9 results about "Biomechanical strength" patented technology

The invention belongs to the technical field of bone tissue storage, and particularly relates to a storage device and method for keeping the biomechanical strength of bone tissue, and the storage device comprises a storage barrel used for placing the bone tissue; a sealing cover is detachably installed at the top of the storage tank, and a fixing pipe used for injecting liquid nitrogen is fixed to the outer wall of the storage tank; the supporting plate is fixed into the storage tank, an inner cavity of the storage tank is divided into a containing cavity and a liquid nitrogen cavity from top to bottom through the supporting plate, a first through groove is formed in the supporting plate, and cold air generated by liquid nitrogen evaporation is introduced into the containing cavity through the first through groove so as to conduct low-temperature storage on the storage barrel; by arranging the gas recovery assembly, cold air is recovered into the liquid nitrogen cavity before the storage barrel is taken out, and cold air leakage is effectively avoided in the process of taking out the storage barrel, so that resources are saved, and people are prevented from being hurt due to cold air leakage; the bone tissue is stored through the device and the method, and the biomechanical strength of the bone tissue can be kept to the maximum extent.

The invention discloses a composite artificial cavity / membrane tissue and a preparation method thereof. The composite artificial cavity / membrane tissue is formed by compounding a synthetic high-molecular material and a natural high-molecular biological material, and the synthetic high-molecular material is selected from more than one of silicone, synthetic high-molecular hydrogel and an acrylic polymer. The natural polymer biological material is selected from more than one of an acellular matrix scaffold material, a non-acellular matrix and non-acellular collagen. The composite artificial cavity / membrane tissue provided by the invention has the advantages of good healing after transplantation, high biomechanical strength, low immunogenicity, smooth surface and the like.

The utility model discloses an implantable lumbosacroiliac joint fixing screw, and relates to the technical field of medical instruments. In order to solve the problem that no special internal fixing device for recovering the stability of the pelvic posterior ring and the lumbar iliac area of a patient exists in the prior art, the following technical scheme is provided: the internal fixing device comprises a screw body and a joint locking piece movably connected to the screw body, and a first external thread is arranged at the front end of the screw body; a plurality of self-tapping grooves are formed in the outer end of the first external thread in the circumferential direction, a bone grafting cavity penetrating through the screw body is formed in the middle of the screw body, and the joint locking piece is arranged in the bone grafting cavity. The joint locking piece comprises a base, supporting rods and locking ends, the base is connected to the rear end of the bone grafting cavity, the supporting rods are symmetrically arranged on the base, and the locking ends are arranged at the tops of the supporting rods and extend towards the two ends of the supporting rods. The utility model has the advantages of small trauma, small intraoperative bleeding, short operation time, relatively simple operation, fast postoperative recovery and satisfactory biomechanical strength.

The application provides application of uterine mesenchymal stem cell exosomes in preparation of drugs for preventing and treating osteoporosis, and belongs to the technical field of biological medicine. The uterine mesenchymal stem cell-derived exosomes provided by the application have extremely low immunogenicity and good biological safety, avoid the immune rejection and adverse reactions possibly caused by traditional drugs or cell therapy, can be effectively targeted to the skeletal system, especially the diseased bone marrow microenvironment, and realize precise drug delivery; the exosomes not only can effectively increase bone density and improve bone microstructure, but also can improve the biomechanical strength of the skeleton, significantly reduce the risk of fracture; in addition, the preparation process is mature and stable, and as a natural cell-free therapeutic product, the exosomes avoid the ethical and safety concerns related to live cell transplantation, and provide a new strategy with great clinical application potential for the prevention and treatment of osteoporosis.

A design method of a Paporosky III-type acetabular defect reconstruction prosthesis comprises the following steps: acquiring pelvic CT images of a defective side and an uninjured side, constructing a three-dimensional pelvic model according to the pelvic CT image of the defective side, and finally adding a bone grafting cage on the surface of a prosthesis model in a second prosthesis optimization model through other eight steps to obtain the Paporosky III-type acetabular defect reconstruction prosthesis. The prosthesis designed by the design method of the Paporosky III type acetabular defect reconstruction prosthesis can reduce tissue irritation and trauma, and has the advantages of upward movement resistance, rotation resistance, high biomechanical strength, initial stability and good long-term stability.

The present invention belongs to the technical field of bone tissue storage, and specifically relates to a storage device and method for maintaining the biomechanical strength of bone tissue, comprising: a storage barrel for storing bone tissue; a storage tank, a sealing cover being detachably mounted on the top of the storage tank, a fixed tube for injecting liquid nitrogen being fixed on the outer wall of the storage tank; a support plate, the support plate being fixed inside the storage tank, the support plate dividing the inner cavity of the storage tank from top to bottom into a storage cavity and a liquid nitrogen cavity by the support plate, a through groove one being provided on the support plate, cold air generated by evaporation of liquid nitrogen being introduced into the storage cavity through the through groove one to store the storage barrel at a low temperature; the present invention recovers the cold air into the liquid nitrogen cavity before removing the storage barrel by arranging a gas recovery component, effectively avoiding leakage of cold air during the process of removing the storage barrel, thereby saving resources and preventing injury from cold air leakage; bone tissue can be stored by using the device and method to maintain the biomechanical strength of the bone tissue to the maximum extent.

The invention relates to a solid or liquid biological material and a preparation method thereof, and belongs to the technical field of biology. The invention provides a method for preparing a biological material, which comprises the following steps: dissolving collagen, collagen-like protein, collagen freeze-dried powder and / or collagen-like freeze-dried powder in a buffer solution, and dissolving auxiliary materials in the buffer solution to obtain a dissolved solution; performing pre-crosslinking on the dissolving solution and then performing crosslinking to obtain the biological material. When the biological material is a solid-state biological material, the method can properly improve the biomechanical strength and light transmittance of the solid-state biological material on the basis of not obviously influencing the water content of the solid-state biological material. When the biological material is a liquid biological material, the method can properly improve the bursting pressure of the liquid biological material on the basis of keeping the high light transmission of the implant bed and the implant, so that the liquid biological material can resist intraocular pressure and has the effect of promoting wound healing in eyes.

The present application relates to a solid or liquid biological material and a preparation method therefor, pertaining to the technical field of biology. The present application provides a method for preparing a biological material. The method comprises: dissolving collagen, a collagen-like protein, a collagen freeze-dried powder, and / or a collagen-like protein freeze-dried powder in a buffer solution, and dissolving an auxiliary material in the buffer solution to obtain a dissolution solution; and subjecting the dissolution solution to pre-crosslinking, followed by crosslinking to obtain the biological material. When the biological material is a solid biological material, the method can properly improve the biomechanical strength and light transmittance of the solid biological material without significantly affecting the water content of the solid biological material. When the biological material is a liquid biological material, the method can properly improve the rupture pressure of the liquid biological material while maintaining high light transmittance of the graft bed and graft, so that the liquid biological material can withstand intraocular pressure and play a role in promoting wound healing in the eye.

The invention discloses application of deaminotyrosine in preparation of a medicine for preventing and / or treating osteoporosis, and belongs to the technical field of medicines. In-vitro cell experiments and in-vivo animal model experiments prove that the deaminotyrosine can remarkably promote proliferation and differentiation of osteoblasts and inhibit generation and activity of osteoclasts, so that the bone density is effectively increased, the bone microstructure is improved, and the bone biomechanical strength is improved. The invention provides a brand-new, safe and effective candidate medicine for preventing and treating osteoporosis.