40 results about "Cartilago articularis" patented technology

The invention discloses a preparing method for infrared response high-strength hydrogel for cartilago articularis repair. The preparing method mainly includes the operation steps that polysaccharide or protein is modified in a double bond forming mode through methacrylic acid, methacrylic anhydride and methacrylate substances, so that the polysaccharide or the protein has a double-bond group in a side chain and is capable of being polymerized to form the hydrogel. Under the action of an initiator and a cross-linking agent, N-isopropyl acrylamide and the polysaccharide or the protein modified in the double bond forming mode form the double-network high-strength hydrogel through in-situ polymerization. The prepared infrared response high-strength hydrogel is high in biocompatibility and excellent in mechanical property and has good application prospects in the field of cartilago articularis repair.

The invention discloses a health product for increasing bone density and a preparation method of the health product. Chinese dwarf cherries, Chinese herbal medicine extracts refined by adopting a modern extraction technology and other raw materials having the function of increasing the bone density are scientifically compounded and are scientifically combined omnibearingly to play a synergistic effect, so as to effectively promote the calcium absorption in multiple aspects, repair and reconstruct the cartilago articularis, promote the generation of synovial fluid, promote the synthesis of collagen in cartilago articularis substrates, prevent the further degradation of cartilage, indirectly reduce the osteoclast function, inhibit the re-absorption of bones, increase the content of bone calcium and perfect the biomechanical properties of the bones, so that the product has a good function of increasing the bone density. A microwave drying technology in the preparation method can be used for further improving the integration and biological stability of the health product, and by means of the antioxidant activity of a grape seed extract in the raw materials, the strong adsorption and inclusion functions of modified dietary fibers and the antifungal propertie of the Chinese herbal medicine extracts, an efficient, safe, nutritional and stable health product having the function of increasing the bone density is prepared finally.

The invention discloses a cartilago articularis vitrification cryoprotectant and a cartilage preservation method. Each 1000ml of a vitrification cryoprotectant comprises 150-250ml of 99.9% dimethyl sulfoxide, 110-200g of acetamide, 70-120ml of 1,2-propylene glycol, 10-80g of polyethylene glycol, 20-100g of trehalose and the balance of deionized water. The cartilage preservation method comprises the following steps: soaking cartilage bone blocks at 4 DEG C by a gradient vitrification cryoprotectant sequentially for 10 minutes, packaging by a refrigerating pipe, putting into liquid nitrogen and storing; taking out before transplanting, rewarming, and carrying out water bath rewarming at 37 DEG C for 10 seconds; then putting cartilage bone blocks in a 10% saccharose solution and a 5% saccharose solution at 37 DEG C respectively, and remaining for 5 minutes; and finally washing by a phosphate buffer for 3 times so as to transplant and apply. According to the invention, the cartilago articularis tissues can be stored for a long time, the relatively high cell survival rate of cartilage is maintained, and the osteochondral graft preservation effect is enhanced; the cartilago articularis vitrification cryoprotectant and the cartilage preservation method are applied to the cartilage tissue library and the clinical cartilage transplantation.

The invention discloses a non-viral nanometer nucleic acid transportation compound used for treating cartilage defect through intra-articular injection which comprises low-molecular chitosan with molecular weight of 5KD-100KDand percentage composition of amino group of 30-70%, and nucleic acid, wherein N/P of the compound is 0.2:1-10:1.The invention degrades high molecular chitosan to low molecular chitosan, increases water solubility of material, reduces viscosity of solution, reduces influence of sour environment of solvent to cell, improves compound size with nanometer, is in favor of performing genetic transmission to cartilago articularis cell, and protects target nucleic acid from neutralizing with synovial fluid and being degrade by nuclease in lysosome. The invention has simple preparation and abroad application scope; can solve engineering roadblock of cartilage repair with no requirement of operation, complex device and bracket material.

The invention discloses a composition for increasing bone mineral density and a preparation method of the composition. Chinese dwarf cherry, a Chinese herbal medicine extract refined by a modern extraction technology and other raw materials with the function of increasing the bone mineral density are scientifically compounded, are scientifically combined in an omnibearing manner, and work together, so as to achieve the effects of effectively promoting absorption of calcium from a plurality of aspects, restoring and rebuilding cartilago articularis, creating synovial fluid, and promoting collagen synthesis in the cartilago articularis, preventing cartilage from further degenerating, indirectly reducing osteoclast action, inhibiting re-absorption of bones, increasing bone calcium content and improving the mechanical property of the bone, so that the product has a good effect of increasing the bone mineral density. The integrating property and the biological stability of the composition can be further improved by a microwave drying technology in the preparation method. Due to the oxidation resistance of a grape pip extract in the raw materials, high adsorption and embedding effects of modified dietary fiber, and antifungal properties of the Chinese herbal medicine extract, the efficient, safe, nutrient and stable composition with the function of increasing the bone mineral density is finally prepared.

