5 results about "Biomechanical strength" patented technology

The invention discloses a composite artificial cavity / membrane tissue and a preparation method thereof. The composite artificial cavity / membrane tissue is formed by compounding a synthetic high-molecular material and a natural high-molecular biological material, and the synthetic high-molecular material is selected from more than one of silicone, synthetic high-molecular hydrogel and an acrylic polymer. The natural polymer biological material is selected from more than one of an acellular matrix scaffold material, a non-acellular matrix and non-acellular collagen. The composite artificial cavity / membrane tissue provided by the invention has the advantages of good healing after transplantation, high biomechanical strength, low immunogenicity, smooth surface and the like.

The application provides application of uterine mesenchymal stem cell exosomes in preparation of drugs for preventing and treating osteoporosis, and belongs to the technical field of biological medicine. The uterine mesenchymal stem cell-derived exosomes provided by the application have extremely low immunogenicity and good biological safety, avoid the immune rejection and adverse reactions possibly caused by traditional drugs or cell therapy, can be effectively targeted to the skeletal system, especially the diseased bone marrow microenvironment, and realize precise drug delivery; the exosomes not only can effectively increase bone density and improve bone microstructure, but also can improve the biomechanical strength of the skeleton, significantly reduce the risk of fracture; in addition, the preparation process is mature and stable, and as a natural cell-free therapeutic product, the exosomes avoid the ethical and safety concerns related to live cell transplantation, and provide a new strategy with great clinical application potential for the prevention and treatment of osteoporosis.

The invention relates to a solid or liquid biological material and a preparation method thereof, and belongs to the technical field of biology. The invention provides a method for preparing a biological material, which comprises the following steps: dissolving collagen, collagen-like protein, collagen freeze-dried powder and / or collagen-like freeze-dried powder in a buffer solution, and dissolving auxiliary materials in the buffer solution to obtain a dissolved solution; performing pre-crosslinking on the dissolving solution and then performing crosslinking to obtain the biological material. When the biological material is a solid-state biological material, the method can properly improve the biomechanical strength and light transmittance of the solid-state biological material on the basis of not obviously influencing the water content of the solid-state biological material. When the biological material is a liquid biological material, the method can properly improve the bursting pressure of the liquid biological material on the basis of keeping the high light transmission of the implant bed and the implant, so that the liquid biological material can resist intraocular pressure and has the effect of promoting wound healing in eyes.

The present application relates to a solid or liquid biological material and a preparation method therefor, pertaining to the technical field of biology. The present application provides a method for preparing a biological material. The method comprises: dissolving collagen, a collagen-like protein, a collagen freeze-dried powder, and / or a collagen-like protein freeze-dried powder in a buffer solution, and dissolving an auxiliary material in the buffer solution to obtain a dissolution solution; and subjecting the dissolution solution to pre-crosslinking, followed by crosslinking to obtain the biological material. When the biological material is a solid biological material, the method can properly improve the biomechanical strength and light transmittance of the solid biological material without significantly affecting the water content of the solid biological material. When the biological material is a liquid biological material, the method can properly improve the rupture pressure of the liquid biological material while maintaining high light transmittance of the graft bed and graft, so that the liquid biological material can withstand intraocular pressure and play a role in promoting wound healing in the eye.

The invention discloses application of deaminotyrosine in preparation of a medicine for preventing and / or treating osteoporosis, and belongs to the technical field of medicines. In-vitro cell experiments and in-vivo animal model experiments prove that the deaminotyrosine can remarkably promote proliferation and differentiation of osteoblasts and inhibit generation and activity of osteoclasts, so that the bone density is effectively increased, the bone microstructure is improved, and the bone biomechanical strength is improved. The invention provides a brand-new, safe and effective candidate medicine for preventing and treating osteoporosis.