base is reduced; meanwhile, a degradable carrier is provided for drug loading of the bone implant material; the preparation method is simple, convenient and easy in operating process; and the prepared coating is strong in bonding force with the base and is controllable in thickness.

The invention relates to a method for wet phosphoric acid producing high pure calcium hydrogen orthophosphate and monoammonium phosphate of fertiliser stage, which is indicated as wet phosphoric acid aminated, filtrating the ground paste after aminated, drying and packing the filter residue and obtaining monoammonium phosphate of fertiliser stage, obtaining high pure monoammonium phosphate crystal after the filtrate evaporated, crystallized and refiltered, generating calcium hydrogen orthophosphate and ammine by taking monoammonium phosphate reacting with calcium hydrogen orthophosphate of technical grade or alimentary products stage, aminating phosphoric acid after ammine recovered, and drying the calcium hydrogen orthophosphate deposition, then the high pure calcium hydrogen orthophosphate products is produced. The method in this invention can use wet method phosphoric acid with high impurity content to produce high pure calcium hydrogen orthophosphate, which can be used as calcium phosphorus additive agent of feed stuff stage or alimentary products stage based on the raw charge.

The invention discloses a calcium-phosphorus-silicon biological ceramic coating and a preparation method and application thereof. After magnesium and alloy of magnesium are put in a calcium-phosphorus electrolyte for powered-on electrolysis for a set time, a sample containing a calcium-phosphorus coating is put in a silicon salt electrolyte for powered-on electrolysis, and the target biological ceramic coating is obtained; and the calcium-phosphorus electrolyte is prepared by adding calcium salt and (NaPO3)6 into a basic electrolyte, and the silicon salt electrolyte is prepared by adding silicate into the basic electrolyte. A compact layer is connected with a basal body, the compact layer and the basal body are tightly combined, and the mechanical property of the basal body can be improved; in addition, pores barely exist in the compact layer, body fluid can be prevented from flowing to the surface of the basal body to make contact with the basal body, metal ions generated after the basal body is corroded also can be prevented from being diffused to the human body, toxicity is reduced, and biocompatibility is effectively improved; and a surface layer is a porous loose layer, combination of an implant and a bone can be effectively improved in the presence of micro-pores, growth of adherence bone tissue of bone cells can be effectively improved, and the biological activity of the coating can be improved.

The invention discloses a hydroxyapatite scaffold material with a graphene-modified surface and a preparation method of the hydroxyapatite scaffold material. The preparation method comprises the following steps: (1), at the normal temperature, respectively preparing a Ca(NO3)2.4H2O solution with a certain concentration and a (NH4)2HPO4 solution with a certain concentration; (2), blending the Ca(NO3)2.4H2O solution and the (NH4)2HPO4 solution obtained in the step (1) according to a certain calcium-phosphorus ratio, stirring for reacting, and regulating and controlling pH of reaction liquid by introducing ammonia water in the reaction process; (3), leaving the reactant obtained in the step (2) to stand overnight and removing impurities so as to obtain a hydroxyapatite material; (4), preparing a graphene solution with a certain concentration, adding the hydroxyapatite obtained in the step (3) into the graphene solution and stirring fully; (5), transferring the mixed solution obtained in the step (4) into a hydrothermal reaction kettle, reacting under sealing conditions and freeze-drying, o as to obtain the novel hydroxyapatite material with the graphene-modified surface. The material has better physical and chemical properties and biocompatibility, and can be clinically used for repairing bone defects.