The invention relates to a tissue engineering cartilago articularis in-vitro construction method and device. The device comprises a swing mechanism, a position adjusting mechanism, a cartilago articularis culture mechanism and a locating and connecting mechanism, wherein the swing mechanism comprises an indicator, a weight tray, a stabilizing rod, a swinging arm, a proximity switch, a sixth fastening screw, a left rotating shaft and a right rotating shaft. The position adjusting mechanism comprises a precision adjusting device, a left adjusting hand wheel, a left supporting plate, a left pressing plate, a first fastening screw, a left sliding plate, a shaft end cover, a right supporting plate, a control motor, a connecting key, the left rotating shaft, the right rotating shaft, a supporting base, a ninth fastening screw, an adjusting rod, a right pressing plate, a twelfth fastening screw, a right sliding plate, a right adjusting hand wheel, a right shaft connecting sleeve and a left shaft connecting sleeve. The construction method simulates a kinematic mechanics environment for in-vitro cartilago articularis, thus providing a method and a device which can apply pressure stress and friction force differing in frequency and weakness and can dynamically construct body cartilago articularis.

The invention discloses a preparation method of a bionic porous tissue-engineered cartilage scaffold. The preparation method comprises the following steps: mixing a decellularized Whartons jelly suspension and chondroitin sulfate at the mixing ratio of the Whartons jelly suspension to chondroitin sulfate being 2.0:0.25-2.0:2.0, adding ethyl dimethylamine propyl carbide dimethylamine and fully uniformly mixing, and crosslinking at room temperature under the UV-irradiation of 258 nm wavelength 5-10 cm from a light source; putting a cross-linked scaffold into a cryogenic refrigerator to make the scaffold to be shaped, carrying out vacuum freeze drying to obtain a molded scaffold, storing the molded scaffold in a hermetic bag and sealing, disinfecting under irradiation at 60 DEG C, and preserving at 4 DEG C for standby. The prepared cartilage scaffold has bionic and porous characteristics, can induce stem cells in vitro to be differentiated to chondrocytes to promote expression of cartilage matrix components proteoglycan and collagen type II, can be used for in vitro construction of tissue-engineered cartilago articularis, and provides a high-quality scaffold material for repairing articular cartilage defects.

The invention belongs to the technical field of nourishment, and particularly relates to a nutritional composition beneficial for joint comfortableness as well as a preparation method and applicationthereof. The nutritional composition beneficial for the joint comfortableness is prepared from collagen powder, anti-inflammation material, a detumescence material and an emulsifier, wherein the anti-inflammation material is prepared from one or several of fish oil, olive oil, rhizoma curcumae longae and piperine; the swelling subsiding material is prepared from bromelain and/or papain. The nutritional composition disclosed by the invention is capable of relieving joint discomfort through nutritional intervention, balancing nutrition and achieving the effects of repairing cartilago articularis, removing inflammatory response, removing arthrocele, strengthening ligamenta and building muscles.

The invention belongs to the technical field of traditional Chinese medicines, relates to a Chinese patent medicine for treating osteoarthritis and a preparation method thereof. The Chinese patent medicine is prepared from the following raw materials in parts by weight: 5-10 parts of chondroitin sulphate sodium, 5-10 parts of glucosamine, 5-10 parts of burdock, 5-10 parts of salviae miltiorrhiza, 2-5 parts of eucommia ulmoides, 2-5 parts of earthworm, 2-5 parts of parasitic loranthus, 2-5 parts of radix achyranthis bidentatae, 2-5 parts of radix angelicae pubescentis, 2-5 parts of asarum, 2-5 root of largeleaf gentian, 2-5 parts of divaricate saposhnikovia root, 2-5 parts of ligusticum wallichii, 2-5 parts of dipsacus root, 2-5 parts of centipede, 2-5 parts of gastrodia elata and 2-5 parts of liquorice. The preparation method comprises the following steps: weighing raw materials in parts by weight; crushing into fine powder, sieving through an 80-100mesh sieve, and enclosing 0.6-0.7g of powder into each hollow capsule; and bottling and sealing. The traditional Chinese medicine components disclosed by the invention are capable of assisting the functions of chondroitin sulphate sodium and glucosamine for repairing cartilago articularis when developing the efficacy of strengthening muscles and bones; and the components of the traditional Chinese medicine and the Western medicine work together to quickly treat the osteoarthritis.

