5 results about "Cartilage bone" patented technology

The invention belongs to the technical field of medicines, and particularly relates to a pharmaceutical composition for improving senescence of a skeletal muscle system and application of the pharmaceutical composition. The pharmaceutical composition is composed of nicotinamide mononucleotide and apigenin. The composition has the advantages of being high in safety and easy to obtain, can synergistically promote cartilage, bone and muscle cell differentiation, delay cartilage degeneration and relieve bone and muscle loss, and has a good effect and application potential in the aspect of treating skeleton and muscle aging.

The utility model relates to a cartilage bone sample collecting device which comprises a fixed bottom plate, a movable bottom plate is slidably connected to the fixed bottom plate in a limiting mode, an installation plate is detachably installed at the top end of the movable bottom plate in the vertical direction, a cutting mechanism is installed on the installation plate, and the cutting mechanism is used for conducting cutting and shape tailoring on a cartilage bone sample. A plurality of cushion blocks are detachably mounted on the cutting mechanism, the cushion blocks are used for adjusting the cutting thickness of the cartilage bone sample, a power supply and a driver are detachably mounted in the cartilage bone sample collecting device, the power supply is used for supplying power to the cartilage bone sample collecting device, and the driver is in communication connection with the cutting mechanism. The cartilage sample cutting device can accurately control the cutting thickness and the cutting shape of a cartilage sample, can avoid the problems of uneven thickness of a bone sample slice and irregular shape of the bone sample slice, can avoid the problems of soft tissue loss and resource waste, and can improve the cutting efficiency and the cutting efficiency of the cartilage sample and the cutting efficiency of the bone sample slice.

The invention discloses a double-layer piezoelectric hydrogel scaffold for realizing articular cartilage injury repair through ultrasonic regulation, the piezoelectric hydrogel scaffold comprises a scaffold upper layer for cartilage repair and a scaffold lower layer for subchondral bone repair, the upper layer and the lower layer both comprise a colloid component and a piezoelectric component, wherein the mass percent concentration of piezoelectric components in the upper layer of the piezoelectric hydrogel stent is lower than that of piezoelectric components in the lower layer of the piezoelectric hydrogel stent. The mechanical property and gradient piezoelectric property of the double-layer piezoelectric hydrogel scaffold are matched with articular bone cartilage tissue regeneration, and cartilage-bone synergistic regeneration can be accurately regulated and controlled. The novel bionic hydrogel scaffold can significantly improve articular cartilage injury, and has a wide clinical application prospect.

This invention relates to the field of organoid bioprinting technology, and discloses a method for preparing articular cartilage organoids, a bio-ink for encapsulating articular cartilage organoids, the preparation method thereon, and their applications. The preparation method includes: pretreating the raw material to be cultured in a basal culture medium containing a nanomedicine additive, wherein the nanomedicine additive chemically comprises mesoporous silica nanoparticles loaded with docetaxel and polyethyleneimine modified on the mesoporous silica nanoparticles; culturing the pretreated raw material in a cartilage organoid induction culture medium containing docetaxel; wherein the raw material to be cultured contains bone marrow mesenchymal stem cells. The articular cartilage organoids prepared by this method have a distinct cartilage-bone bio-interface, and the pretreatment process can help maintain the long-term phenotype of the cartilage organoids by inhibiting endochondral ossification during their development.

The utility model relates to the technical field of medical instruments, in particular to an osteotome and a device for orthopedic surgery, the osteotome is used for cutting off end plates or cartilages, the osteotome comprises a blade and a handle, the blade is an annular blade with a hollow middle part, an inclined surface inclined towards the hollow middle part is formed on the inner wall of the blade, and the inclined surface is intersected with the outer side wall of the blade to form an annular cutting blade. The osteotome can be used for excising end plates and cartilages, during one-way rotary excision, the middle of the annular cutting edge is hollowed out, tissue chips can be discharged easily, the annular cutting edge formed by intersecting the inclined face and the outer side wall of the cutting edge is sharp, the excising efficiency of the end plates and the cartilages is effectively improved, the operation time is greatly shortened, and the operation efficiency is improved. And the potential risk caused by overlong operation time is reduced. According to the device for the orthopedic surgery, the transmission shaft is connected with the external motor, the external motor rotates to drive the transmission shaft to do one-way rotation motion, and then the cutting edge is driven to do one-way rotation motion to cut off an end plate or cartilage.