Artificial rotator cuff patch capable of inducing tendon-bone gradient structure formation and preparation method thereof

Abstract

The invention belongs to the technical field of surgical patches, and provides an artificial rotator cuff patch capable of inducing tendon-bone gradient structure formation and a preparation method thereof. The method comprises the following steps: selecting PET yarns as an inner layer and a gelatin solution in which CTGF, KGN and induction factors of nano-hydroxyapatite are respectively dispersedas an outer layer; spraying the gelatin solution onto the PET yarns by using an electrostatic spinning technology so as to obtian CTGF yarns, KGN yarns and nano hydroxyapatite yarns, wherein the three kinds of yarns are all nanofiber yarns with a double-layer structure; and then performing weaving according to the direction of CTGF-KGN-nano hydroxyapatite to obtain a nanofiber yarn stent with a knitted double-layer structure, namely the artificial rotator cuff patch capable of inducing the formation of a tendon-bone gradient structure. The preparation method of the artificial rotator cuff patch capable of inducing formation of the tendon-bone gradient structure is simple, and the obtained three-section artificial rotator cuff patch can promote formation of the tendon-fibrous cartilage-bone gradient structure, and has good mechanical properties, biocompatibility and clinical application prospects.

Description

technical field [0001] The invention belongs to the technical field of surgical patches, and in particular relates to an artificial rotator cuff patch capable of inducing the formation of a tendon-bone gradient structure and a preparation method thereof. Background technique [0002] The rotator cuff is an important structure that supports and stabilizes the glenohumeral joint, and plays an important role in maintaining the sealing function of the shoulder joint cavity, maintaining the synovial fluid to nourish the articular cartilage, and preventing secondary osteoarthritis. Rotator cuff tear is a common shoulder joint disease, and the incidence rate gradually increases with age. Rotator cuff tear is a common cause of shoulder joint pain, reduced mobility, and reduced function, accounting for about 60% of shoulder lesions. For patients who fail conservative treatment and patients with large rotator cuff injuries, surgery is usually required to repair the torn rotator cuff,...

AI Technical Summary

Problems solved by technology

The autograft materials are mainly derived from the fascia lata and the long head tendon of the biceps brachii, etc. The biggest advantage is that it has good biocompatibility, but it will cause additional trauma when the materials are taken, resulting in damage to the donor site.

Allogeneic tissue graft materials are usually derived from allogeneic rotator cuff, tibialis anterior tendon, patellar tendon, Achilles tendon, etc. Although the postoperative range of motion and muscle strength of the shoulder joint are significantly improved, they lack stable mechanical strength and are prone to failure after transplantation. Immune rejection, risk of infection, and limited sources

Decellularized tissue grafts mainly include xenogeneic tissue transplantation and allogeneic tissue transplantation, such as animal dermis, small intestine, pericardium, etc., using inherent collagen, non-collagen, and three-dimensional structures as scaffolds to pr

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