The invention discloses a preparation method of self-repairing bionic low-friction hydrogel cartilago articularis on the basis of agar. The method includes the steps of adopting agar hydrogel as a physical cross-linking network and polyacrylic acid-polyacrylamide hydrogel as a chemical cross-linking network to form a double-layer network structure, and introducing iron ions to achieve a coordination effect with polyacrylic acid to prepare hydrogel with a porous aqueous structure. Dynamic reversible ionic coordination bonds and hydrogen bonds between the networks are utilized to endow the agar/polyacrylic acid-polyacrylamide-iron ion double network hydrogel with high self-repairing capability and mechanical performance. Compared with pure agar hydrogel, the agar/polyacrylic acid-polyacrylamide-iron ion double network self-repairing hydrogel cartilago articularis has the advantages that the compression modulus is increased by 80-120%, and good self-repairing performance is achieved.

The invention discloses a sole structure of a high-heeled shoe and the high-heeled shoe. The sole structure of the high-heeled shoe comprises a midsole and heightening platform assembly and an insole. A heightening platform and a midsole are connected to form the midsole and heightening platform assembly, a first convex block made of a damping material is arranged at the bottom of the part, making contact with the front foot sole, of the insole, and a groove for containing the first convex block is formed in the heightening platform. The high-heeled shoe with the sole structure further comprises a vamp, an outsole and a heel. The convex block is arranged at the bottom of the insole, the thickness of the damping material is increased, the damping rate is increased, the high-heeled shoe can protect the cartilago articularis and achieve the damping effect, and occupied space in the shoe is not increased; the thickness and shape of the damping material for filling are adjusted, and cost can be reduced to the maximum by adjusting the thickness of the damping material according to different heel differences; stress can be evenly dispersed through the first convex block in arc transition, and therefore the foot sole feels the same softness in all directions.

The invention relates to an application of LCA (9, 9'-O-bi-(E)-feruloylated-meso-5, 5'-dimethoxy secoisolariciresinol) in preparation of drug for treating arthritis or cartilago articularis and bone destruction. By using a cell heat transfer technology, the compound LCA can be combined with MEK1 protein and cathepsinK protein in cells, animal tests verify that the LCA can improve the symptoms of a rat with rheumatoid arthritis and the research results show that LCA has a double target effects of simultaneously inhibiting immune inflammation and preventing and treating bone destruction and has a board application prospect in clinical treatment of diseases such as rheumatoid arthritis, osteoarthritis, osteoporosis and the like.

The invention discloses composite hydrogel as well as a preparation method and application thereof. The composite hydrogel is prepared from methacrylate sulphobetaine, ethylene glycol dimethacrylate and glyceryl polyether through free radical polymerization and ester exchange reaction. According to the invention, GE is introduced into PSBMA hydrogel, new chemical crosslinking is generated through transesterification, a composite hydrogel network GE-PSBMA is formed, compared with pure PSBMA hydrogel, the GE-PSBMA composite hydrogel has the advantages that the compressive strength is obviously enhanced and is increased by nearly 40 times, the composite hydrogel has a low friction coefficient, and the composite hydrogel shows relatively good biocompatibility, hydrophilicity and thermal stability, and can be applied to the field of biomedical materials. The material has potential to become an articular cartilage substitute material.

The present invention discloses a cereal powder for repairing scoliosis, and particularly relates to the technical field of cereal. The cereal powder comprises a phase A component and a phase B component. The phase A component comprises the following components: ganoderma lucidum, blueberry and black sesame; and the phase B component consists of the following components: white sesames, soybeans, oats, peanuts, ginseng, caulis spatholobi, pseudo-ginseng, ligusticum wallichii, peach kernels, safflower carthamus, radix paeoniae rubra, radix salviae miltiorrhizae, trogopterus dung and rhizoma drynariae. The processed cereal powder has relatively strong synergistic effects of dispelling wind and easing pain, clearing and activating the channels and collateral, warming channels and tonifying yang, and enhancing synergistic effect among elements such as calcium, phosphorus and iron, improves metabolism of connective tissues and permeability of capillary vessels, promotes transformation and absorption of hyperplasia lesions and fading of focus tissues, and repairs atrophic connective tissues. In addition, the cereal powder can repair a damaged cartilago articularis platform, relieve pain, improve rigid joints, and recover the elasticity, obtains stable softness again, and repairs scoliosis.

The invention discloses a retractable brush for an arthroscope. The retractable brush comprises a brush head, a brush handle and a casing tube; the brush head is arranged at the front end of the brushhandle; the inner diameter of the casing pipe is greater than the outer diameter of the brush handle, the casing tube sleeves the brush head and the brush handle, and the length of the casing tube isgreater than or equal to that of the brush head. The retractable brush is convenient to operate. Compared with conventional planing cutter heads and radio frequency vaporization cutter heads, the retractable brush has the advantages that not only can diseased tissue on the surface of a joint be removed to the maximum extent, but also the cartilago articularis cannot be damaged, and convenience isprovided for the brush to get in or get out of a micro incision.