The invention belongs to the field of flower fertilizers, and discloses a high-efficiency fertilizer for epipremnum aureum in a seedling growing period. The high-efficiency fertilizer is prepared from the following components of sodium alginate, expanded graphene, calcium peroxide, rose essential oil, triacontanol, peat, coconut residue, plant ash, corn protein meal, hydrolyzed feather meal, bacillus subtilis, saccharomycetes, ammonium iron(III) phosphate, actinomycetes, barley green, copper sulfate, ammonium molybdate, aspartic acid, tryptophan, vitamin B, indoleacetic acid, thiophanate methyl, agricultural streptomycin, chitosan, Arabic gum, hydroxypropyl methyl cellulose, soluble calcium phosphorus magnesium, diatomite and an appropriate amount of water. According to the high-efficiency fertilizer disclosed by the invention, the fertilizer for the epipremnum aureum in the seedling growing period is prepared by adopting a film-coating solution comprising a fermented particle fertilizer, is rich in nutrition and is capable of promoting rooting, sprouting, stem and leaf growing and the like of the epipremnum aureum; meanwhile, the high-efficiency fertilizer has the effects of increasing the content of chlorophyll and enhancing the photosynthesis, the color of seedlings of the epipremnum aureum can be improved by the added barley green, and the ornamental effect of the epipremnum aureum can be increased.

The invention provides a method for preparing an apatite coating on a pure magnesium surface. The specific proposal is adopting a two-step acid and alkali method, which comprises the steps of activating the surface of a buffed and cleaned pure magnesium substrate, soaking the substrate in the solvent of CaCl2 and K2HPO4 for pre-calcification treatment, forming a layer of unformed calcium phosphate on the pure magnesium surface, putting the pure magnesium substrate into a calcium phosphorus saturated solution for certain time, and forming a layer of even apatite coating on the surface of the pure magnesium substarte.

The invention provides a 3D printing preparation method of a bone defect repair stent. The method comprises the following steps: taking calcium phosphate bone cement and calcium-containing mesoporous silicon as raw materials, mixing, and grinding to obtain calcium phosphorus silicon-based active bone repair material powder; and then uniformly mixing the calcium phosphorus silicon-based active bone repair material powder with curing liquid, and constructing the obtained mixture to obtain the bone defect repair stent by virtue of a 3D printing rapid prototyping method. The bone repair material stent is prepared by virtue of the 3D printing method, so that the shape, the structure and the porosity of the stent can be accurately controlled, and the cell attachment proliferation can be facilitated; and meanwhile, the selected calcium phosphorus silicon-based active bone repair material has good biological activity and bone forming effect and is suitable for being used as a novel bone defect repair stent.

The invention relates to a microsphere tissue engineering scaffold used in beauty filling, and a preparation method of the microsphere tissue engineering scaffold, and belongs to the field of tissue engineering scaffold materials. The method comprises the following processing steps: (1) preparing polyurethane microspheres: feeding isocyanate monomers and oligomer divalent alcohol into a reaction vessel, carrying out 1.5 to 3.5 h's reaction under 70 to 90 DEG C, feeding hydrophilic chain extender, viscosity modifier and catalyst, heating till the temperature is 45 to 55 DEG C, and carrying out reaction for 3 to 4 h; feeding the reaction liquid into salt forming agent solution in a high-speed stirring manner, shearing and emulsifying for 1 to 3.5 h, cleaning the microspheres with deionized water, and carrying out vacuum freeze drying; (2) preparing a polyurethane microsphere scaffold: dispersing the polyurethane microspheres in NaCl solution to form uniform emulsion, pouring the emulsion into a die, and carrying out freeze drying under -50 to -20 DEG C; and (3), conducting mineralization treatment on the surface of the scaffold: fixing the polyurethane microsphere scaffold in calcium-phosphorus supersaturated solution containing urease in a slowly stirring manner, carrying out mineralization treatment for 2 to 24 h, cleaning the scaffold for 2 to 24 h with deionized water, and carrying out freeze drying.

The invention relates to a method for in-situ preparation of a modified hydroxyapatite/polyvinyl alcohol nano-composite film. The method comprises the following steps: dropping a doped calcium nitrate solution to a polyvinyl alcohol water solution under a stirring condition, and then dropping a diammonium hydrogen phosphate solution and stirring at 40-70 DEG C for 12-24h, so that the in-situ generation of a doped modified hydroxyapatite/polyvinyl alcohol solution is achieved, wherein a calcium-phosphorus ratio is at 1.67; and then adding maleic anhydride and a catalyst, conducting stirring for 4-6h, so that a mixed solution is obtained, conducting electrostatic spinning, and drying an obtained film, so that the in-situ preparation of the modified hydroxyapatite/polyvinyl alcohol nano-composite film is achieved. The method disclosed by the invention is simple to operate; the interior of the film, which is prepared through in-situ cross-linking of the doped modified hydroxyapatite which is obtained from in-situ generation, has good dispersibility and stability, and meanwhile, the film has good biocompatibility; and the film, which can be used for separating and adsorbing a plurality of proteins, bio-enzymes as well as other bio-products, has a good adsorptive selectivity on the separation of the various proteins.

The preparation method of bone material containing nanometer phase calcium phosphorus salt, collagen and aliginate includes the following steps: slowly drop-adding solution containing calcium iron into acid-soluble collagen solution, then slowly drop-adding aqueous solution containing phosphoric acid radical ion into said solution while stirring, and slowly drop-adding alkali liquor to regulate pH value while stirring, standing still and removing supernatant fluid, centrifugal separation, precipitation, grinding to obtain dried powder, mixing the dried powder with sodium alginate and water toobtain a product, placing said product into mould, forming, demoulding, soaking in distilled water, drying to obtain the invented bone material with excellent biological compatibility and imitation bone property in structure, reasonable strengthen and void volume. Said invented bone material can be used as implanted degradable bone material.

The invention discloses a method for preparing nano-hydroxyapatite-protein artificial bone imitation materials. The method includes steps of respectively preparing Ca(NO3)2 solution and Na3PO4 solution, dissolving proteins in the Ca(NO3)2 solution, controlling feeding according to a certain calcium-phosphorus molar ratio and carrying out reaction in a rotary packed bed; ageing reacted precipitates at the room temperature; carrying out pumping filtration on the precipitates and washing, drying and grinding the precipitates to obtain nano-hydroxyapatite-protein composite materials; pouring the ground composite materials into cylinder tablet compressing molds and carrying out pressure casting on the composite materials to obtain the cylindrical materials. The method has the advantages that high-gravity technologies and co-precipitation in-situ synthesis processes are combined with one another, so that the nano-hydroxyapatite-protein artificial bone imitation materials with high organic contents can be efficiently prepared; reaction conditions such as the concentration of raw components and the rotational speeds of the rotary packed bed are controlled, so that the artificial bone imitation materials can be prepared; the method is high in efficiency and low in cost, equipment is simple, techniques are safe and stable, the nano-hydroxyapatite-protein artificial bone imitation materials are high in organic content and can be produced under regulation and control, the proteins which are raw material are universal, and a novel way is provided for producing biological materials on a large scale.

The invention discloses a preparation method of nanometer hydroxylapatite with high dispersivity, which prepares the nanometer hydroxylapatite by taking a phosphorus compound and a calcic compound as raw materials through a solvent hot method. The method comprises the following technical steps of: (1) dissolving calcium salt in 5-75 percent organic diamine hydrosolvent ; (2) preparing a phosphide hydrosolvent according to a calcium-phosphorus ratio of 1.67; and (3) adding the calcium salt solution in the step (1) into the phosphide hydrosolvent obtained from step (2), stirring and mixing, then heating to 180 DEG C, preserving temperature for 24 hours, cooling, centrifugate-washing the obtained precipitate to be neutral by using distilled water or absolute ethyl alcohol as a lotion, drying in a drying box at the temperature of 60 DEG C, and then obtaining the hydroxylapatite powder product with high dispersivity. Compared with the prior art, the product obtained by the method has good dispersivity and is crystalline state directly without sinter crystallization, and the method has brief technology, simple equipment, simple and convenient operation, recoverable waste liquor, controllable particle size and broad application prospect.

The invention discloses a preparation method for constructing a collagen-based bio-macromolecular/hydroxyapatite microsphere composite bracket material. The preparation method is characterized in that: micron-sized CaCO3 microspheres are synthesized in the presence of bio-macromolecules, mainly collagen; the CaCO3 microspheres are taken as a template; hydroxyapatite microspheres are obtained by transforming the CaCO3 microsphere template into a calcium-phosphorus mineral in the phosphate solution environment; meanwhile, hybrid gel combined with hydroxyapatite microspheres is obtained by usinga three-dimensional fiber network formed through self-assembly of collagen macromolecules, the collagen-based bio-macromolecular/hydroxyapatite microsphere composite bracket material is further obtained, and in-situ synthesis of micron-sized hydroxyapatite microspheres in a bio-macromolecular substrate is realized under the mild condition. The calcium-phosphorus microspheres in the collagen-basedcomposite bracket material are made from carbonic acid hydroxyapatite, and have high bionics and biocompatibility on the aspect of component; and meanwhile, the composite bracket material has the nanometer-micron-macroscopic multi-scale distribution characteristic on the aspect of structure.

The invention belongs to the technical field of biological tissue engineering, and discloses a piezoelectric polyether-ether-ketone composite material with antibacterial properties, and a preparation method and application thereof. The composite material is obtained by the following steps that: polyether-ether-ketone and niobate are blended after being dried, at a temperature of 350-450DEG C, a forming method is adopted to prepare polyether-ether-ketone/ niobate composite fiber material, and after the composite fiber material is processed and is dipped in solvent containing antibacterial medicines to be loaded, the obtained material is dried in vacuum at a temperature of 40-80DEG C. The polyether-ether-ketone composite material can accelerate the generation of calcium phosphorus salt on the surface of an implant, can accelerate bone cell proliferation and differentiation as well as cell adhesion under the function of an external electromagnetic field, and has the characteristics of no inflammation, no toxin, good biocompatibility, simple preparation method and the like.

A mineralized polypeptide material used for treating bone defficiency and bone fracture features high bioactivity, biocompatibility and biodegradability. Its microstructure is a 3D network of polypeptide fibers with calcium-phosphorus salt crystals attached on their surfaces. The amino acid sequence of said po0lypeptide has the repeated Gly-X-Y structure, where X and Y may be any amino acid other than Gly.

The invention discloses biphase calcium phosphate (BCP) composite powder synthesized by a high-temperature solid phase reaction. BCP powder is biphase composite powder prepared from hydroxyapatite (HA) and beta-tricalcium phosphate (beta-TCP), in which the molar ratio Ca/P of calcium to phosphorus is 1.5 to 1.67, wherein the value ranges of the relative mass percent of HA and beta-TCP two phases are each 1 to 99 percent; the sizes of crystalline grains of the HA and beta-TCP two phases are 20nm to 300 microns; the crystallinity is 50 to 100 percent. The invention also discloses a preparation method of the BCP composite powder synthesized by the high-temperature solid phase reaction. The BCP composite powder is prepared through the high-temperature solid phase reaction of a calcium-containing solid compound and a calcium-phosphorus solid containing compound. The BCP composite powder has the advantages that a reaction period is short; the costs of raw materials are low; the equipment investment is low; no waste gas and waste water are discharged; further, the proportion of the HA and beta-TCP two phase in the BCP powder is easily regulated and controlled at the same time; the two phases are distributed uniformly; the sizes of the crystal grains and the crystallinity are controllable; finally; the production requirement that the compression strength of BCP biphase composite ceramic is improved or a degradation speed is regulated and controlled is met.

The invention discloses a microorganism self-assembly nanometer material and a preparation method and application thereof.In particular, according to the microorganism self-assembly nanometer material and the preparation method and application thereof, a Shewanella sp.strain CF8-6 which can efficiently remove phosphorus in high-salinity wastewater under an aerobiotic condition and meanwhile can synthesize calcium-phosphorus nanometer particles through raw materials in the wastewater under a low-saturability condition is utilized, phosphorus in the wastewater is removed, a calcium-phosphorus nanometer material is synthesized, and particularly the calcium-phosphorus nanometer particles are synthesized under the low phosphorus saturability condition.The method and the nanometer material prepared through the method play an important role in the fields of environmental pollution removal, biomedicine and the like.